{"text_format":"3","workbook":"xls","n_sheets":1,"sheets":["Sheet1"],"not_rendered":{"external_links":1,"defined_names":1},"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Sheet1","index":0,"n_rows":656,"n_cols":39,"rows_kept":656,"flags":["formulas_cached_only"]}
["Gene","L1_count","L2_count","L3_count","baseMean","B1_count","B2_count","B3_count","Log2FoldChange","pval","padj","Up/Down","Significant","Location","Source_Gene","NR:Seq-id","NR:Score","NR:Evalue","NR:Description","NT:Seq-id","NT:Score","NT:Evalue","NT:Description","Uniprot:UniProtKB-AC","Uniprot:Score","Uniprot:Evalue","Uniprot:Description","COG:gene","COG:Score","COG:Eval","COG:num","Pfam:pfam_ID","Pfam:pfam_Name","Pfam:pfam_Description","GO:biological_process","GO:cellular_component","GO:molecular_function","KEGG:KO","KEGG:Description"]
["bta_circ_0000016",0,13,10,2.5082105424752,0,0,0,4.53021958935948,0.0220794409319204,"NA","up","Z","NC_037328.1:106576649..106705966:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0000047",13,77,51,58.0061247294525,34,169,60,-1.16051605217253,0.0361836576857628,0.439730132358439,"down","yes","NC_037328.1:108898153..108900630:-","gene889","gi|742117911|ref|XP_010838158.1|",3858,0,"PREDICTED: elongation factor G, mitochondrial [Bison bison bison]","gi|329663784|ref|NM_001206149.1|",3416,0,"Bos taurus G elongation factor, mitochondrial 1 (GFM1), mRNA","Q07803",1405,0,"Elongation factor G, mitochondrial","YLR069c",780,0,"COG0480","pfam00009","GTP_EFTU","Elongation factor Tu GTP binding domain. This domain contains a P-loop motif, also found in several other families such as pfam00071, pfam00025 and pfam00063. Elongation factor Tu consists of three structural domains, this plus two C-terminal beta barrel domains.","GO:0070125|mitochondrial translational elongation;","GO:0005739|mitochondrion;","GO:0005525|GTP binding;GO:0003924|GTPase activity;GO:0003746|translation elongation factor activity;","K02355","fusA, GFM, EFG; elongation factor G"]
["bta_circ_0000097",0,0,0,3.09550173466491,0,10,10,-4.94174503039084,0.0103776379900976,"NA","down","yes","NC_037328.1:126274923..126298301:-","gene1035","gi|528937692|ref|XP_005201902.1|",4094,0,"PREDICTED: short transient receptor potential channel 1 isoform X1 [Bos taurus]","gi|982911784|ref|XM_005201845.3|",4148,0,"PREDICTED: Bos taurus transient receptor potential cation channel, subfamily C, member 1 (TRPC1), transcript variant X1, mRNA","P48995",1518,0,"Short transient receptor potential channel 1",".",".",".",".","pfam08344","TRP_2","Transient receptor ion channel II. This domain is found in the transient receptor ion channel (Trp) family of proteins. There is strong evidence that Trp proteins are structural elements of calcium-ion entry channels activated by G protein-coupled receptors. This domain does not tend to appear with the TRP domain (pfam06011) but is often found to the C-terminus of Ankyrin repeats (pfam00023).","GO:0070588|calcium ion transmembrane transport;GO:0006816|calcium ion transport;GO:0006828|manganese ion transport;GO:0042438|melanin biosynthetic process;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:1903779|regulation of cardiac conduction;GO:0051480|cytosolic calcium ion homeostasis;GO:0051592|response to calcium ion;","GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;GO:0043235|receptor complex;","GO:0005262|calcium channel activity;GO:0005261|cation channel activity;GO:0070679|inositol 1,4,5 trisphosphate binding;GO:0044325|ion channel binding;GO:0015279|store-operated calcium channel activity;","K04964","TRPC1; transient receptor potential cation channel subfamily C member 1"]
["bta_circ_0000125",50,504,376,142.821259045687,47,85,62,1.75840171771868,0.000231768788355878,0.0225462640500222,"up","yes","NC_037328.1:126977498..126984860:+","gene1042","gi|528937716|ref|XP_005201914.1|",1606,0,"PREDICTED: transcription factor Dp-2 isoform X5 [Bos taurus]","gi|982911818|ref|XM_015473189.1|",7353,0,"PREDICTED: Bos taurus transcription factor Dp-2 (E2F dimerization partner 2) (TFDP2), transcript variant X11, mRNA","Q14188",603,0,"Transcription factor Dp-2",".",".",".",".","pfam08781","DP","Transcription factor DP. DP forms a heterodimer with E2F and regulates genes involved in cell cycle progression. The transcriptional activity of E2F is inhibited by the retinoblastoma protein which binds to the E2F-DP heterodimer and negatively regulates the G1-S transition.","GO:0006977|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007507|heart development;GO:0070317|negative regulation of G0 to G1 transition;GO:0045892|negative regulation of transcription, DNA-templated;GO:1900740|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0000083|regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0006366|transcription from RNA polymerase II promoter;","GO:0005739|mitochondrion;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0090575|RNA polymerase II transcription factor complex;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0019904|protein domain specific binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003712|transcription cofactor activity;GO:0008134|transcription factor binding;","K09392","TFDP2; transcription factor Dp-2"]
["bta_circ_0000141",0,0,0,2.19369518242872,3,9,2,-4.5716114138243,0.0192885541142555,"NA","down","yes","NC_037328.1:130387365..130407755:+","gene1084","gi|329665037|ref|NP_001192976.1|",5534,0,"phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [Bos taurus]","gi|742195426|ref|XM_010858211.1|",4651,0,"PREDICTED: Bison bison bison phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta (PIK3CB), mRNA","P42338",2047,0,"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform","SPAC458.05",191,{"v":4e-49,"d":"4.00E-49"},"COG5032","pfam00613","PI3Ka","Phosphoinositide 3-kinase family, accessory domain (PIK domain). PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation.","GO:0000187|activation of MAPK activity;GO:0002250|adaptive immune response;GO:0060055|angiogenesis involved in wound healing;GO:0006914|autophagy;GO:0007411|axon guidance;GO:0060326|cell chemotaxis;GO:0016477|cell migration;GO:0006874|cellular calcium ion homeostasis;GO:0006935|chemotaxis;GO:0019221|cytokine-mediated signaling pathway;GO:0040016|embryonic cleavage;GO:0001935|endothelial cell proliferation;GO:0038095|Fc-epsilon receptor signaling pathway;GO:0038096|Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0007186|G-protein coupled receptor signaling pathway;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0006954|inflammatory response;GO:0045087|innate immune response;GO:0050900|leukocyte migration;GO:0014065|phosphatidylinositol 3-kinase signaling;GO:0048015|phosphatidylinositol-mediated signaling;GO:0016310|phosphorylation;GO:0030168|platelet activation;GO:0070527|platelet aggregation;GO:0010508|positive regulation of autophagy;GO:0010628|positive regulation of gene expression;GO:0033031|positive regulation of neutrophil apoptotic process;GO:0051897|positive regulation of protein kinase B signaling;GO:0001952|regulation of cell-matrix adhesion;GO:2000369|regulation of clathrin-mediated endocytosis;GO:0007165|signal transduction;GO:0050852|T cell receptor signaling pathway;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0048010|vascular endothelial growth factor receptor signaling pathway;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0030496|midbody;GO:0005730|nucleolus;GO:0005634|nucleus;GO:0005942|phosphatidylinositol 3-kinase complex;GO:0005886|plasma membrane;","GO:0016303|1-phosphatidylinositol-3-kinase activity;GO:0035005|1-phosphatidylinositol-4-phosphate 3-kinase activity;GO:0005524|ATP binding;GO:0043560|insulin receptor substrate binding;GO:0016301|kinase activity;GO:0035004|phosphatidylinositol 3-kinase activity;GO:0046934|phosphatidylinositol-4,5-bisphosphate 3-kinase activity;","K00922","PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]"]
["bta_circ_0000146",4,10,0,2.13222964447117,0,0,0,4.20703017064327,0.0372259441361834,"NA","up","yes","NC_037328.1:130560930..130592231:+","gene1087","gi|742195444|ref|XP_010856516.1|",2721,0,"PREDICTED: centrosomal protein of 70 kDa isoform X1 [Bison bison bison]","gi|982976735|ref|XM_010824426.2|",3588,0,"PREDICTED: Bos taurus centrosomal protein 70kDa (CEP70), transcript variant X3, mRNA","Q5RDE3",892,0,"Centrosomal protein of 70 kDa",".",".",".",".","pfam10211","Ax_dynein_light","Axonemal dynein light chain. Axonemal dynein light chain proteins play a dynamic role in flagellar and cilia motility. Eukaryotic cilia and flagella are complex organelles consisting of a core structure, the axoneme, which is composed of nine microtubule doublets forming a cylinder that surrounds a pair of central singlet microtubules. This ultra-structural arrangement seems to be one of the most stable micro-tubular assemblies known and is responsible for the flagellar and ciliary movement of a large number of organisms ranging from protozoan to mammals. This light chain interacts directly with the N-terminal half of the heavy chains.","GO:0060271|cilium morphogenesis;GO:0070507|regulation of microtubule cytoskeleton organization;","GO:0005813|centrosome;GO:0005737|cytoplasm;","GO:0043015|gamma-tubulin binding;","K16802","CEP70; centrosomal protein CEP70"]
["bta_circ_0000147",0,0,0,5.51779564221933,15,8,7,-5.91837529088317,0.000946004936009513,"NA","down","yes","NC_037328.1:130560930..130595112:+","gene1087","gi|742195444|ref|XP_010856516.1|",2721,0,"PREDICTED: centrosomal protein of 70 kDa isoform X1 [Bison bison bison]","gi|982976735|ref|XM_010824426.2|",3588,0,"PREDICTED: Bos taurus centrosomal protein 70kDa (CEP70), transcript variant X3, mRNA","Q5RDE3",892,0,"Centrosomal protein of 70 kDa",".",".",".",".","pfam10211","Ax_dynein_light","Axonemal dynein light chain. Axonemal dynein light chain proteins play a dynamic role in flagellar and cilia motility. Eukaryotic cilia and flagella are complex organelles consisting of a core structure, the axoneme, which is composed of nine microtubule doublets forming a cylinder that surrounds a pair of central singlet microtubules. This ultra-structural arrangement seems to be one of the most stable micro-tubular assemblies known and is responsible for the flagellar and ciliary movement of a large number of organisms ranging from protozoan to mammals. This light chain interacts directly with the N-terminal half of the heavy chains.","GO:0060271|cilium morphogenesis;GO:0070507|regulation of microtubule cytoskeleton organization;","GO:0005813|centrosome;GO:0005737|cytoplasm;","GO:0043015|gamma-tubulin binding;","K16802","CEP70; centrosomal protein CEP70"]
["bta_circ_0000152",4,83,131,34.1849580676842,16,22,12,1.574262846211,0.0324997754886413,0.428634275476763,"up","yes","NC_037328.1:130571851..130596464:+","gene1087","gi|742195444|ref|XP_010856516.1|",2721,0,"PREDICTED: centrosomal protein of 70 kDa isoform X1 [Bison bison bison]","gi|982976735|ref|XM_010824426.2|",3588,0,"PREDICTED: Bos taurus centrosomal protein 70kDa (CEP70), transcript variant X3, mRNA","Q5RDE3",892,0,"Centrosomal protein of 70 kDa",".",".",".",".","pfam10211","Ax_dynein_light","Axonemal dynein light chain. Axonemal dynein light chain proteins play a dynamic role in flagellar and cilia motility. Eukaryotic cilia and flagella are complex organelles consisting of a core structure, the axoneme, which is composed of nine microtubule doublets forming a cylinder that surrounds a pair of central singlet microtubules. This ultra-structural arrangement seems to be one of the most stable micro-tubular assemblies known and is responsible for the flagellar and ciliary movement of a large number of organisms ranging from protozoan to mammals. This light chain interacts directly with the N-terminal half of the heavy chains.","GO:0060271|cilium morphogenesis;GO:0070507|regulation of microtubule cytoskeleton organization;","GO:0005813|centrosome;GO:0005737|cytoplasm;","GO:0043015|gamma-tubulin binding;","K16802","CEP70; centrosomal protein CEP70"]
["bta_circ_0000182",10,96,26,19.2750548526042,3,15,7,1.91598281289755,0.014048781704745,0.298906981742218,"up","yes","NC_037328.1:133198529..133204662:-","gene1117","gi|528937873|ref|XP_005201978.1|",5952,0,"PREDICTED: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [Bos taurus]","gi|982976750|ref|XM_015462140.1|",6657,0,"PREDICTED: Bos taurus protein phosphatase 2 regulatory subunit B'', alpha (PPP2R3A), transcript variant X4, mRNA","Q06190",2065,0,"Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha",".",".",".",".","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0001754|eye photoreceptor cell differentiation;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:0045732|positive regulation of protein catabolic process;GO:0006470|protein dephosphorylation;GO:0090249|regulation of cell motility involved in somitogenic axis elongation;GO:0007525|somatic muscle development;GO:0061053|somite development;GO:0090244|Wnt signaling pathway involved in somitogenesis;","GO:0000159|protein phosphatase type 2A complex;","GO:0005509|calcium ion binding;GO:0030674|protein binding, bridging;GO:0019888|protein phosphatase regulator activity;","K11583","PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B''"]
["bta_circ_0000219",0,0,0,2.12330279077099,0,8,6,-4.37241338018326,0.0285190567515153,"NA","down","yes","NC_037328.1:137148527..137163971:-","gene1149","gi|166091511|ref|NP_001107217.1|",11443,0,"dnaJ homolog subfamily C member 13 [Bos taurus]","gi|982912076|ref|XM_005201940.3|",7808,0,"PREDICTED: Bos taurus DnaJ heat shock protein family (Hsp40) member C13 (DNAJC13), transcript variant X1, mRNA","O75165",4326,0,"DnaJ homolog subfamily C member 13","PA4760",54.7,{"v":2e-06,"d":"2.00E-06"},"COG0484","pfam00226","DnaJ","DnaJ domain. DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.","GO:0007032|endosome organization;GO:0043312|neutrophil degranulation;GO:0001649|osteoblast differentiation;GO:0015031|protein transport;GO:0006898|receptor-mediated endocytosis;GO:2000641|regulation of early endosome to late endosome transport;GO:1902954|regulation of early endosome to recycling endosome transport;","GO:0035577|azurophil granule membrane;GO:0005829|cytosol;GO:0031901|early endosome membrane;GO:0010008|endosome membrane;GO:0070062|extracellular exosome;GO:0043231|intracellular membrane-bounded organelle;GO:0005765|lysosomal membrane;GO:0016020|membrane;GO:0005886|plasma membrane;GO:0030667|secretory granule membrane;",".","K09533","DNAJC13; DnaJ homolog subfamily C member 13"]
["bta_circ_0000228",0,0,0,1.81918092113124,6,4,0,-4.0955899082643,0.0435962346374214,"NA","down","yes","NC_037328.1:139235494..139257733:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0000239",7,5,0,2.53896692949002,0,0,0,4.41329739412458,0.0269831608562091,"NA","up","yes","NC_037328.1:139296447..139301216:-","gene1167","gi|157041264|ref|NP_001096644.1|",10890,0,"bromodomain and WD repeat-containing protein 1 [Bos taurus]","gi|594061479|ref|XM_006054758.1|",9329,0,"PREDICTED: Bubalus bubalis bromodomain and WD repeat domain containing 1 (BRWD1), partial mRNA","Q9NSI6",3717,0,"Bromodomain and WD repeat-containing protein 1","all0283_3",129,{"v":4e-29,"d":"4.00E-29"},"COG2319","pfam00439","Bromodomain","Bromodomain. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.","GO:0006325|chromatin organization;GO:0007010|cytoskeleton organization;GO:0038111|interleukin-7-mediated signaling pathway;GO:0008360|regulation of cell shape;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0006351|transcription, DNA-templated;","GO:0005829|cytosol;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;",".","K11798","BRWD1_3; bromodomain and WD repeat domain containing protein 1/3"]
["bta_circ_0000268",0,22,12,20.1488405085942,22,41,36,-2.00456665301899,0.009964414720932,0.250500751472732,"down","yes","NC_037328.1:145016085..145029722:+","gene1264","gi|528900172|ref|XP_005196052.1|",3520,0,"PREDICTED: double-stranded RNA-specific editase 1 isoform X1 [Bos taurus]","gi|982976892|ref|XM_005195995.3|",6723,0,"PREDICTED: Bos taurus adenosine deaminase, RNA-specific, B1 (ADARB1), transcript variant X1, mRNA","Q91ZS8",1176,0,"Double-stranded RNA-specific editase 1",".",".",".",".","pfam02137","A_deamin","Adenosine-deaminase (editase) domain. Adenosine deaminases acting on RNA (ADARs) can deaminate adenosine to form inosine. In long double-stranded RNA, this process is non-specific; it occurs site-specifically in RNA transcripts. The former is important in defence against viruses, whereas the latter may affect splicing or untranslated regions. They are primarily nuclear proteins, but a longer isoform of ADAR1 is found predominantly in the cytoplasm. ADARs are derived from the Tad1-like tRNA deaminases that are present across eukaryotes. These in turn belong to the nucleotide/nucleic acid deaminase superfamily and are characterized by a distinct insert between the two conserved cysteines that are involved in binding zinc.","GO:0006382|adenosine to inosine editing;GO:0016553|base conversion or substitution editing;GO:0021610|facial nerve morphogenesis;GO:0021618|hypoglossal nerve morphogenesis;GO:0060384|innervation;GO:0097049|motor neuron apoptotic process;GO:0016556|mRNA modification;GO:0006397|mRNA processing;GO:0035264|multicellular organism growth;GO:0060415|muscle tissue morphogenesis;GO:0030336|negative regulation of cell migration;GO:0008285|negative regulation of cell proliferation;GO:0044387|negative regulation of protein kinase activity by regulation of protein phosphorylation;GO:0050884|neuromuscular process controlling posture;GO:0007274|neuromuscular synaptic transmission;GO:0050685|positive regulation of mRNA processing;GO:0045070|positive regulation of viral genome replication;GO:0051726|regulation of cell cycle;GO:0006396|RNA processing;GO:0021965|spinal cord ventral commissure morphogenesis;","GO:0005829|cytosol;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003726|double-stranded RNA adenosine deaminase activity;GO:0003725|double-stranded RNA binding;GO:0046872|metal ion binding;GO:0042803|protein homodimerization activity;GO:0003723|RNA binding;","K13194","ADARB; double stranded RNA-specific editase B [EC:3.5.-.-]"]
["bta_circ_0000270",0,10,7,1.84160269601273,0,0,0,4.07438527654215,0.0452393392201481,"NA","up","yes","NC_037328.1:145907725..145914383:-","gene1279","gi|296490842|tpg|DAA32955.1|",3938,0,"TPA: lanosterol synthase [Bos taurus]","gi|942074350|ref|XM_005902331.2|",3715,0,"PREDICTED: Bos mutus lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) (LSS), transcript variant X1, mRNA","P84466",1490,0,"Lanosterol synthase","YHR072w",529,{"v":2e-168,"d":"2.00E-168"},"COG1657","pfam13249","Prenyltrans_2","Prenyltransferase-like.","GO:0006694|steroid biosynthetic process;","GO:0005789|endoplasmic reticulum membrane;","GO:0000250|lanosterol synthase activity;","K01852","E5.4.99.7, LSS, ERG7; lanosterol synthase [EC:5.4.99.7]"]
["bta_circ_0000281",0,0,0,1.78912440569359,4,7,0,-4.08821352533039,0.044054743333277,"NA","down","yes","NC_037328.1:146321517..146327298:+","gene1288","gi|594638803|ref|XP_007172684.1|",2297,0,"PREDICTED: protein arginine N-methyltransferase 2 isoform X1 [Balaenoptera acutorostrata scammoni]","gi|594045231|ref|XM_006047032.1|",2012,0,"PREDICTED: Bubalus bubalis protein arginine methyltransferase 2 (PRMT2), mRNA","P55345",774,0,"Protein arginine N-methyltransferase 2","YBR034c",214,{"v":2e-61,"d":"2.00E-61"},"COG0500","pfam14604","SH3_9","Variant SH3 domain.","GO:0048588|developmental cell growth;GO:0016571|histone methylation;GO:2000134|negative regulation of G1/S transition of mitotic cell cycle;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0045892|negative regulation of transcription, DNA-templated;GO:0043065|positive regulation of apoptotic process;GO:0045893|positive regulation of transcription, DNA-templated;GO:0006479|protein methylation;GO:0060765|regulation of androgen receptor signaling pathway;GO:0007165|signal transduction;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0050681|androgen receptor binding;GO:0030331|estrogen receptor binding;GO:0042054|histone methyltransferase activity;GO:0008469|histone-arginine N-methyltransferase activity;GO:0042975|peroxisome proliferator activated receptor binding;GO:0033142|progesterone receptor binding;GO:0042803|protein homodimerization activity;GO:0016274|protein-arginine N-methyltransferase activity;GO:0035242|protein-arginine omega-N asymmetric methyltransferase activity;GO:0042974|retinoic acid receptor binding;GO:0046966|thyroid hormone receptor binding;GO:0003713|transcription coactivator activity;","K11435","PRMT2; protein arginine N-methyltransferase 2 [EC:2.1.1.-]"]
["bta_circ_0000310",0,0,0,2.04484679488321,5,2,4,-4.4433305089876,0.0240246503185103,"NA","down","yes","NC_037328.1:149360754..149399212:+","gene1322","gi|931715870|ref|NP_001103237.2|",9667,0,"E3 ubiquitin-protein ligase TTC3 [Bos taurus]","gi|931715869|ref|NM_001109767.3|",7356,0,"Bos taurus tetratricopeptide repeat domain 3 (TTC3), mRNA","P53804",2950,0,"E3 ubiquitin-protein ligase TTC3",".",".",".",".","pfam13414","TPR_11","TPR repeat.","GO:0070936|protein K48-linked ubiquitination;GO:0006511|ubiquitin-dependent protein catabolic process;","GO:0005829|cytosol;GO:0005730|nucleolus;GO:0005634|nucleus;","GO:0046872|metal ion binding;GO:0004842|ubiquitin-protein transferase activity;","K15712","TTC3; E3 ubiquitin-protein ligase TTC3 [EC:2.3.2.27]"]
["bta_circ_0000415",0,0,0,1.87065310090543,5,6,0,-4.15306280682625,0.0400339162609007,"NA","down","yes","NC_037328.1:2881166..2893638:+","gene58","gi|741912810|ref|XP_005201143.2|",7231,0,"PREDICTED: synaptojanin-1 isoform X1 [Bos taurus]","gi|982909318|ref|XM_005201086.3|",6939,0,"PREDICTED: Bos taurus synaptojanin 1 (SYNJ1), transcript variant X1, mRNA","O43426",2527,0,"Synaptojanin-1","YNL106c_2",237,{"v":2e-64,"d":"2.00E-64"},"COG5411","pfam02383","Syja_N","SacI homology domain. This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.","GO:0046855|inositol phosphate dephosphorylation;GO:0043647|inositol phosphate metabolic process;GO:0007612|learning;GO:0061024|membrane organization;GO:0006836|neurotransmitter transport;GO:0006661|phosphatidylinositol biosynthetic process;GO:0046856|phosphatidylinositol dephosphorylation;GO:0046488|phosphatidylinositol metabolic process;GO:0048488|synaptic vesicle endocytosis;GO:0016082|synaptic vesicle priming;GO:0048489|synaptic vesicle transport;GO:0016191|synaptic vesicle uncoating;","GO:0030132|clathrin coat of coated pit;GO:0005829|cytosol;GO:0030117|membrane coat;GO:0048471|perinuclear region of cytoplasm;GO:0098793|presynapse;GO:0097060|synaptic membrane;GO:0043195|terminal bouton;GO:0012506|vesicle membrane;","GO:0052659|inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity;GO:0052658|inositol-1,4,5-trisphosphate 5-phosphatase activity;GO:0034596|phosphatidylinositol phosphate 4-phosphatase activity;GO:0034595|phosphatidylinositol phosphate 5-phosphatase activity;GO:0052629|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity;GO:0043813|phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity;GO:0004438|phosphatidylinositol-3-phosphatase activity;GO:0004439|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0043812|phosphatidylinositol-4-phosphate phosphatase activity;GO:0003723|RNA binding;",".","."]
["bta_circ_0000421",0,0,0,2.88083231651674,6,8,3,-4.98805599866004,0.0086214345109878,"NA","down","yes","NC_037328.1:29189316..29211673:-","gene195","gi|296491590|tpg|DAA33633.1|",3250,0,"TPA: glucan (1,4-alpha-), branching enzyme 1 [Bos taurus]","gi|965916962|ref|XM_004002835.3|",3033,0,"PREDICTED: Ovis aries glucan (1,4-alpha-), branching enzyme 1 (GBE1), mRNA","Q6EAS5",1189,0,"1,4-alpha-glucan-branching enzyme","YEL011w",703,0,"COG0296","pfam00128","Alpha-amylase","Alpha amylase, catalytic domain. Alpha amylase is classified as family 13 of the glycosyl hydrolases. The structure is an 8 stranded alpha/beta barrel containing the active site, interrupted by a ~70 a.a. calcium-binding domain protruding between beta strand 3 and alpha helix 3, and a carboxyl-terminal Greek key beta-barrel domain.","GO:0005978|glycogen biosynthetic process;",".","GO:0003844|1,4-alpha-glucan branching enzyme activity;GO:0043169|cation binding;GO:0004553|hydrolase activity, hydrolyzing O-glycosyl compounds;","K00700","glgB; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18]"]
["bta_circ_0000427",0,0,0,1.83031722468535,4,2,4,-4.28026935930021,0.0313834535393553,"NA","down","yes","NC_037328.1:29258391..29352878:-","gene195","gi|296491590|tpg|DAA33633.1|",3250,0,"TPA: glucan (1,4-alpha-), branching enzyme 1 [Bos taurus]","gi|965916962|ref|XM_004002835.3|",3033,0,"PREDICTED: Ovis aries glucan (1,4-alpha-), branching enzyme 1 (GBE1), mRNA","Q6EAS5",1189,0,"1,4-alpha-glucan-branching enzyme","YEL011w",703,0,"COG0296","pfam00128","Alpha-amylase","Alpha amylase, catalytic domain. Alpha amylase is classified as family 13 of the glycosyl hydrolases. The structure is an 8 stranded alpha/beta barrel containing the active site, interrupted by a ~70 a.a. calcium-binding domain protruding between beta strand 3 and alpha helix 3, and a carboxyl-terminal Greek key beta-barrel domain.","GO:0005978|glycogen biosynthetic process;",".","GO:0003844|1,4-alpha-glucan branching enzyme activity;GO:0043169|cation binding;GO:0004553|hydrolase activity, hydrolyzing O-glycosyl compounds;","K00700","glgB; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18]"]
["bta_circ_0000451",48,182,71,54.7648923704093,18,45,25,1.47629913684859,0.00384165671935478,0.151012033222637,"up","yes","NC_037328.1:43063944..43076653:+","gene267","gi|440905195|gb|ELR55611.1|",1805,0,"Type 2 lactosamine alpha-2,3-sialyltransferase, partial [Bos mutus]","gi|982909697|ref|XM_010801005.2|",4761,0,"PREDICTED: Bos taurus ST3 beta-galactoside alpha-2,3-sialyltransferase 6 (ST3GAL6), transcript variant X1, mRNA","Q6H8M7",691,0,"Type 2 lactosamine alpha-2,3-sialyltransferase",".",".",".",".","pfam00777","Glyco_transf_29","Glycosyltransferase family 29 (sialyltransferase). Members of this family belong to glycosyltransferase family 29.","GO:0006464|cellular protein modification process;GO:0071354|cellular response to interleukin-6;GO:0006664|glycolipid metabolic process;GO:0009311|oligosaccharide metabolic process;GO:0018279|protein N-linked glycosylation via asparagine;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0052798|beta-galactoside alpha-2,3-sialyltransferase activity;","K03792","SIAT10, ST3GAL6; beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 10) [EC:2.4.99.10]"]
["bta_circ_0000457",17,18,0,6.7248034902668,0,0,0,4.63725606258841,0.0235582096210062,0.375453490305658,"up","yes","NC_037328.1:44107798..44116119:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0000466",5,10,2,2.68041570516352,0,0,0,4.68414131151812,0.0161054232626886,"NA","up","yes","NC_037328.1:44605259..44607853:+","gene277","gi|472343926|ref|XP_004391716.1|",3612,0,"PREDICTED: TBC1 domain family member 23 isoform X1 [Odobenus rosmarus divergens]","gi|742133061|ref|XM_010841947.1|",3829,0,"PREDICTED: Bison bison bison TBC1 domain family, member 23 (TBC1D23), transcript variant X1, mRNA","Q9NUY8",1352,0,"TBC1 domain family member 23",".",".",".",".","pfam00566","RabGAP-TBC","Rab-GTPase-TBC domain. Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.","GO:0007420|brain development;GO:1990403|embryonic brain development;GO:0031175|neuron projection development;GO:0032755|positive regulation of interleukin-6 production;GO:0050727|regulation of inflammatory response;GO:0032680|regulation of tumor necrosis factor production;GO:0042147|retrograde transport, endosome to Golgi;GO:0016192|vesicle-mediated transport;","GO:0005829|cytosol;GO:0005794|Golgi apparatus;GO:0005802|trans-Golgi network;GO:0071203|WASH complex;",".",".","."]
["bta_circ_0000486",0,0,0,1.85965664530163,0,10,3,-4.15964776646341,0.0397893226465806,"NA","down","yes","NC_037328.1:45925101..45970859:-","gene288","gi|156120425|ref|NP_001095358.1|",5272,0,"sentrin-specific protease 7 [Bos taurus]","gi|982909816|ref|XM_005201223.3|",4870,0,"PREDICTED: Bos taurus SUMO1/sentrin specific peptidase 7 (SENP7), transcript variant X1, mRNA","A7MBJ2",2030,0,"Sentrin-specific protease 7","SPAC17A5.07c",143,{"v":3e-34,"d":"3.00E-34"},"COG5160","pfam02902","Peptidase_C48","Ulp1 protease family, C-terminal catalytic domain. This domain contains the catalytic triad Cys-His-Asn.","GO:0007188|adenylate cyclase-modulating G-protein coupled receptor signaling pathway;","GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0008234|cysteine-type peptidase activity;GO:0004930|G-protein coupled receptor activity;","K08596","SENP7; sentrin-specific protease 7 [EC:3.4.22.68]"]
["bta_circ_0000486",0,0,0,1.85965664530163,0,10,3,-4.15964776646341,0.0397893226465806,"NA","down","yes","NC_037328.1:45925101..45970859:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0000500",0,0,0,1.85730104079895,0,6,6,-4.16237806537761,0.0394769919390397,"NA","down","yes","NC_037328.1:53203217..53208896:-","gene325","gi|296491471|tpg|DAA33524.1|",9555,0,"TPA: KIAA1000 protein-like [Bos taurus]","gi|965910408|ref|XM_015091018.1|",5333,0,"PREDICTED: Ovis aries musimon myosin, heavy chain 15 (MYH15), transcript variant X2, mRNA","Q9Y2K3",2924,0,"Myosin-15","SPCC645.05c",712,0,"COG5022","pfam00063","Myosin_head","Myosin head (motor domain).","GO:0002074|extraocular skeletal muscle development;GO:0007018|microtubule-based movement;","GO:0030016|myofibril;GO:0032982|myosin filament;","GO:0051015|actin filament binding;GO:0005524|ATP binding;GO:0005516|calmodulin binding;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;","K10352","MYH; myosin heavy chain"]
["bta_circ_0000514",7,0,3,2.44241640901839,0,0,0,4.33072410590961,0.0309183648300408,"NA","up","yes","NC_037328.1:56668569..56670067:+","gene351","gi|982910007|ref|XP_015326521.1|",6609,0,"PREDICTED: pleckstrin homology-like domain family B member 2 isoform X1 [Bos taurus]","gi|982910016|ref|XM_015471039.1|",6107,0,"PREDICTED: Bos taurus pleckstrin homology-like domain, family B, member 2 (PHLDB2), transcript variant X5, mRNA","Q86SQ0",1989,0,"Pleckstrin homology-like domain family B member 2",".",".",".",".","pfam00169","PH","PH domain. PH stands for pleckstrin homology.","GO:0045184|establishment of protein localization;GO:0000226|microtubule cytoskeleton organization;GO:0051895|negative regulation of focal adhesion assembly;GO:0051497|negative regulation of stress fiber assembly;GO:1903690|negative regulation of wound healing, spreading of epidermal cells;GO:1904261|positive regulation of basement membrane assembly involved in embryonic body morphogenesis;GO:0010717|regulation of epithelial to mesenchymal transition;GO:0010470|regulation of gastrulation;GO:0070507|regulation of microtubule cytoskeleton organization;","GO:0045180|basal cortex;GO:0031252|cell leading edge;GO:0005829|cytosol;GO:0045111|intermediate filament cytoskeleton;GO:0005886|plasma membrane;","GO:0045296|cadherin binding;",".","."]
["bta_circ_0000578",0,0,0,2.38445348378735,7,0,5,-4.49811675786419,0.0233006917722457,"NA","down","yes","NC_037328.1:69976881..70006973:-","gene490","gi|555985339|ref|XP_005904547.1|",3809,0,"PREDICTED: oxysterol-binding protein-related protein 11 [Bos mutus]","gi|300795253|ref|NM_001193008.1|",3361,0,"Bos taurus oxysterol binding protein like 11 (OSBPL11), mRNA","Q9BXB4",1364,0,"Oxysterol-binding protein-related protein 11",".",".",".",".","pfam01237","Oxysterol_BP","Oxysterol-binding protein.","GO:0045444|fat cell differentiation;GO:0006869|lipid transport;GO:0010890|positive regulation of sequestering of triglyceride;","GO:0005794|Golgi apparatus;GO:0031902|late endosome membrane;GO:0005654|nucleoplasm;","GO:0008289|lipid binding;",".","."]
["bta_circ_0000583",5,0,9,2.61412248384099,0,0,0,4.48088525464149,0.0241594936993562,"NA","up","yes","NC_037328.1:70141816..70148137:-","gene492","gi|803241277|ref|XP_011980720.1|",3524,0,"PREDICTED: leishmanolysin-like peptidase isoform X3 [Ovis aries musimon]","gi|742094302|ref|XM_010834296.1|",3032,0,"PREDICTED: Bison bison bison leishmanolysin-like (metallopeptidase M8 family) (LMLN), transcript variant X2, mRNA","Q8BMN4",1144,0,"Leishmanolysin-like peptidase",".",".",".",".","pfam01457","Peptidase_M8","Leishmanolysin.","GO:0007155|cell adhesion;GO:0007049|cell cycle;GO:0051301|cell division;","GO:0005829|cytosol;GO:0005925|focal adhesion;GO:0005811|lipid particle;GO:0016020|membrane;","GO:0046872|metal ion binding;GO:0004222|metalloendopeptidase activity;","K13539","LMLN; leishmanolysin-like peptidase [EC:3.4.24.-]"]
["bta_circ_0000597",0,0,0,2.53887002310991,4,6,5,-4.81031320039143,0.0122198533268918,"NA","down","yes","NC_037328.1:70258272..70289666:-","gene496","gi|297470947|ref|XP_002684845.1|",3669,0,"PREDICTED: leucine-rich repeat and calponin homology domain-containing protein 3 isoform X3 [Bos taurus]","gi|982976160|ref|XM_015462033.1|",5146,0,"PREDICTED: Bos taurus leucine-rich repeats and calponin homology (CH) domain containing 3 (LRCH3), transcript variant X3, mRNA","Q96II8",1249,0,"Leucine-rich repeat and calponin homology domain-containing protein 3","MA2301_1",111,{"v":3e-25,"d":"3.00E-25"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0007165|signal transduction;","GO:0005829|cytosol;GO:0005576|extracellular region;GO:0005886|plasma membrane;",".",".","."]
["bta_circ_0000647",0,0,0,1.90070961634308,7,3,0,-4.14825121798422,0.0404479780193707,"NA","down","yes","NC_037328.1:73847675..73851901:-","gene571","gi|742094795|ref|XP_010832719.1|",5284,0,"PREDICTED: dynamin-like 120 kDa protein, mitochondrial [Bison bison bison]","gi|982910644|ref|XM_005201499.3|",6277,0,"PREDICTED: Bos taurus optic atrophy 1 (autosomal dominant) (OPA1), transcript variant X1, mRNA","O60313",1844,0,"Dynamin-like 120 kDa protein, mitochondrial","YLL001w",112,{"v":7e-24,"d":"7.00E-24"},"COG0699","pfam00350","Dynamin_N","Dynamin family.","GO:0006915|apoptotic process;GO:0019896|axon transport of mitochondrion;GO:0036444|calcium ion transmembrane import into mitochondrion;GO:0071333|cellular response to glucose stimulus;GO:0071456|cellular response to hypoxia;GO:0090398|cellular senescence;GO:0090102|cochlea development;GO:0003374|dynamin polymerization involved in mitochondrial fission;GO:0046039|GTP metabolic process;GO:0007007|inner mitochondrial membrane organization;GO:0048312|intracellular distribution of mitochondria;GO:0000266|mitochondrial fission;GO:0008053|mitochondrial fusion;GO:0000002|mitochondrial genome maintenance;GO:0070584|mitochondrion morphogenesis;GO:0007005|mitochondrion organization;GO:0043066|negative regulation of apoptotic process;GO:1902236|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:0090201|negative regulation of release of cytochrome c from mitochondria;GO:0061003|positive regulation of dendritic spine morphogenesis;GO:2001275|positive regulation of glucose import in response to insulin stimulus;GO:0010636|positive regulation of mitochondrial fusion;GO:0014042|positive regulation of neuron maturation;GO:0051259|protein oligomerization;GO:1904643|response to curcumin;GO:0051602|response to electrical stimulus;GO:0014850|response to muscle activity;GO:0060041|retina development in camera-type eye;GO:0007601|visual perception;","GO:1904115|axon cytoplasm;GO:0005829|cytosol;GO:0030425|dendrite;GO:0031314|extrinsic component of mitochondrial inner membrane;GO:0016021|integral component of membrane;GO:0016020|membrane;GO:0030061|mitochondrial crista;GO:0005743|mitochondrial inner membrane;GO:0005758|mitochondrial intermembrane space;GO:0005741|mitochondrial outer membrane;GO:0005739|mitochondrion;GO:0005654|nucleoplasm;","GO:1901612|cardiolipin binding;GO:0005525|GTP binding;GO:0003924|GTPase activity;GO:0019900|kinase binding;GO:0000287|magnesium ion binding;GO:0008017|microtubule binding;GO:0070300|phosphatidic acid binding;","K17079","OPA1; optic atrophy protein 1 [EC:3.6.5.5]"]
["bta_circ_0000648",0,0,0,13.6062961806179,23,36,22,-7.20518957972329,{"v":1.37682846341581e-05,"d":"1.38E-05"},0.00246966335638563,"down","yes","NC_037328.1:74168650..74175616:-","gene576","gi|594696107|ref|XP_007195249.1|",875,{"v":2e-107,"d":"2.00E-107"},"PREDICTED: phospholipid-metabolizing enzyme A-C1 isoform X4 [Balaenoptera acutorostrata scammoni]","gi|931717468|ref|NM_001076225.3|",2740,0,"Bos taurus HRAS like suppressor (HRASLS), transcript variant 2, mRNA","Q9QZU4",250,{"v":8e-76,"d":"8.00E-76"},"Phospholipid-metabolizing enzyme A-C1",".",".",".",".","pfam04970","LRAT","Lecithin retinol acyltransferase. The full-length members of this family are representatives of a novel class II tumor-suppressor family, designated as H-REV107-like. This domain is the catalytic N-terminal proline-rich region of the protein. The downstream region is a putative C-terminal transmembrane domain which is found to be crucial for cellular localisation, but not necessary for the enzyme activity. H-REV107-like proteins are homologous to lecithin retinol acyltransferase (LRAT), an enzyme that catalyses the transfer of the sn-1 acyl group of phosphatidylcholine to all-trans-retinol and forming a retinyl ester.","GO:0046485|ether lipid metabolic process;GO:0016042|lipid catabolic process;GO:0007031|peroxisome organization;GO:0007265|Ras protein signal transduction;GO:0001558|regulation of cell growth;","GO:0005737|cytoplasm;GO:0016021|integral component of membrane;GO:0005641|nuclear envelope lumen;GO:0005777|peroxisome;","GO:0004620|phospholipase activity;GO:0016740|transferase activity;",".","."]
["bta_circ_0000699",0,0,0,1.70524010597907,3,4,3,-4.19544627199463,0.035742357707695,"NA","down","yes","NC_037328.1:84059133..84075777:+","gene710","gi|478500843|ref|XP_004424736.1|",916,{"v":4e-144,"d":"4.00E-144"},"PREDICTED: DCN1-like protein 1 isoform X1 [Ceratotherium simum simum]","gi|982910996|ref|XM_005201614.3|",3797,0,"PREDICTED: Bos taurus defective in cullin neddylation 1 domain containing 1 (DCUN1D1), transcript variant X1, mRNA","Q96GG9",356,{"v":3e-145,"d":"3.00E-145"},"DCN1-like protein 1",".",".",".",".","pfam03556","Cullin_binding","Cullin binding. This domain binds to cullins and to Rbx-1, components of an E3 ubiquitin ligase complex for neddylation. Neddylation is the process by which the C-terminal glycine of the ubiquitin-like protein Nedd8 is covalently linked to lysine residues in a protein through an isopeptide bond. The structure of this domain is composed entirely of alpha helices.","GO:2000436|positive regulation of protein neddylation;GO:0051443|positive regulation of ubiquitin-protein transferase activity;GO:0043687|post-translational protein modification;GO:0045116|protein neddylation;","GO:0005829|cytosol;GO:0005634|nucleus;GO:0000151|ubiquitin ligase complex;","GO:0097602|cullin family protein binding;GO:0031624|ubiquitin conjugating enzyme binding;GO:0032182|ubiquitin-like protein binding;","K17822","DCUN1D1_2; DCN1-like protein 1/2"]
["bta_circ_0000719",0,0,0,4.83387105540568,11,4,11,-5.71842441474479,0.00162348240282607,"NA","down","yes","NC_037328.1:87380533..87457859:-","gene732","gi|982911108|ref|XP_015327854.1|",4070,0,"PREDICTED: ubiquitin carboxyl-terminal hydrolase 13 isoform X1 [Bos taurus]","gi|982911107|ref|XM_015472368.1|",7365,0,"PREDICTED: Bos taurus ubiquitin specific peptidase 13 (isopeptidase T-3) (USP13), transcript variant X1, mRNA","E1BMF7",1565,0,"Ubiquitin carboxyl-terminal hydrolase 13","SPBC6B1.06c",353,{"v":2e-102,"d":"2.00E-102"},"COG5207","pfam00443","UCH","Ubiquitin carboxyl-terminal hydrolase.","GO:0006914|autophagy;GO:0008283|cell proliferation;GO:1904378|maintenance of unfolded protein involved in ERAD pathway;GO:0035523|protein K29-linked deubiquitination;GO:0044313|protein K6-linked deubiquitination;GO:0070536|protein K63-linked deubiquitination;GO:0050821|protein stabilization;GO:0010506|regulation of autophagy;GO:0006355|regulation of transcription, DNA-templated;GO:0006511|ubiquitin-dependent protein catabolic process;",".","GO:1904288|BAT3 complex binding;GO:0051087|chaperone binding;GO:0004197|cysteine-type endopeptidase activity;GO:0070628|proteasome binding;GO:0004843|ubiquitin-specific protease activity;GO:0036459|ubiquitinyl hydrolase activity;GO:0043130|ubiquitin binding;GO:0031625|ubiquitin protein ligase binding;GO:1904454|ubiquitin-specific protease activity involved in positive regulation of ERAD pathway;GO:0008270|zinc ion binding;","K11836","USP5_13, UBP14; ubiquitin carboxyl-terminal hydrolase 5/13 [EC:3.4.19.12]"]
["bta_circ_0000730",0,43,27,34.2485658230358,38,56,63,-1.70309496074901,0.0174531967310963,0.31640326128788,"down","yes","NC_037328.1:87431631..87457859:-","gene732","gi|982911108|ref|XP_015327854.1|",4070,0,"PREDICTED: ubiquitin carboxyl-terminal hydrolase 13 isoform X1 [Bos taurus]","gi|982911107|ref|XM_015472368.1|",7365,0,"PREDICTED: Bos taurus ubiquitin specific peptidase 13 (isopeptidase T-3) (USP13), transcript variant X1, mRNA","E1BMF7",1565,0,"Ubiquitin carboxyl-terminal hydrolase 13","SPBC6B1.06c",353,{"v":2e-102,"d":"2.00E-102"},"COG5207","pfam00443","UCH","Ubiquitin carboxyl-terminal hydrolase.","GO:0006914|autophagy;GO:0008283|cell proliferation;GO:1904378|maintenance of unfolded protein involved in ERAD pathway;GO:0035523|protein K29-linked deubiquitination;GO:0044313|protein K6-linked deubiquitination;GO:0070536|protein K63-linked deubiquitination;GO:0050821|protein stabilization;GO:0010506|regulation of autophagy;GO:0006355|regulation of transcription, DNA-templated;GO:0006511|ubiquitin-dependent protein catabolic process;",".","GO:1904288|BAT3 complex binding;GO:0051087|chaperone binding;GO:0004197|cysteine-type endopeptidase activity;GO:0070628|proteasome binding;GO:0004843|ubiquitin-specific protease activity;GO:0036459|ubiquitinyl hydrolase activity;GO:0043130|ubiquitin binding;GO:0031625|ubiquitin protein ligase binding;GO:1904454|ubiquitin-specific protease activity involved in positive regulation of ERAD pathway;GO:0008270|zinc ion binding;","K11836","USP5_13, UBP14; ubiquitin carboxyl-terminal hydrolase 5/13 [EC:3.4.19.12]"]
["bta_circ_0000731",0,0,0,1.73765222591941,5,5,0,-4.03466302515196,0.0475458789136191,"NA","down","yes","NC_037328.1:87435127..87457859:-","gene732","gi|982911108|ref|XP_015327854.1|",4070,0,"PREDICTED: ubiquitin carboxyl-terminal hydrolase 13 isoform X1 [Bos taurus]","gi|982911107|ref|XM_015472368.1|",7365,0,"PREDICTED: Bos taurus ubiquitin specific peptidase 13 (isopeptidase T-3) (USP13), transcript variant X1, mRNA","E1BMF7",1565,0,"Ubiquitin carboxyl-terminal hydrolase 13","SPBC6B1.06c",353,{"v":2e-102,"d":"2.00E-102"},"COG5207","pfam00443","UCH","Ubiquitin carboxyl-terminal hydrolase.","GO:0006914|autophagy;GO:0008283|cell proliferation;GO:1904378|maintenance of unfolded protein involved in ERAD pathway;GO:0035523|protein K29-linked deubiquitination;GO:0044313|protein K6-linked deubiquitination;GO:0070536|protein K63-linked deubiquitination;GO:0050821|protein stabilization;GO:0010506|regulation of autophagy;GO:0006355|regulation of transcription, DNA-templated;GO:0006511|ubiquitin-dependent protein catabolic process;",".","GO:1904288|BAT3 complex binding;GO:0051087|chaperone binding;GO:0004197|cysteine-type endopeptidase activity;GO:0070628|proteasome binding;GO:0004843|ubiquitin-specific protease activity;GO:0036459|ubiquitinyl hydrolase activity;GO:0043130|ubiquitin binding;GO:0031625|ubiquitin protein ligase binding;GO:1904454|ubiquitin-specific protease activity involved in positive regulation of ERAD pathway;GO:0008270|zinc ion binding;","K11836","USP5_13, UBP14; ubiquitin carboxyl-terminal hydrolase 5/13 [EC:3.4.19.12]"]
["bta_circ_0000777",8,0,8,3.37102592857292,0,0,0,4.82677696131702,0.0131341280724404,"NA","up","yes","NC_037328.1:98341286..98342533:+","gene822","gi|982911485|ref|XP_015328339.1|",5610,0,"PREDICTED: MDS1 and EVI1 complex locus protein EVI1 isoform X7 [Bos taurus]","gi|982976510|ref|XM_010824390.2|",5209,0,"PREDICTED: Bos taurus MDS1 and EVI1 complex locus (MECOM), transcript variant X8, mRNA","Q03112",2062,0,"MDS1 and EVI1 complex locus protein",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0006915|apoptotic process;GO:0030154|cell differentiation;GO:0071425|hematopoietic stem cell proliferation;GO:0046329|negative regulation of JNK cascade;GO:0043069|negative regulation of programmed cell death;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0051726|regulation of cell cycle;GO:0006351|transcription, DNA-templated;","GO:0005829|cytosol;GO:0016607|nuclear speck;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0018024|histone-lysine N-methyltransferase activity;GO:0046872|metal ion binding;GO:0042803|protein homodimerization activity;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K04462","EVI1; ecotropic virus integration site 1 protein"]
["bta_circ_0000785",3,43,11,27.3192748853648,37,42,42,-1.6022044787505,0.0186074952172351,0.329128306374723,"down","yes","NC_037329.1:104071958..104097340:-","gene2212","gi|528900938|ref|XP_874305.5|",1527,0,"PREDICTED: peroxisomal trans-2-enoyl-CoA reductase [Bos taurus]","gi|982977663|ref|XM_869212.8|",1443,0,"PREDICTED: Bos taurus peroxisomal trans-2-enoyl-CoA reductase (PECR), mRNA","Q9BY49",438,{"v":3e-150,"d":"3.00E-150"},"Peroxisomal trans-2-enoyl-CoA reductase",".",".",".",".","pfam13561","adh_short_C2","Enoyl-(Acyl carrier protein) reductase.","GO:0001561|fatty acid alpha-oxidation;GO:0006633|fatty acid biosynthetic process;GO:0055114|oxidation-reduction process;GO:0033306|phytol metabolic process;GO:0006625|protein targeting to peroxisome;","GO:0005829|cytosol;GO:0005739|mitochondrion;GO:0005778|peroxisomal membrane;GO:0005777|peroxisome;","GO:0005102|receptor binding;GO:0019166|trans-2-enoyl-CoA reductase (NADPH) activity;","K07753","PECR; peroxisomal trans-2-enoyl-CoA reductase [EC:1.3.1.38]"]
["bta_circ_0000789",35,97,65,39.2784822542688,24,21,20,1.2656433126398,0.0193941760175672,0.333714374080912,"up","yes","NC_037329.1:104087615..104105147:-","gene2212","gi|528900938|ref|XP_874305.5|",1527,0,"PREDICTED: peroxisomal trans-2-enoyl-CoA reductase [Bos taurus]","gi|982977663|ref|XM_869212.8|",1443,0,"PREDICTED: Bos taurus peroxisomal trans-2-enoyl-CoA reductase (PECR), mRNA","Q9BY49",438,{"v":3e-150,"d":"3.00E-150"},"Peroxisomal trans-2-enoyl-CoA reductase",".",".",".",".","pfam13561","adh_short_C2","Enoyl-(Acyl carrier protein) reductase.","GO:0001561|fatty acid alpha-oxidation;GO:0006633|fatty acid biosynthetic process;GO:0055114|oxidation-reduction process;GO:0033306|phytol metabolic process;GO:0006625|protein targeting to peroxisome;","GO:0005829|cytosol;GO:0005739|mitochondrion;GO:0005778|peroxisomal membrane;GO:0005777|peroxisome;","GO:0005102|receptor binding;GO:0019166|trans-2-enoyl-CoA reductase (NADPH) activity;","K07753","PECR; peroxisomal trans-2-enoyl-CoA reductase [EC:1.3.1.38]"]
["bta_circ_0000901",6,15,0,3.19834446670676,0,0,0,4.79324467356997,0.0139076868938444,"NA","up","yes","NC_037329.1:124466400..124473287:-","gene2513","gi|742229535|ref|XP_010828500.1|",4592,0,"PREDICTED: protein 4.1 isoform X4 [Bison bison bison]","gi|742229530|ref|XM_010830197.1|",3868,0,"PREDICTED: Bison bison bison erythrocyte membrane protein band 4.1 (EPB41), transcript variant X4, mRNA","Q6Q7P4",1153,0,"Protein 4.1",".",".",".",".","pfam05902","4_1_CTD","4.1 protein C-terminal domain (CTD). At the C-terminus of all known 4.1 proteins is a sequence domain unique to these proteins, known as the C-terminal domain (CTD). Mammalian CTDs are associated with a growing number of protein-protein interactions, although such activities have yet to be associated with invertebrate CTDs. Mammalian CTDs are generally defined by sequence alignment as encoded by exons 18-21. Comparison of known vertebrate 4.1 proteins with invertebrate 4.1 proteins indicates that mammalian 4.1 exon 19 represents a vertebrate adaptation that extends the sequence of the CTD with a Ser/Thr-rich sequence. The CTD was first described as a 22/24-kDa domain by chymotryptic digestion of erythrocyte 4.1 (4.1R). CTD is thought to represent an independent folding structure which has gained function since the divergence of vertebrates from invertebrates.","GO:0031032|actomyosin structure organization;GO:0007049|cell cycle;GO:0051301|cell division;GO:0030866|cortical actin cytoskeleton organization;","GO:0099738|cell cortex region;GO:0005856|cytoskeleton;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0003779|actin binding;GO:0005516|calmodulin binding;GO:0005200|structural constituent of cytoskeleton;","K06107","EPB41, 4.1R; erythrocyte membrane protein band 4.1"]
["bta_circ_0000913",0,0,0,1.99265752028766,0,11,3,-4.26469568950264,0.0339644305306098,"NA","down","yes","NC_037329.1:124957865..125007155:-","gene2533","gi|982915493|ref|XP_005203199.3|",2654,0,"PREDICTED: phosphatase and actin regulator 4 isoform X1 [Bos taurus]","gi|982915492|ref|XM_005203142.3|",4429,0,"PREDICTED: Bos taurus phosphatase and actin regulator 4 (PHACTR4), transcript variant X1, mRNA","F1MCY2",968,0,"Phosphatase and actin regulator 4",".",".",".",".","pfam02755","RPEL","RPEL repeat. The RPEL repeat is named after four conserved amino acids it contains. The function of the RPEL repeat is unknown however it might be a DNA binding repeat based on the observation that he Drosophila myocardin-related transcription factor contains a pfam02037 domain that is also implicated in DNA binding.","GO:0030036|actin cytoskeleton organization;GO:0061386|closure of optic fissure;GO:0048484|enteric nervous system development;GO:2001045|negative regulation of integrin-mediated signaling pathway;GO:0001755|neural crest cell migration;GO:0001843|neural tube closure;GO:0043085|positive regulation of catalytic activity;GO:0051726|regulation of cell cycle;GO:0007266|Rho protein signal transduction;","GO:0005737|cytoplasm;GO:0030027|lamellipodium;","GO:0003779|actin binding;GO:0008157|protein phosphatase 1 binding;GO:0072542|protein phosphatase activator activity;","K17585","PHACTR4; phosphatase and actin regulator 4"]
["bta_circ_0000925",0,0,0,1.5286908074986,3,4,2,-4.02030426064568,0.0465919556406166,"NA","down","yes","NC_037329.1:126676281..126693349:-","gene2589","gi|528941014|ref|XP_005203237.1|",1704,0,"PREDICTED: dehydrodolichyl diphosphate syntase complex subunit DHDDS isoform X1 [Bos taurus]","gi|982915552|ref|XM_005203180.3|",3194,0,"PREDICTED: Bos taurus dehydrodolichyl diphosphate synthase subunit (DHDDS), transcript variant X1, mRNA","Q86SQ9",623,0,"Dehydrodolichyl diphosphate synthase complex subunit DHDDS","MK0767",204,{"v":8e-58,"d":"8.00E-58"},"COG0020","pfam01255","Prenyltransf","Putative undecaprenyl diphosphate synthase. Previously known as uncharacterized protein family UPF0015, a single member of this family has been identified as an undecaprenyl diphosphate synthase.","GO:0016094|polyprenol biosynthetic process;GO:0006486|protein glycosylation;","GO:0005789|endoplasmic reticulum membrane;","GO:0016765|transferase activity, transferring alkyl or aryl (other than methyl) groups;","K11778","DHDDS, RER2, SRT1; ditrans,polycis-polyprenyl diphosphate synthase [EC:2.5.1.87]"]
["bta_circ_0000933",4,12,23,24.594143368938,41,17,47,-1.79973171611042,0.0143187657187662,0.298906981742218,"down","yes","NC_037329.1:127105655..127107259:+","gene2609","gi|27807031|ref|NP_776995.1|",2119,0,"platelet-activating factor acetylhydrolase 2, cytoplasmic [Bos taurus]","gi|75775492|gb|BC105148.1|",2314,0,"Bos taurus platelet-activating factor acetylhydrolase 2, 40kDa, mRNA (cDNA clone MGC:127261 IMAGE:7946914), complete cds","P79106",820,0,"Platelet-activating factor acetylhydrolase 2, cytoplasmic",".",".",".",".","pfam03403","PAF-AH_p_II","Platelet-activating factor acetylhydrolase, isoform II. Platelet-activating factor acetylhydrolase (PAF-AH) is a subfamily of phospholipases A2, responsible for inactivation of platelet-activating factor through cleavage of an acetyl group. Three known PAF-AHs are the brain heterotrimeric PAF-AH Ib, whose catalytic beta and gamma subunits are aligned in pfam02266, the extracellular, plasma PAF-AH (pPAF-AH), and the intracellular PAF-AH isoform II (PAF-AH II). This family aligns pPAF-AH and PAF-AH II, whose similarity was previously noted.","GO:0016042|lipid catabolic process;","GO:0005829|cytosol;GO:0005789|endoplasmic reticulum membrane;","GO:0003847|1-alkyl-2-acetylglycerophosphocholine esterase activity;","K01062","PAFAH; platelet-activating factor acetylhydrolase [EC:3.1.1.47]"]
["bta_circ_0000997",0,7,9,1.8090339476539,0,0,0,4.04254352497548,0.0473631419442961,"NA","up","yes","NC_037329.1:133964785..133974033:-","gene2763","gi|982915672|ref|XP_015316176.1|",1968,0,"PREDICTED: paired box protein Pax-7 [Bos taurus]","gi|982978118|ref|XM_015462509.1|",1297,0,"PREDICTED: Bos taurus paired box protein Pax-7 (LOC536229), mRNA","P47239",712,0,"Paired box protein Pax-7",".",".",".",".","pfam00292","PAX","'Paired box' domain.","GO:0009887|organ morphogenesis;GO:0051216|cartilage development;GO:0006338|chromatin remodeling;GO:0021904|dorsal/ventral neural tube patterning;GO:0048706|embryonic skeletal system development;GO:0060415|muscle tissue morphogenesis;GO:0048663|neuron fate commitment;GO:0031062|positive regulation of histone methylation;GO:2000288|positive regulation of myoblast proliferation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0010453|regulation of cell fate commitment;GO:0010468|regulation of gene expression;GO:0043393|regulation of protein binding;GO:0006355|regulation of transcription, DNA-templated;GO:0014813|skeletal muscle satellite cell commitment;GO:0007519|skeletal muscle tissue development;GO:0043403|skeletal muscle tissue regeneration;GO:0021527|spinal cord association neuron differentiation;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0000983|transcription factor activity, RNA polymerase II core promoter sequence-specific;","K09381","PAX3_7; paired box protein 3/7"]
["bta_circ_0001026",0,0,0,2.37345702818355,2,4,8,-4.68257493131949,0.0157696972894958,"NA","down","yes","NC_037329.1:17355643..17361532:+","gene1561","gi|528938767|ref|XP_005202329.1|",2058,0,"PREDICTED: zinc finger protein 385B isoform X2 [Bos taurus]","gi|742201733|ref|XM_010859745.1|",2931,0,"PREDICTED: Bison bison bison zinc finger protein 385B (ZNF385B), mRNA","Q569K4",713,0,"Zinc finger protein 385B",".",".",".",".","pfam12874","zf-met","Zinc-finger of C2H2 type. This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.","GO:0072332|intrinsic apoptotic signaling pathway by p53 class mediator;","GO:0001650|fibrillar center;GO:0005634|nucleus;","GO:0002039|p53 binding;GO:0003723|RNA binding;GO:0008270|zinc ion binding;",".","."]
["bta_circ_0001029",0,0,0,3.61708602587626,8,5,7,-5.32004647683927,0.00418702664167703,"NA","down","yes","NC_037329.1:17357162..17403907:+","gene1561","gi|528938767|ref|XP_005202329.1|",2058,0,"PREDICTED: zinc finger protein 385B isoform X2 [Bos taurus]","gi|742201733|ref|XM_010859745.1|",2931,0,"PREDICTED: Bison bison bison zinc finger protein 385B (ZNF385B), mRNA","Q569K4",713,0,"Zinc finger protein 385B",".",".",".",".","pfam12874","zf-met","Zinc-finger of C2H2 type. This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.","GO:0072332|intrinsic apoptotic signaling pathway by p53 class mediator;","GO:0001650|fibrillar center;GO:0005634|nucleus;","GO:0002039|p53 binding;GO:0003723|RNA binding;GO:0008270|zinc ion binding;",".","."]
["bta_circ_0001034",0,12,6,1.90558446812552,0,0,0,4.12437402171394,0.042080533658968,"NA","up","yes","NC_037329.1:17669239..17694828:+","gene1567","gi|594071592|ref|XP_006059651.1|",3572,0,"PREDICTED: SEC14 domain and spectrin repeat-containing protein 1 isoform X1 [Bubalus bubalis]","gi|965882813|ref|XM_012153989.2|",6627,0,"PREDICTED: Ovis aries musimon SEC14 and spectrin domain containing 1 (SESTD1), transcript variant X1, mRNA","Q86VW0",1360,0,"SEC14 domain and spectrin repeat-containing protein 1",".",".",".",".","pfam13716","CRAL_TRIO_2","Divergent CRAL/TRIO domain. This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues.",".","GO:0045111|intermediate filament cytoskeleton;","GO:0070300|phosphatidic acid binding;GO:0043325|phosphatidylinositol-3,4-bisphosphate binding;GO:0080025|phosphatidylinositol-3,5-bisphosphate binding;GO:0032266|phosphatidylinositol-3-phosphate binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0070273|phosphatidylinositol-4-phosphate binding;GO:0010314|phosphatidylinositol-5-phosphate binding;",".","."]
["bta_circ_0001038",15,101,45,25.1819803793188,3,20,12,1.8030565681839,0.00963126997314035,0.247890543832493,"up","yes","NC_037329.1:17723958..17728102:+","gene1567","gi|594071592|ref|XP_006059651.1|",3572,0,"PREDICTED: SEC14 domain and spectrin repeat-containing protein 1 isoform X1 [Bubalus bubalis]","gi|965882813|ref|XM_012153989.2|",6627,0,"PREDICTED: Ovis aries musimon SEC14 and spectrin domain containing 1 (SESTD1), transcript variant X1, mRNA","Q86VW0",1360,0,"SEC14 domain and spectrin repeat-containing protein 1",".",".",".",".","pfam13716","CRAL_TRIO_2","Divergent CRAL/TRIO domain. This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues.",".","GO:0045111|intermediate filament cytoskeleton;","GO:0070300|phosphatidic acid binding;GO:0043325|phosphatidylinositol-3,4-bisphosphate binding;GO:0080025|phosphatidylinositol-3,5-bisphosphate binding;GO:0032266|phosphatidylinositol-3-phosphate binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0070273|phosphatidylinositol-4-phosphate binding;GO:0010314|phosphatidylinositol-5-phosphate binding;",".","."]
["bta_circ_0001043",0,0,0,1.77884504491116,5,0,4,-4.04923082852261,0.0466318155344839,"NA","down","yes","NC_037329.1:18073739..18079014:+","gene1570","gi|555991603|ref|XP_005907585.1|",114793,0,"PREDICTED: titin [Bos mutus]","gi|742201765|ref|XM_010859754.1|",65337,0,"PREDICTED: Bison bison bison titin (TTN), mRNA","Q8WZ42",{"v":42310,"d":"4.23E+04"},0,"Titin",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0060048|cardiac muscle contraction;GO:0048739|cardiac muscle fiber development;GO:0003300|cardiac muscle hypertrophy;GO:0055008|cardiac muscle tissue morphogenesis;GO:0055003|cardiac myofibril assembly;GO:0035995|detection of muscle stretch;GO:0007076|mitotic chromosome condensation;GO:0006936|muscle contraction;GO:0030049|muscle filament sliding;GO:0002576|platelet degranulation;GO:0010628|positive regulation of gene expression;GO:0050714|positive regulation of protein secretion;GO:0010737|protein kinase A signaling;GO:0050790|regulation of catalytic activity;GO:0045859|regulation of protein kinase activity;GO:0051592|response to calcium ion;GO:0045214|sarcomere organization;GO:0048769|sarcomerogenesis;GO:0030241|skeletal muscle myosin thick filament assembly;GO:0030240|skeletal muscle thin filament assembly;GO:0006941|striated muscle contraction;","GO:0000794|condensed nuclear chromosome;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0031674|I band;GO:0031430|M band;GO:0005859|muscle myosin complex;GO:0005865|striated muscle thin filament;GO:0030018|Z disc;","GO:0051015|actin filament binding;GO:0042805|actinin binding;GO:0005524|ATP binding;GO:0005509|calcium ion binding;GO:0005516|calmodulin binding;GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0051371|muscle alpha-actinin binding;GO:0002020|protease binding;GO:0019901|protein kinase binding;GO:0043621|protein self-association;GO:0004674|protein serine/threonine kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0008307|structural constituent of muscle;GO:0097493|structural molecule activity conferring elasticity;GO:0031433|telethonin binding;","K12567","TTN; titin [EC:2.7.11.1]"]
["bta_circ_0001112",113,161,147,220.916872504727,272,277,331,-1.19328267988712,0.00433033819659427,0.166212334507454,"down","yes","NC_037329.1:18170955..18174439:+","gene1570","gi|555991603|ref|XP_005907585.1|",114793,0,"PREDICTED: titin [Bos mutus]","gi|742201765|ref|XM_010859754.1|",65337,0,"PREDICTED: Bison bison bison titin (TTN), mRNA","Q8WZ42",{"v":42310,"d":"4.23E+04"},0,"Titin",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0060048|cardiac muscle contraction;GO:0048739|cardiac muscle fiber development;GO:0003300|cardiac muscle hypertrophy;GO:0055008|cardiac muscle tissue morphogenesis;GO:0055003|cardiac myofibril assembly;GO:0035995|detection of muscle stretch;GO:0007076|mitotic chromosome condensation;GO:0006936|muscle contraction;GO:0030049|muscle filament sliding;GO:0002576|platelet degranulation;GO:0010628|positive regulation of gene expression;GO:0050714|positive regulation of protein secretion;GO:0010737|protein kinase A signaling;GO:0050790|regulation of catalytic activity;GO:0045859|regulation of protein kinase activity;GO:0051592|response to calcium ion;GO:0045214|sarcomere organization;GO:0048769|sarcomerogenesis;GO:0030241|skeletal muscle myosin thick filament assembly;GO:0030240|skeletal muscle thin filament assembly;GO:0006941|striated muscle contraction;","GO:0000794|condensed nuclear chromosome;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0031674|I band;GO:0031430|M band;GO:0005859|muscle myosin complex;GO:0005865|striated muscle thin filament;GO:0030018|Z disc;","GO:0051015|actin filament binding;GO:0042805|actinin binding;GO:0005524|ATP binding;GO:0005509|calcium ion binding;GO:0005516|calmodulin binding;GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0051371|muscle alpha-actinin binding;GO:0002020|protease binding;GO:0019901|protein kinase binding;GO:0043621|protein self-association;GO:0004674|protein serine/threonine kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0008307|structural constituent of muscle;GO:0097493|structural molecule activity conferring elasticity;GO:0031433|telethonin binding;","K12567","TTN; titin [EC:2.7.11.1]"]
["bta_circ_0001120",0,9,10,12.8369648053712,25,11,22,-2.09867496338691,0.0238656671936012,0.375453490305658,"down","yes","NC_037329.1:18175049..18184377:+","gene1570","gi|555991603|ref|XP_005907585.1|",114793,0,"PREDICTED: titin [Bos mutus]","gi|742201765|ref|XM_010859754.1|",65337,0,"PREDICTED: Bison bison bison titin (TTN), mRNA","Q8WZ42",{"v":42310,"d":"4.23E+04"},0,"Titin",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0060048|cardiac muscle contraction;GO:0048739|cardiac muscle fiber development;GO:0003300|cardiac muscle hypertrophy;GO:0055008|cardiac muscle tissue morphogenesis;GO:0055003|cardiac myofibril assembly;GO:0035995|detection of muscle stretch;GO:0007076|mitotic chromosome condensation;GO:0006936|muscle contraction;GO:0030049|muscle filament sliding;GO:0002576|platelet degranulation;GO:0010628|positive regulation of gene expression;GO:0050714|positive regulation of protein secretion;GO:0010737|protein kinase A signaling;GO:0050790|regulation of catalytic activity;GO:0045859|regulation of protein kinase activity;GO:0051592|response to calcium ion;GO:0045214|sarcomere organization;GO:0048769|sarcomerogenesis;GO:0030241|skeletal muscle myosin thick filament assembly;GO:0030240|skeletal muscle thin filament assembly;GO:0006941|striated muscle contraction;","GO:0000794|condensed nuclear chromosome;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0031674|I band;GO:0031430|M band;GO:0005859|muscle myosin complex;GO:0005865|striated muscle thin filament;GO:0030018|Z disc;","GO:0051015|actin filament binding;GO:0042805|actinin binding;GO:0005524|ATP binding;GO:0005509|calcium ion binding;GO:0005516|calmodulin binding;GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0051371|muscle alpha-actinin binding;GO:0002020|protease binding;GO:0019901|protein kinase binding;GO:0043621|protein self-association;GO:0004674|protein serine/threonine kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0008307|structural constituent of muscle;GO:0097493|structural molecule activity conferring elasticity;GO:0031433|telethonin binding;","K12567","TTN; titin [EC:2.7.11.1]"]
["bta_circ_0001122",0,0,0,2.51759420672369,0,3,12,-4.58938696902377,0.0200755107384222,"NA","down","yes","NC_037329.1:18177611..18180018:+","gene1570","gi|555991603|ref|XP_005907585.1|",114793,0,"PREDICTED: titin [Bos mutus]","gi|742201765|ref|XM_010859754.1|",65337,0,"PREDICTED: Bison bison bison titin (TTN), mRNA","Q8WZ42",{"v":42310,"d":"4.23E+04"},0,"Titin",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0060048|cardiac muscle contraction;GO:0048739|cardiac muscle fiber development;GO:0003300|cardiac muscle hypertrophy;GO:0055008|cardiac muscle tissue morphogenesis;GO:0055003|cardiac myofibril assembly;GO:0035995|detection of muscle stretch;GO:0007076|mitotic chromosome condensation;GO:0006936|muscle contraction;GO:0030049|muscle filament sliding;GO:0002576|platelet degranulation;GO:0010628|positive regulation of gene expression;GO:0050714|positive regulation of protein secretion;GO:0010737|protein kinase A signaling;GO:0050790|regulation of catalytic activity;GO:0045859|regulation of protein kinase activity;GO:0051592|response to calcium ion;GO:0045214|sarcomere organization;GO:0048769|sarcomerogenesis;GO:0030241|skeletal muscle myosin thick filament assembly;GO:0030240|skeletal muscle thin filament assembly;GO:0006941|striated muscle contraction;","GO:0000794|condensed nuclear chromosome;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0031674|I band;GO:0031430|M band;GO:0005859|muscle myosin complex;GO:0005865|striated muscle thin filament;GO:0030018|Z disc;","GO:0051015|actin filament binding;GO:0042805|actinin binding;GO:0005524|ATP binding;GO:0005509|calcium ion binding;GO:0005516|calmodulin binding;GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0051371|muscle alpha-actinin binding;GO:0002020|protease binding;GO:0019901|protein kinase binding;GO:0043621|protein self-association;GO:0004674|protein serine/threonine kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0008307|structural constituent of muscle;GO:0097493|structural molecule activity conferring elasticity;GO:0031433|telethonin binding;","K12567","TTN; titin [EC:2.7.11.1]"]
["bta_circ_0001178",0,0,0,3.48336805606887,2,15,6,-5.26046738114144,0.00490362572339207,"NA","down","yes","NC_037329.1:18194590..18207428:+","gene1570","gi|555991603|ref|XP_005907585.1|",114793,0,"PREDICTED: titin [Bos mutus]","gi|742201765|ref|XM_010859754.1|",65337,0,"PREDICTED: Bison bison bison titin (TTN), mRNA","Q8WZ42",{"v":42310,"d":"4.23E+04"},0,"Titin",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0060048|cardiac muscle contraction;GO:0048739|cardiac muscle fiber development;GO:0003300|cardiac muscle hypertrophy;GO:0055008|cardiac muscle tissue morphogenesis;GO:0055003|cardiac myofibril assembly;GO:0035995|detection of muscle stretch;GO:0007076|mitotic chromosome condensation;GO:0006936|muscle contraction;GO:0030049|muscle filament sliding;GO:0002576|platelet degranulation;GO:0010628|positive regulation of gene expression;GO:0050714|positive regulation of protein secretion;GO:0010737|protein kinase A signaling;GO:0050790|regulation of catalytic activity;GO:0045859|regulation of protein kinase activity;GO:0051592|response to calcium ion;GO:0045214|sarcomere organization;GO:0048769|sarcomerogenesis;GO:0030241|skeletal muscle myosin thick filament assembly;GO:0030240|skeletal muscle thin filament assembly;GO:0006941|striated muscle contraction;","GO:0000794|condensed nuclear chromosome;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0031674|I band;GO:0031430|M band;GO:0005859|muscle myosin complex;GO:0005865|striated muscle thin filament;GO:0030018|Z disc;","GO:0051015|actin filament binding;GO:0042805|actinin binding;GO:0005524|ATP binding;GO:0005509|calcium ion binding;GO:0005516|calmodulin binding;GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0051371|muscle alpha-actinin binding;GO:0002020|protease binding;GO:0019901|protein kinase binding;GO:0043621|protein self-association;GO:0004674|protein serine/threonine kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0008307|structural constituent of muscle;GO:0097493|structural molecule activity conferring elasticity;GO:0031433|telethonin binding;","K12567","TTN; titin [EC:2.7.11.1]"]
["bta_circ_0001202",0,0,0,1.99265752028766,0,11,3,-4.26469568950264,0.0339644305306098,"NA","down","yes","NC_037329.1:18202675..18203363:+","gene1570","gi|555991603|ref|XP_005907585.1|",114793,0,"PREDICTED: titin [Bos mutus]","gi|742201765|ref|XM_010859754.1|",65337,0,"PREDICTED: Bison bison bison titin (TTN), mRNA","Q8WZ42",{"v":42310,"d":"4.23E+04"},0,"Titin",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0060048|cardiac muscle contraction;GO:0048739|cardiac muscle fiber development;GO:0003300|cardiac muscle hypertrophy;GO:0055008|cardiac muscle tissue morphogenesis;GO:0055003|cardiac myofibril assembly;GO:0035995|detection of muscle stretch;GO:0007076|mitotic chromosome condensation;GO:0006936|muscle contraction;GO:0030049|muscle filament sliding;GO:0002576|platelet degranulation;GO:0010628|positive regulation of gene expression;GO:0050714|positive regulation of protein secretion;GO:0010737|protein kinase A signaling;GO:0050790|regulation of catalytic activity;GO:0045859|regulation of protein kinase activity;GO:0051592|response to calcium ion;GO:0045214|sarcomere organization;GO:0048769|sarcomerogenesis;GO:0030241|skeletal muscle myosin thick filament assembly;GO:0030240|skeletal muscle thin filament assembly;GO:0006941|striated muscle contraction;","GO:0000794|condensed nuclear chromosome;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0031674|I band;GO:0031430|M band;GO:0005859|muscle myosin complex;GO:0005865|striated muscle thin filament;GO:0030018|Z disc;","GO:0051015|actin filament binding;GO:0042805|actinin binding;GO:0005524|ATP binding;GO:0005509|calcium ion binding;GO:0005516|calmodulin binding;GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0051371|muscle alpha-actinin binding;GO:0002020|protease binding;GO:0019901|protein kinase binding;GO:0043621|protein self-association;GO:0004674|protein serine/threonine kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0008307|structural constituent of muscle;GO:0097493|structural molecule activity conferring elasticity;GO:0031433|telethonin binding;","K12567","TTN; titin [EC:2.7.11.1]"]
["bta_circ_0001215",60,0,105,30.9890463472297,0,0,0,4.71485930011634,0.0239651164024888,0.375453490305658,"up","yes","NC_037329.1:18205882..18206773:+","gene1570","gi|555991603|ref|XP_005907585.1|",114793,0,"PREDICTED: titin [Bos mutus]","gi|742201765|ref|XM_010859754.1|",65337,0,"PREDICTED: Bison bison bison titin (TTN), mRNA","Q8WZ42",{"v":42310,"d":"4.23E+04"},0,"Titin",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0060048|cardiac muscle contraction;GO:0048739|cardiac muscle fiber development;GO:0003300|cardiac muscle hypertrophy;GO:0055008|cardiac muscle tissue morphogenesis;GO:0055003|cardiac myofibril assembly;GO:0035995|detection of muscle stretch;GO:0007076|mitotic chromosome condensation;GO:0006936|muscle contraction;GO:0030049|muscle filament sliding;GO:0002576|platelet degranulation;GO:0010628|positive regulation of gene expression;GO:0050714|positive regulation of protein secretion;GO:0010737|protein kinase A signaling;GO:0050790|regulation of catalytic activity;GO:0045859|regulation of protein kinase activity;GO:0051592|response to calcium ion;GO:0045214|sarcomere organization;GO:0048769|sarcomerogenesis;GO:0030241|skeletal muscle myosin thick filament assembly;GO:0030240|skeletal muscle thin filament assembly;GO:0006941|striated muscle contraction;","GO:0000794|condensed nuclear chromosome;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0031674|I band;GO:0031430|M band;GO:0005859|muscle myosin complex;GO:0005865|striated muscle thin filament;GO:0030018|Z disc;","GO:0051015|actin filament binding;GO:0042805|actinin binding;GO:0005524|ATP binding;GO:0005509|calcium ion binding;GO:0005516|calmodulin binding;GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0051371|muscle alpha-actinin binding;GO:0002020|protease binding;GO:0019901|protein kinase binding;GO:0043621|protein self-association;GO:0004674|protein serine/threonine kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0008307|structural constituent of muscle;GO:0097493|structural molecule activity conferring elasticity;GO:0031433|telethonin binding;","K12567","TTN; titin [EC:2.7.11.1]"]
["bta_circ_0001233",5,68,0,7.95969822619429,0,0,0,4.56816826904062,0.0270053981469296,0.402659798576978,"up","yes","NC_037329.1:18206690..18211998:+","gene1570","gi|555991603|ref|XP_005907585.1|",114793,0,"PREDICTED: titin [Bos mutus]","gi|742201765|ref|XM_010859754.1|",65337,0,"PREDICTED: Bison bison bison titin (TTN), mRNA","Q8WZ42",{"v":42310,"d":"4.23E+04"},0,"Titin",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0060048|cardiac muscle contraction;GO:0048739|cardiac muscle fiber development;GO:0003300|cardiac muscle hypertrophy;GO:0055008|cardiac muscle tissue morphogenesis;GO:0055003|cardiac myofibril assembly;GO:0035995|detection of muscle stretch;GO:0007076|mitotic chromosome condensation;GO:0006936|muscle contraction;GO:0030049|muscle filament sliding;GO:0002576|platelet degranulation;GO:0010628|positive regulation of gene expression;GO:0050714|positive regulation of protein secretion;GO:0010737|protein kinase A signaling;GO:0050790|regulation of catalytic activity;GO:0045859|regulation of protein kinase activity;GO:0051592|response to calcium ion;GO:0045214|sarcomere organization;GO:0048769|sarcomerogenesis;GO:0030241|skeletal muscle myosin thick filament assembly;GO:0030240|skeletal muscle thin filament assembly;GO:0006941|striated muscle contraction;","GO:0000794|condensed nuclear chromosome;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0031674|I band;GO:0031430|M band;GO:0005859|muscle myosin complex;GO:0005865|striated muscle thin filament;GO:0030018|Z disc;","GO:0051015|actin filament binding;GO:0042805|actinin binding;GO:0005524|ATP binding;GO:0005509|calcium ion binding;GO:0005516|calmodulin binding;GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0051371|muscle alpha-actinin binding;GO:0002020|protease binding;GO:0019901|protein kinase binding;GO:0043621|protein self-association;GO:0004674|protein serine/threonine kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0008307|structural constituent of muscle;GO:0097493|structural molecule activity conferring elasticity;GO:0031433|telethonin binding;","K12567","TTN; titin [EC:2.7.11.1]"]
["bta_circ_0001255",3,2,6,1.83534777381056,0,0,0,4.14002333807813,0.0399033775844808,"NA","up","yes","NC_037329.1:18207777..18210992:+","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0001282",6,3,0,2.05360691630561,0,0,0,4.08848584475618,0.0444444271444124,"NA","up","yes","NC_037329.1:18210948..18211790:+","gene1570","gi|555991603|ref|XP_005907585.1|",114793,0,"PREDICTED: titin [Bos mutus]","gi|742201765|ref|XM_010859754.1|",65337,0,"PREDICTED: Bison bison bison titin (TTN), mRNA","Q8WZ42",{"v":42310,"d":"4.23E+04"},0,"Titin",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0060048|cardiac muscle contraction;GO:0048739|cardiac muscle fiber development;GO:0003300|cardiac muscle hypertrophy;GO:0055008|cardiac muscle tissue morphogenesis;GO:0055003|cardiac myofibril assembly;GO:0035995|detection of muscle stretch;GO:0007076|mitotic chromosome condensation;GO:0006936|muscle contraction;GO:0030049|muscle filament sliding;GO:0002576|platelet degranulation;GO:0010628|positive regulation of gene expression;GO:0050714|positive regulation of protein secretion;GO:0010737|protein kinase A signaling;GO:0050790|regulation of catalytic activity;GO:0045859|regulation of protein kinase activity;GO:0051592|response to calcium ion;GO:0045214|sarcomere organization;GO:0048769|sarcomerogenesis;GO:0030241|skeletal muscle myosin thick filament assembly;GO:0030240|skeletal muscle thin filament assembly;GO:0006941|striated muscle contraction;","GO:0000794|condensed nuclear chromosome;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0031674|I band;GO:0031430|M band;GO:0005859|muscle myosin complex;GO:0005865|striated muscle thin filament;GO:0030018|Z disc;","GO:0051015|actin filament binding;GO:0042805|actinin binding;GO:0005524|ATP binding;GO:0005509|calcium ion binding;GO:0005516|calmodulin binding;GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0051371|muscle alpha-actinin binding;GO:0002020|protease binding;GO:0019901|protein kinase binding;GO:0043621|protein self-association;GO:0004674|protein serine/threonine kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0008307|structural constituent of muscle;GO:0097493|structural molecule activity conferring elasticity;GO:0031433|telethonin binding;","K12567","TTN; titin [EC:2.7.11.1]"]
["bta_circ_0001286",14,0,10,5.3920640965197,0,0,0,4.4173520185328,0.032234556355243,"NA","up","yes","NC_037329.1:18211915..18213310:+","gene1570","gi|555991603|ref|XP_005907585.1|",114793,0,"PREDICTED: titin [Bos mutus]","gi|742201765|ref|XM_010859754.1|",65337,0,"PREDICTED: Bison bison bison titin (TTN), mRNA","Q8WZ42",{"v":42310,"d":"4.23E+04"},0,"Titin",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0060048|cardiac muscle contraction;GO:0048739|cardiac muscle fiber development;GO:0003300|cardiac muscle hypertrophy;GO:0055008|cardiac muscle tissue morphogenesis;GO:0055003|cardiac myofibril assembly;GO:0035995|detection of muscle stretch;GO:0007076|mitotic chromosome condensation;GO:0006936|muscle contraction;GO:0030049|muscle filament sliding;GO:0002576|platelet degranulation;GO:0010628|positive regulation of gene expression;GO:0050714|positive regulation of protein secretion;GO:0010737|protein kinase A signaling;GO:0050790|regulation of catalytic activity;GO:0045859|regulation of protein kinase activity;GO:0051592|response to calcium ion;GO:0045214|sarcomere organization;GO:0048769|sarcomerogenesis;GO:0030241|skeletal muscle myosin thick filament assembly;GO:0030240|skeletal muscle thin filament assembly;GO:0006941|striated muscle contraction;","GO:0000794|condensed nuclear chromosome;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0031674|I band;GO:0031430|M band;GO:0005859|muscle myosin complex;GO:0005865|striated muscle thin filament;GO:0030018|Z disc;","GO:0051015|actin filament binding;GO:0042805|actinin binding;GO:0005524|ATP binding;GO:0005509|calcium ion binding;GO:0005516|calmodulin binding;GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0051371|muscle alpha-actinin binding;GO:0002020|protease binding;GO:0019901|protein kinase binding;GO:0043621|protein self-association;GO:0004674|protein serine/threonine kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0008307|structural constituent of muscle;GO:0097493|structural molecule activity conferring elasticity;GO:0031433|telethonin binding;","K12567","TTN; titin [EC:2.7.11.1]"]
["bta_circ_0001308",0,0,0,1.92212528067962,4,8,0,-4.20039776669978,0.0373364173010268,"NA","down","yes","NC_037329.1:18237703..18239940:+","gene1570","gi|555991603|ref|XP_005907585.1|",114793,0,"PREDICTED: titin [Bos mutus]","gi|742201765|ref|XM_010859754.1|",65337,0,"PREDICTED: Bison bison bison titin (TTN), mRNA","Q8WZ42",{"v":42310,"d":"4.23E+04"},0,"Titin",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0060048|cardiac muscle contraction;GO:0048739|cardiac muscle fiber development;GO:0003300|cardiac muscle hypertrophy;GO:0055008|cardiac muscle tissue morphogenesis;GO:0055003|cardiac myofibril assembly;GO:0035995|detection of muscle stretch;GO:0007076|mitotic chromosome condensation;GO:0006936|muscle contraction;GO:0030049|muscle filament sliding;GO:0002576|platelet degranulation;GO:0010628|positive regulation of gene expression;GO:0050714|positive regulation of protein secretion;GO:0010737|protein kinase A signaling;GO:0050790|regulation of catalytic activity;GO:0045859|regulation of protein kinase activity;GO:0051592|response to calcium ion;GO:0045214|sarcomere organization;GO:0048769|sarcomerogenesis;GO:0030241|skeletal muscle myosin thick filament assembly;GO:0030240|skeletal muscle thin filament assembly;GO:0006941|striated muscle contraction;","GO:0000794|condensed nuclear chromosome;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0031674|I band;GO:0031430|M band;GO:0005859|muscle myosin complex;GO:0005865|striated muscle thin filament;GO:0030018|Z disc;","GO:0051015|actin filament binding;GO:0042805|actinin binding;GO:0005524|ATP binding;GO:0005509|calcium ion binding;GO:0005516|calmodulin binding;GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0051371|muscle alpha-actinin binding;GO:0002020|protease binding;GO:0019901|protein kinase binding;GO:0043621|protein self-association;GO:0004674|protein serine/threonine kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0008307|structural constituent of muscle;GO:0097493|structural molecule activity conferring elasticity;GO:0031433|telethonin binding;","K12567","TTN; titin [EC:2.7.11.1]"]
["bta_circ_0001362",0,0,0,2.05598309843732,3,0,8,-4.27243182799033,0.033574852292125,"NA","down","yes","NC_037329.1:19417590..19420660:-","gene1588","gi|332078536|ref|NP_001193648.1|",3258,0,"alkyldihydroxyacetonephosphate synthase, peroxisomal [Bos taurus]","gi|332078535|ref|NM_001206719.1|",3862,0,"Bos taurus alkylglycerone phosphate synthase (AGPS), mRNA","O00116",1232,0,"Alkyldihydroxyacetonephosphate synthase, peroxisomal","MT2311",259,{"v":6e-74,"d":"6.00E-74"},"COG0277","pfam02913","FAD-oxidase_C","FAD linked oxidases, C-terminal domain. This domain has a ferredoxin-like fold.","GO:0008611|ether lipid biosynthetic process;GO:0008610|lipid biosynthetic process;GO:0006625|protein targeting to peroxisome;","GO:0005829|cytosol;GO:0016020|membrane;GO:0005739|mitochondrion;GO:0005730|nucleolus;GO:0005782|peroxisomal matrix;GO:0005778|peroxisomal membrane;GO:0005777|peroxisome;","GO:0008609|alkylglycerone-phosphate synthase activity;GO:0071949|FAD binding;GO:0016614|oxidoreductase activity, acting on CH-OH group of donors;","K00803","AGPS, agpS; alkyldihydroxyacetonephosphate synthase [EC:2.5.1.26]"]
["bta_circ_0001366",10,32,21,28.8748858713885,33,43,42,-1.19820606701494,0.0394849122607308,0.441608034848668,"down","yes","NC_037329.1:20912016..20937104:+","gene1613","gi|742201920|ref|XP_010858096.1|",1819,0,"PREDICTED: protein lunapark isoform X2 [Bison bison bison]","gi|850477813|gb|CP011887.1|",6916,0,"Ovis canadensis canadensis isolate 43U chromosome 2 sequence","Q9C0E8",627,0,"Endoplasmic reticulum junction formation protein lunapark","ECU09g0710",56.2,{"v":3e-07,"d":"3.00E-07"},"COG5415","pfam10058","DUF2296","Predicted integral membrane metal-binding protein (DUF2296). This domain, found in various hypothetical bacterial and eukaryotic metal-binding proteins, has no known function.","GO:0007596|blood coagulation;GO:0042733|embryonic digit morphogenesis;GO:0035115|embryonic forelimb morphogenesis;GO:0071788|endoplasmic reticulum tubular network maintenance;GO:0060173|limb development;GO:1903373|positive regulation of endoplasmic reticulum tubular network organization;GO:0032330|regulation of chondrocyte differentiation;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0098826|endoplasmic reticulum tubular network membrane;GO:0030176|integral component of endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0005654|nucleoplasm;","GO:0042802|identical protein binding;GO:0046872|metal ion binding;",".","."]
["bta_circ_0001381",5,6,7,2.93287561980011,0,0,0,4.84028494030738,0.0118613992357573,"NA","up","yes","NC_037329.1:22806401..22807760:+","gene1639","gi|803230398|ref|XP_011975451.1|",3182,0,"PREDICTED: transcription factor Sp3 isoform X2 [Ovis aries musimon]","gi|965808774|ref|XM_012120061.2|",3815,0,"PREDICTED: Ovis aries musimon Sp3 transcription factor (SP3), transcript variant X2, mRNA","Q02447",1212,0,"Transcription factor Sp3",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0030183|B cell differentiation;GO:0060216|definitive hemopoiesis;GO:0048596|embryonic camera-type eye morphogenesis;GO:0001892|embryonic placenta development;GO:0060136|embryonic process involved in female pregnancy;GO:0048706|embryonic skeletal system development;GO:0043353|enucleate erythrocyte differentiation;GO:0030851|granulocyte differentiation;GO:0001889|liver development;GO:0030324|lung development;GO:0030219|megakaryocyte differentiation;GO:0030224|monocyte differentiation;GO:0001779|natural killer cell differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0001503|ossification;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0006355|regulation of transcription, DNA-templated;GO:0030217|T cell differentiation;GO:0006351|transcription, DNA-templated;GO:0001829|trophectodermal cell differentiation;","GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0016605|PML body;GO:0032993|protein-DNA complex;GO:0017053|transcriptional repressor complex;","GO:0003682|chromatin binding;GO:0046872|metal ion binding;GO:0000987|core promoter proximal region sequence-specific DNA binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K09193","SP3; transcription factor Sp3"]
["bta_circ_0001454",0,0,0,1.87943379995685,3,0,7,-4.13549299830096,0.0412350178633223,"NA","down","yes","NC_037329.1:29000368..29000655:+","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0001454",0,0,0,1.87943379995685,3,0,7,-4.13549299830096,0.0412350178633223,"NA","down","yes","NC_037329.1:29000368..29000655:+","gene1718","gi|296490637|tpg|DAA32750.1|",16280,0,"TPA: xin actin-binding repeat containing 2 [Bos taurus]","gi|982977277|ref|XM_002703606.5|",12111,0,"PREDICTED: Bos taurus xin actin binding repeat containing 2 (XIRP2), transcript variant X1, mRNA","A4UGR9",4896,0,"Xin actin-binding repeat-containing protein 2",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0030036|actin cytoskeleton organization;GO:0055008|cardiac muscle tissue morphogenesis;GO:0045216|cell-cell junction organization;GO:0003281|ventricular septum development;","GO:0030054|cell junction;GO:0030018|Z disc;","GO:0003779|actin binding;GO:0051393|alpha-actinin binding;",".","."]
["bta_circ_0001462",11,13,20,7.72276056856411,0,0,4,3.02018674992806,0.0127263900635765,0.289625845446867,"up","yes","NC_037329.1:31781105..31787090:+","gene1743","gi|218749853|ref|NP_001011681.2|",2773,0,"growth factor receptor-bound protein 14 [Bos taurus]","gi|218749852|ref|NM_001011681.3|",2648,0,"Bos taurus growth factor receptor bound protein 14 (GRB14), mRNA","Q5ICW4",1064,0,"Growth factor receptor-bound protein 14",".",".",".",".","pfam08947","BPS","BPS (Between PH and SH2). The BPS (Between PH and SH2) domain, comprised of 2 beta strands and a C-terminal helix, is an approximately 45 residue region found in the adaptor proteins Grb7/10/14 that mediates inhibition of the tyrosine kinase domain of the insulin receptor by binding of the N-terminal portion of the BPS domain to the substrate peptide groove of the kinase, acting as a pseudosubstrate inhibitor.","GO:0007165|signal transduction;","GO:0010008|endosome membrane;","GO:0005070|SH3/SH2 adaptor activity;",".","."]
["bta_circ_0001464",6,5,0,2.24439650803913,0,0,0,4.24101401352786,0.0353662669739191,"NA","up","yes","NC_037329.1:34406495..34415007:+","gene1756","gi|27806655|ref|NP_776464.1|",3066,0,"dipeptidyl peptidase 4 [Bos taurus]","gi|942058500|ref|XM_005897282.2|",2659,0,"PREDICTED: Bos mutus dipeptidyl-peptidase 4 (DPP4), mRNA","P81425",1186,0,"Dipeptidyl peptidase 4","SPACUNK4.08",266,{"v":1e-74,"d":"1.00E-74"},"COG1506","pfam00930","DPPIV_N","Dipeptidyl peptidase IV (DPP IV) N-terminal region. This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.","GO:0007155|cell adhesion;GO:0043542|endothelial cell migration;GO:0010716|negative regulation of extracellular matrix disassembly;GO:0008284|positive regulation of cell proliferation;GO:0031295|T cell costimulation;","GO:0016324|apical plasma membrane;GO:0030054|cell junction;GO:0009986|cell surface;GO:0030139|endocytic vesicle;GO:0005576|extracellular region;GO:0016021|integral component of membrane;GO:0071438|invadopodium membrane;GO:0030027|lamellipodium;GO:0031258|lamellipodium membrane;GO:0045121|membrane raft;","GO:0008239|dipeptidyl-peptidase activity;GO:0002020|protease binding;GO:0042803|protein homodimerization activity;GO:0004252|serine-type endopeptidase activity;GO:0005102|receptor binding;","K01278","DPP4; dipeptidyl-peptidase 4 [EC:3.4.14.5]"]
["bta_circ_0001517",0,0,0,2.99798567894327,8,3,5,-5.01940668902779,0.00814909018585748,"NA","down","yes","NC_037329.1:44433741..44437725:+","gene1832","gi|545191056|ref|XP_001915890.3|",39265,0,"PREDICTED: nebulin [Equus caballus]","gi|982977377|ref|XM_010826468.2|",14337,0,"PREDICTED: Bos taurus nebulin (NEB), mRNA","P20929",8578,0,"Nebulin",".",".",".",".","pfam00880","Nebulin","Nebulin repeat.","GO:0030049|muscle filament sliding;GO:0007517|muscle organ development;GO:0030832|regulation of actin filament length;GO:0007525|somatic muscle development;","GO:0015629|actin cytoskeleton;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0030018|Z disc;","GO:0003779|actin binding;GO:0008307|structural constituent of muscle;","K18267","NEB; nebulin"]
["bta_circ_0001548",6,26,12,25.3399535700753,43,30,36,-1.69751618075017,0.00962407217622546,0.247890543832493,"down","yes","NC_037329.1:44511818..44515315:+","gene1832","gi|545191056|ref|XP_001915890.3|",39265,0,"PREDICTED: nebulin [Equus caballus]","gi|982977377|ref|XM_010826468.2|",14337,0,"PREDICTED: Bos taurus nebulin (NEB), mRNA","P20929",8578,0,"Nebulin",".",".",".",".","pfam00880","Nebulin","Nebulin repeat.","GO:0030049|muscle filament sliding;GO:0007517|muscle organ development;GO:0030832|regulation of actin filament length;GO:0007525|somatic muscle development;","GO:0015629|actin cytoskeleton;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0030018|Z disc;","GO:0003779|actin binding;GO:0008307|structural constituent of muscle;","K18267","NEB; nebulin"]
["bta_circ_0001555",0,10,9,17.7978334905294,27,40,26,-2.65674116935178,0.000842875386030413,0.0492512590431825,"down","yes","NC_037329.1:44525700..44531086:+","gene1832","gi|545191056|ref|XP_001915890.3|",39265,0,"PREDICTED: nebulin [Equus caballus]","gi|982977377|ref|XM_010826468.2|",14337,0,"PREDICTED: Bos taurus nebulin (NEB), mRNA","P20929",8578,0,"Nebulin",".",".",".",".","pfam00880","Nebulin","Nebulin repeat.","GO:0030049|muscle filament sliding;GO:0007517|muscle organ development;GO:0030832|regulation of actin filament length;GO:0007525|somatic muscle development;","GO:0015629|actin cytoskeleton;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0030018|Z disc;","GO:0003779|actin binding;GO:0008307|structural constituent of muscle;","K18267","NEB; nebulin"]
["bta_circ_0001596",0,0,0,2.14529570197858,10,0,0,-4.09775057491162,0.0456499808126436,"NA","down","yes","NC_037329.1:44636795..44640748:+","gene1832","gi|545191056|ref|XP_001915890.3|",39265,0,"PREDICTED: nebulin [Equus caballus]","gi|982977377|ref|XM_010826468.2|",14337,0,"PREDICTED: Bos taurus nebulin (NEB), mRNA","P20929",8578,0,"Nebulin",".",".",".",".","pfam00880","Nebulin","Nebulin repeat.","GO:0030049|muscle filament sliding;GO:0007517|muscle organ development;GO:0030832|regulation of actin filament length;GO:0007525|somatic muscle development;","GO:0015629|actin cytoskeleton;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0030018|Z disc;","GO:0003779|actin binding;GO:0008307|structural constituent of muscle;","K18267","NEB; nebulin"]
["bta_circ_0001599",0,4,0,15.5640442371737,31,23,31,-4.63422497222279,{"v":7.02946947615293e-06,"d":"7.03E-06"},0.00168863477860474,"down","yes","NC_037329.1:44637936..44643004:+","gene1832","gi|545191056|ref|XP_001915890.3|",39265,0,"PREDICTED: nebulin [Equus caballus]","gi|982977377|ref|XM_010826468.2|",14337,0,"PREDICTED: Bos taurus nebulin (NEB), mRNA","P20929",8578,0,"Nebulin",".",".",".",".","pfam00880","Nebulin","Nebulin repeat.","GO:0030049|muscle filament sliding;GO:0007517|muscle organ development;GO:0030832|regulation of actin filament length;GO:0007525|somatic muscle development;","GO:0015629|actin cytoskeleton;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0030018|Z disc;","GO:0003779|actin binding;GO:0008307|structural constituent of muscle;","K18267","NEB; nebulin"]
["bta_circ_0001602",0,0,0,2.01800282671993,2,0,9,-4.2315668046309,0.0358864197419878,"NA","down","yes","NC_037329.1:44639641..44643004:+","gene1832","gi|545191056|ref|XP_001915890.3|",39265,0,"PREDICTED: nebulin [Equus caballus]","gi|982977377|ref|XM_010826468.2|",14337,0,"PREDICTED: Bos taurus nebulin (NEB), mRNA","P20929",8578,0,"Nebulin",".",".",".",".","pfam00880","Nebulin","Nebulin repeat.","GO:0030049|muscle filament sliding;GO:0007517|muscle organ development;GO:0030832|regulation of actin filament length;GO:0007525|somatic muscle development;","GO:0015629|actin cytoskeleton;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0030018|Z disc;","GO:0003779|actin binding;GO:0008307|structural constituent of muscle;","K18267","NEB; nebulin"]
["bta_circ_0001605",0,0,0,4.49105181922717,10,11,5,-5.64251328583883,0.00192627419250398,"NA","down","yes","NC_037329.1:44640656..44643004:+","gene1832","gi|545191056|ref|XP_001915890.3|",39265,0,"PREDICTED: nebulin [Equus caballus]","gi|982977377|ref|XM_010826468.2|",14337,0,"PREDICTED: Bos taurus nebulin (NEB), mRNA","P20929",8578,0,"Nebulin",".",".",".",".","pfam00880","Nebulin","Nebulin repeat.","GO:0030049|muscle filament sliding;GO:0007517|muscle organ development;GO:0030832|regulation of actin filament length;GO:0007525|somatic muscle development;","GO:0015629|actin cytoskeleton;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0030018|Z disc;","GO:0003779|actin binding;GO:0008307|structural constituent of muscle;","K18267","NEB; nebulin"]
["bta_circ_0001613",0,0,0,2.10424273093714,3,7,3,-4.52192249013404,0.0208922133492204,"NA","down","yes","NC_037329.1:44667714..44675631:-","gene1834","gi|119887681|ref|XP_615269.3|",11816,0,"PREDICTED: telomere-associated protein RIF1 isoform X1 [Bos taurus]","gi|982977382|ref|XM_010826492.2|",9577,0,"PREDICTED: Bos taurus replication timing regulatory factor 1 (RIF1), transcript variant X5, mRNA","Q5UIP0",3533,0,"Telomere-associated protein RIF1",".",".",".",".","pfam12231","Rif1_N","Rap1-interacting factor 1 N terminal. This domain family is found in eukaryotes, and is typically between 135 and 146 amino acids in length. Rif1 is a protein which interacts with Rap1 to regulate telomere length. Interaction with telomeres limits their length. The N terminal region contains many HEAT- and ARMADILLO- type repeats. These are helical folds which form extended curved proteins or RNA interface surfaces.","GO:0007049|cell cycle;GO:0006974|cellular response to DNA damage stimulus;GO:1990830|cellular response to leukemia inhibitory factor;GO:0006348|chromatin silencing at telomere;GO:0006303|double-strand break repair via nonhomologous end joining;GO:2000042|negative regulation of double-strand break repair via homologous recombination;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:2001034|positive regulation of double-strand break repair via nonhomologous end joining;GO:0051574|positive regulation of histone H3-K9 methylation;GO:0045830|positive regulation of isotype switching;GO:0019827|stem cell population maintenance;GO:0000723|telomere maintenance;GO:0043247|telomere maintenance in response to DNA damage;","GO:0000781|chromosome, telomeric region;GO:0000793|condensed chromosome;GO:0005737|cytoplasm;GO:0001939|female pronucleus;GO:0001940|male pronucleus;GO:0016604|nuclear body;GO:0000790|nuclear chromatin;GO:0031965|nuclear membrane;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0035861|site of double-strand break;GO:0051233|spindle midzone;",".","K11138","RIF1; telomere-associated protein RIF1"]
["bta_circ_0001629",2,0,13,2.23764249797125,0,0,0,4.2647196431109,0.0343604191592178,"NA","up","yes","NC_037329.1:47853191..48008099:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0001646",0,0,2,4.53321058759483,15,4,3,-3.37234429916367,0.0229779564599846,"NA","down","yes","NC_037329.1:48309834..48316688:-","gene1858","gi|281353901|gb|EFB29485.1|",2635,0,"hypothetical protein PANDA_012344, partial [Ailuropoda melanoleuca]","gi|147899459|ref|NM_174227.3|",4395,0,"Bos taurus activin A receptor type IIA (ACVR2A), mRNA","Q28043",965,0,"Activin receptor type-2A",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0009952|anterior/posterior pattern specification;GO:0030509|BMP signaling pathway;GO:0007368|determination of left/right symmetry;GO:0048706|embryonic skeletal system development;GO:0001702|gastrulation with mouth forming second;GO:0007498|mesoderm development;GO:0043084|penile erection;GO:0032927|positive regulation of activin receptor signaling pathway;GO:0030501|positive regulation of bone mineralization;GO:0045648|positive regulation of erythrocyte differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0030510|regulation of BMP signaling pathway;GO:0050999|regulation of nitric-oxide synthase activity;GO:0060011|Sertoli cell proliferation;GO:0042713|sperm ejaculation;GO:0007283|spermatogenesis;","GO:0009986|cell surface;GO:0005737|cytoplasm;GO:0034673|inhibin-betaglycan-ActRII complex;GO:0016021|integral component of membrane;GO:0043235|receptor complex;","GO:0048185|activin binding;GO:0017002|activin-activated receptor activity;GO:0005524|ATP binding;GO:0098821|BMP receptor activity;GO:0015026|coreceptor activity;GO:0019838|growth factor binding;GO:0034711|inhibin binding;GO:0046872|metal ion binding;GO:0030165|PDZ domain binding;GO:0043621|protein self-association;","K04670","ACVR2A; activin receptor type-2A [EC:2.7.11.30]"]
["bta_circ_0001714",0,14,5,1.96956624023832,0,0,0,4.16970611211419,0.0393827908396483,"NA","up","yes","NC_037329.1:71814940..71822750:+","gene1969","gi|528939530|ref|XP_005202620.1|",3748,0,"PREDICTED: band 4.1-like protein 5 isoform X2 [Bos taurus]","gi|982914037|ref|XM_005202563.3|",6626,0,"PREDICTED: Bos taurus erythrocyte membrane protein band 4.1 like 5 (EPB41L5), transcript variant X2, mRNA","Q9HCM4",1230,0,"Band 4.1-like protein 5",".",".",".",".","pfam09380","FERM_C","FERM C-terminal PH-like domain.","GO:0031032|actomyosin structure organization;GO:0003383|apical constriction;GO:0048319|axial mesoderm morphogenesis;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0007398|ectoderm development;GO:0048617|embryonic foregut morphogenesis;GO:0007492|endoderm development;GO:0001837|epithelial to mesenchymal transition;GO:0001701|in utero embryonic development;GO:0070986|left/right axis specification;GO:0007509|mesoderm migration involved in gastrulation;GO:0022408|negative regulation of cell-cell adhesion;GO:0032091|negative regulation of protein binding;GO:0001839|neural plate morphogenesis;GO:0048339|paraxial mesoderm development;GO:0010634|positive regulation of epithelial cell migration;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0051894|positive regulation of focal adhesion assembly;GO:0032092|positive regulation of protein binding;GO:0010608|posttranscriptional regulation of gene expression;GO:0070201|regulation of establishment of protein localization;GO:0032525|somite rostral/caudal axis specification;GO:0006931|substrate-dependent cell migration, cell attachment to substrate;GO:0009826|unidimensional cell growth;","GO:0005856|cytoskeleton;GO:0005829|cytosol;GO:0005925|focal adhesion;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0032587|ruffle membrane;","GO:0008092|cytoskeletal protein binding;GO:0019904|protein domain specific binding;GO:0005200|structural constituent of cytoskeleton;",".","."]
["bta_circ_0001718",7,3,4,2.85540861623941,0,0,0,4.73392754000947,0.0147264841476914,"NA","up","yes","NC_037329.1:7289998..7305116:+","gene1498","gi|556751440|ref|XP_005971122.1|",1974,0,"PREDICTED: collagen alpha-2(V) chain-like [Pantholops hodgsonii]","gi|742214764|ref|XM_010862914.1|",6349,0,"PREDICTED: Bison bison bison collagen, type V, alpha 2 (COL5A2), transcript variant X1, mRNA","P05997",713,0,"Collagen alpha-2(V) chain",".",".",".",".","pfam01410","COLFI","Fibrillar collagen C-terminal domain. Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.","GO:0071230|cellular response to amino acid stimulus;GO:0030199|collagen fibril organization;GO:0030198|extracellular matrix organization;GO:0048592|eye morphogenesis;GO:1903225|negative regulation of endodermal cell differentiation;GO:0001503|ossification;GO:0001501|skeletal system development;GO:0043588|skin development;","GO:0005588|collagen type V trimer;GO:0005788|endoplasmic reticulum lumen;GO:0031012|extracellular matrix;GO:0005576|extracellular region;","GO:0005201|extracellular matrix structural constituent;GO:0046872|metal ion binding;GO:0046332|SMAD binding;",".","."]
["bta_circ_0001743",0,0,0,1.81918092113124,6,4,0,-4.0955899082643,0.0435962346374214,"NA","down","yes","NC_037329.1:79850032..79921070:+","gene2009","gi|741917017|ref|XP_010800455.1|",5784,0,"PREDICTED: unconventional myosin-Ib isoform X1 [Bos taurus]","gi|156121044|ref|NM_001102199.1|",4814,0,"Bos taurus myosin IB (MYO1B), mRNA","O43795",2168,0,"Unconventional myosin-Ib","SPBC146.13c",527,{"v":5e-161,"d":"5.00E-161"},"COG5022","pfam00063","Myosin_head","Myosin head (motor domain).","GO:0051017|actin filament bundle assembly;GO:0007015|actin filament organization;GO:0030048|actin filament-based movement;GO:0007018|microtubule-based movement;GO:0006892|post-Golgi vesicle-mediated transport;","GO:0005884|actin filament;GO:0045177|apical part of cell;GO:0005903|brush border;GO:0071944|cell periphery;GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0010008|endosome membrane;GO:0070062|extracellular exosome;GO:0030175|filopodium;GO:0016459|myosin complex;GO:0048471|perinuclear region of cytoplasm;GO:0005886|plasma membrane;","GO:0051015|actin filament binding;GO:0030898|actin-dependent ATPase activity;GO:0005524|ATP binding;GO:0045296|cadherin binding;GO:0005516|calmodulin binding;GO:0000146|microfilament motor activity;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;","K10356","MYO1; myosin I"]
["bta_circ_0001746",0,0,0,1.99030191578497,0,7,6,-4.27148943016322,0.0334416442708374,"NA","down","yes","NC_037329.1:810533..811606:-","gene1428","gi|329663335|ref|NP_001193010.1|",22804,0,"E3 ubiquitin-protein ligase HERC2 [Bos taurus]","gi|741915816|ref|XM_005202179.2|",14245,0,"PREDICTED: Bos taurus HECT and RLD domain containing E3 ubiquitin protein ligase 2 (HERC2), transcript variant X1, mRNA","O95714",8400,0,"E3 ubiquitin-protein ligase HERC2","SPBC557.03c",105,{"v":7e-22,"d":"7.00E-22"},"COG5184","pfam11515","Cul7","Mouse development and cellular proliferation protein Cullin-7. The Cullin Ring Ligase family member, Cul7, is required for normal mouse development and cellular proliferation. Cul7 has a CPH domain which is a p53 interaction domain. The CPH domain interaction surface of P53 is present in the tetramerization domain.","GO:0006974|cellular response to DNA damage stimulus;GO:0006303|double-strand break repair via nonhomologous end joining;GO:0006886|intracellular protein transport;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567|protein ubiquitination;GO:0007283|spermatogenesis;","GO:0005814|centriole;GO:0005737|cytoplasm;GO:0016020|membrane;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0032183|SUMO binding;GO:0061630|ubiquitin protein ligase activity;GO:0031625|ubiquitin protein ligase binding;GO:0004842|ubiquitin-protein transferase activity;GO:0008270|zinc ion binding;","K10595","HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]"]
["bta_circ_0001749",0,0,0,2.22139609336368,5,2,5,-4.56936234536652,0.0193206446379133,"NA","down","yes","NC_037329.1:834247..850978:-","gene1428","gi|329663335|ref|NP_001193010.1|",22804,0,"E3 ubiquitin-protein ligase HERC2 [Bos taurus]","gi|741915816|ref|XM_005202179.2|",14245,0,"PREDICTED: Bos taurus HECT and RLD domain containing E3 ubiquitin protein ligase 2 (HERC2), transcript variant X1, mRNA","O95714",8400,0,"E3 ubiquitin-protein ligase HERC2","SPBC557.03c",105,{"v":7e-22,"d":"7.00E-22"},"COG5184","pfam11515","Cul7","Mouse development and cellular proliferation protein Cullin-7. The Cullin Ring Ligase family member, Cul7, is required for normal mouse development and cellular proliferation. Cul7 has a CPH domain which is a p53 interaction domain. The CPH domain interaction surface of P53 is present in the tetramerization domain.","GO:0006974|cellular response to DNA damage stimulus;GO:0006303|double-strand break repair via nonhomologous end joining;GO:0006886|intracellular protein transport;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567|protein ubiquitination;GO:0007283|spermatogenesis;","GO:0005814|centriole;GO:0005737|cytoplasm;GO:0016020|membrane;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0032183|SUMO binding;GO:0061630|ubiquitin protein ligase activity;GO:0031625|ubiquitin protein ligase binding;GO:0004842|ubiquitin-protein transferase activity;GO:0008270|zinc ion binding;","K10595","HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]"]
["bta_circ_0001768",8,206,112,47.8067240758098,13,41,19,1.61214148633559,0.0149416977720158,0.298906981742218,"up","yes","NC_037329.1:86226993..86290747:-","gene2047","gi|795075574|ref|XP_011844543.1|",1278,{"v":1e-169,"d":"1.00E-169"},"PREDICTED: protein boule-like isoform X1 [Mandrillus leucophaeus]","gi|555965204|ref|XM_005894599.1|",1784,0,"PREDICTED: Bos mutus boule-like RNA-binding protein (BOLL), transcript variant X1, mRNA","Q8WP23",446,{"v":4e-152,"d":"4.00E-152"},"Protein boule-like","TP0356",56.6,{"v":1e-08,"d":"1.00E-08"},"COG0724","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0007281|germ cell development;GO:0007275|multicellular organismal development;GO:0006417|regulation of translation;GO:0007283|spermatogenesis;","GO:0005737|cytoplasm;","GO:0003729|mRNA binding;",".","."]
["bta_circ_0001774",0,16,8,2.54077929083403,0,0,0,4.54816684729558,0.0214317588202087,"NA","up","yes","NC_037329.1:86260609..86290747:-","gene2047","gi|795075574|ref|XP_011844543.1|",1278,{"v":1e-169,"d":"1.00E-169"},"PREDICTED: protein boule-like isoform X1 [Mandrillus leucophaeus]","gi|555965204|ref|XM_005894599.1|",1784,0,"PREDICTED: Bos mutus boule-like RNA-binding protein (BOLL), transcript variant X1, mRNA","Q8WP23",446,{"v":4e-152,"d":"4.00E-152"},"Protein boule-like","TP0356",56.6,{"v":1e-08,"d":"1.00E-08"},"COG0724","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0007281|germ cell development;GO:0007275|multicellular organismal development;GO:0006417|regulation of translation;GO:0007283|spermatogenesis;","GO:0005737|cytoplasm;","GO:0003729|mRNA binding;",".","."]
["bta_circ_0001775",19,301,218,76.3585004244442,10,55,28,2.05886369851999,0.000788520486680768,0.0492512590431825,"up","yes","NC_037329.1:86270848..86290747:-","gene2047","gi|795075574|ref|XP_011844543.1|",1278,{"v":1e-169,"d":"1.00E-169"},"PREDICTED: protein boule-like isoform X1 [Mandrillus leucophaeus]","gi|555965204|ref|XM_005894599.1|",1784,0,"PREDICTED: Bos mutus boule-like RNA-binding protein (BOLL), transcript variant X1, mRNA","Q8WP23",446,{"v":4e-152,"d":"4.00E-152"},"Protein boule-like","TP0356",56.6,{"v":1e-08,"d":"1.00E-08"},"COG0724","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0007281|germ cell development;GO:0007275|multicellular organismal development;GO:0006417|regulation of translation;GO:0007283|spermatogenesis;","GO:0005737|cytoplasm;","GO:0003729|mRNA binding;",".","."]
["bta_circ_0001776",0,20,11,3.30278193316327,0,0,0,4.92737042239985,0.0106828860610288,"NA","up","yes","NC_037329.1:86283257..86290747:-","gene2047","gi|795075574|ref|XP_011844543.1|",1278,{"v":1e-169,"d":"1.00E-169"},"PREDICTED: protein boule-like isoform X1 [Mandrillus leucophaeus]","gi|555965204|ref|XM_005894599.1|",1784,0,"PREDICTED: Bos mutus boule-like RNA-binding protein (BOLL), transcript variant X1, mRNA","Q8WP23",446,{"v":4e-152,"d":"4.00E-152"},"Protein boule-like","TP0356",56.6,{"v":1e-08,"d":"1.00E-08"},"COG0724","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0007281|germ cell development;GO:0007275|multicellular organismal development;GO:0006417|regulation of translation;GO:0007283|spermatogenesis;","GO:0005737|cytoplasm;","GO:0003729|mRNA binding;",".","."]
["bta_circ_0001777",6,3,3,2.43403037516779,0,0,0,4.50602310597401,0.0221364496741692,"NA","up","yes","NC_037329.1:86284995..86290747:-","gene2047","gi|795075574|ref|XP_011844543.1|",1278,{"v":1e-169,"d":"1.00E-169"},"PREDICTED: protein boule-like isoform X1 [Mandrillus leucophaeus]","gi|555965204|ref|XM_005894599.1|",1784,0,"PREDICTED: Bos mutus boule-like RNA-binding protein (BOLL), transcript variant X1, mRNA","Q8WP23",446,{"v":4e-152,"d":"4.00E-152"},"Protein boule-like","TP0356",56.6,{"v":1e-08,"d":"1.00E-08"},"COG0724","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0007281|germ cell development;GO:0007275|multicellular organismal development;GO:0006417|regulation of translation;GO:0007283|spermatogenesis;","GO:0005737|cytoplasm;","GO:0003729|mRNA binding;",".","."]
["bta_circ_0001778",65,428,216,107.292909946197,18,73,36,2.09854919680228,{"v":1.48499646776195e-05,"d":"1.48E-05"},0.00246966335638563,"up","yes","NC_037329.1:86287796..86290747:-","gene2047","gi|795075574|ref|XP_011844543.1|",1278,{"v":1e-169,"d":"1.00E-169"},"PREDICTED: protein boule-like isoform X1 [Mandrillus leucophaeus]","gi|555965204|ref|XM_005894599.1|",1784,0,"PREDICTED: Bos mutus boule-like RNA-binding protein (BOLL), transcript variant X1, mRNA","Q8WP23",446,{"v":4e-152,"d":"4.00E-152"},"Protein boule-like","TP0356",56.6,{"v":1e-08,"d":"1.00E-08"},"COG0724","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0007281|germ cell development;GO:0007275|multicellular organismal development;GO:0006417|regulation of translation;GO:0007283|spermatogenesis;","GO:0005737|cytoplasm;","GO:0003729|mRNA binding;",".","."]
["bta_circ_0001819",21,71,45,57.312045639565,67,71,84,-1.03159101610822,0.0310979836949594,0.428634275476763,"down","yes","NC_037329.1:91235148..91285510:+","gene2108","gi|742207048|ref|XP_010859302.1|",2863,0,"PREDICTED: calcium-responsive transcription factor isoform X4 [Bison bison bison]","gi|742207047|ref|XM_010861000.1|",3245,0,"PREDICTED: Bison bison bison calcium responsive transcription factor (CARF), transcript variant X9, mRNA","Q58CW6",1019,0,"Calcium-responsive transcription factor",".",".",".",".","pfam15299","ALS2CR8","Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8. This domain is found in amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein.","GO:0071277|cellular response to calcium ion;GO:0035865|cellular response to potassium ion;GO:0061400|positive regulation of transcription from RNA polymerase II promoter in response to calcium ion;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;",".","."]
["bta_circ_0001839",0,0,0,1.72430016581292,0,5,6,-4.0436666411325,0.0469482969777028,"NA","down","yes","NC_037329.1:94463754..94477004:-","gene2132","gi|27807355|ref|NP_777245.1|",3905,0,"NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor [Bos taurus]","gi|982914407|ref|XM_005202713.3|",3915,0,"PREDICTED: Bos taurus NADH:ubiquinone oxidoreductase core subunit S1 (NDUFS1), transcript variant X1, mRNA","P15690",1508,0,"NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial","CC1946",677,0,"COG1034","pfam00384","Molybdopterin","Molybdopterin oxidoreductase.","GO:0008637|apoptotic mitochondrial changes;GO:0046034|ATP metabolic process;GO:0042773|ATP synthesis coupled electron transport;GO:0045333|cellular respiration;GO:0072593|reactive oxygen species metabolic process;GO:0051881|regulation of mitochondrial membrane potential;","GO:0005758|mitochondrial intermembrane space;GO:0005747|mitochondrial respiratory chain complex I;GO:0005739|mitochondrion;GO:0043209|myelin sheath;","GO:0051537|2 iron, 2 sulfur cluster binding;GO:0051539|4 iron, 4 sulfur cluster binding;GO:0009055|electron carrier activity;GO:0051536|iron-sulfur cluster binding;GO:0046872|metal ion binding;GO:0008137|NADH dehydrogenase (ubiquinone) activity;","K03934","NDUFS1; NADH dehydrogenase (ubiquinone) Fe-S protein 1 [EC:1.6.5.3 1.6.99.3]"]
["bta_circ_0001863",0,8,10,2.03123656314139,0,0,0,4.21514809347415,0.0367195670272668,"NA","up","yes","NC_037329.1:97706420..97710565:+","gene2177","gi|594100257|ref|XP_006073233.1|",16183,0,"PREDICTED: protein unc-80 homolog isoform X1 [Bubalus bubalis]","gi|965922329|ref|XM_012144806.2|",8934,0,"PREDICTED: Ovis aries unc-80 homolog, NALCN activator (UNC80), transcript variant X7, mRNA","Q8N2C7",3397,0,"Protein unc-80 homolog",".",".",".",".","pfam06293","Kdo","Lipopolysaccharide kinase (Kdo/WaaP) family. These lipopolysaccharide kinases are related to protein kinases pfam00069. This family includes waaP (rfaP) gene product is required for the addition of phosphate to O-4 of the first heptose residue of the lipopolysaccharide (LPS) inner core region. It has previously been shown that WaaP is necessary for resistance to hydrophobic and polycationic antimicrobials in Escherichia coli and that it is required for virulence in invasive strains of S. enterica.","GO:0034220|ion transmembrane transport;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;",".",".","."]
["bta_circ_0001865",0,3,0,4.26429276671722,7,8,8,-3.07000426136996,0.0303659656687123,"NA","down","yes","NC_037329.1:97867586..97921405:-","gene2179","gi|555953751|ref|XP_005889047.1|",4908,0,"PREDICTED: KAT8 regulatory NSL complex subunit 1-like protein [Bos mutus]","gi|742207406|ref|XM_010861095.1|",4413,0,"PREDICTED: Bison bison bison KAT8 regulatory NSL complex subunit 1-like (KANSL1L), transcript variant X1, mRNA","A0AUZ9",1604,0,"KAT8 regulatory NSL complex subunit 1-like protein",".",".",".",".","pfam15275","PEHE","PEHE domain. This domain was first identified in drosophila MSL1 (male-specific lethal 1). In drosophila it binds to the histone acetyltransferase males-absent on the first protein (MOF) and to protein male-specific lethal-3 (MSL3).",".","GO:0000123|histone acetyltransferase complex;",".",".","."]
["bta_circ_0001868",0,0,0,4.58692936526749,8,3,14,-5.63105448897971,0.00205396729641361,"NA","down","yes","NC_037329.1:97890634..97921405:-","gene2179","gi|555953751|ref|XP_005889047.1|",4908,0,"PREDICTED: KAT8 regulatory NSL complex subunit 1-like protein [Bos mutus]","gi|742207406|ref|XM_010861095.1|",4413,0,"PREDICTED: Bison bison bison KAT8 regulatory NSL complex subunit 1-like (KANSL1L), transcript variant X1, mRNA","A0AUZ9",1604,0,"KAT8 regulatory NSL complex subunit 1-like protein",".",".",".",".","pfam15275","PEHE","PEHE domain. This domain was first identified in drosophila MSL1 (male-specific lethal 1). In drosophila it binds to the histone acetyltransferase males-absent on the first protein (MOF) and to protein male-specific lethal-3 (MSL3).",".","GO:0000123|histone acetyltransferase complex;",".",".","."]
["bta_circ_0001871",11,56,29,39.316626981632,41,55,62,-1.10095677255913,0.0420061981820073,0.456494092506297,"down","yes","NC_037329.1:97911403..97921405:-","gene2179","gi|555953751|ref|XP_005889047.1|",4908,0,"PREDICTED: KAT8 regulatory NSL complex subunit 1-like protein [Bos mutus]","gi|742207406|ref|XM_010861095.1|",4413,0,"PREDICTED: Bison bison bison KAT8 regulatory NSL complex subunit 1-like (KANSL1L), transcript variant X1, mRNA","A0AUZ9",1604,0,"KAT8 regulatory NSL complex subunit 1-like protein",".",".",".",".","pfam15275","PEHE","PEHE domain. This domain was first identified in drosophila MSL1 (male-specific lethal 1). In drosophila it binds to the histone acetyltransferase males-absent on the first protein (MOF) and to protein male-specific lethal-3 (MSL3).",".","GO:0000123|histone acetyltransferase complex;",".",".","."]
["bta_circ_0001874",4,15,29,22.9781489473065,24,39,36,-1.34151094377495,0.0498077302375492,0.476348344536443,"down","yes","NC_037329.1:97921264..97949942:-","gene2179","gi|555953751|ref|XP_005889047.1|",4908,0,"PREDICTED: KAT8 regulatory NSL complex subunit 1-like protein [Bos mutus]","gi|742207406|ref|XM_010861095.1|",4413,0,"PREDICTED: Bison bison bison KAT8 regulatory NSL complex subunit 1-like (KANSL1L), transcript variant X1, mRNA","A0AUZ9",1604,0,"KAT8 regulatory NSL complex subunit 1-like protein",".",".",".",".","pfam15275","PEHE","PEHE domain. This domain was first identified in drosophila MSL1 (male-specific lethal 1). In drosophila it binds to the histone acetyltransferase males-absent on the first protein (MOF) and to protein male-specific lethal-3 (MSL3).",".","GO:0000123|histone acetyltransferase complex;",".",".","."]
["bta_circ_0001875",62,339,301,242.467347608576,265,314,312,-0.77518292503243,0.0495387630857542,0.476348344536443,"down","yes","NC_037329.1:97948826..97949942:-","gene2179","gi|555953751|ref|XP_005889047.1|",4908,0,"PREDICTED: KAT8 regulatory NSL complex subunit 1-like protein [Bos mutus]","gi|742207406|ref|XM_010861095.1|",4413,0,"PREDICTED: Bison bison bison KAT8 regulatory NSL complex subunit 1-like (KANSL1L), transcript variant X1, mRNA","A0AUZ9",1604,0,"KAT8 regulatory NSL complex subunit 1-like protein",".",".",".",".","pfam15275","PEHE","PEHE domain. This domain was first identified in drosophila MSL1 (male-specific lethal 1). In drosophila it binds to the histone acetyltransferase males-absent on the first protein (MOF) and to protein male-specific lethal-3 (MSL3).",".","GO:0000123|histone acetyltransferase complex;",".",".","."]
["bta_circ_0001917",0,11,7,1.93699749187949,0,0,0,4.14962021198193,0.0405207360649149,"NA","up","yes","NC_037330.1:103592509..103601069:-","gene4451","gi|594089949|ref|XP_006068388.1|",2945,0,"PREDICTED: coiled-coil domain-containing protein 30 isoform X1 [Bubalus bubalis]","gi|982979633|ref|XR_001496160.1|",2337,0,"PREDICTED: Bos taurus TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L pseudogene (LOC538699), misc_RNA","O75529",1056,0,"TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L",".",".",".",".","pfam04494","TFIID_90kDa","WD40 associated region in TFIID subunit. This region, possibly a domain is found in subunits of transcription factor TFIID. The function of this region is unknown.","GO:0043966|histone H3 acetylation;GO:0006366|transcription from RNA polymerase II promoter;","GO:0036464|cytoplasmic ribonucleoprotein granule;GO:0016607|nuclear speck;GO:0005634|nucleus;GO:0030914|STAGA complex;GO:0033276|transcription factor TFTC complex;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0003713|transcription coactivator activity;","K03130","TAF5; transcription initiation factor TFIID subunit 5"]
["bta_circ_0001935",0,0,0,1.84145352823946,2,0,8,-4.09373446956485,0.0439610261947129,"NA","down","yes","NC_037330.1:103927120..103968312:+","gene4456","gi|602680547|ref|XP_007453081.1|",1775,0,"PREDICTED: forkhead box protein J3, partial [Lipotes vexillifer]","gi|594053423|ref|XM_006050947.1|",4736,0,"PREDICTED: Bubalus bubalis forkhead box J3 (FOXJ3), transcript variant X2, mRNA","Q9UPW0",660,0,"Forkhead box protein J3","ECU11g1330",105,{"v":2e-23,"d":"2.00E-23"},"COG5025","pfam00250","Fork_head","Fork head domain.","GO:0009653|anatomical structure morphogenesis;GO:0030154|cell differentiation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;","GO:0005634|nucleus;","GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0001228|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;","K09403","FOXJ2_3; forkhead box protein J2/3"]
["bta_circ_0001947",6,6,16,4.36871641783756,0,0,0,5.40335909587339,0.00357576120839452,"NA","up","yes","NC_037330.1:105062331..105069354:+","gene4464","gi|741921999|ref|XP_010802000.1|",3089,0,"PREDICTED: polycomb protein SCMH1 isoform X4 [Bos taurus]","gi|982920179|ref|XM_010803698.2|",3480,0,"PREDICTED: Bos taurus sex comb on midleg homolog 1 (Drosophila) (SCMH1), transcript variant X4, mRNA","Q96GD3",1116,0,"Polycomb protein SCMH1",".",".",".",".","pfam12140","DUF3588","Protein of unknown function (DUF3588). This family of proteins is found in eukaryotes. Proteins in this family are typically between 129 and 866 amino acids in length, and the family is found in association with pfam02820. The exact function of this family is not known.","GO:0009952|anterior/posterior pattern specification;GO:0006338|chromatin remodeling;GO:0016458|gene silencing;GO:0045892|negative regulation of transcription, DNA-templated;GO:0007283|spermatogenesis;GO:0006351|transcription, DNA-templated;","GO:0010369|chromocenter;GO:0005654|nucleoplasm;",".","K11461","SCMH1; polycomb protein SCMH1"]
["bta_circ_0001950",0,0,0,2.49839429893952,10,0,2,-4.52823663657354,0.0224161615016364,"NA","down","yes","NC_037330.1:105069120..105096234:+","gene4464","gi|741921999|ref|XP_010802000.1|",3089,0,"PREDICTED: polycomb protein SCMH1 isoform X4 [Bos taurus]","gi|982920179|ref|XM_010803698.2|",3480,0,"PREDICTED: Bos taurus sex comb on midleg homolog 1 (Drosophila) (SCMH1), transcript variant X4, mRNA","Q96GD3",1116,0,"Polycomb protein SCMH1",".",".",".",".","pfam12140","DUF3588","Protein of unknown function (DUF3588). This family of proteins is found in eukaryotes. Proteins in this family are typically between 129 and 866 amino acids in length, and the family is found in association with pfam02820. The exact function of this family is not known.","GO:0009952|anterior/posterior pattern specification;GO:0006338|chromatin remodeling;GO:0016458|gene silencing;GO:0045892|negative regulation of transcription, DNA-templated;GO:0007283|spermatogenesis;GO:0006351|transcription, DNA-templated;","GO:0010369|chromocenter;GO:0005654|nucleoplasm;",".","K11461","SCMH1; polycomb protein SCMH1"]
["bta_circ_0001980",0,0,0,1.90320506879608,0,9,4,-4.20148622069518,0.0372898688738234,"NA","down","yes","NC_037330.1:110381599..110391630:-","gene4578","gi|742124920|ref|XP_010839496.1|",7828,0,"PREDICTED: zinc finger MYM-type protein 4 isoform X3 [Bison bison bison]","gi|982979735|ref|XM_005197944.3|",6881,0,"PREDICTED: Bos taurus zinc finger, MYM-type 4 (ZMYM4), transcript variant X2, mRNA","Q5VZL5",2902,0,"Zinc finger MYM-type protein 4",".",".",".",".","pfam12012","DUF3504","Domain of unknown function (DUF3504). This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 156 to 173 amino acids in length.","GO:0007010|cytoskeleton organization;GO:0007275|multicellular organismal development;GO:0022604|regulation of cell morphogenesis;","GO:0005737|cytoplasm;GO:0005654|nucleoplasm;","GO:0003677|DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0008270|zinc ion binding;",".","."]
["bta_circ_0002003",0,0,0,4.04057701449492,11,6,5,-5.46916654134557,0.00297977535455895,"NA","down","yes","NC_037330.1:112553316..112557663:+","gene4604","gi|156120403|ref|NP_001095347.1|",2524,0,"PERQ amino acid-rich with GYF domain-containing protein 2 [Bos taurus]","gi|742125049|ref|XM_010841228.1|",6816,0,"PREDICTED: Bison bison bison GRB10 interacting GYF protein 2 (GIGYF2), transcript variant X3, mRNA","Q6Y7W6",920,0,"GRB10-interacting GYF protein 2",".",".",".",".","pfam02213","GYF","GYF domain. The GYF domain is named because of the presence of Gly-Tyr-Phe residues. The GYF domain is a proline-binding domain in CD2-binding protein.","GO:0008344|adult locomotory behavior;GO:0044267|cellular protein metabolic process;GO:0007631|feeding behavior;GO:0048873|homeostasis of number of cells within a tissue;GO:0048009|insulin-like growth factor receptor signaling pathway;GO:0031571|mitotic G1 DNA damage checkpoint;GO:0061157|mRNA destabilization;GO:0035264|multicellular organism growth;GO:0050881|musculoskeletal movement;GO:0017148|negative regulation of translation;GO:0050885|neuromuscular process controlling balance;GO:0009791|post-embryonic development;GO:0016441|posttranscriptional gene silencing;GO:0021522|spinal cord motor neuron differentiation;","GO:0010494|cytoplasmic stress granule;GO:0005829|cytosol;GO:0005783|endoplasmic reticulum;GO:0005768|endosome;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;GO:0016020|membrane;GO:0043204|perikaryon;GO:0032991|macromolecular complex;GO:1990635|proximal dendrite;","GO:0045296|cadherin binding;GO:0070064|proline-rich region binding;GO:0003723|RNA binding;","K18730","GIGYF; PERQ amino acid-rich with GYF domain-containing protein"]
["bta_circ_0002016",0,0,0,2.3678888764065,3,5,6,-4.69978278255238,0.0151224262592572,"NA","down","yes","NC_037330.1:113241468..113248753:-","gene4616","gi|741875435|ref|XP_010798959.1|",5128,0,"PREDICTED: ubiquitin carboxyl-terminal hydrolase 40 isoform X2 [Bos taurus]","gi|982979800|ref|XR_803882.2|",5638,0,"PREDICTED: Bos taurus ubiquitin specific peptidase 40 (USP40), transcript variant X6, misc_RNA","Q9NVE5",1708,0,"Ubiquitin carboxyl-terminal hydrolase 40","YMR304w",149,{"v":3e-35,"d":"3.00E-35"},"COG5077","pfam00443","UCH","Ubiquitin carboxyl-terminal hydrolase.","GO:0016579|protein deubiquitination;GO:0006511|ubiquitin-dependent protein catabolic process;",".","GO:0036459|ubiquitinyl hydrolase activity;","K11869","USP40; ubiquitin carboxyl-terminal hydrolase 40 [EC:3.4.19.12]"]
["bta_circ_0002043",0,0,0,1.77884504491116,5,0,4,-4.04923082852261,0.0466318155344839,"NA","down","yes","NC_037330.1:117175722..117176436:+","gene4661","gi|528945485|ref|XP_005205050.1|",4469,0,"PREDICTED: leucine-rich repeat flightless-interacting protein 1 isoform X1 [Bos taurus]","gi|982920558|ref|XM_005204993.3|",4437,0,"PREDICTED: Bos taurus leucine rich repeat (in FLII) interacting protein 1 (LRRFIP1), transcript variant X1, mRNA","Q66HF9",288,{"v":1e-80,"d":"1.00E-80"},"Leucine-rich repeat flightless-interacting protein 1",".",".",".",".","pfam09738","DUF2051","Double stranded RNA binding protein (DUF2051). This is a novel protein identified as interacting with the leucine-rich repeat domain of human flightless-I, FliI protein.","GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0003677|DNA binding;",".","."]
["bta_circ_0002285",14,16,27,11.360473945135,2,6,6,1.86371579320403,0.0373935995501569,0.439730132358439,"up","yes","NC_037330.1:42834877..42845844:-","gene3807","gi|741920763|ref|XP_010801584.1|",2734,0,"PREDICTED: dual specificity protein phosphatase CDC14A isoform X6 [Bos taurus]","gi|982978981|ref|XM_015462655.1|",4222,0,"PREDICTED: Bos taurus cell division cycle 14A (CDC14A), transcript variant X6, mRNA","Q9UNH5",990,0,"Dual specificity protein phosphatase CDC14A","SPAC1782.09c",254,{"v":9e-72,"d":"9.00E-72"},"COG2453","pfam14671","DSPn","Dual specificity protein phosphatase, N-terminal half. The active core of the dual specificity protein phosphatase is made up of two globular domains both with the DSP-like fold. This family represents the N-terminal half of the core. These domains are arranged in tandem, and are associated via an extensive interface to form a single globular whole. The conserved PTP signature motif (Cys-[X]5-Arg) that defines the catalytic centre of all PTP-family members is located within the C-terminal domain, family DSPc, pfam00782. Although the centre of the catalytic site is formed from DSPc, two loops from the N-terminal domain, DSPn, also contribute to the catalytic site, facilitating peptide substrate specificity.","GO:0051301|cell division;GO:0008283|cell proliferation;GO:0060271|cilium morphogenesis;GO:0071850|mitotic cell cycle arrest;GO:0051256|mitotic spindle midzone assembly;GO:0007096|regulation of exit from mitosis;","GO:0005813|centrosome;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0060091|kinocilium;GO:0072686|mitotic spindle;GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0000922|spindle pole;","GO:0004721|phosphoprotein phosphatase activity;GO:0004722|protein serine/threonine phosphatase activity;GO:0004725|protein tyrosine phosphatase activity;GO:0008138|protein tyrosine/serine/threonine phosphatase activity;","K06639","CDC14; cell division cycle 14 [EC:3.1.3.16 3.1.3.48]"]
["bta_circ_0002286",0,8,9,1.90442874352066,0,0,0,4.12100174644978,0.0422674506686738,"NA","up","yes","NC_037330.1:42834877..42889181:-","gene3807","gi|741920763|ref|XP_010801584.1|",2734,0,"PREDICTED: dual specificity protein phosphatase CDC14A isoform X6 [Bos taurus]","gi|982978981|ref|XM_015462655.1|",4222,0,"PREDICTED: Bos taurus cell division cycle 14A (CDC14A), transcript variant X6, mRNA","Q9UNH5",990,0,"Dual specificity protein phosphatase CDC14A","SPAC1782.09c",254,{"v":9e-72,"d":"9.00E-72"},"COG2453","pfam14671","DSPn","Dual specificity protein phosphatase, N-terminal half. The active core of the dual specificity protein phosphatase is made up of two globular domains both with the DSP-like fold. This family represents the N-terminal half of the core. These domains are arranged in tandem, and are associated via an extensive interface to form a single globular whole. The conserved PTP signature motif (Cys-[X]5-Arg) that defines the catalytic centre of all PTP-family members is located within the C-terminal domain, family DSPc, pfam00782. Although the centre of the catalytic site is formed from DSPc, two loops from the N-terminal domain, DSPn, also contribute to the catalytic site, facilitating peptide substrate specificity.","GO:0051301|cell division;GO:0008283|cell proliferation;GO:0060271|cilium morphogenesis;GO:0071850|mitotic cell cycle arrest;GO:0051256|mitotic spindle midzone assembly;GO:0007096|regulation of exit from mitosis;","GO:0005813|centrosome;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0060091|kinocilium;GO:0072686|mitotic spindle;GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0000922|spindle pole;","GO:0004721|phosphoprotein phosphatase activity;GO:0004722|protein serine/threonine phosphatase activity;GO:0004725|protein tyrosine phosphatase activity;GO:0008138|protein tyrosine/serine/threonine phosphatase activity;","K06639","CDC14; cell division cycle 14 [EC:3.1.3.16 3.1.3.48]"]
["bta_circ_0002287",0,0,0,1.91976967617693,4,4,3,-4.37328858680636,0.0268586071391793,"NA","down","yes","NC_037330.1:42834877..42921729:-","gene3807","gi|741920763|ref|XP_010801584.1|",2734,0,"PREDICTED: dual specificity protein phosphatase CDC14A isoform X6 [Bos taurus]","gi|982978981|ref|XM_015462655.1|",4222,0,"PREDICTED: Bos taurus cell division cycle 14A (CDC14A), transcript variant X6, mRNA","Q9UNH5",990,0,"Dual specificity protein phosphatase CDC14A","SPAC1782.09c",254,{"v":9e-72,"d":"9.00E-72"},"COG2453","pfam14671","DSPn","Dual specificity protein phosphatase, N-terminal half. The active core of the dual specificity protein phosphatase is made up of two globular domains both with the DSP-like fold. This family represents the N-terminal half of the core. These domains are arranged in tandem, and are associated via an extensive interface to form a single globular whole. The conserved PTP signature motif (Cys-[X]5-Arg) that defines the catalytic centre of all PTP-family members is located within the C-terminal domain, family DSPc, pfam00782. Although the centre of the catalytic site is formed from DSPc, two loops from the N-terminal domain, DSPn, also contribute to the catalytic site, facilitating peptide substrate specificity.","GO:0051301|cell division;GO:0008283|cell proliferation;GO:0060271|cilium morphogenesis;GO:0071850|mitotic cell cycle arrest;GO:0051256|mitotic spindle midzone assembly;GO:0007096|regulation of exit from mitosis;","GO:0005813|centrosome;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0060091|kinocilium;GO:0072686|mitotic spindle;GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0000922|spindle pole;","GO:0004721|phosphoprotein phosphatase activity;GO:0004722|protein serine/threonine phosphatase activity;GO:0004725|protein tyrosine phosphatase activity;GO:0008138|protein tyrosine/serine/threonine phosphatase activity;","K06639","CDC14; cell division cycle 14 [EC:3.1.3.16 3.1.3.48]"]
["bta_circ_0002289",28,65,80,30.922551901815,13,16,8,1.92460292999499,0.0015308079468451,0.0827401695269775,"up","yes","NC_037330.1:42845757..42889181:-","gene3807","gi|741920763|ref|XP_010801584.1|",2734,0,"PREDICTED: dual specificity protein phosphatase CDC14A isoform X6 [Bos taurus]","gi|982978981|ref|XM_015462655.1|",4222,0,"PREDICTED: Bos taurus cell division cycle 14A (CDC14A), transcript variant X6, mRNA","Q9UNH5",990,0,"Dual specificity protein phosphatase CDC14A","SPAC1782.09c",254,{"v":9e-72,"d":"9.00E-72"},"COG2453","pfam14671","DSPn","Dual specificity protein phosphatase, N-terminal half. The active core of the dual specificity protein phosphatase is made up of two globular domains both with the DSP-like fold. This family represents the N-terminal half of the core. These domains are arranged in tandem, and are associated via an extensive interface to form a single globular whole. The conserved PTP signature motif (Cys-[X]5-Arg) that defines the catalytic centre of all PTP-family members is located within the C-terminal domain, family DSPc, pfam00782. Although the centre of the catalytic site is formed from DSPc, two loops from the N-terminal domain, DSPn, also contribute to the catalytic site, facilitating peptide substrate specificity.","GO:0051301|cell division;GO:0008283|cell proliferation;GO:0060271|cilium morphogenesis;GO:0071850|mitotic cell cycle arrest;GO:0051256|mitotic spindle midzone assembly;GO:0007096|regulation of exit from mitosis;","GO:0005813|centrosome;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0060091|kinocilium;GO:0072686|mitotic spindle;GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0000922|spindle pole;","GO:0004721|phosphoprotein phosphatase activity;GO:0004722|protein serine/threonine phosphatase activity;GO:0004725|protein tyrosine phosphatase activity;GO:0008138|protein tyrosine/serine/threonine phosphatase activity;","K06639","CDC14; cell division cycle 14 [EC:3.1.3.16 3.1.3.48]"]
["bta_circ_0002293",42,118,82,37.4372650340731,6,8,6,3.25956772821831,{"v":5.22474825894088e-08,"d":"5.22E-08"},{"v":2.82397643395755e-05,"d":"2.82E-05"},"up","yes","NC_037330.1:42865184..42889181:-","gene3807","gi|741920763|ref|XP_010801584.1|",2734,0,"PREDICTED: dual specificity protein phosphatase CDC14A isoform X6 [Bos taurus]","gi|982978981|ref|XM_015462655.1|",4222,0,"PREDICTED: Bos taurus cell division cycle 14A (CDC14A), transcript variant X6, mRNA","Q9UNH5",990,0,"Dual specificity protein phosphatase CDC14A","SPAC1782.09c",254,{"v":9e-72,"d":"9.00E-72"},"COG2453","pfam14671","DSPn","Dual specificity protein phosphatase, N-terminal half. The active core of the dual specificity protein phosphatase is made up of two globular domains both with the DSP-like fold. This family represents the N-terminal half of the core. These domains are arranged in tandem, and are associated via an extensive interface to form a single globular whole. The conserved PTP signature motif (Cys-[X]5-Arg) that defines the catalytic centre of all PTP-family members is located within the C-terminal domain, family DSPc, pfam00782. Although the centre of the catalytic site is formed from DSPc, two loops from the N-terminal domain, DSPn, also contribute to the catalytic site, facilitating peptide substrate specificity.","GO:0051301|cell division;GO:0008283|cell proliferation;GO:0060271|cilium morphogenesis;GO:0071850|mitotic cell cycle arrest;GO:0051256|mitotic spindle midzone assembly;GO:0007096|regulation of exit from mitosis;","GO:0005813|centrosome;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0060091|kinocilium;GO:0072686|mitotic spindle;GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0000922|spindle pole;","GO:0004721|phosphoprotein phosphatase activity;GO:0004722|protein serine/threonine phosphatase activity;GO:0004725|protein tyrosine phosphatase activity;GO:0008138|protein tyrosine/serine/threonine phosphatase activity;","K06639","CDC14; cell division cycle 14 [EC:3.1.3.16 3.1.3.48]"]
["bta_circ_0002295",33,84,115,44.5426226829145,12,50,17,1.36048987216418,0.0174059369898374,0.31640326128788,"up","yes","NC_037330.1:42865184..42928048:-","gene3807","gi|741920763|ref|XP_010801584.1|",2734,0,"PREDICTED: dual specificity protein phosphatase CDC14A isoform X6 [Bos taurus]","gi|982978981|ref|XM_015462655.1|",4222,0,"PREDICTED: Bos taurus cell division cycle 14A (CDC14A), transcript variant X6, mRNA","Q9UNH5",990,0,"Dual specificity protein phosphatase CDC14A","SPAC1782.09c",254,{"v":9e-72,"d":"9.00E-72"},"COG2453","pfam14671","DSPn","Dual specificity protein phosphatase, N-terminal half. The active core of the dual specificity protein phosphatase is made up of two globular domains both with the DSP-like fold. This family represents the N-terminal half of the core. These domains are arranged in tandem, and are associated via an extensive interface to form a single globular whole. The conserved PTP signature motif (Cys-[X]5-Arg) that defines the catalytic centre of all PTP-family members is located within the C-terminal domain, family DSPc, pfam00782. Although the centre of the catalytic site is formed from DSPc, two loops from the N-terminal domain, DSPn, also contribute to the catalytic site, facilitating peptide substrate specificity.","GO:0051301|cell division;GO:0008283|cell proliferation;GO:0060271|cilium morphogenesis;GO:0071850|mitotic cell cycle arrest;GO:0051256|mitotic spindle midzone assembly;GO:0007096|regulation of exit from mitosis;","GO:0005813|centrosome;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0060091|kinocilium;GO:0072686|mitotic spindle;GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0000922|spindle pole;","GO:0004721|phosphoprotein phosphatase activity;GO:0004722|protein serine/threonine phosphatase activity;GO:0004725|protein tyrosine phosphatase activity;GO:0008138|protein tyrosine/serine/threonine phosphatase activity;","K06639","CDC14; cell division cycle 14 [EC:3.1.3.16 3.1.3.48]"]
["bta_circ_0002298",9,97,97,30.8508371304618,6,31,7,1.80394648632581,0.0120499049851956,0.280127898688096,"up","yes","NC_037330.1:42865184..42930170:-","gene3807","gi|741920763|ref|XP_010801584.1|",2734,0,"PREDICTED: dual specificity protein phosphatase CDC14A isoform X6 [Bos taurus]","gi|982978981|ref|XM_015462655.1|",4222,0,"PREDICTED: Bos taurus cell division cycle 14A (CDC14A), transcript variant X6, mRNA","Q9UNH5",990,0,"Dual specificity protein phosphatase CDC14A","SPAC1782.09c",254,{"v":9e-72,"d":"9.00E-72"},"COG2453","pfam14671","DSPn","Dual specificity protein phosphatase, N-terminal half. The active core of the dual specificity protein phosphatase is made up of two globular domains both with the DSP-like fold. This family represents the N-terminal half of the core. These domains are arranged in tandem, and are associated via an extensive interface to form a single globular whole. The conserved PTP signature motif (Cys-[X]5-Arg) that defines the catalytic centre of all PTP-family members is located within the C-terminal domain, family DSPc, pfam00782. Although the centre of the catalytic site is formed from DSPc, two loops from the N-terminal domain, DSPn, also contribute to the catalytic site, facilitating peptide substrate specificity.","GO:0051301|cell division;GO:0008283|cell proliferation;GO:0060271|cilium morphogenesis;GO:0071850|mitotic cell cycle arrest;GO:0051256|mitotic spindle midzone assembly;GO:0007096|regulation of exit from mitosis;","GO:0005813|centrosome;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0060091|kinocilium;GO:0072686|mitotic spindle;GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0000922|spindle pole;","GO:0004721|phosphoprotein phosphatase activity;GO:0004722|protein serine/threonine phosphatase activity;GO:0004725|protein tyrosine phosphatase activity;GO:0008138|protein tyrosine/serine/threonine phosphatase activity;","K06639","CDC14; cell division cycle 14 [EC:3.1.3.16 3.1.3.48]"]
["bta_circ_0002303",0,0,0,4.179146041258,10,6,7,-5.52941775468004,0.00255563440806821,"NA","down","yes","NC_037330.1:43006920..43011881:-","gene3810","gi|114051395|ref|NP_001039520.1|",1838,0,"RNA 3'-terminal phosphate cyclase [Bos taurus]","gi|982916948|ref|XM_010803158.2|",2013,0,"PREDICTED: Bos taurus RNA 3'-terminal phosphate cyclase (RTCA), transcript variant X2, mRNA","Q2HJ88",712,0,"RNA 3'-terminal phosphate cyclase","PAE3596",236,{"v":5e-70,"d":"5.00E-70"},"COG0430","pfam01137","RTC","RNA 3'-terminal phosphate cyclase. RNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organisms. They catalyse the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of RNA, in a reaction involving formation of the covalent AMP-cyclase intermediate. The structure of RTC demonstrates that RTCs are comprised two domain. The larger domain contains an insert domain of approximately 100 amino acids.","GO:0006396|RNA processing;","GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0003963|RNA-3'-phosphate cyclase activity;","K01974","RTCA, rtcA; RNA 3'-terminal phosphate cyclase (ATP) [EC:6.5.1.4]"]
["bta_circ_0002378",0,0,0,2.16449560976275,0,3,10,-4.36668401813516,0.0289768452979023,"NA","down","yes","NC_037330.1:52267989..52329861:+","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0002441",5,33,11,6.90086848359064,0,4,2,2.49782218385953,0.0294900341462604,0.423218637145628,"up","yes","NC_037330.1:636480..644274:-","gene2820","gi|528941562|ref|XP_005203450.1|",4187,0,"PREDICTED: DDB1- and CUL4-associated factor 6 isoform X2 [Bos taurus]","gi|982915876|ref|XM_005203393.3|",3472,0,"PREDICTED: Bos taurus DDB1 and CUL4 associated factor 6 (DCAF6), transcript variant X3, mRNA","Q5R9B8",868,0,"DDB1- and CUL4-associated factor 6",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.","GO:0016567|protein ubiquitination;","GO:0080008|Cul4-RING E3 ubiquitin ligase complex;GO:0005634|nucleus;",".","K11795","IQWD1, NRIP, ARCAP; nuclear receptor interaction protein"]
["bta_circ_0002461",0,0,0,3.31867215596388,6,2,10,-5.15464126146068,0.0062083042793809,"NA","down","yes","NC_037330.1:66831129..66867279:-","gene4030","gi|742192999|ref|XP_010855914.1|",3385,0,"PREDICTED: protein FAM73A [Bison bison bison]","gi|982979248|ref|XM_015462722.1|",5402,0,"PREDICTED: Bos taurus family with sequence similarity 73 member A (FAM73A), transcript variant X2, mRNA","Q8NAN2",1113,0,"Mitoguardin 1",".",".",".",".","pfam10265","DUF2217","Uncharacterized conserved protein (DUF2217). This is a family of conserved proteins of from 500 - 600 residues found from worms to humans. Its function is not known.","GO:0008053|mitochondrial fusion;","GO:0005887|integral component of plasma membrane;GO:0005741|mitochondrial outer membrane;","GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;",".","."]
["bta_circ_0002481",6,9,3,3.00639915036837,0,0,0,4.85114425290774,0.0116890227028954,"NA","up","yes","NC_037330.1:703523..757358:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0002516",4,17,0,2.79999321553851,0,0,0,4.61325624946868,0.0192787721216244,"NA","up","yes","NC_037330.1:80643813..80649275:-","gene4118","gi|741874957|ref|XP_010825293.1|",3510,0,"PREDICTED: ribonucleoprotein PTB-binding 2 isoform X1 [Bos taurus]","gi|982979324|ref|XM_010826991.2|",4311,0,"PREDICTED: Bos taurus ribonucleoprotein, PTB-binding 2 (RAVER2), transcript variant X1, mRNA","Q9HCJ3",1238,0,"Ribonucleoprotein PTB-binding 2",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0000398|mRNA splicing, via spliceosome;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0003676|nucleic acid binding;GO:0003723|RNA binding;",".","."]
["bta_circ_0002517",3,4,4,1.77252172630263,0,0,0,4.1096577464225,0.0415939881244885,"NA","up","yes","NC_037330.1:80643813..80649278:-","gene4118","gi|741874957|ref|XP_010825293.1|",3510,0,"PREDICTED: ribonucleoprotein PTB-binding 2 isoform X1 [Bos taurus]","gi|982979324|ref|XM_010826991.2|",4311,0,"PREDICTED: Bos taurus ribonucleoprotein, PTB-binding 2 (RAVER2), transcript variant X1, mRNA","Q9HCJ3",1238,0,"Ribonucleoprotein PTB-binding 2",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0000398|mRNA splicing, via spliceosome;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0003676|nucleic acid binding;GO:0003723|RNA binding;",".","."]
["bta_circ_0002556",3,4,13,2.91379210288918,0,0,0,4.83303676221534,0.012163018294864,"NA","up","yes","NC_037330.1:83633487..83641177:-","gene4147","gi|742092748|ref|XP_010832211.1|",9403,0,"PREDICTED: inaD-like protein isoform X1 [Bison bison bison]","gi|742092747|ref|XM_010833909.1|",7570,0,"PREDICTED: Bison bison bison InaD-like (Drosophila) (INADL), transcript variant X1, mRNA","Q8NI35",2958,0,"InaD-like protein",".",".",".",".","pfam09045","L27_2","L27_2. The L27_2 domain is a protein-protein interaction domain capable of organizing scaffold proteins into supramolecular assemblies by formation of heteromeric L27_2 domain complexes. L27_2 domain-mediated protein assemblies have been shown to play essential roles in cellular processes including asymmetric cell division, establishment and maintenance of cell polarity, and clustering of receptors and ion channels. Members of this family form specific heterotetrameric complexes, in which each domain contains three alpha-helices. The two N-terminal helices of each L27_2 domain pack together to form a tight, four-helix bundle in the heterodimer, whilst the third helix of each L27_2 domain forms another four-helix bundle that assembles the two units of the heterodimer into a tetramer.","GO:0070830|bicellular tight junction assembly;GO:0035556|intracellular signal transduction;","GO:0016324|apical plasma membrane;GO:0005923|bicellular tight junction;GO:0030054|cell junction;GO:0005813|centrosome;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005815|microtubule organizing center;GO:0048471|perinuclear region of cytoplasm;GO:0005886|plasma membrane;GO:0032991|macromolecular complex;",".",".","."]
["bta_circ_0002574",0,0,2,3.97364602466609,6,9,7,-3.2279130521381,0.0277907495827301,"NA","down","yes","NC_037330.1:85851152..85870854:+","gene4161","gi|297473111|ref|XP_002686394.1|",2608,0,"PREDICTED: cytochrome P450 2J2 isoform X1 [Bos taurus]","gi|594047891|ref|XM_006048292.1|",2130,0,"PREDICTED: Bubalus bubalis cytochrome P450 2J2-like (LOC102411786), mRNA","P51589",838,0,"Cytochrome P450 2J2","BH0579",124,{"v":8e-29,"d":"8.00E-29"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0019373|epoxygenase P450 pathway;GO:0006690|icosanoid metabolic process;GO:0043651|linoleic acid metabolic process;GO:0008016|regulation of heart contraction;GO:0006805|xenobiotic metabolic process;","GO:0005789|endoplasmic reticulum membrane;GO:0070062|extracellular exosome;GO:0031090|organelle membrane;","GO:0008405|arachidonic acid 11,12-epoxygenase activity;GO:0008404|arachidonic acid 14,15-epoxygenase activity;GO:0008392|arachidonic acid epoxygenase activity;GO:0070330|aromatase activity;GO:0020037|heme binding;GO:0005506|iron ion binding;GO:0071614|linoleic acid epoxygenase activity;GO:0004497|monooxygenase activity;","K07418","CYP2J; cytochrome P450, family 2, subfamily J [EC:1.14.14.1]"]
["bta_circ_0002624",17,85,80,90.5381196834781,112,142,138,-1.49204683192338,0.000795642479700119,0.0492512590431825,"down","yes","NC_037330.1:93341091..93365353:-","gene4240","gi|296489064|tpg|DAA31177.1|",2691,0,"TPA: non-specific lipid-transfer protein [Bos taurus]","gi|742154918|ref|XM_010847201.1|",3045,0,"PREDICTED: Bison bison bison sterol carrier protein 2 (SCP2), mRNA","P07857",1038,0,"Non-specific lipid-transfer protein",".",".",".",".","pfam02036","SCP2","SCP-2 sterol transfer family. This domain is involved in binding sterols. It is found in the SCP2 protein, as well as the C terminus of the enzyme estradiol 17 beta-dehydrogenase EC:1.1.1.62. The UNC-24 protein contains an SPFH domain pfam01145.","GO:1901373|lipid hydroperoxide transport;GO:0015914|phospholipid transport;GO:0032385|positive regulation of intracellular cholesterol transport;GO:0006694|steroid biosynthetic process;","GO:0005739|mitochondrion;GO:0005777|peroxisome;","GO:0033814|propanoyl-CoA C-acyltransferase activity;GO:0032934|sterol binding;GO:0015248|sterol transporter activity;","K08764","SCP2, SCPX; sterol carrier protein 2 [EC:2.3.1.176]"]
["bta_circ_0002648",11,53,28,39.7711754732132,45,71,50,-1.19817349803506,0.0237195140554316,0.375453490305658,"down","yes","NC_037330.1:93865563..93907176:+","gene4247","gi|528944390|ref|XP_005204617.1|",8094,0,"PREDICTED: terminal uridylyltransferase 4 isoform X1 [Bos taurus]","gi|982919737|ref|XM_005204560.2|",5294,0,"PREDICTED: Bos taurus zinc finger, CCHC domain containing 11 (ZCCHC11), transcript variant X1, mRNA","Q5TAX3",2702,0,"Terminal uridylyltransferase 4","SPAC19D5.03",127,{"v":2e-29,"d":"2.00E-29"},"COG5260","pfam03828","PAP_assoc","Cid1 family poly A polymerase. This domain is found in poly(A) polymerases and has been shown to have polynucleotide adenylyltransferase activity. Proteins in this family have been located to both the nucleus and the cytoplasm.","GO:0010587|miRNA catabolic process;GO:0010586|miRNA metabolic process;GO:0000289|nuclear-transcribed mRNA poly(A) tail shortening;GO:0031054|pre-miRNA processing;GO:0031123|RNA 3'-end processing;GO:0019827|stem cell population maintenance;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005615|extracellular space;GO:0005730|nucleolus;","GO:0003723|RNA binding;GO:0050265|RNA uridylyltransferase activity;GO:0008270|zinc ion binding;","K13291","TUT; terminal uridylyltransferase [EC:2.7.7.52]"]
["bta_circ_0002655",0,0,0,1.92769343245667,3,7,2,-4.37876033524168,0.0267598414110024,"NA","down","yes","NC_037330.1:93898635..93907176:+","gene4247","gi|528944390|ref|XP_005204617.1|",8094,0,"PREDICTED: terminal uridylyltransferase 4 isoform X1 [Bos taurus]","gi|982919737|ref|XM_005204560.2|",5294,0,"PREDICTED: Bos taurus zinc finger, CCHC domain containing 11 (ZCCHC11), transcript variant X1, mRNA","Q5TAX3",2702,0,"Terminal uridylyltransferase 4","SPAC19D5.03",127,{"v":2e-29,"d":"2.00E-29"},"COG5260","pfam03828","PAP_assoc","Cid1 family poly A polymerase. This domain is found in poly(A) polymerases and has been shown to have polynucleotide adenylyltransferase activity. Proteins in this family have been located to both the nucleus and the cytoplasm.","GO:0010587|miRNA catabolic process;GO:0010586|miRNA metabolic process;GO:0000289|nuclear-transcribed mRNA poly(A) tail shortening;GO:0031054|pre-miRNA processing;GO:0031123|RNA 3'-end processing;GO:0019827|stem cell population maintenance;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005615|extracellular space;GO:0005730|nucleolus;","GO:0003723|RNA binding;GO:0050265|RNA uridylyltransferase activity;GO:0008270|zinc ion binding;","K13291","TUT; terminal uridylyltransferase [EC:2.7.7.52]"]
["bta_circ_0002672",0,0,0,1.70759571048176,3,8,0,-4.01580330599944,0.04893592088949,"NA","down","yes","NC_037330.1:94483923..94493055:+","gene4259","gi|555965463|ref|XP_005894789.1|",5530,0,"PREDICTED: nardilysin isoform X1 [Bos mutus]","gi|332801062|ref|NM_001206991.1|",4380,0,"Bos taurus nardilysin convertase (NRDC), mRNA","O43847",1905,0,"Nardilysin","YLR389c",399,{"v":8e-118,"d":"8.00E-118"},"COG1025","pfam00675","Peptidase_M16","Insulinase (Peptidase family M16).","GO:0016477|cell migration;GO:0008283|cell proliferation;GO:0007528|neuromuscular junction development;GO:0051044|positive regulation of membrane protein ectodomain proteolysis;GO:0006508|proteolysis;GO:0052548|regulation of endopeptidase activity;","GO:0009986|cell surface;GO:0005829|cytosol;GO:0005739|mitochondrion;","GO:0048408|epidermal growth factor binding;GO:0046872|metal ion binding;GO:0004222|metalloendopeptidase activity;","K01411","NRD1; nardilysin [EC:3.4.24.61]"]
["bta_circ_0002687",0,0,0,2.16992391358949,6,0,5,-4.35661160125004,0.0293371552158517,"NA","down","yes","NC_037330.1:94859225..94866448:+","gene4264","gi|148223255|ref|NP_001091556.1|",4078,0,"epidermal growth factor receptor substrate 15 [Bos taurus]","gi|982919761|ref|XM_010803527.2|",2924,0,"PREDICTED: Bos taurus epidermal growth factor receptor pathway substrate 15 (EPS15), transcript variant X5, mRNA","P42566",1439,0,"Epidermal growth factor receptor substrate 15",".",".",".",".","pfam12763","EF-hand_4","Cytoskeletal-regulatory complex EF hand. This is an efhand family from the N-terminal of actin cytoskeleton-regulatory complex END3 and similar proteins from fungi and closely related species.","GO:0008283|cell proliferation;GO:0048268|clathrin coat assembly;GO:0032456|endocytic recycling;GO:0007173|epidermal growth factor receptor signaling pathway;GO:0006895|Golgi to endosome transport;GO:0061024|membrane organization;GO:0042059|negative regulation of epidermal growth factor receptor signaling pathway;GO:0001921|positive regulation of receptor recycling;GO:0015031|protein transport;GO:0019065|receptor-mediated endocytosis of virus by host cell;GO:0042127|regulation of cell proliferation;GO:0016050|vesicle organization;GO:0046718|viral entry into host cell;","GO:0016235|aggresome;GO:0030122|AP-2 adaptor complex;GO:0016324|apical plasma membrane;GO:0009925|basal plasma membrane;GO:0060170|ciliary membrane;GO:0005905|coated pit;GO:0005829|cytosol;GO:0031901|early endosome membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0016020|membrane;GO:0005886|plasma membrane;","GO:0045296|cadherin binding;GO:0005509|calcium ion binding;GO:0042802|identical protein binding;GO:0031593|polyubiquitin binding;GO:0017124|SH3 domain binding;","K12472","EPS15; epidermal growth factor receptor substrate 15"]
["bta_circ_0002725",30,171,90,54.0486377597507,25,50,31,1.05831649763063,0.0331091230363642,0.428634275476763,"up","yes","NC_037331.1:103179038..103180121:-","gene5632","gi|803269922|ref|XP_011994680.1|",1729,0,"PREDICTED: homeodomain-interacting protein kinase 2 isoform X2 [Ovis aries musimon]","gi|156120492|ref|NM_001101922.1|",1439,0,"Bos taurus homeodomain interacting protein kinase 2 (HIPK2), mRNA","Q9QZR5",657,0,"Homeodomain-interacting protein kinase 2",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0008344|adult locomotory behavior;GO:0007628|adult walking behavior;GO:0009952|anterior/posterior pattern specification;GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:0048596|embryonic camera-type eye morphogenesis;GO:0060059|embryonic retina morphogenesis in camera-type eye;GO:0042771|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0061072|iris morphogenesis;GO:0060235|lens induction in camera-type eye;GO:0030514|negative regulation of BMP signaling pathway;GO:0043524|negative regulation of neuron apoptotic process;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:2000059|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0030182|neuron differentiation;GO:0018105|peptidyl-serine phosphorylation;GO:0018107|peptidyl-threonine phosphorylation;GO:0045766|positive regulation of angiogenesis;GO:0008284|positive regulation of cell proliferation;GO:0043388|positive regulation of DNA binding;GO:0051091|positive regulation of sequence-specific DNA binding transcription factor activity;GO:0046330|positive regulation of JNK cascade;GO:0032092|positive regulation of protein binding;GO:0001934|positive regulation of protein phosphorylation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0030511|positive regulation of transforming growth factor beta receptor signaling pathway;GO:0006468|protein phosphorylation;GO:0010842|retina layer formation;GO:0060395|SMAD protein signal transduction;GO:0007224|smoothened signaling pathway;GO:0006366|transcription from RNA polymerase II promoter;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0050882|voluntary musculoskeletal movement;","GO:0005737|cytoplasm;GO:0016604|nuclear body;GO:0005634|nucleus;GO:0016605|PML body;GO:0090575|RNA polymerase II transcription factor complex;","GO:0005524|ATP binding;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0001102|RNA polymerase II activating transcription factor binding;GO:0046332|SMAD binding;GO:0003714|transcription corepressor activity;GO:0046790|virion binding;","K08826","HIPK; homeodomain interacting protein kinase [EC:2.7.11.1]"]
["bta_circ_0002741",16,27,22,13.1874120580442,5,10,4,1.60275209289952,0.0495456178123617,0.476348344536443,"up","yes","NC_037331.1:104848012..104860877:+","gene5658","gi|982922267|ref|XP_015326251.1|",2247,0,"PREDICTED: acylglycerol kinase, mitochondrial isoform X1 [Bos taurus]","gi|151554537|gb|BC150065.1|",2796,0,"Bos taurus acylglycerol kinase, mRNA (cDNA clone MGC:159846 IMAGE:8627019), complete cds","Q53H12",803,0,"Acylglycerol kinase, mitochondrial","YLR260w",69.7,{"v":2e-11,"d":"2.00E-11"},"COG1597","pfam00781","DAGK_cat","Diacylglycerol kinase catalytic domain. Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologues. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.","GO:0046513|ceramide biosynthetic process;GO:0046474|glycerophospholipid biosynthetic process;GO:0045039|protein import into mitochondrial inner membrane;","GO:0005829|cytosol;GO:0031305|integral component of mitochondrial inner membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0005743|mitochondrial inner membrane;GO:0042721|mitochondrial inner membrane protein insertion complex;GO:0005758|mitochondrial intermembrane space;GO:0005741|mitochondrial outer membrane;GO:0005739|mitochondrion;","GO:0047620|acylglycerol kinase activity;GO:0005524|ATP binding;GO:0001729|ceramide kinase activity;GO:0004143|diacylglycerol kinase activity;GO:0003951|NAD+ kinase activity;","K09881","AGK; acylglycerol kinase [EC:2.7.1.94]"]
["bta_circ_0002746",0,8,0,6.99200226003099,8,18,12,-2.58247930247015,0.0326451831700265,0.428634275476763,"down","yes","NC_037331.1:10622748..10647235:+","gene4838","gi|742117554|ref|XP_010838078.1|",4948,0,"PREDICTED: coiled-coil domain-containing protein 132 [Bison bison bison]","gi|402692933|ref|NM_001105413.2|",3581,0,"Bos taurus VPS50 EARP/GARPII complex subunit (VPS50), mRNA","Q96JG6",1875,0,"Syndetin",".",".",".",".","pfam10475","DUF2450","Protein of unknown function N-terminal domain (DUF2450). This protein is found in eukaryotes but its function is not known. The C-terminal part of some members is DUF2451.","GO:0032456|endocytic recycling;GO:0015031|protein transport;","GO:1990745|EARP complex;GO:0070062|extracellular exosome;GO:0016020|membrane;GO:0055037|recycling endosome;","GO:0000149|SNARE binding;",".","."]
["bta_circ_0002760",0,0,0,2.46526508417782,2,10,4,-4.75448377816049,0.0137870469084937,"NA","down","yes","NC_037331.1:112039053..112048779:-","gene5819","gi|671009273|ref|XP_008695492.1|",3515,0,"PREDICTED: histone-lysine N-methyltransferase EZH2 isoform X2 [Ursus maritimus]","gi|594093782|ref|XM_006070143.1|",2377,0,"PREDICTED: Bubalus bubalis histone-lysine N-methyltransferase EZH2-like (LOC102405899), partial mRNA","Q15910",1219,0,"Histone-lysine N-methyltransferase EZH2","ECU09g1750",166,{"v":2e-42,"d":"2.00E-42"},"COG2940","pfam00856","SET","SET domain. SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.","GO:0014898|cardiac muscle hypertrophy in response to stress;GO:0070301|cellular response to hydrogen peroxide;GO:0035984|cellular response to trichostatin A;GO:0021695|cerebellar cortex development;GO:0006325|chromatin organization;GO:0006306|DNA methylation;GO:0070314|G1 to G0 transition;GO:0036333|hepatocyte homeostasis;GO:0021766|hippocampus development;GO:0070734|histone H3-K27 methylation;GO:0098532|histone H3-K27 trimethylation;GO:0016571|histone methylation;GO:0097421|liver regeneration;GO:0043433|negative regulation of sequence-specific DNA binding transcription factor activity;GO:0045605|negative regulation of epidermal cell differentiation;GO:0070317|negative regulation of G0 to G1 transition;GO:2000134|negative regulation of G1/S transition of mitotic cell cycle;GO:0045814|negative regulation of gene expression, epigenetic;GO:0048387|negative regulation of retinoic acid receptor signaling pathway;GO:0051154|negative regulation of striated muscle cell differentiation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0034244|negative regulation of transcription elongation from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:1900006|positive regulation of dendrite development;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0043547|positive regulation of GTPase activity;GO:0043406|positive regulation of MAP kinase activity;GO:0071902|positive regulation of protein serine/threonine kinase activity;GO:0071168|protein localization to chromatin;GO:0042127|regulation of cell proliferation;GO:0042752|regulation of circadian rhythm;GO:0014013|regulation of gliogenesis;GO:0006355|regulation of transcription, DNA-templated;GO:0032355|response to estradiol;GO:0048511|rhythmic process;GO:0014834|skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0035098|ESC/E(Z) complex;GO:0000790|nuclear chromatin;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0045120|pronucleus;","GO:0003682|chromatin binding;GO:0031490|chromatin DNA binding;GO:0001047|core promoter binding;GO:0003677|DNA binding;GO:0042054|histone methyltransferase activity;GO:0046976|histone methyltransferase activity (H3-K27 specific);GO:0018024|histone-lysine N-methyltransferase activity;GO:0070878|primary miRNA binding;GO:1990841|promoter-specific chromatin binding;GO:0016279|protein-lysine N-methyltransferase activity;GO:0043021|ribonucleoprotein complex binding;GO:0000979|RNA polymerase II core promoter sequence-specific DNA binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K11430","EZH2; histone-lysine N-methyltransferase EZH2 [EC:2.1.1.43]"]
["bta_circ_0002774",9,4,8,4.04717553349086,0,0,0,5.24509229141941,0.00518463338446911,"NA","up","yes","NC_037331.1:114009784..114024148:-","gene5909","gi|528947692|ref|XP_005205918.1|",938,{"v":1e-122,"d":"1.00E-122"},"PREDICTED: GTP-binding protein Rheb isoform X1 [Bos taurus]","gi|528947691|ref|XM_005205861.1|",1162,0,"PREDICTED: Bos taurus Ras homolog enriched in brain (RHEB), transcript variant X1, mRNA","Q62639",342,{"v":1e-114,"d":"1.00E-114"},"GTP-binding protein Rheb",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0032008|positive regulation of TOR signaling;GO:0048168|regulation of neuronal synaptic plasticity;GO:0007264|small GTPase mediated signal transduction;","GO:0005829|cytosol;GO:0030425|dendrite;GO:0005789|endoplasmic reticulum membrane;GO:0000139|Golgi membrane;GO:0043025|neuronal cell body;","GO:0019003|GDP binding;GO:0005525|GTP binding;GO:0003924|GTPase activity;GO:0046872|metal ion binding;","K07208","RHEB; Ras homolog enriched in brain"]
["bta_circ_0002775",13,78,50,22.5560568035606,14,0,11,1.80113781590279,0.0359403417628337,0.439730132358439,"up","yes","NC_037331.1:114017504..114024148:-","gene5909","gi|528947692|ref|XP_005205918.1|",938,{"v":1e-122,"d":"1.00E-122"},"PREDICTED: GTP-binding protein Rheb isoform X1 [Bos taurus]","gi|528947691|ref|XM_005205861.1|",1162,0,"PREDICTED: Bos taurus Ras homolog enriched in brain (RHEB), transcript variant X1, mRNA","Q62639",342,{"v":1e-114,"d":"1.00E-114"},"GTP-binding protein Rheb",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0032008|positive regulation of TOR signaling;GO:0048168|regulation of neuronal synaptic plasticity;GO:0007264|small GTPase mediated signal transduction;","GO:0005829|cytosol;GO:0030425|dendrite;GO:0005789|endoplasmic reticulum membrane;GO:0000139|Golgi membrane;GO:0043025|neuronal cell body;","GO:0019003|GDP binding;GO:0005525|GTP binding;GO:0003924|GTPase activity;GO:0046872|metal ion binding;","K07208","RHEB; Ras homolog enriched in brain"]
["bta_circ_0002788",5,5,0,1.94982608658825,0,0,0,4.04273317719192,0.047352037077062,"NA","up","yes","NC_037331.1:114688123..114690380:-","gene5913","gi|982924151|ref|XP_015326324.1|",22041,0,"PREDICTED: histone-lysine N-methyltransferase 2C isoform X1 [Bos taurus]","gi|982924150|ref|XM_015470838.1|",16642,0,"PREDICTED: Bos taurus lysine (K)-specific methyltransferase 2C (KMT2C), transcript variant X1, mRNA","Q8NEZ4",5126,0,"Histone-lysine N-methyltransferase 2C","SPCC306.04c",139,{"v":8e-32,"d":"8.00E-32"},"COG2940","pfam00856","SET","SET domain. SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.","GO:0045652|regulation of megakaryocyte differentiation;GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0035097|histone methyltransferase complex;GO:0044666|MLL3/4 complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0042800|histone methyltransferase activity (H3-K4 specific);GO:0018024|histone-lysine N-methyltransferase activity;GO:0046872|metal ion binding;GO:0003723|RNA binding;GO:0016746|transferase activity, transferring acyl groups;","K09188","MLL3; histone-lysine N-methyltransferase MLL3 [EC:2.1.1.43]"]
["bta_circ_0002794",24,31,46,50.1461511163117,60,88,55,-1.12437417739786,0.0317390622561316,0.428634275476763,"down","yes","NC_037331.1:115133974..115146620:+","gene5917","gi|548464360|ref|XP_005679727.1|",1649,0,"PREDICTED: actin-related protein 3B [Capra hircus]","gi|982981283|ref|XM_015463199.1|",1233,0,"PREDICTED: Bos taurus ARP3 actin-related protein 3 homolog B (yeast) (ACTR3B), transcript variant X4, mRNA","Q9P1U1",604,0,"Actin-related protein 3B","YJR065c",384,{"v":2e-119,"d":"2.00E-119"},"COG5277","pfam00022","Actin","Actin.","GO:0034314|Arp2/3 complex-mediated actin nucleation;","GO:0005885|Arp2/3 protein complex;GO:0042995|cell projection;GO:0005737|cytoplasm;GO:0070062|extracellular exosome;","GO:0003779|actin binding;GO:0005524|ATP binding;","K18584","ACTR3, ARP3; actin-related protein 3"]
["bta_circ_0002863",0,0,0,1.74086477319377,4,0,5,-4.01986307890338,0.0486117283269939,"NA","down","yes","NC_037331.1:24481830..24500748:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0002872",0,4,0,4.56322067717805,3,12,11,-2.82857563373789,0.0423362888573709,"NA","down","yes","NC_037331.1:26324862..26336408:-","gene4945","gi|741923159|ref|XP_003585999.3|",5045,0,"PREDICTED: sorting nexin-13 isoform X1 [Bos taurus]","gi|982921089|ref|XM_003585951.4|",6319,0,"PREDICTED: Bos taurus sorting nexin 13 (SNX13), transcript variant X1, mRNA","Q6PHS6",1838,0,"Sorting nexin-13",".",".",".",".","pfam02194","PXA","PXA domain. This domain is associated with PX domains pfam00787.","GO:0006886|intracellular protein transport;GO:0009968|negative regulation of signal transduction;GO:0043547|positive regulation of GTPase activity;","GO:0005769|early endosome;GO:0031901|early endosome membrane;","GO:0035091|phosphatidylinositol binding;GO:0032266|phosphatidylinositol-3-phosphate binding;","K17925","SNX13; sorting nexin-13"]
["bta_circ_0002888",2,0,8,9.68796997613181,21,7,15,-2.19953343211166,0.0449802823997703,0.456494092506297,"down","yes","NC_037331.1:27365363..27403622:+","gene4949","gi|528903160|ref|XP_005198073.1|",5011,0,"PREDICTED: histone deacetylase 9 isoform X1 [Bos taurus]","gi|742099675|ref|XM_010835591.1|",5376,0,"PREDICTED: Bison bison bison histone deacetylase 9 (HDAC9), transcript variant X2, mRNA","Q9UKV0",1699,0,"Histone deacetylase 9","SPBC800.03",265,{"v":8e-74,"d":"8.00E-74"},"COG0123","pfam00850","Hist_deacetyl","Histone deacetylase domain. Histones can be reversibly acetylated on several lysine residues. Regulation of transcription is caused in part by this mechanism. Histone deacetylases catalyse the removal of the acetyl group. Histone deacetylases are related to other proteins.","GO:0042113|B cell activation;GO:0030183|B cell differentiation;GO:0032869|cellular response to insulin stimulus;GO:0007507|heart development;GO:0016575|histone deacetylation;GO:0070932|histone H3 deacetylation;GO:0070933|histone H4 deacetylation;GO:0006954|inflammatory response;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0030182|neuron differentiation;GO:0034983|peptidyl-lysine deacetylation;GO:0090050|positive regulation of cell migration involved in sprouting angiogenesis;GO:0048742|regulation of skeletal muscle fiber development;GO:0051153|regulation of striated muscle cell differentiation;GO:0001975|response to amphetamine;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0000118|histone deacetylase complex;GO:0035097|histone methyltransferase complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0004407|histone deacetylase activity;GO:0042826|histone deacetylase binding;GO:0046872|metal ion binding;GO:0032041|NAD-dependent histone deacetylase activity (H3-K14 specific);GO:0033558|protein deacetylase activity;GO:0005080|protein kinase C binding;GO:0070491|repressing transcription factor binding;GO:0003714|transcription corepressor activity;GO:0008134|transcription factor binding;","K11409","HDAC9; histone deacetylase 9 [EC:3.5.1.98]"]
["bta_circ_0002889",0,2,0,4.28840693777969,9,7,7,-3.52903328754583,0.015524341622687,"NA","down","yes","NC_037331.1:27365363..27438844:+","gene4949","gi|528903160|ref|XP_005198073.1|",5011,0,"PREDICTED: histone deacetylase 9 isoform X1 [Bos taurus]","gi|742099675|ref|XM_010835591.1|",5376,0,"PREDICTED: Bison bison bison histone deacetylase 9 (HDAC9), transcript variant X2, mRNA","Q9UKV0",1699,0,"Histone deacetylase 9","SPBC800.03",265,{"v":8e-74,"d":"8.00E-74"},"COG0123","pfam00850","Hist_deacetyl","Histone deacetylase domain. Histones can be reversibly acetylated on several lysine residues. Regulation of transcription is caused in part by this mechanism. Histone deacetylases catalyse the removal of the acetyl group. Histone deacetylases are related to other proteins.","GO:0042113|B cell activation;GO:0030183|B cell differentiation;GO:0032869|cellular response to insulin stimulus;GO:0007507|heart development;GO:0016575|histone deacetylation;GO:0070932|histone H3 deacetylation;GO:0070933|histone H4 deacetylation;GO:0006954|inflammatory response;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0030182|neuron differentiation;GO:0034983|peptidyl-lysine deacetylation;GO:0090050|positive regulation of cell migration involved in sprouting angiogenesis;GO:0048742|regulation of skeletal muscle fiber development;GO:0051153|regulation of striated muscle cell differentiation;GO:0001975|response to amphetamine;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0000118|histone deacetylase complex;GO:0035097|histone methyltransferase complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0004407|histone deacetylase activity;GO:0042826|histone deacetylase binding;GO:0046872|metal ion binding;GO:0032041|NAD-dependent histone deacetylase activity (H3-K14 specific);GO:0033558|protein deacetylase activity;GO:0005080|protein kinase C binding;GO:0070491|repressing transcription factor binding;GO:0003714|transcription corepressor activity;GO:0008134|transcription factor binding;","K11409","HDAC9; histone deacetylase 9 [EC:3.5.1.98]"]
["bta_circ_0002915",0,0,0,2.5633583867705,7,4,3,-4.79255214395397,0.0127644381316561,"NA","down","yes","NC_037331.1:33134052..33143401:-","gene5009","gi|29135283|ref|NP_803460.1|",3328,0,"peroxisomal carnitine O-octanoyltransferase [Bos taurus]","gi|31343509|ref|NM_177494.2|",2988,0,"Bos taurus carnitine O-octanoyltransferase (CROT), mRNA","O19094",1286,0,"Peroxisomal carnitine O-octanoyltransferase",".",".",".",".","pfam00755","Carn_acyltransf","Choline/Carnitine o-acyltransferase.","GO:0009437|carnitine metabolic process;GO:0015936|coenzyme A metabolic process;GO:0006635|fatty acid beta-oxidation;GO:0006631|fatty acid metabolic process;GO:0006091|generation of precursor metabolites and energy;GO:0051791|medium-chain fatty acid metabolic process;","GO:0005777|peroxisome;","GO:0008458|carnitine O-octanoyltransferase activity;","K05940","CROT; carnitine O-octanoyltransferase [EC:2.3.1.137]"]
["bta_circ_0002919",0,2,0,5.74991790089493,8,5,18,-3.95267612516566,0.00457936309751569,0.170699707186705,"down","yes","NC_037331.1:33540911..33554590:+","gene5016","gi|982921144|ref|XP_015324044.1|",5479,0,"PREDICTED: UPF0577 protein KIAA1324-like homolog isoform X1 [Bos taurus]","gi|982921143|ref|XM_015468558.1|",4699,0,"PREDICTED: Bos taurus KIAA1324-like ortholog (KIAA1324L), transcript variant X1, mRNA","A8MWY0",1941,0,"UPF0577 protein KIAA1324-like",".",".",".",".","pfam07699","GCC2_GCC3","GCC2 and GCC3.",".","GO:0016021|integral component of membrane;",".",".","."]
["bta_circ_0002938",0,2,4,5.50975916646421,8,10,10,-2.41350172128721,0.0453583040293949,"NA","down","yes","NC_037331.1:40060802..40082374:+","gene5042","gi|155371895|ref|NP_001094552.1|",4101,0,"semaphorin-3C precursor [Bos taurus]","gi|942039757|ref|XM_005890240.2|",4832,0,"PREDICTED: Bos mutus sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C (SEMA3C), transcript variant X1, mRNA","A7MB70",1584,0,"Semaphorin-3C",".",".",".",".","pfam01403","Sema","Sema domain. The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and human plexin A-3.","GO:0007411|axon guidance;GO:0001974|blood vessel remodeling;GO:0003215|cardiac right ventricle morphogenesis;GO:0060666|dichotomous subdivision of terminal units involved in salivary gland branching;GO:0060174|limb bud formation;GO:0050919|negative chemotaxis;GO:0001755|neural crest cell migration;GO:0021915|neural tube development;GO:0003148|outflow tract septum morphogenesis;GO:0009791|post-embryonic development;GO:0003350|pulmonary myocardium development;GO:0071526|semaphorin-plexin signaling pathway;GO:0001756|somitogenesis;","GO:0005615|extracellular space;","GO:0038191|neuropilin binding;GO:0030215|semaphorin receptor binding;","K06840","SEMA3; semaphorin 3"]
["bta_circ_0002939",0,0,0,1.78676880119091,4,3,3,-4.25571567454143,0.0325416421682752,"NA","down","yes","NC_037331.1:40060802..40095356:+","gene5042","gi|155371895|ref|NP_001094552.1|",4101,0,"semaphorin-3C precursor [Bos taurus]","gi|942039757|ref|XM_005890240.2|",4832,0,"PREDICTED: Bos mutus sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C (SEMA3C), transcript variant X1, mRNA","A7MB70",1584,0,"Semaphorin-3C",".",".",".",".","pfam01403","Sema","Sema domain. The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and human plexin A-3.","GO:0007411|axon guidance;GO:0001974|blood vessel remodeling;GO:0003215|cardiac right ventricle morphogenesis;GO:0060666|dichotomous subdivision of terminal units involved in salivary gland branching;GO:0060174|limb bud formation;GO:0050919|negative chemotaxis;GO:0001755|neural crest cell migration;GO:0021915|neural tube development;GO:0003148|outflow tract septum morphogenesis;GO:0009791|post-embryonic development;GO:0003350|pulmonary myocardium development;GO:0071526|semaphorin-plexin signaling pathway;GO:0001756|somitogenesis;","GO:0005615|extracellular space;","GO:0038191|neuropilin binding;GO:0030215|semaphorin receptor binding;","K06840","SEMA3; semaphorin 3"]
["bta_circ_0002949",0,2,0,3.32734429743988,7,3,7,-3.13462136469831,0.0441984872722052,"NA","down","yes","NC_037331.1:40394812..40398355:-","gene5046","gi|521258696|ref|NP_776435.2|",2414,0,"platelet glycoprotein 4 [Bos taurus]","gi|850481938|gb|CP011889.1|",2115,0,"Ovis canadensis canadensis isolate 43U chromosome 4 sequence","P26201",934,0,"Platelet glycoprotein 4",".",".",".",".","pfam01130","CD36","CD36 family. The CD36 family is thought to be a novel class of scavenger receptors. There is also evidence suggesting a possible role in signal transduction. CD36 is involved in cell adhesion.","GO:1990000|amyloid fibril formation;GO:0007155|cell adhesion;GO:0007166|cell surface receptor signaling pathway;GO:0071726|cellular response to diacyl bacterial lipopeptide;GO:0071404|cellular response to low-density lipoprotein particle stimulus;GO:0070508|cholesterol import;GO:0097009|energy homeostasis;GO:0006955|immune response;GO:0050702|interleukin-1 beta secretion;GO:0050892|intestinal absorption;GO:0030299|intestinal cholesterol absorption;GO:0044539|long-chain fatty acid import;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:1900227|positive regulation of NLRP3 inflammasome complex assembly;GO:0031623|receptor internalization;GO:0070542|response to fatty acid;GO:0070543|response to linoleic acid;GO:0033993|response to lipid;GO:0050909|sensory perception of taste;GO:0034197|triglyceride transport;","GO:0016324|apical plasma membrane;GO:0031526|brush border membrane;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;GO:0016020|membrane;GO:0045121|membrane raft;",".","K06259","CD36; CD36 antigen"]
["bta_circ_0002950",0,0,0,3.03289325133661,3,10,6,-5.07631700025512,0.00717250224093093,"NA","down","yes","NC_037331.1:40394812..40416284:-","gene5046","gi|521258696|ref|NP_776435.2|",2414,0,"platelet glycoprotein 4 [Bos taurus]","gi|850481938|gb|CP011889.1|",2115,0,"Ovis canadensis canadensis isolate 43U chromosome 4 sequence","P26201",934,0,"Platelet glycoprotein 4",".",".",".",".","pfam01130","CD36","CD36 family. The CD36 family is thought to be a novel class of scavenger receptors. There is also evidence suggesting a possible role in signal transduction. CD36 is involved in cell adhesion.","GO:1990000|amyloid fibril formation;GO:0007155|cell adhesion;GO:0007166|cell surface receptor signaling pathway;GO:0071726|cellular response to diacyl bacterial lipopeptide;GO:0071404|cellular response to low-density lipoprotein particle stimulus;GO:0070508|cholesterol import;GO:0097009|energy homeostasis;GO:0006955|immune response;GO:0050702|interleukin-1 beta secretion;GO:0050892|intestinal absorption;GO:0030299|intestinal cholesterol absorption;GO:0044539|long-chain fatty acid import;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:1900227|positive regulation of NLRP3 inflammasome complex assembly;GO:0031623|receptor internalization;GO:0070542|response to fatty acid;GO:0070543|response to linoleic acid;GO:0033993|response to lipid;GO:0050909|sensory perception of taste;GO:0034197|triglyceride transport;","GO:0016324|apical plasma membrane;GO:0031526|brush border membrane;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;GO:0016020|membrane;GO:0045121|membrane raft;",".","K06259","CD36; CD36 antigen"]
["bta_circ_0002953",0,20,6,2.66874283505962,0,0,0,4.61202602219068,0.0192392616101246,"NA","up","yes","NC_037331.1:41060658..41061598:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0002967",18,15,10,8.64485643091826,3,0,0,3.41378834690111,0.00544930554423215,0.19002255784887,"up","yes","NC_037331.1:43476701..43480930:-","gene5056","gi|76662501|ref|XP_614755.2|",3763,0,"PREDICTED: round spermatid basic protein 1-like protein [Bos taurus]","gi|982980478|ref|XM_614755.7|",5773,0,"PREDICTED: Bos taurus round spermatid basic protein 1-like (RSBN1L), mRNA","Q6PCB5",1265,0,"Round spermatid basic protein 1-like protein",".",".",".",".","pfam10317","7TM_GPCR_Srd","Serpentine type 7TM GPCR chemoreceptor Srd. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.",".","GO:0005634|nucleus;",".",".","."]
["bta_circ_0002975",3,8,0,16.3068934510104,24,37,26,-3.0946313618102,0.000432103938868601,0.0359311044551506,"down","yes","NC_037331.1:44064027..44111664:+","gene5068","gi|359064661|ref|XP_002686818.2|",1955,0,"PREDICTED: protein FAM185A isoform X1 [Bos taurus]","gi|982980484|ref|XM_015463014.1|",2771,0,"PREDICTED: Bos taurus family with sequence similarity 185 member A (FAM185A), transcript variant X1, mRNA","Q8N0U4",581,0,"Protein FAM185A",".",".",".",".","pfam13345","DUF4098","Domain of unknown function (DUF4098). This domain is a C-terminal repeat found in many bacterial species.",".","GO:0005829|cytosol;",".",".","."]
["bta_circ_0002979",15,69,27,17.3918204350139,0,17,4,2.12797394635523,0.0154716934116312,0.298906981742218,"up","yes","NC_037331.1:44450397..44450703:-","gene5073","gi|440906484|gb|ELR56738.1|",2020,0,"N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D, partial [Bos mutus]","gi|942053271|ref|XM_005895252.2|",3988,0,"PREDICTED: Bos mutus N-acyl phosphatidylethanolamine phospholipase D (NAPEPLD), transcript variant X2, mRNA","Q58CN9",773,0,"N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D","RSp1389",237,{"v":2e-67,"d":"2.00E-67"},"COG2220","pfam12706","Lactamase_B_2","Beta-lactamase superfamily domain. This family is part of the beta-lactamase superfamily and is related to pfam00753.","GO:0070291|N-acylethanolamine metabolic process;GO:0009395|phospholipid catabolic process;","GO:0005829|cytosol;GO:0016020|membrane;","GO:0042802|identical protein binding;GO:0070290|N-acylphosphatidylethanolamine-specific phospholipase D activity;GO:0008270|zinc ion binding;","K13985","NAPEPLD; N-acyl-phosphatidylethanolamine-hydrolysing phospholipase D [EC:3.1.4.54]"]
["bta_circ_0002989",0,0,0,2.5633583867705,7,4,3,-4.79255214395397,0.0127644381316561,"NA","down","yes","NC_037331.1:46224738..46285203:+","gene5084","gi|742130863|ref|XP_010839734.1|",8321,0,"PREDICTED: histone-lysine N-methyltransferase 2E isoform X1 [Bison bison bison]","gi|982921379|ref|XM_005205364.3|",6919,0,"PREDICTED: Bos taurus lysine (K)-specific methyltransferase 2E (KMT2E), transcript variant X3, mRNA","Q8IZD2",3006,0,"Inactive histone-lysine N-methyltransferase 2E","SPAC22E12.11c",100,{"v":3e-20,"d":"3.00E-20"},"COG2940","pfam00856","SET","SET domain. SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.","GO:0007050|cell cycle arrest;GO:0006306|DNA methylation;GO:0030218|erythrocyte differentiation;GO:0042119|neutrophil activation;GO:0002446|neutrophil mediated immunity;GO:1900087|positive regulation of G1/S transition of mitotic cell cycle;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045652|regulation of megakaryocyte differentiation;GO:0006351|transcription, DNA-templated;","GO:0000785|chromatin;GO:0005737|cytoplasm;GO:0005815|microtubule organizing center;GO:0016607|nuclear speck;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0032991|macromolecular complex;GO:0035327|transcriptionally active chromatin;","GO:0019899|enzyme binding;GO:0018024|histone-lysine N-methyltransferase activity;GO:0046872|metal ion binding;GO:0035064|methylated histone binding;","K09189","MLL5; histone-lysine N-methyltransferase MLL5 [EC:2.1.1.43]"]
["bta_circ_0002998",0,0,0,1.79233695296796,3,2,5,-4.25024607832348,0.0329436429275932,"NA","down","yes","NC_037331.1:46614012..46630646:-","gene5091","gi|528946459|ref|XP_005205427.1|",3453,0,"PREDICTED: pseudouridylate synthase 7 homolog isoform X1 [Bos taurus]","gi|982921390|ref|XM_015468980.1|",3568,0,"PREDICTED: Bos taurus pseudouridylate synthase 7 (putative) (PUS7), transcript variant X6, mRNA","Q08DI8",1288,0,"Pseudouridylate synthase 7 homolog","SPBC1A4.09",377,{"v":2e-114,"d":"2.00E-114"},"COG0585","pfam01142","TruD","tRNA pseudouridine synthase D (TruD). TruD is responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs. The structure of TruD reveals an overall V-shaped molecule which contains an RNA-binding cleft.","GO:0001522|pseudouridine synthesis;GO:0008033|tRNA processing;","GO:0005634|nucleus;","GO:0009982|pseudouridine synthase activity;GO:0003723|RNA binding;","K06176","truD, PUS7; tRNA pseudouridine13 synthase [EC:5.4.99.27]"]
["bta_circ_0003016",0,0,0,2.13665485087747,5,8,0,-4.36216404155275,0.0290206012034963,"NA","down","yes","NC_037331.1:48606395..48612838:+","gene5115","gi|84000125|ref|NP_001033164.1|",1024,{"v":3e-133,"d":"3.00E-133"},"B-cell receptor-associated protein 29 [Bos taurus]","gi|982921483|ref|XM_005205407.3|",1686,0,"PREDICTED: Bos taurus B-cell receptor-associated protein 29 (BCAP29), transcript variant X1, mRNA","Q32KL9",399,{"v":1e-134,"d":"1.00E-134"},"B-cell receptor-associated protein 29",".",".",".",".","pfam05529","Bap31","B-cell receptor-associated protein 31-like. Bap31 is a polytopic integral protein of the endoplasmic reticulum membrane and a substrate of caspase-8. Bap31 is cleaved within its cytosolic domain, generating pro-apoptotic p20 Bap31.","GO:0006915|apoptotic process;GO:0006888|ER to Golgi vesicle-mediated transport;GO:0006886|intracellular protein transport;GO:0070973|protein localization to endoplasmic reticulum exit site;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;",".",".","."]
["bta_circ_0003034",0,0,0,2.14779115443158,3,6,4,-4.55615576722426,0.0196213301774734,"NA","down","yes","NC_037331.1:51703801..51705017:-","gene5152","gi|555974401|ref|XP_005899193.1|",7202,0,"PREDICTED: hepatocyte growth factor receptor isoform X1 [Bos mutus]","gi|742233738|ref|XM_010831212.1|",6208,0,"PREDICTED: Bison bison bison MET proto-oncogene, receptor tyrosine kinase (MET), transcript variant X2, mRNA","Q769I5",2763,0,"Hepatocyte growth factor receptor","YAR019c",103,{"v":3e-21,"d":"3.00E-21"},"COG0515","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0050918|positive chemotaxis;GO:2001028|positive regulation of endothelial cell chemotaxis;GO:0071526|semaphorin-plexin signaling pathway;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;","GO:0016021|integral component of membrane;","GO:0005524|ATP binding;GO:0004714|transmembrane receptor protein tyrosine kinase activity;","K05099","MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]"]
["bta_circ_0003040",0,0,0,1.85730104079895,0,6,6,-4.16237806537761,0.0394769919390397,"NA","down","yes","NC_037331.1:54207309..54213761:-","gene5161","gi|555973949|ref|XP_005898970.1|",2143,0,"PREDICTED: forkhead box protein P2 isoform X3 [Bos mutus]","gi|982921480|ref|XM_015469121.1|",5655,0,"PREDICTED: Bos taurus forkhead box P2 (FOXP2), transcript variant X1, mRNA","Q5QL03",800,0,"Forkhead box protein P2","SPBC32H8.11",85.9,{"v":5e-16,"d":"5.00E-16"},"COG5025","pfam00250","Fork_head","Fork head domain.","GO:0021757|caudate nucleus development;GO:0021758|putamen development;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0042803|protein homodimerization activity;GO:0043565|sequence-specific DNA binding;",".","."]
["bta_circ_0003044",0,0,0,2.52302251055043,6,0,7,-4.589851884329,0.0199235927005455,"NA","down","yes","NC_037331.1:54207314..54345486:-","gene5161","gi|555973949|ref|XP_005898970.1|",2143,0,"PREDICTED: forkhead box protein P2 isoform X3 [Bos mutus]","gi|982921480|ref|XM_015469121.1|",5655,0,"PREDICTED: Bos taurus forkhead box P2 (FOXP2), transcript variant X1, mRNA","Q5QL03",800,0,"Forkhead box protein P2","SPBC32H8.11",85.9,{"v":5e-16,"d":"5.00E-16"},"COG5025","pfam00250","Fork_head","Fork head domain.","GO:0021757|caudate nucleus development;GO:0021758|putamen development;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0042803|protein homodimerization activity;GO:0043565|sequence-specific DNA binding;",".","."]
["bta_circ_0003060",0,0,0,2.66865835082156,5,12,0,-4.70308617532358,0.016300491357842,"NA","down","yes","NC_037331.1:55172616..55210979:-","gene5165",".",".",".",".","gi|965931783|ref|XR_001434575.1|",356,0,"PREDICTED: Ovis aries uncharacterized LOC105610466 (LOC105610466), ncRNA",".",".",".",".",".",".",".",".","pfam05784","Herpes_UL82_83","Betaherpesvirus UL82/83 protein N terminus. This family represents the N terminal region of the Betaherpesvirus UL82 and UL83 proteins. As viruses are reliant upon their host cell to serve as proper environments for their replication, many have evolved mechanisms to alter intracellular conditions to suit their own needs. Human cytomegalovirus induces quiescent cells to enter the cell cycle and then arrests them in late G(1), before they enter the S phase, a cell cycle compartment that is presumably favourable for viral replication. The protein product of the human cytomegalovirus UL82 gene, pp71, can accelerate the movement of cells through the G(1) phase of the cell cycle. This activity would help infected cells reach the late G(1) arrest point sooner and thus may stimulate the infectious cycle. pp71 also induces DNA synthesis in quiescent cells, but a pp71 mutant protein that is unable to induce quiescent cells to enter the cell cycle still retains the ability to accelerate the G(1) phase. Thus, the mechanism through which pp71 accelerates G(1) cell cycle progression appears to be distinct from the one that it employs to induce quiescent cells to exit G(0) and subsequently enter the S phase.",".",".",".",".","."]
["bta_circ_0003087",47,181,80,162.407533588808,193,285,237,-1.53882329074059,{"v":7.63202978561563e-05,"d":"7.63E-05"},0.00970614611558882,"down","yes","NC_037331.1:56932286..56934945:+","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0003088",2,12,12,19.2313957954573,20,56,24,-2.17593485738847,0.00295035064648401,0.127573161953968,"down","yes","NC_037331.1:56932286..56935635:+","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0003115",0,0,0,2.45177317612102,4,8,3,-4.75259222148929,0.0137192945305042,"NA","down","yes","NC_037331.1:63586321..63697966:-","gene5219","gi|300797295|ref|NP_001179782.1|",4753,0,"protein PTHB1 [Bos taurus]","gi|982921634|ref|XM_005205478.3|",3774,0,"PREDICTED: Bos taurus Bardet-Biedl syndrome 9 (BBS9), transcript variant X1, mRNA","Q3SYG4",1701,0,"Protein PTHB1",".",".",".",".","pfam14727","PHTB1_N","PTHB1 N-terminus. This family includes the N-terminus of PTHB1 protein. This protein forms a part of the BBSome complex, which is required for ciliogenesis.","GO:0060271|cilium morphogenesis;GO:0045444|fat cell differentiation;GO:0061512|protein localization to cilium;GO:0015031|protein transport;GO:0050896|response to stimulus;GO:0007601|visual perception;","GO:0034464|BBSome;GO:0034451|centriolar satellite;GO:0060170|ciliary membrane;GO:0035869|ciliary transition zone;GO:0005929|cilium;GO:0005829|cytosol;GO:0016020|membrane;GO:0000242|pericentriolar material;",".","K19398","BBS9; Bardet-Biedl syndrome 9 protein"]
["bta_circ_0003129",0,0,0,2.48182969155867,6,5,3,-4.75699315196251,0.0136053724682983,"NA","down","yes","NC_037331.1:67415459..67422158:-","gene5262","gi|545214298|ref|XP_005609331.1|",1398,{"v":1e-169,"d":"1.00E-169"},"PREDICTED: cyclic AMP-responsive element-binding protein 5 isoform X4 [Equus caballus]","gi|985701054|ref|NM_001319882.1|",8271,0,"Bos taurus cAMP responsive element binding protein 5 (CREB5), mRNA","Q02930",497,{"v":8e-155,"d":"8.00E-155"},"Cyclic AMP-responsive element-binding protein 5",".",".",".",".","pfam00170","bZIP_1","bZIP transcription factor. The Pfam entry includes the basic region and the leucine zipper region.","GO:0045893|positive regulation of transcription, DNA-templated;GO:0006366|transcription from RNA polymerase II promoter;","GO:0070062|extracellular exosome;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K09047","CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5"]
["bta_circ_0003155",29,88,71,35.9686868206532,15,22,22,1.35215916482189,0.0126930240352011,0.289625845446867,"up","yes","NC_037331.1:74948084..74949436:+","gene5342","gi|982921886|ref|XP_015325528.1|",7900,0,"PREDICTED: tensin-3 isoform X1 [Bos taurus]","gi|982980769|ref|XM_005198091.3|",7305,0,"PREDICTED: Bos taurus tensin 3 (TNS3), transcript variant X7, mRNA","Q68CZ2",2289,0,"Tensin-3","SPBC609.02",85.9,{"v":1e-16,"d":"1.00E-16"},"COG2453","pfam08416","PTB","Phosphotyrosine-binding domain. The phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus. Tensin is a multi-domain protein that binds to actin filaments and functions as a focal-adhesion molecule (focal adhesions are regions of plasma membrane through which cells attach to the extracellular matrix). Human tensin has actin-binding sites, an SH2 (pfam00017) domain and a region similar to the tumor suppressor PTEN. The PTB domain interacts with the cytoplasmic tails of beta integrin by binding to an NPXY motif.","GO:0016477|cell migration;GO:0048286|lung alveolus development;GO:0008284|positive regulation of cell proliferation;","GO:0005829|cytosol;GO:0005925|focal adhesion;",".","K18080","TNS; tensin"]
["bta_circ_0003166",0,12,14,2.92004702509135,0,0,0,4.74689402822973,0.0150429198767674,"NA","up","yes","NC_037331.1:77086257..77091688:+","gene5380","gi|741924132|ref|XP_010802680.1|",3128,0,"PREDICTED: calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [Bos taurus]","gi|982921865|ref|XM_010804378.2|",3866,0,"PREDICTED: Bos taurus calcium/calmodulin-dependent protein kinase II beta (CAMK2B), transcript variant X1, mRNA","Q13554",1174,0,"Calcium/calmodulin-dependent protein kinase type II subunit beta",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0060333|interferon-gamma-mediated signaling pathway;GO:0035556|intracellular signal transduction;GO:0000165|MAPK cascade;GO:0018105|peptidyl-serine phosphorylation;GO:0018107|peptidyl-threonine phosphorylation;GO:0061003|positive regulation of dendritic spine morphogenesis;GO:0010976|positive regulation of neuron projection development;GO:0090129|positive regulation of synapse maturation;GO:0046777|protein autophosphorylation;GO:0006468|protein phosphorylation;GO:0051924|regulation of calcium ion transport;GO:0060998|regulation of dendritic spine development;GO:0048169|regulation of long-term neuronal synaptic plasticity;GO:0014733|regulation of skeletal muscle adaptation;GO:0051823|regulation of synapse structural plasticity;GO:0007165|signal transduction;","GO:0030054|cell junction;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0030666|endocytic vesicle membrane;GO:0005815|microtubule organizing center;GO:0043005|neuron projection;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0033017|sarcoplasmic reticulum membrane;GO:0045202|synapse;","GO:0003779|actin binding;GO:0005524|ATP binding;GO:0005516|calmodulin binding;GO:0004683|calmodulin-dependent protein kinase activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0004674|protein serine/threonine kinase activity;GO:0005088|Ras guanyl-nucleotide exchange factor activity;","K04515","CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]"]
["bta_circ_0003175",2,16,22,20.448577167423,37,24,25,-1.54993781892782,0.0374678098914145,0.439730132358439,"down","yes","NC_037331.1:80897691..80914402:-","gene5404","gi|157279981|ref|NP_001098506.1|",2275,0,"succinate--hydroxymethylglutarate CoA-transferase [Bos taurus]","gi|157279980|ref|NM_001105036.1|",1899,0,"Bos taurus succinyl-CoA:glutarate-CoA transferase (SUGCT), mRNA","Q9HAC7",813,0,"Succinate--hydroxymethylglutarate CoA-transferase","PA0446",354,{"v":1e-114,"d":"1.00E-114"},"COG1804","pfam02515","CoA_transf_3","CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.",".","GO:0005739|mitochondrion;","GO:0047369|succinate-hydroxymethylglutarate CoA-transferase activity;","K18703","SUGCT; succinate---hydroxymethylglutarate CoA-transferase [EC:2.8.3.13]"]
["bta_circ_0003216",75,124,97,130.372754880931,138,211,150,-0.875125036568636,0.0346934159119583,0.439730132358439,"down","yes","NC_037331.1:86568132..86586880:-","gene5448","gi|555964831|ref|XP_005894477.1|",4901,0,"PREDICTED: alpha-aminoadipic semialdehyde synthase, mitochondrial isoform X1 [Bos mutus]","gi|965932642|ref|XM_012177031.2|",3834,0,"PREDICTED: Ovis aries aminoadipate-semialdehyde synthase (AASS), transcript variant X1, mRNA","A8E657",1882,0,"Alpha-aminoadipic semialdehyde synthase, mitochondrial","YNR050c",347,{"v":5e-104,"d":"5.00E-104"},"COG1748","pfam03435","Saccharop_dh","Saccharopine dehydrogenase. This family comprised of three structural domains that can not be separated in the linear sequence. In some organisms this enzyme is found as a bifunctional polypeptide with lysine ketoglutarate reductase. The saccharopine dehydrogenase can also function as a saccharopine reductase.","GO:0006091|generation of precursor metabolites and energy;GO:0033512|L-lysine catabolic process to acetyl-CoA via saccharopine;GO:0019878|lysine biosynthetic process via aminoadipic acid;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;","GO:0047131|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity;GO:0047130|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity;GO:0004753|saccharopine dehydrogenase activity;","K14157","AASS; alpha-aminoadipic semialdehyde synthase [EC:1.5.1.8 1.5.1.9]"]
["bta_circ_0003313",0,15,14,3.20623141269164,0,0,0,4.88376670382249,0.011618760183683,"NA","up","yes","NC_037331.1:98929370..98996232:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0003317",3,11,0,1.93305401888705,0,0,0,4.07134956202423,0.045531204242812,"NA","up","yes","NC_037331.1:99073990..99084530:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0003335",0,7,11,14.2629764742182,21,26,24,-2.33522240969208,0.00694597069981222,0.208572064624917,"down","yes","NC_037332.1:107633565..107643676:+","gene7518","gi|528951325|ref|XP_005207349.1|",8522,0,"PREDICTED: serine/threonine-protein kinase WNK1 isoform X19 [Bos taurus]","gi|982982510|ref|XM_015463544.1|",9668,0,"PREDICTED: Bos taurus WNK lysine deficient protein kinase 1 (WNK1), transcript variant X19, mRNA","Q6R2V0",2702,0,"Serine/threonine-protein kinase WNK1",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0010923|negative regulation of phosphatase activity;","GO:0005737|cytoplasm;","GO:0005524|ATP binding;GO:0019902|phosphatase binding;GO:0004860|protein kinase inhibitor activity;GO:0004674|protein serine/threonine kinase activity;",".","."]
["bta_circ_0003338",0,2,0,3.79131101022893,4,10,8,-3.357071697104,0.0248348144462443,"NA","down","yes","NC_037332.1:107697313..107699988:+","gene7518","gi|528951325|ref|XP_005207349.1|",8522,0,"PREDICTED: serine/threonine-protein kinase WNK1 isoform X19 [Bos taurus]","gi|982982510|ref|XM_015463544.1|",9668,0,"PREDICTED: Bos taurus WNK lysine deficient protein kinase 1 (WNK1), transcript variant X19, mRNA","Q6R2V0",2702,0,"Serine/threonine-protein kinase WNK1",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0010923|negative regulation of phosphatase activity;","GO:0005737|cytoplasm;","GO:0005524|ATP binding;GO:0019902|phosphatase binding;GO:0004860|protein kinase inhibitor activity;GO:0004674|protein serine/threonine kinase activity;",".","."]
["bta_circ_0003346",57,136,173,79.3982952836463,46,69,49,0.891180764213897,0.0442372571314023,0.456494092506297,"up","yes","NC_037332.1:10800896..10820190:+","gene6027","gi|741925360|ref|XP_010803058.1|",3037,0,"PREDICTED: acyl-CoA synthetase short-chain family member 3, mitochondrial isoform X2 [Bos taurus]","gi|982924408|ref|XM_010804756.2|",4057,0,"PREDICTED: Bos taurus acyl-CoA synthetase short-chain family member 3 (ACSS3), transcript variant X3, mRNA","A7MB45",1093,0,"Acyl-CoA synthetase short-chain family member 3, mitochondrial","mll5286",531,{"v":3e-171,"d":"3.00E-171"},"COG0365","pfam00501","AMP-binding","AMP-binding enzyme.","GO:0008152|metabolic process;","GO:0005739|mitochondrion;","GO:0003987|acetate-CoA ligase activity;GO:0005524|ATP binding;","K01908","E6.2.1.17, prpE; propionyl-CoA synthetase [EC:6.2.1.17]"]
["bta_circ_0003372",7,46,22,10.1226720840857,0,0,5,3.16530118056611,0.00473275649402286,0.173427449831821,"up","yes","NC_037332.1:111614599..111618260:+","gene7628","gi|741928535|ref|XP_010804057.1|",7217,0,"PREDICTED: trinucleotide repeat-containing gene 6B protein isoform X4 [Bos taurus]","gi|982927405|ref|XM_010805755.2|",6546,0,"PREDICTED: Bos taurus trinucleotide repeat containing 6B (TNRC6B), transcript variant X6, mRNA","Q9UPQ9",2626,0,"Trinucleotide repeat-containing gene 6B protein",".",".",".",".","pfam10427","Ago_hook","Argonaute hook. This region has been called the argonaute hook. It has been shown to bind to the Piwi domain pfam02171 of Argnonaute proteins.","GO:0031047|gene silencing by RNA;GO:0035278|negative regulation of translation involved in gene silencing by miRNA;GO:1900153|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0060213|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;GO:0035194|posttranscriptional gene silencing by RNA;GO:0045652|regulation of megakaryocyte differentiation;GO:0007223|Wnt signaling pathway, calcium modulating pathway;","GO:0005829|cytosol;GO:0000932|cytoplasmic mRNA processing body;","GO:0003723|RNA binding;","K18412","TNRC6, GW182; trinucleotide repeat-containing gene 6 protein"]
["bta_circ_0003392",2,2,9,1.92120081122186,0,0,0,4.21679216948298,0.0356289812800261,"NA","up","yes","NC_037332.1:113629705..113631287:-","gene7706","gi|115495145|ref|NP_001069442.1|",2432,0,"ADP-ribosylation factor GTPase-activating protein 3 [Bos taurus]","gi|115495144|ref|NM_001075974.1|",2675,0,"Bos taurus ADP ribosylation factor GTPase activating protein 3 (ARFGAP3), mRNA","Q17R07",941,0,"ADP-ribosylation factor GTPase-activating protein 3","SPAC22E12.17c",139,{"v":7e-34,"d":"7.00E-34"},"COG5347","pfam01412","ArfGap","Putative GTPase activating protein for Arf. Putative zinc fingers with GTPase activating proteins (GAPs) towards the small GTPase, Arf. The GAP of ARD1 stimulates GTPase hydrolysis for ARD1 but not ARFs.","GO:0009306|protein secretion;GO:0016192|vesicle-mediated transport;","GO:0005829|cytosol;GO:0000139|Golgi membrane;","GO:0005096|GTPase activator activity;GO:0046872|metal ion binding;","K12493","ARFGAP2_3; ADP-ribosylation factor GTPase-activating protein 2/3"]
["bta_circ_0003411",0,2,0,6.56377066337055,6,17,16,-4.1731267727017,0.0017258002423227,0.0847995482704926,"down","yes","NC_037332.1:117073025..117132238:+","gene7774","gi|528951948|ref|XP_005207589.1|",2722,0,"PREDICTED: TBC1 domain family member 22A isoform X1 [Bos taurus]","gi|982927626|ref|XM_005207532.3|",2167,0,"PREDICTED: Bos taurus TBC1 domain family member 22A (TBC1D22A), transcript variant X1, mRNA","Q8WUA7",719,0,"TBC1 domain family member 22A",".",".",".",".","pfam00566","RabGAP-TBC","Rab-GTPase-TBC domain. Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.","GO:0090630|activation of GTPase activity;GO:0006886|intracellular protein transport;GO:0031338|regulation of vesicle fusion;","GO:0012505|endomembrane system;GO:0005622|intracellular;","GO:0071889|14-3-3 protein binding;GO:0005096|GTPase activator activity;GO:0042803|protein homodimerization activity;GO:0017137|Rab GTPase binding;",".","."]
["bta_circ_0003417",2,9,8,2.46215656266847,0,0,0,4.62423281044998,0.017863770507498,"NA","up","yes","NC_037332.1:119720278..119728007:+","gene7820","gi|982982829|ref|XP_015319148.1|",4318,0,"PREDICTED: serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X5 [Bos taurus]","gi|982982830|ref|XM_015463663.1|",2315,0,"PREDICTED: Bos taurus protein phosphatase 6 regulatory subunit 2 (PPP6R2), transcript variant X6, mRNA","O75170",1220,0,"Serine/threonine-protein phosphatase 6 regulatory subunit 2",".",".",".",".","pfam04499","SAPS","SIT4 phosphatase-associated protein. This family includes a conserved region from a group of yeast proteins that associate with the SIT4 phosphatase. This association is required for SIT4's role in G1 cyclin transcription and for bud formation. This family also includes homologous regions from other eukaryotes.",".","GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;",".","K15500","PPP6R2, SAPS2; serine/threonine-protein phosphatase 6 regulatory subunit 2"]
["bta_circ_0003427",0,0,0,4.39938361118322,3,7,16,-5.58679829498434,0.00228173140861658,"NA","down","yes","NC_037332.1:12489243..12491217:+","gene6034","gi|297474370|ref|XP_002687226.1|",4157,0,"PREDICTED: transmembrane and TPR repeat-containing protein 2 isoform X2 [Bos taurus]","gi|982981507|ref|XM_010827581.2|",5101,0,"PREDICTED: Bos taurus transmembrane and tetratricopeptide repeat containing 2 (TMTC2), transcript variant X2, mRNA","Q56A06",1516,0,"Transmembrane and TPR repeat-containing protein 2",".",".",".",".","pfam08409","DUF1736","Domain of unknown function (DUF1736). This domain of unknown function is found in various hypothetical metazoan proteins.","GO:0055074|calcium ion homeostasis;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;",".",".","."]
["bta_circ_0003428",0,2,0,5.63026908601539,13,4,12,-3.913364880592,0.00531957550366039,"NA","down","yes","NC_037332.1:12489243..12521930:+","gene6034","gi|297474370|ref|XP_002687226.1|",4157,0,"PREDICTED: transmembrane and TPR repeat-containing protein 2 isoform X2 [Bos taurus]","gi|982981507|ref|XM_010827581.2|",5101,0,"PREDICTED: Bos taurus transmembrane and tetratricopeptide repeat containing 2 (TMTC2), transcript variant X2, mRNA","Q56A06",1516,0,"Transmembrane and TPR repeat-containing protein 2",".",".",".",".","pfam08409","DUF1736","Domain of unknown function (DUF1736). This domain of unknown function is found in various hypothetical metazoan proteins.","GO:0055074|calcium ion homeostasis;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;",".",".","."]
["bta_circ_0003457",0,0,0,2.69885471420953,0,11,7,-4.73908571626023,0.0152156810077275,"NA","down","yes","NC_037332.1:23119397..23121079:-","gene6104",".",".",".",".","gi|850480667|gb|CP011888.1|",491,0,"Ovis canadensis canadensis isolate 43U chromosome 3 sequence",".",".",".",".",".",".",".",".","pfam15252","DUF4589","Domain of unknown function (DUF4589). This protein family is a domain of unknown function. The precise function of the protein domain remains to be elucidated. This family of proteins is found in eukaryotes and are typically between 215 and 293 amino acids in length. The protein contains two conserved sequence motifs: SSS and KST.",".",".",".",".","."]
["bta_circ_0003505",0,0,0,2.1454355499289,3,2,7,-4.51633737100402,0.0212679439946128,"NA","down","yes","NC_037332.1:29755141..29765202:+","gene6298","gi|594105784|ref|XP_006075834.1|",1878,0,"PREDICTED: LOW QUALITY PROTEIN: ceramide synthase 5 [Bubalus bubalis]","gi|982925027|ref|XM_005206307.3|",2025,0,"PREDICTED: Bos taurus ceramide synthase 5 (CERS5), transcript variant X1, mRNA","Q8N5B7",656,0,"Ceramide synthase 5","ECU08g1350",110,{"v":1e-25,"d":"1.00E-25"},"COG5058","pfam03798","TRAM_LAG1_CLN8","TLC domain.","GO:0046513|ceramide biosynthetic process;GO:0030148|sphingolipid biosynthetic process;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0031965|nuclear membrane;","GO:0003677|DNA binding;GO:0050291|sphingosine N-acyltransferase activity;","K04710","CERS; ceramide synthetase [EC:2.3.1.24]"]
["bta_circ_0003540",0,0,0,2.66394714181619,5,4,6,-4.86967393478584,0.0109114373273254,"NA","down","yes","NC_037332.1:36927002..36967844:+","gene6444","gi|982925347|ref|XP_015326515.1|",9800,0,"PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform X1 [Bos taurus]","gi|982925346|ref|XM_015471029.1|",6047,0,"PREDICTED: Bos taurus ADAM metallopeptidase with thrombospondin type 1 motif 20 (ADAMTS20), transcript variant X1, mRNA","P59511",3021,0,"A disintegrin and metalloproteinase with thrombospondin motifs 20",".",".",".",".","pfam08685","GON","GON domain. The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.","GO:0030198|extracellular matrix organization;GO:0043066|negative regulation of apoptotic process;GO:0045636|positive regulation of melanocyte differentiation;GO:0009967|positive regulation of signal transduction;GO:0006508|proteolysis;GO:0048070|regulation of developmental pigmentation;","GO:0005615|extracellular space;","GO:0004175|endopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0008270|zinc ion binding;","K09609","ADAMTS20; a disintegrin and metalloproteinase with thrombospondin motifs 20 [EC:3.4.24.-]"]
["bta_circ_0003550",0,0,0,1.78912440569359,4,7,0,-4.08821352533039,0.044054743333277,"NA","down","yes","NC_037332.1:36982203..37086354:+","gene6444","gi|982925347|ref|XP_015326515.1|",9800,0,"PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform X1 [Bos taurus]","gi|982925346|ref|XM_015471029.1|",6047,0,"PREDICTED: Bos taurus ADAM metallopeptidase with thrombospondin type 1 motif 20 (ADAMTS20), transcript variant X1, mRNA","P59511",3021,0,"A disintegrin and metalloproteinase with thrombospondin motifs 20",".",".",".",".","pfam08685","GON","GON domain. The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.","GO:0030198|extracellular matrix organization;GO:0043066|negative regulation of apoptotic process;GO:0045636|positive regulation of melanocyte differentiation;GO:0009967|positive regulation of signal transduction;GO:0006508|proteolysis;GO:0048070|regulation of developmental pigmentation;","GO:0005615|extracellular space;","GO:0004175|endopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0008270|zinc ion binding;","K09609","ADAMTS20; a disintegrin and metalloproteinase with thrombospondin motifs 20 [EC:3.4.24.-]"]
["bta_circ_0003658",7,8,8,3.83961387405614,0,0,0,5.21854091480931,0.00540010434190087,"NA","up","yes","NC_037332.1:49120186..49124222:-","gene6572","gi|300797986|ref|NP_001179815.1|",1115,{"v":1e-147,"d":"1.00E-147"},"ras association domain-containing protein 3 [Bos taurus]","gi|330417946|ref|NM_001192886.2|",1566,0,"Bos taurus Ras association (RalGDS/AF-6) domain family member 3 (RASSF3), mRNA","Q86WH2",395,{"v":5e-134,"d":"5.00E-134"},"Ras association domain-containing protein 3",".",".",".",".","pfam00788","RA","Ras association (RalGDS/AF-6) domain. RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Recent evidence (not yet in MEDLINE) shows that some RA domains do NOT bind RasGTP. Predicted structure similar to that determined, and that of the RasGTP-binding domain of Raf kinase.","GO:0042981|regulation of apoptotic process;GO:0007165|signal transduction;","GO:0005829|cytosol;GO:0005874|microtubule;GO:0005886|plasma membrane;","GO:0042802|identical protein binding;","K09852","RASSF3; Ras association domain-containing protein 3"]
["bta_circ_0003700",40,121,107,53.0987258450637,18,49,33,1.16351453367288,0.017561698128837,0.31640326128788,"up","yes","NC_037332.1:62694549..62702306:+","gene6881","gi|593725462|ref|XP_007108834.1|",2271,0,"PREDICTED: LOW QUALITY PROTEIN: lamina-associated polypeptide 2, isoforms beta/gamma [Physeter catodon]","gi|982925647|ref|XM_005206550.3|",3625,0,"PREDICTED: Bos taurus thymopoietin (TMPO), transcript variant X2, mRNA","P42167",764,0,"Lamina-associated polypeptide 2, isoforms beta/gamma",".",".",".",".","pfam08198","Thymopoietin","Thymopoietin protein. Short protein of 49 amino acid isolated from bovine spleen cells. Thymopoietins (TMPOs) are a group of ubiquitously expressed nuclear proteins. They are suggested to play an important role in nuclear envelope organisation and cell cycle control.",".","GO:0005737|cytoplasm;GO:0016021|integral component of membrane;GO:0016020|membrane;GO:0005635|nuclear envelope;GO:0005637|nuclear inner membrane;GO:0031965|nuclear membrane;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0005521|lamin binding;",".","."]
["bta_circ_0003724",0,0,0,3.59495326671835,5,11,6,-5.33327372651834,0.00403968750662379,"NA","down","yes","NC_037332.1:65420190..65430982:+","gene6914","gi|741926594|ref|XP_010803456.1|",6073,0,"PREDICTED: myosin-binding protein C, slow-type isoform X3 [Bos taurus]","gi|982925666|ref|XM_010805154.2|",3745,0,"PREDICTED: Bos taurus myosin binding protein C, slow type (MYBPC1), transcript variant X3, mRNA","Q00872",2048,0,"Myosin-binding protein C, slow-type",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007015|actin filament organization;GO:0007155|cell adhesion;GO:0030049|muscle filament sliding;GO:0045214|sarcomere organization;GO:0006941|striated muscle contraction;GO:0071688|striated muscle myosin thick filament assembly;","GO:0005829|cytosol;GO:0031430|M band;GO:0005859|muscle myosin complex;GO:0030016|myofibril;GO:0032982|myosin filament;GO:0030018|Z disc;","GO:0051015|actin filament binding;GO:0051371|muscle alpha-actinin binding;GO:0008307|structural constituent of muscle;GO:0097493|structural molecule activity conferring elasticity;GO:0031432|titin binding;","K12557","MYBPC1; myosin-binding protein C, slow-type"]
["bta_circ_0003751",0,0,0,2.7501870460334,6,11,0,-4.7478672499451,0.0150075636158716,"NA","down","yes","NC_037332.1:65430944..65480521:+","gene6914","gi|741926594|ref|XP_010803456.1|",6073,0,"PREDICTED: myosin-binding protein C, slow-type isoform X3 [Bos taurus]","gi|982925666|ref|XM_010805154.2|",3745,0,"PREDICTED: Bos taurus myosin binding protein C, slow type (MYBPC1), transcript variant X3, mRNA","Q00872",2048,0,"Myosin-binding protein C, slow-type",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007015|actin filament organization;GO:0007155|cell adhesion;GO:0030049|muscle filament sliding;GO:0045214|sarcomere organization;GO:0006941|striated muscle contraction;GO:0071688|striated muscle myosin thick filament assembly;","GO:0005829|cytosol;GO:0031430|M band;GO:0005859|muscle myosin complex;GO:0030016|myofibril;GO:0032982|myosin filament;GO:0030018|Z disc;","GO:0051015|actin filament binding;GO:0051371|muscle alpha-actinin binding;GO:0008307|structural constituent of muscle;GO:0097493|structural molecule activity conferring elasticity;GO:0031432|titin binding;","K12557","MYBPC1; myosin-binding protein C, slow-type"]
["bta_circ_0003777",55,139,228,249.99232170151,280,486,379,-1.69694998159182,{"v":2.16111906363542e-05,"d":"2.16E-05"},0.00310784804924015,"down","yes","NC_037332.1:65453070..65494938:+","gene6914","gi|741926594|ref|XP_010803456.1|",6073,0,"PREDICTED: myosin-binding protein C, slow-type isoform X3 [Bos taurus]","gi|982925666|ref|XM_010805154.2|",3745,0,"PREDICTED: Bos taurus myosin binding protein C, slow type (MYBPC1), transcript variant X3, mRNA","Q00872",2048,0,"Myosin-binding protein C, slow-type",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007015|actin filament organization;GO:0007155|cell adhesion;GO:0030049|muscle filament sliding;GO:0045214|sarcomere organization;GO:0006941|striated muscle contraction;GO:0071688|striated muscle myosin thick filament assembly;","GO:0005829|cytosol;GO:0031430|M band;GO:0005859|muscle myosin complex;GO:0030016|myofibril;GO:0032982|myosin filament;GO:0030018|Z disc;","GO:0051015|actin filament binding;GO:0051371|muscle alpha-actinin binding;GO:0008307|structural constituent of muscle;GO:0097493|structural molecule activity conferring elasticity;GO:0031432|titin binding;","K12557","MYBPC1; myosin-binding protein C, slow-type"]
["bta_circ_0003846",0,0,0,1.88735755623659,2,3,6,-4.33623089289243,0.0287104921867047,"NA","down","yes","NC_037332.1:73819221..73824890:-","gene7009","gi|27806939|ref|NP_776306.1|",793,{"v":1e-102,"d":"1.00E-102"},"myoglobin [Bos taurus]","gi|319015077|ref|NM_173881.2|",1085,0,"Bos taurus myoglobin (MB), mRNA","P02192",310,{"v":4e-104,"d":"4.00E-104"},"Myoglobin",".",".",".",".","pfam00042","Globin","Globin.","GO:0050873|brown fat cell differentiation;GO:0043353|enucleate erythrocyte differentiation;GO:0007507|heart development;GO:0001666|response to hypoxia;",".","GO:0020037|heme binding;GO:0046872|metal ion binding;GO:0019825|oxygen binding;GO:0005344|oxygen transporter activity;",".","."]
["bta_circ_0003858",0,0,0,2.29985208925146,0,8,7,-4.49381127010353,0.0233636912660622,"NA","down","yes","NC_037332.1:77155510..77156329:-","gene7074","gi|62087720|dbj|BAD92307.1|",3544,0,"Dynamin-like protein DYNIV-11 variant [Homo sapiens]","gi|982926415|ref|XM_005206854.3|",2976,0,"PREDICTED: Bos taurus dynamin 1-like (DNM1L), transcript variant X1, mRNA","Q2KIA5",1360,0,"Dynamin-1-like protein","YLL001w",561,0,"COG0699","pfam01031","Dynamin_M","Dynamin central region. This region lies between the GTPase domain, see pfam00350, and the pleckstrin homology (PH) domain, see pfam00169.","GO:0003374|dynamin polymerization involved in mitochondrial fission;GO:0006897|endocytosis;GO:0048312|intracellular distribution of mitochondria;GO:0061025|membrane fusion;GO:0000266|mitochondrial fission;GO:0043653|mitochondrial fragmentation involved in apoptotic process;GO:0090149|mitochondrial membrane fission;GO:0070584|mitochondrion morphogenesis;GO:0070266|necroptotic process;GO:0016559|peroxisome fission;GO:2001244|positive regulation of intrinsic apoptotic signaling pathway;GO:0090141|positive regulation of mitochondrial fission;GO:0050714|positive regulation of protein secretion;GO:0090200|positive regulation of release of cytochrome c from mitochondria;GO:0051259|protein oligomerization;GO:0051260|protein homooligomerization;GO:0051289|protein homotetramerization;GO:1903146|regulation of mitophagy;GO:1900063|regulation of peroxisome organization;GO:0032459|regulation of protein oligomerization;GO:0001836|release of cytochrome c from mitochondria;","GO:0030054|cell junction;GO:0005905|coated pit;GO:0005829|cytosol;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005874|microtubule;GO:0031966|mitochondrial membrane;GO:0005741|mitochondrial outer membrane;GO:0005739|mitochondrion;GO:0048471|perinuclear region of cytoplasm;GO:0005777|peroxisome;GO:0032991|macromolecular complex;GO:0030672|synaptic vesicle membrane;","GO:0005525|GTP binding;GO:0030742|GTP-dependent protein binding;GO:0003924|GTPase activity;GO:0008289|lipid binding;GO:0008017|microtubule binding;GO:0042803|protein homodimerization activity;GO:0017137|Rab GTPase binding;GO:0031625|ubiquitin protein ligase binding;","K17065","DNM1L; dynamin 1-like protein [EC:3.6.5.5]"]
["bta_circ_0003872",6,23,7,23.503714529257,42,38,26,-1.88785877448878,0.00599457124592418,0.193436761696837,"down","yes","NC_037332.1:78472336..78487311:+","gene7085","gi|982926390|ref|XP_015326662.1|",6868,0,"PREDICTED: DENN domain-containing protein 5B isoform X4 [Bos taurus]","gi|982926389|ref|XM_015471176.1|",9043,0,"PREDICTED: Bos taurus DENN/MADD domain containing 5B (DENND5B), transcript variant X4, mRNA","Q6ZUT9",2449,0,"DENN domain-containing protein 5B",".",".",".",".","pfam02141","DENN","DENN (AEX-3) domain. DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.","GO:0050982|detection of mechanical stimulus;","GO:0005829|cytosol;GO:0016021|integral component of membrane;GO:0016020|membrane;","GO:0005262|calcium channel activity;GO:0017112|Rab guanyl-nucleotide exchange factor activity;",".","."]
["bta_circ_0003873",0,9,2,7.81683280630374,9,12,18,-2.2516922061934,0.0375709198440794,0.439730132358439,"down","yes","NC_037332.1:78472336..78512388:+","gene7085","gi|982926390|ref|XP_015326662.1|",6868,0,"PREDICTED: DENN domain-containing protein 5B isoform X4 [Bos taurus]","gi|982926389|ref|XM_015471176.1|",9043,0,"PREDICTED: Bos taurus DENN/MADD domain containing 5B (DENND5B), transcript variant X4, mRNA","Q6ZUT9",2449,0,"DENN domain-containing protein 5B",".",".",".",".","pfam02141","DENN","DENN (AEX-3) domain. DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.","GO:0050982|detection of mechanical stimulus;","GO:0005829|cytosol;GO:0016021|integral component of membrane;GO:0016020|membrane;","GO:0005262|calcium channel activity;GO:0017112|Rab guanyl-nucleotide exchange factor activity;",".","."]
["bta_circ_0003874",0,0,0,3.1040027378157,12,0,3,-4.86184818223392,0.0123653429024931,"NA","down","yes","NC_037332.1:78472336..78528744:+","gene7085","gi|982926390|ref|XP_015326662.1|",6868,0,"PREDICTED: DENN domain-containing protein 5B isoform X4 [Bos taurus]","gi|982926389|ref|XM_015471176.1|",9043,0,"PREDICTED: Bos taurus DENN/MADD domain containing 5B (DENND5B), transcript variant X4, mRNA","Q6ZUT9",2449,0,"DENN domain-containing protein 5B",".",".",".",".","pfam02141","DENN","DENN (AEX-3) domain. DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.","GO:0050982|detection of mechanical stimulus;","GO:0005829|cytosol;GO:0016021|integral component of membrane;GO:0016020|membrane;","GO:0005262|calcium channel activity;GO:0017112|Rab guanyl-nucleotide exchange factor activity;",".","."]
["bta_circ_0003909",0,0,0,3.57910575415887,7,5,8,-5.30789385356086,0.0043000120237551,"NA","down","yes","NC_037332.1:84820288..84839270:+","gene7134","gi|114053315|ref|NP_001039747.1|",3312,0,"protein CASC1 [Bos taurus]","gi|402692011|ref|NM_001046282.2|",2455,0,"Bos taurus cancer susceptibility candidate 1 (CASC1), mRNA","Q29RU8",1280,0,"Protein CASC1",".",".",".",".","pfam12366","Casc1","Cancer susceptibility candidate 1. This domain family is found in eukaryotes, and is typically between 216 and 263 amino acids in length. Casc1 has many SNPs associated with cancer susceptibility.",".",".",".","K17580","CASC1; cancer susceptibility candidate protein 1"]
["bta_circ_0003930",7,12,17,6.06866062803162,0,0,4,2.63886455867249,0.0396262528957639,0.441608034848668,"up","yes","NC_037332.1:88298151..88337287:+","gene7152","gi|528950513|ref|XP_005207021.1|",7786,0,"PREDICTED: ATP-binding cassette sub-family C member 9 isoform X2 [Bos taurus]","gi|982982182|ref|XM_015463439.1|",9140,0,"PREDICTED: Bos taurus ATP binding cassette subfamily C member 9 (ABCC9), transcript variant X3, mRNA","O60706",2946,0,"ATP-binding cassette sub-family C member 9","YDR135c",619,0,"COG1132","pfam00664","ABC_membrane","ABC transporter transmembrane region. This family represents a unit of six transmembrane helices. Many members of the ABC transporter family (pfam00005) have two such regions.","GO:0051607|defense response to virus;GO:0010107|potassium ion import;GO:0006813|potassium ion transport;GO:0042493|response to drug;GO:0055085|transmembrane transport;","GO:0008282|ATP-sensitive potassium channel complex;GO:0005886|plasma membrane;GO:0042383|sarcolemma;GO:0030017|sarcomere;","GO:0005524|ATP binding;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;GO:0043225|anion transmembrane-transporting ATPase activity;GO:0044325|ion channel binding;GO:0005267|potassium channel activity;GO:0015459|potassium channel regulator activity;GO:0008281|sulfonylurea receptor activity;GO:0005215|transporter activity;","K05033","ABCC9, SUR2; ATP-binding cassette subfamily C (CFTR/MRP) member 9"]
["bta_circ_0003932",2,9,2,1.70130964494409,0,0,0,4.06038167199791,0.0449680400918381,"NA","up","yes","NC_037332.1:88298151..88349622:+","gene7152","gi|528950513|ref|XP_005207021.1|",7786,0,"PREDICTED: ATP-binding cassette sub-family C member 9 isoform X2 [Bos taurus]","gi|982982182|ref|XM_015463439.1|",9140,0,"PREDICTED: Bos taurus ATP binding cassette subfamily C member 9 (ABCC9), transcript variant X3, mRNA","O60706",2946,0,"ATP-binding cassette sub-family C member 9","YDR135c",619,0,"COG1132","pfam00664","ABC_membrane","ABC transporter transmembrane region. This family represents a unit of six transmembrane helices. Many members of the ABC transporter family (pfam00005) have two such regions.","GO:0051607|defense response to virus;GO:0010107|potassium ion import;GO:0006813|potassium ion transport;GO:0042493|response to drug;GO:0055085|transmembrane transport;","GO:0008282|ATP-sensitive potassium channel complex;GO:0005886|plasma membrane;GO:0042383|sarcolemma;GO:0030017|sarcomere;","GO:0005524|ATP binding;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;GO:0043225|anion transmembrane-transporting ATPase activity;GO:0044325|ion channel binding;GO:0005267|potassium channel activity;GO:0015459|potassium channel regulator activity;GO:0008281|sulfonylurea receptor activity;GO:0005215|transporter activity;","K05033","ABCC9, SUR2; ATP-binding cassette subfamily C (CFTR/MRP) member 9"]
["bta_circ_0003986",6,6,0,2.3397913039059,0,0,0,4.30951355641776,0.0317929327404115,"NA","up","yes","NC_037332.1:95349789..95350237:+","gene7213","gi|741927569|ref|XP_005207028.2|",2833,0,"PREDICTED: phospholipase B-like 1 isoform X1 [Bos taurus]","gi|982926708|ref|XM_005206971.3|",2432,0,"PREDICTED: Bos taurus phospholipase B domain containing 1 (PLBD1), transcript variant X1, mRNA","Q9GL30",952,0,"Phospholipase B-like 1",".",".",".",".","pfam04916","Phospholip_B","Phospholipase B. Phospholipase B (PLB) catalyses the hydrolytic cleavage of both acylester bonds of glycerophospholipids. This family of PLB enzymes has been identified in mammals, flies and nematodes but not in yeast. In Drosophila this protein was named LAMA for laminin ancestor since it is expressed in the neuronal and glial precursors that surround the lamina.","GO:0016042|lipid catabolic process;","GO:0005615|extracellular space;GO:0005764|lysosome;","GO:0016787|hydrolase activity;",".","."]
["bta_circ_0004020",0,0,0,2.03135488682641,7,0,3,-4.24035681407945,0.035261257709165,"NA","down","yes","NC_037333.1:102070207..102093416:-","gene8643","gi|296486379|tpg|DAA28492.1|",3302,0,"TPA: KIAA1378 protein-like [Bos taurus]","gi|982928797|ref|XM_005208211.3|",5337,0,"PREDICTED: Bos taurus AF4/FMR2 family member 1 (AFF1), transcript variant X1, mRNA","Q9P2G9",1167,0,"Kelch-like protein 8",".",".",".",".","pfam07707","BACK","BTB And C-terminal Kelch. This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).","GO:0016567|protein ubiquitination;GO:0006511|ubiquitin-dependent protein catabolic process;","GO:0031463|Cul3-RING ubiquitin ligase complex;GO:0005654|nucleoplasm;",".","K10446","KLHL8; kelch-like protein 8"]
["bta_circ_0004027",0,0,4,5.55798750858914,12,8,8,-2.85652825417436,0.0306371359023762,"NA","down","yes","NC_037333.1:102822482..102828861:+","gene8658","gi|965943289|ref|XP_004010034.2|",2445,0,"PREDICTED: protein phosphatase 2, regulatory subunit B, gamma isoform X2 [Ovis aries]","gi|982983596|ref|XM_015463829.1|",3929,0,"PREDICTED: Bos taurus protein phosphatase 2 regulatory subunit B, gamma (PPP2R2C), transcript variant X2, mRNA","Q9Y2T4",909,0,"Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform","SPAC227.07c",464,{"v":4e-149,"d":"4.00E-149"},"COG5170","pfam00400","WD40","WD domain, G-beta repeat.","GO:0032502|developmental process;GO:0000278|mitotic cell cycle;GO:0070262|peptidyl-serine dephosphorylation;","GO:0005829|cytosol;GO:0000159|protein phosphatase type 2A complex;","GO:0019888|protein phosphatase regulator activity;","K04354","PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B"]
["bta_circ_0004060",0,27,16,4.95768319929518,0,0,2,3.20439398143124,0.0332785190380252,"NA","up","yes","NC_037333.1:114390080..114415690:-","gene8750","gi|594036825|ref|XP_006043061.1|",3180,0,"PREDICTED: actin-binding LIM protein 2 isoform X3 [Bubalus bubalis]","gi|982983940|ref|XM_010798038.2|",3527,0,"PREDICTED: Bos taurus actin binding LIM protein family member 2 (ABLIM2), transcript variant X1, mRNA","Q6H8Q1",954,0,"Actin-binding LIM protein 2",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0030036|actin cytoskeleton organization;GO:0006351|transcription, DNA-templated;","GO:0015629|actin cytoskeleton;GO:0005737|cytoplasm;","GO:0003779|actin binding;GO:0046872|metal ion binding;","K07520","ABLIM; actin-binding LIM protein"]
["bta_circ_0004064",6,184,52,32.3685813553164,7,16,16,1.96289131328444,0.00785850774674658,0.229595861465758,"up","yes","NC_037333.1:115815774..115823274:-","gene8778","gi|528953802|ref|XP_005208290.1|",3415,0,"PREDICTED: alpha-adducin isoform X4 [Bos taurus]","gi|982928862|ref|XM_005208233.3|",2311,0,"PREDICTED: Bos taurus adducin 1 (ADD1), transcript variant X7, mRNA","P35611",1108,0,"Alpha-adducin","CC1201",176,{"v":2e-47,"d":"2.00E-47"},"COG0235","pfam00596","Aldolase_II","Class II Aldolase and Adducin N-terminal domain. This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.","GO:0030036|actin cytoskeleton organization;GO:0051017|actin filament bundle assembly;GO:0051016|barbed-end actin filament capping;GO:0000902|cell morphogenesis;GO:0006884|cell volume homeostasis;GO:0071277|cellular response to calcium ion;GO:0030218|erythrocyte differentiation;GO:0020027|hemoglobin metabolic process;GO:0048873|homeostasis of number of cells within a tissue;GO:0001701|in utero embryonic development;GO:0036498|IRE1-mediated unfolded protein response;GO:0035264|multicellular organism growth;GO:1903393|positive regulation of adherens junction organization;GO:1903142|positive regulation of establishment of endothelial barrier;GO:0032092|positive regulation of protein binding;GO:0055085|transmembrane transport;","GO:0005913|cell-cell adherens junction;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0008290|F-actin capping protein complex;GO:0005925|focal adhesion;GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0003779|actin binding;GO:0051015|actin filament binding;GO:0045296|cadherin binding;GO:0005516|calmodulin binding;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;GO:0003723|RNA binding;GO:0030507|spectrin binding;GO:0005198|structural molecule activity;GO:0008134|transcription factor binding;","K18622","ADD; adducin"]
["bta_circ_0004138",5,0,5,2.10689120535808,0,0,0,4.14934328614932,0.0406319064516502,"NA","up","yes","NC_037333.1:22256852..22302423:-","gene8026","gi|742158574|ref|XP_010846583.1|",4733,0,"PREDICTED: nuclear factor NF-kappa-B p105 subunit isoform X1 [Bison bison bison]","gi|157279381|gb|BC153232.1|",3710,0,"Bos taurus nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, mRNA (cDNA clone MGC:159793 IMAGE:8566028), complete cds","Q6F3J0",1665,0,"Nuclear factor NF-kappa-B p105 subunit","all2748",73.6,{"v":1e-12,"d":"1.00E-12"},"COG0666","pfam00554","RHD","Rel homology domain (RHD). Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See pfam01833) that binds to DNA.","GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0006954|inflammatory response;GO:0045087|innate immune response;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0038061|NIK/NF-kappaB signaling;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0034097|response to cytokine;GO:0006351|transcription, DNA-templated;","GO:0005829|cytosol;GO:0033256|I-kappaB/NF-kappaB complex;GO:0005634|nucleus;","GO:0003682|chromatin binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0044212|transcription regulatory region DNA binding;","K02580","NFKB1; nuclear factor NF-kappa-B p105 subunit"]
["bta_circ_0004169",7,22,21,30.1832037720853,40,62,37,-1.73406845178478,0.00307230784369896,0.130241756040728,"down","yes","NC_037333.1:2640524..2663368:+","gene7859","gi|375312545|ref|NP_001069120.2|",1392,0,"H/ACA ribonucleoprotein complex non-core subunit NAF1 [Bos taurus]","gi|375312544|ref|NM_001075652.2|",1916,0,"Bos taurus nuclear assembly factor 1 ribonucleoprotein (NAF1), mRNA","Q96HR8",471,{"v":6e-158,"d":"6.00E-158"},"H/ACA ribonucleoprotein complex non-core subunit NAF1",".",".",".",".","pfam04410","Gar1","Gar1/Naf1 RNA binding region. Gar1 is a small nucleolar RNP that is required for pre-mRNA processing and pseudouridylation. It is co-immunoprecipitated with the H/ACA families of snoRNAs. This family represents the conserved central region of Gar1. This region is necessary and sufficient for normal cell growth, and specifically binds two snoRNAs snR10 and snR30. This region is also necessary for nucleolar targeting, and it is thought that the protein is co-transported to the nucleolus as part of a nucleoprotein complex. In humans, Gar1 is also component of telomerase in vivo. Naf1 is an essentail protein that plays a role in ribosome biogenesis, modification of spliceosomal small nuclear RNAs and telomere synthesis, and is homologous to Gar1.","GO:0000493|box H/ACA snoRNP assembly;GO:0051973|positive regulation of telomerase activity;GO:0032212|positive regulation of telomere maintenance via telomerase;GO:1904358|positive regulation of telomere maintenance via telomere lengthening;GO:0042254|ribosome biogenesis;GO:0043489|RNA stabilization;GO:0000454|snoRNA guided rRNA pseudouridine synthesis;","GO:0005737|cytoplasm;GO:0005634|nucleus;GO:0005732|small nucleolar ribonucleoprotein complex;","GO:0003723|RNA binding;GO:0070034|telomeric RNA binding;","K14763","NAF1; H/ACA ribonucleoprotein complex non-core subunit NAF1"]
["bta_circ_0004174",0,13,10,2.5082105424752,0,0,0,4.53021958935948,0.0220794409319204,"NA","up","yes","NC_037333.1:29380709..29391726:-","gene8083","gi|528952494|ref|XP_005207775.1|",2782,0,"PREDICTED: bone morphogenetic protein receptor type-1B isoform X2 [Bos taurus]","gi|982927970|ref|XM_010805972.2|",5815,0,"PREDICTED: Bos taurus bone morphogenetic protein receptor type IB (BMPR1B), transcript variant X7, mRNA","O00238",1015,0,"Bone morphogenetic protein receptor type-1B","SP1732_1",77,{"v":1e-13,"d":"1.00E-13"},"COG0515","pfam00069","Pkinase","Protein kinase domain.","GO:0030509|BMP signaling pathway;GO:0001502|cartilage condensation;GO:0071773|cellular response to BMP stimulus;GO:0002063|chondrocyte development;GO:0009953|dorsal/ventral pattern formation;GO:0060350|endochondral bone morphogenesis;GO:0001654|eye development;GO:0006954|inflammatory response;GO:0035108|limb morphogenesis;GO:1902731|negative regulation of chondrocyte proliferation;GO:0001550|ovarian cumulus expansion;GO:0042698|ovulation cycle;GO:0030501|positive regulation of bone mineralization;GO:0061036|positive regulation of cartilage development;GO:0045597|positive regulation of cell differentiation;GO:0032332|positive regulation of chondrocyte differentiation;GO:1902043|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0045669|positive regulation of osteoblast differentiation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0006468|protein phosphorylation;GO:0030166|proteoglycan biosynthetic process;GO:0060041|retina development in camera-type eye;GO:0031290|retinal ganglion cell axon guidance;GO:0001501|skeletal system development;","GO:0030425|dendrite;GO:1990712|HFE-transferrin receptor complex;GO:0005887|integral component of plasma membrane;GO:0043025|neuronal cell body;GO:0005886|plasma membrane;GO:0043235|receptor complex;","GO:0005524|ATP binding;GO:0046872|metal ion binding;GO:0004674|protein serine/threonine kinase activity;GO:0046332|SMAD binding;GO:0005025|transforming growth factor beta receptor activity, type I;GO:0004675|transmembrane receptor protein serine/threonine kinase activity;","K13578","BMPR1B, ALK6; bone morphogenetic protein receptor type-1B [EC:2.7.11.30]"]
["bta_circ_0004185",0,14,4,1.84275842061759,0,0,0,4.06688918527597,0.0458318613876356,"NA","up","yes","NC_037333.1:35734619..35827231:+","gene8104","gi|528952568|ref|XP_005207808.1|",3183,0,"PREDICTED: protein FAM13A isoform X7 [Bos taurus]","gi|742203465|ref|XM_010860162.1|",5095,0,"PREDICTED: Bison bison bison family with sequence similarity 13, member A (FAM13A), transcript variant X8, mRNA","Q8HYW0",1190,0,"Protein FAM13A",".",".",".",".","pfam09030","Creb_binding","Creb binding. The Creb binding domain assumes a structure comprising of three alpha-helices which pack in a bundle, exposing a hydrophobic groove between alpha-1 and alpha-3 within which complimentary domains found in the protein 'activator for thyroid hormone and retinoid receptors' (ACTR) can dock. Docking of these domains is required for the recruitment of RNA polymerase II and the basal transcription machinery.",".",".",".",".","."]
["bta_circ_0004190",0,0,2,3.70207612291699,7,8,5,-3.11011479622525,0.0375400335607027,"NA","down","yes","NC_037333.1:35966076..35975330:+","gene8104","gi|528952568|ref|XP_005207808.1|",3183,0,"PREDICTED: protein FAM13A isoform X7 [Bos taurus]","gi|742203465|ref|XM_010860162.1|",5095,0,"PREDICTED: Bison bison bison family with sequence similarity 13, member A (FAM13A), transcript variant X8, mRNA","Q8HYW0",1190,0,"Protein FAM13A",".",".",".",".","pfam09030","Creb_binding","Creb binding. The Creb binding domain assumes a structure comprising of three alpha-helices which pack in a bundle, exposing a hydrophobic groove between alpha-1 and alpha-3 within which complimentary domains found in the protein 'activator for thyroid hormone and retinoid receptors' (ACTR) can dock. Docking of these domains is required for the recruitment of RNA polymerase II and the basal transcription machinery.",".",".",".",".","."]
["bta_circ_0004207",0,0,0,2.16920681876812,0,11,4,-4.40085959308298,0.027329477758447,"NA","down","yes","NC_037333.1:37490708..37506353:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0004208",0,17,11,3.01659754556298,0,0,0,4.79807505858004,0.0136757106575043,"NA","up","yes","NC_037333.1:37491609..37496958:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0004220",0,3,4,8.61192034032567,14,7,22,-2.91542429254992,0.00738321186088831,0.2186644389485,"down","yes","NC_037333.1:42028769..42079755:-","gene8139","gi|741929656|ref|XP_010804350.1|",6277,0,"PREDICTED: adhesion G protein-coupled receptor A3 [Bos taurus]","gi|982983114|ref|XM_015463732.1|",4583,0,"PREDICTED: Bos taurus adhesion G protein-coupled receptor A3 (ADGRA3), mRNA","Q8IWK6",2312,0,"Adhesion G protein-coupled receptor A3",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.","GO:0007166|cell surface receptor signaling pathway;GO:0007186|G-protein coupled receptor signaling pathway;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G-protein coupled receptor activity;","K08462","GPR125; G protein-coupled receptor 125"]
["bta_circ_0004225",5,50,34,40.5583096898588,38,82,62,-1.43290571443016,0.0119879452965069,0.280127898688096,"down","yes","NC_037333.1:42042573..42079755:-","gene8139","gi|741929656|ref|XP_010804350.1|",6277,0,"PREDICTED: adhesion G protein-coupled receptor A3 [Bos taurus]","gi|982983114|ref|XM_015463732.1|",4583,0,"PREDICTED: Bos taurus adhesion G protein-coupled receptor A3 (ADGRA3), mRNA","Q8IWK6",2312,0,"Adhesion G protein-coupled receptor A3",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.","GO:0007166|cell surface receptor signaling pathway;GO:0007186|G-protein coupled receptor signaling pathway;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G-protein coupled receptor activity;","K08462","GPR125; G protein-coupled receptor 125"]
["bta_circ_0004268",2,19,5,3.03568106247391,0,0,0,4.91423247424798,0.010399915009815,"NA","up","yes","NC_037333.1:45335391..45335961:-","gene8165","gi|330864722|ref|NP_001193485.1|",5815,0,"protein sel-1 homolog 3 [Bos taurus]","gi|359751363|ref|NM_001206556.2|",4392,0,"Bos taurus sel-1 suppressor of lin-12-like 3 (C. elegans) (SEL1L3), mRNA","Q68CR1",2053,0,"Protein sel-1 homolog 3","STM0654",70.1,{"v":1e-11,"d":"1.00E-11"},"COG0790","pfam08238","Sel1","Sel1 repeat. This short repeat is found in the Sel1 protein. It is related to TPR repeats.",".","GO:0016021|integral component of membrane;GO:0005654|nucleoplasm;GO:0005634|nucleus;",".",".","."]
["bta_circ_0004279",0,10,9,2.09521833525418,0,0,0,4.26492980100286,0.0340047325912377,"NA","up","yes","NC_037333.1:46076428..46097099:+","gene8175","gi|116004097|ref|NP_001070406.1|",2699,0,"TBC1 domain family member 19 [Bos taurus]","gi|116004096|ref|NM_001076938.1|",2712,0,"Bos taurus TBC1 domain family member 19 (TBC1D19), mRNA","Q8N5T2",1022,0,"TBC1 domain family member 19",".",".",".",".","pfam00566","RabGAP-TBC","Rab-GTPase-TBC domain. Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.",".",".","GO:0005096|GTPase activator activity;",".","."]
["bta_circ_0004286",3,6,10,2.72415823576052,0,0,0,4.75590707840185,0.0139848230033737,"NA","up","yes","NC_037333.1:4641773..4704816:+","gene7874","gi|742195860|ref|XP_010856614.1|",3029,0,"PREDICTED: PR domain zinc finger protein 5 isoform X1 [Bison bison bison]","gi|982927693|ref|XM_015471479.1|",6125,0,"PREDICTED: Bos taurus PR domain containing 5 (PRDM5), transcript variant X4, mRNA","Q9NQX1",1070,0,"PR domain zinc finger protein 5",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:1990830|cellular response to leukemia inhibitory factor;GO:0016575|histone deacetylation;GO:0051567|histone H3-K9 methylation;GO:0000278|mitotic cell cycle;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0016604|nuclear body;GO:0005730|nucleolus;GO:0005634|nucleus;","GO:0046872|metal ion binding;GO:0008168|methyltransferase activity;GO:0070491|repressing transcription factor binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0044212|transcription regulatory region DNA binding;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;",".","."]
["bta_circ_0004301",5,6,7,2.93287561980011,0,0,0,4.84028494030738,0.0118613992357573,"NA","up","yes","NC_037333.1:57410882..57412352:+","gene8206","gi|528952773|ref|XP_005207892.1|",6258,0,"PREDICTED: TBC1 domain family member 1 isoform X1 [Bos taurus]","gi|742173327|ref|XM_010852415.1|",5586,0,"PREDICTED: Bison bison bison TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 (TBC1D1), transcript variant X1, mRNA","Q60949",2103,0,"TBC1 domain family member 1",".",".",".",".","pfam00566","RabGAP-TBC","Rab-GTPase-TBC domain. Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.","GO:0090630|activation of GTPase activity;GO:0006886|intracellular protein transport;GO:0032880|regulation of protein localization;GO:0031338|regulation of vesicle fusion;","GO:0005829|cytosol;GO:0012505|endomembrane system;GO:0005622|intracellular;GO:0005634|nucleus;","GO:0005096|GTPase activator activity;GO:0017137|Rab GTPase binding;","K18341","TBC1D1; TBC1 domain family member 1"]
["bta_circ_0004351",0,0,0,1.79233695296796,3,2,5,-4.25024607832348,0.0329436429275932,"NA","down","yes","NC_037333.1:6097922..6119588:-","gene7890","gi|62752057|ref|NP_001015676.1|",1164,{"v":3e-156,"d":"3.00E-156"},"myozenin-2 [Bos taurus]","gi|982927752|ref|XM_005207588.3|",1245,0,"PREDICTED: Bos taurus myozenin 2 (MYOZ2), transcript variant X1, mRNA","Q5E9V3",452,{"v":1e-157,"d":"1.00E-157"},"Myozenin-2",".",".",".",".","pfam05556","Calsarcin","Calcineurin-binding protein (Calsarcin). This family consists of several mammalian calcineurin-binding proteins. The calcium- and calmodulin-dependent protein phosphatase calcineurin has been implicated in the transduction of signals that control the hypertrophy of cardiac muscle and slow fibre gene expression in skeletal muscle. Calsarcin-1 and calsarcin-2 are expressed in developing cardiac and skeletal muscle during embryogenesis, but calsarcin-1 is expressed specifically in adult cardiac and slow-twitch skeletal muscle, whereas calsarcin-2 is restricted to fast skeletal muscle. Calsarcins represent a novel family of sarcomeric proteins that link calcineurin with the contractile apparatus, thereby potentially coupling muscle activity to calcineurin activation. Calsarcin-3, is expressed specifically in skeletal muscle and is enriched in fast-twitch muscle fibres. Like calsarcin-1 and calsarcin-2, calsarcin-3 interacts with calcineurin, and the Z-disc proteins alpha-actinin, gamma-filamin, and telethonin.","GO:0030239|myofibril assembly;","GO:0015629|actin cytoskeleton;GO:0030018|Z disc;","GO:0003779|actin binding;GO:0051373|FATZ binding;GO:0031433|telethonin binding;",".","."]
["bta_circ_0004352",30,11,118,123.77525977238,164,239,181,-1.91115297243072,0.0291991521763342,0.423218637145628,"down","yes","NC_037333.1:6105778..6119588:-","gene7890","gi|62752057|ref|NP_001015676.1|",1164,{"v":3e-156,"d":"3.00E-156"},"myozenin-2 [Bos taurus]","gi|982927752|ref|XM_005207588.3|",1245,0,"PREDICTED: Bos taurus myozenin 2 (MYOZ2), transcript variant X1, mRNA","Q5E9V3",452,{"v":1e-157,"d":"1.00E-157"},"Myozenin-2",".",".",".",".","pfam05556","Calsarcin","Calcineurin-binding protein (Calsarcin). This family consists of several mammalian calcineurin-binding proteins. The calcium- and calmodulin-dependent protein phosphatase calcineurin has been implicated in the transduction of signals that control the hypertrophy of cardiac muscle and slow fibre gene expression in skeletal muscle. Calsarcin-1 and calsarcin-2 are expressed in developing cardiac and skeletal muscle during embryogenesis, but calsarcin-1 is expressed specifically in adult cardiac and slow-twitch skeletal muscle, whereas calsarcin-2 is restricted to fast skeletal muscle. Calsarcins represent a novel family of sarcomeric proteins that link calcineurin with the contractile apparatus, thereby potentially coupling muscle activity to calcineurin activation. Calsarcin-3, is expressed specifically in skeletal muscle and is enriched in fast-twitch muscle fibres. Like calsarcin-1 and calsarcin-2, calsarcin-3 interacts with calcineurin, and the Z-disc proteins alpha-actinin, gamma-filamin, and telethonin.","GO:0030239|myofibril assembly;","GO:0015629|actin cytoskeleton;GO:0030018|Z disc;","GO:0003779|actin binding;GO:0051373|FATZ binding;GO:0031433|telethonin binding;",".","."]
["bta_circ_0004354",0,0,2,3.97600162916878,6,13,4,-3.22501992405295,0.0290927853490791,"NA","down","yes","NC_037333.1:6105778..6122837:-","gene7890","gi|62752057|ref|NP_001015676.1|",1164,{"v":3e-156,"d":"3.00E-156"},"myozenin-2 [Bos taurus]","gi|982927752|ref|XM_005207588.3|",1245,0,"PREDICTED: Bos taurus myozenin 2 (MYOZ2), transcript variant X1, mRNA","Q5E9V3",452,{"v":1e-157,"d":"1.00E-157"},"Myozenin-2",".",".",".",".","pfam05556","Calsarcin","Calcineurin-binding protein (Calsarcin). This family consists of several mammalian calcineurin-binding proteins. The calcium- and calmodulin-dependent protein phosphatase calcineurin has been implicated in the transduction of signals that control the hypertrophy of cardiac muscle and slow fibre gene expression in skeletal muscle. Calsarcin-1 and calsarcin-2 are expressed in developing cardiac and skeletal muscle during embryogenesis, but calsarcin-1 is expressed specifically in adult cardiac and slow-twitch skeletal muscle, whereas calsarcin-2 is restricted to fast skeletal muscle. Calsarcins represent a novel family of sarcomeric proteins that link calcineurin with the contractile apparatus, thereby potentially coupling muscle activity to calcineurin activation. Calsarcin-3, is expressed specifically in skeletal muscle and is enriched in fast-twitch muscle fibres. Like calsarcin-1 and calsarcin-2, calsarcin-3 interacts with calcineurin, and the Z-disc proteins alpha-actinin, gamma-filamin, and telethonin.","GO:0030239|myofibril assembly;","GO:0015629|actin cytoskeleton;GO:0030018|Z disc;","GO:0003779|actin binding;GO:0051373|FATZ binding;GO:0031433|telethonin binding;",".","."]
["bta_circ_0004355",0,0,0,3.93455995562249,7,9,7,-5.46326416913283,0.00296462927117978,"NA","down","yes","NC_037333.1:6114228..6119588:-","gene7890","gi|62752057|ref|NP_001015676.1|",1164,{"v":3e-156,"d":"3.00E-156"},"myozenin-2 [Bos taurus]","gi|982927752|ref|XM_005207588.3|",1245,0,"PREDICTED: Bos taurus myozenin 2 (MYOZ2), transcript variant X1, mRNA","Q5E9V3",452,{"v":1e-157,"d":"1.00E-157"},"Myozenin-2",".",".",".",".","pfam05556","Calsarcin","Calcineurin-binding protein (Calsarcin). This family consists of several mammalian calcineurin-binding proteins. The calcium- and calmodulin-dependent protein phosphatase calcineurin has been implicated in the transduction of signals that control the hypertrophy of cardiac muscle and slow fibre gene expression in skeletal muscle. Calsarcin-1 and calsarcin-2 are expressed in developing cardiac and skeletal muscle during embryogenesis, but calsarcin-1 is expressed specifically in adult cardiac and slow-twitch skeletal muscle, whereas calsarcin-2 is restricted to fast skeletal muscle. Calsarcins represent a novel family of sarcomeric proteins that link calcineurin with the contractile apparatus, thereby potentially coupling muscle activity to calcineurin activation. Calsarcin-3, is expressed specifically in skeletal muscle and is enriched in fast-twitch muscle fibres. Like calsarcin-1 and calsarcin-2, calsarcin-3 interacts with calcineurin, and the Z-disc proteins alpha-actinin, gamma-filamin, and telethonin.","GO:0030239|myofibril assembly;","GO:0015629|actin cytoskeleton;GO:0030018|Z disc;","GO:0003779|actin binding;GO:0051373|FATZ binding;GO:0031433|telethonin binding;",".","."]
["bta_circ_0004411",2,10,11,13.8572696821812,27,12,20,-1.76551312136574,0.0357936714737352,0.439730132358439,"down","yes","NC_037333.1:67740025..67771188:+","gene8306","gi|478489472|ref|XP_004419114.1|",1122,{"v":5e-136,"d":"5.00E-136"},"PREDICTED: DCN1-like protein 4 isoform X3 [Ceratotherium simum simum]","gi|982928392|ref|XM_015471619.1|",3938,0,"PREDICTED: Bos taurus defective in cullin neddylation 1 domain containing 4 (DCUN1D4), transcript variant X4, mRNA","Q92564",435,{"v":6e-137,"d":"6.00E-137"},"DCN1-like protein 4",".",".",".",".","pfam03556","Cullin_binding","Cullin binding. This domain binds to cullins and to Rbx-1, components of an E3 ubiquitin ligase complex for neddylation. Neddylation is the process by which the C-terminal glycine of the ubiquitin-like protein Nedd8 is covalently linked to lysine residues in a protein through an isopeptide bond. The structure of this domain is composed entirely of alpha helices.","GO:0051443|positive regulation of ubiquitin-protein transferase activity;GO:0045116|protein neddylation;","GO:0005634|nucleus;GO:0000151|ubiquitin ligase complex;","GO:0097602|cullin family protein binding;GO:0031624|ubiquitin conjugating enzyme binding;GO:0032182|ubiquitin-like protein binding;","K17824","DCUN1D4_5; DCN1-like protein 4/5"]
["bta_circ_0004413",0,0,0,2.62039871832175,5,5,5,-4.85170150166152,0.0112761149327385,"NA","down","yes","NC_037333.1:67749051..67771188:+","gene8306","gi|478489472|ref|XP_004419114.1|",1122,{"v":5e-136,"d":"5.00E-136"},"PREDICTED: DCN1-like protein 4 isoform X3 [Ceratotherium simum simum]","gi|982928392|ref|XM_015471619.1|",3938,0,"PREDICTED: Bos taurus defective in cullin neddylation 1 domain containing 4 (DCUN1D4), transcript variant X4, mRNA","Q92564",435,{"v":6e-137,"d":"6.00E-137"},"DCN1-like protein 4",".",".",".",".","pfam03556","Cullin_binding","Cullin binding. This domain binds to cullins and to Rbx-1, components of an E3 ubiquitin ligase complex for neddylation. Neddylation is the process by which the C-terminal glycine of the ubiquitin-like protein Nedd8 is covalently linked to lysine residues in a protein through an isopeptide bond. The structure of this domain is composed entirely of alpha helices.","GO:0051443|positive regulation of ubiquitin-protein transferase activity;GO:0045116|protein neddylation;","GO:0005634|nucleus;GO:0000151|ubiquitin ligase complex;","GO:0097602|cullin family protein binding;GO:0031624|ubiquitin conjugating enzyme binding;GO:0032182|ubiquitin-like protein binding;","K17824","DCUN1D4_5; DCN1-like protein 4/5"]
["bta_circ_0004421",68,51,52,41.2003634596772,23,16,15,1.64718332197001,0.0114471891058403,0.271965086228865,"up","yes","NC_037333.1:69042728..69043607:-","gene8324","gi|136256122|ref|NP_001069702.2|",3608,0,"E3 ubiquitin-protein ligase LNX [Bos taurus]","gi|982928395|ref|XM_005207970.3|",3286,0,"PREDICTED: Bos taurus ligand of numb-protein X 1, E3 ubiquitin protein ligase (LNX1), transcript variant X2, mRNA","Q8TBB1",1254,0,"E3 ubiquitin-protein ligase LNX",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0051260|protein homooligomerization;GO:0006511|ubiquitin-dependent protein catabolic process;","GO:0005737|cytoplasm;","GO:0046872|metal ion binding;GO:0030165|PDZ domain binding;GO:0004842|ubiquitin-protein transferase activity;","K10692","LNX1_2; ligand of Numb protein X 1/2 [EC:2.3.2.27]"]
["bta_circ_0004453",5,4,23,19.7728574071784,33,37,17,-1.60024630813687,0.044395951637882,0.456494092506297,"down","yes","NC_037333.1:83251905..83271930:-","gene8403","gi|528953248|ref|XP_005208087.1|",4601,0,"PREDICTED: centromere protein C isoform X1 [Bos taurus]","gi|982928513|ref|XM_005208030.3|",3385,0,"PREDICTED: Bos taurus centromere protein C (CENPC), transcript variant X1, mRNA","Q03188",1075,0,"Centromere protein C",".",".",".",".","pfam15622","CENP_C_N","Kinetochore assembly subunit CENP-C N-terminal. CENP-C is a vertebrate family that forms a core component of the centromeric chromatin. On depletion of CENP-C proper formation of both centromeres and kinetochores is prevented. The N-terminal of CENP-C is necessary for recruitment of some but not all components of the Mis12 complex of the kinetochore.","GO:0051315|attachment of mitotic spindle microtubules to kinetochore;GO:0051455|attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation;GO:0051301|cell division;GO:0034080|CENP-A containing nucleosome assembly;GO:0007059|chromosome segregation;GO:0051382|kinetochore assembly;GO:0000278|mitotic cell cycle;","GO:0032154|cleavage furrow;GO:0000778|condensed nuclear chromosome kinetochore;GO:0000780|condensed nuclear chromosome, centromeric region;GO:0005829|cytosol;GO:0090543|Flemming body;GO:0045171|intercellular bridge;GO:0000776|kinetochore;GO:0030496|midbody;GO:0016604|nuclear body;GO:0031618|nuclear pericentric heterochromatin;GO:0005654|nucleoplasm;GO:0005721|pericentric heterochromatin;","GO:0019237|centromeric DNA binding;GO:0003677|DNA binding;","K11497","CENPC; centromere protein C"]
["bta_circ_0004465",0,0,0,2.43035751178448,7,3,3,-4.70226825711314,0.0151846441123597,"NA","down","yes","NC_037333.1:84112810..84114156:+","gene8418","gi|114051698|ref|NP_001039985.1|",1826,0,"YTH domain-containing protein 1 [Bos taurus]","gi|742091950|ref|XM_010833728.1|",3301,0,"PREDICTED: Bison bison bison YTH domain containing 1 (YTHDC1), transcript variant X2, mRNA","Q96MU7",689,0,"YTH domain-containing protein 1",".",".",".",".","pfam04146","YTH","YT521-B-like domain. A protein of the YTH family has been shown to selectively remove transcripts of meiosis-specific genes expressed in mitotic cells. It has been speculated that in higher eukaryotic YTH-family members may be involved in similar mechanisms to suppress gene regulation during gametogenesis or general silencing. The rat protein YT521-B is a tyrosine-phosphorylated nuclear protein, that interacts with the nuclear transcriptosomal component scaffold attachment factor B, and the 68-kDa Src substrate associated during mitosis, Sam68. In vivo splicing assays demonstrated that YT521-B modulates alternative splice site selection in a concentration-dependent manner. The YTH domain has been identified as part of the PUA superfamily.","GO:0006376|mRNA splice site selection;GO:0010608|posttranscriptional regulation of gene expression;GO:0048024|regulation of mRNA splicing, via spliceosome;","GO:0016607|nuclear speck;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:1990247|N6-methyladenosine-containing RNA binding;GO:0003723|RNA binding;",".","."]
["bta_circ_0004556",0,0,0,2.12080733831799,7,2,2,-4.46896404038292,0.0232003775072356,"NA","down","yes","NC_037333.1:97846353..97855495:+","gene8608","gi|528953642|ref|XP_005208232.1|",1874,0,"PREDICTED: COP9 signalosome complex subunit 4 isoform X1 [Bos taurus]","gi|742150484|ref|XM_010845948.1|",1597,0,"PREDICTED: Bison bison bison COP9 signalosome subunit 4 (COPS4), transcript variant X2, mRNA","Q3SZA0",689,0,"COP9 signalosome complex subunit 4",".",".",".",".","pfam01399","PCI","PCI domain. This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).","GO:0000338|protein deneddylation;","GO:0030054|cell junction;GO:0008180|COP9 signalosome;GO:0005829|cytosol;GO:0008021|synaptic vesicle;",".","K12178","COPS4, CSN4; COP9 signalosome complex subunit 4"]
["bta_circ_0004565",0,0,0,2.41379290440363,3,8,4,-4.73358844369766,0.0142132700278073,"NA","down","yes","NC_037333.1:98214973..98220276:-","gene8619","gi|742150513|ref|XP_010844257.1|",4975,0,"PREDICTED: helicase POLQ-like isoform X1 [Bison bison bison]","gi|742150512|ref|XM_010845955.1|",4021,0,"PREDICTED: Bison bison bison helicase, POLQ-like (HELQ), transcript variant X1, mRNA","Q8TDG4",1699,0,"Helicase POLQ-like","MA3203",209,{"v":3e-55,"d":"3.00E-55"},"COG1204","pfam00270","DEAD","DEAD/DEAH box helicase. Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolizm, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.","GO:0000724|double-strand break repair via homologous recombination;GO:0010501|RNA secondary structure unwinding;","GO:0005737|cytoplasm;GO:0005730|nucleolus;","GO:0005524|ATP binding;GO:0004004|ATP-dependent RNA helicase activity;GO:0003677|DNA binding;","K19178","HELQ; POLQ-like helicase [EC:3.6.4.12]"]
["bta_circ_0004591",0,0,0,2.6394587781556,2,6,8,-4.85140645643713,0.0114192172050112,"NA","down","yes","NC_037334.1:102156189..102161566:+","gene10719","gi|741934744|ref|XP_010805948.1|",5607,0,"PREDICTED: inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X13 [Bos taurus]","gi|803261616|ref|XR_001031240.1|",3861,0,"PREDICTED: Ovis aries musimon diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2), transcript variant X23, misc_RNA","O43314",2118,0,"Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2",".",".",".",".","pfam00328","His_Phos_2","Histidine phosphatase superfamily (branch 2). The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches.The smaller branch 2 contains predominantly eukaryotic proteins. The catalytic functions in members include phytase, glucose-1-phosphatase and multiple inositol polyphosphate phosphatase. The in vivo roles of the mammalian acid phosphatases in branch 2 are not fully understood, although activity against lysophosphatidic acid and tyrosine-phosphorylated proteins has been demonstrated.","GO:0006020|inositol metabolic process;GO:0032958|inositol phosphate biosynthetic process;GO:0043647|inositol phosphate metabolic process;","GO:0005829|cytosol;","GO:0005524|ATP binding;GO:0033857|diphosphoinositol-pentakisphosphate kinase activity;GO:0000829|inositol heptakisphosphate kinase activity;GO:0052723|inositol hexakisphosphate 1-kinase activity;GO:0052724|inositol hexakisphosphate 3-kinase activity;GO:0000832|inositol hexakisphosphate 5-kinase activity;GO:0000828|inositol hexakisphosphate kinase activity;GO:0000827|inositol-1,3,4,5,6-pentakisphosphate kinase activity;","K13024","PPIP5K, VIP; inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase [EC:2.7.4.24]"]
["bta_circ_0004595",0,0,0,2.28400457669197,2,2,9,-4.59429878230203,0.0187047832942732,"NA","down","yes","NC_037334.1:107167018..107352844:-","gene10738","gi|965846881|ref|XP_014963067.1|",2018,0,"PREDICTED: F-box/LRR-repeat protein 17 isoform X2 [Ovis aries musimon]","gi|594087999|ref|XM_006067398.1|",3434,0,"PREDICTED: Bubalus bubalis F-box and leucine-rich repeat protein 17 (FBXL17), partial mRNA","Q9UF56",759,0,"F-box/LRR-repeat protein 17",".",".",".",".","pfam12937","F-box-like","F-box-like. This is an F-box-like family.",".",".",".","K10283","FBXL17; F-box and leucine-rich repeat protein 17"]
["bta_circ_0004600",0,5,0,6.65185024020352,16,10,8,-3.10534094047891,0.0132860786429966,0.296128886867615,"down","yes","NC_037334.1:107326443..107495239:-","gene10738","gi|965846881|ref|XP_014963067.1|",2018,0,"PREDICTED: F-box/LRR-repeat protein 17 isoform X2 [Ovis aries musimon]","gi|594087999|ref|XM_006067398.1|",3434,0,"PREDICTED: Bubalus bubalis F-box and leucine-rich repeat protein 17 (FBXL17), partial mRNA","Q9UF56",759,0,"F-box/LRR-repeat protein 17",".",".",".",".","pfam12937","F-box-like","F-box-like. This is an F-box-like family.",".",".",".","K10283","FBXL17; F-box and leucine-rich repeat protein 17"]
["bta_circ_0004604",6,8,0,2.53058089563942,0,0,0,4.43519599521923,0.0259769729780572,"NA","up","yes","NC_037334.1:107464046..107495239:-","gene10738","gi|965846881|ref|XP_014963067.1|",2018,0,"PREDICTED: F-box/LRR-repeat protein 17 isoform X2 [Ovis aries musimon]","gi|594087999|ref|XM_006067398.1|",3434,0,"PREDICTED: Bubalus bubalis F-box and leucine-rich repeat protein 17 (FBXL17), partial mRNA","Q9UF56",759,0,"F-box/LRR-repeat protein 17",".",".",".",".","pfam12937","F-box-like","F-box-like. This is an F-box-like family.",".",".",".","K10283","FBXL17; F-box and leucine-rich repeat protein 17"]
["bta_circ_0004616",24,124,124,40.2912368226667,0,32,8,2.39263536258342,0.0390509645757725,0.439730132358439,"up","yes","NC_037334.1:109741418..109746023:+","gene10755","gi|528908009|ref|XP_005198828.1|",2031,0,"PREDICTED: solute carrier family 25 member 46 isoform X2 [Bos taurus]","gi|982985858|ref|XM_005198771.2|",4715,0,"PREDICTED: Bos taurus solute carrier family 25 member 46 (SLC25A46), transcript variant X2, mRNA","Q96AG3",719,0,"Solute carrier family 25 member 46",".",".",".",".","pfam00153","Mito_carr","Mitochondrial carrier protein.","GO:0090149|mitochondrial membrane fission;","GO:0016021|integral component of membrane;GO:0005741|mitochondrial outer membrane;GO:0005739|mitochondrion;",".","K03454","SLC25A46; solute carrier family 25, member 46"]
["bta_circ_0004617",0,8,13,2.41166002200357,0,0,0,4.46250253576534,0.0247844335040173,"NA","up","yes","NC_037334.1:109741418..109756054:+","gene10755","gi|528908009|ref|XP_005198828.1|",2031,0,"PREDICTED: solute carrier family 25 member 46 isoform X2 [Bos taurus]","gi|982985858|ref|XM_005198771.2|",4715,0,"PREDICTED: Bos taurus solute carrier family 25 member 46 (SLC25A46), transcript variant X2, mRNA","Q96AG3",719,0,"Solute carrier family 25 member 46",".",".",".",".","pfam00153","Mito_carr","Mitochondrial carrier protein.","GO:0090149|mitochondrial membrane fission;","GO:0016021|integral component of membrane;GO:0005741|mitochondrial outer membrane;GO:0005739|mitochondrion;",".","K03454","SLC25A46; solute carrier family 25, member 46"]
["bta_circ_0004647",5,7,0,2.14061567832177,0,0,0,4.19310828194765,0.0379922968309685,"NA","up","yes","NC_037334.1:14421358..14421640:+","gene9376","gi|593715849|ref|XP_007104382.1|",442,{"v":4e-51,"d":"4.00E-51"},"PREDICTED: ubiquitin-like protein 5 isoform X1 [Physeter catodon]","gi|982930282|ref|XM_015464956.1|",525,0,"PREDICTED: Bos taurus ubiquitin like 5 (UBL5), transcript variant X1, mRNA","Q791B0",150,{"v":1e-45,"d":"1.00E-45"},"Ubiquitin-like protein 5",".",".",".",".","pfam00240","ubiquitin","Ubiquitin family. This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) Nedd8, Elongin B, Rub1, and Parkin. A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites.",".","GO:0005737|cytoplasm;",".",".","."]
["bta_circ_0004664",0,0,0,2.76218029235919,3,0,12,-4.71128327865484,0.0162435353320785,"NA","down","yes","NC_037334.1:18389467..18390601:+","gene9569","gi|742218103|ref|XP_010826522.1|",3400,0,"PREDICTED: DNA-binding protein RFX2 isoform X3 [Bison bison bison]","gi|742218102|ref|XM_010828220.1|",3685,0,"PREDICTED: Bison bison bison regulatory factor X, 2 (influences HLA class II expression) (RFX2), transcript variant X3, mRNA","A6QLW9",1246,0,"DNA-binding protein RFX2",".",".",".",".","pfam04589","RFX1_trans_act","RFX1 transcription activation region. The RFX family is a family of winged-helix DNA binding proteins. RFX1 is a regulatory factor essential for expression of MHC class II genes. This region is to found N terminal to the RFX DNA binding region (pfam02257) in some mammalian RFX proteins, and is thought to activate transcription when associated with DNA. Deletion analysis has identified the region 233-351 in human RFX1 as being required for maximal activation.","GO:0001675|acrosome assembly;GO:1990830|cellular response to leukemia inhibitory factor;GO:0060271|cilium morphogenesis;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0007286|spermatid development;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;","K09173","RFX1_2_3; regulatory factor X 1/2/3"]
["bta_circ_0004726",8,46,38,12.6360689780552,5,0,0,3.34651829422634,0.00169767438160651,0.0847995482704926,"up","yes","NC_037334.1:25804926..25812952:-","gene9755","gi|803073562|ref|XP_012033566.1|",5615,0,"PREDICTED: solute carrier family 12 member 2 isoform X1 [Ovis aries]","gi|741932906|ref|XM_005209086.2|",6805,0,"PREDICTED: Bos taurus solute carrier family 12 (sodium/potassium/chloride transporter), member 2 (SLC12A2), transcript variant X1, mRNA","P55011",2058,0,"Solute carrier family 12 member 2","SPBC18H10.16",261,{"v":3e-70,"d":"3.00E-70"},"COG0531","pfam00324","AA_permease","Amino acid permease.","GO:0007568|aging;GO:0015696|ammonium transport;GO:0007214|gamma-aminobutyric acid signaling pathway;GO:0006972|hyperosmotic response;GO:0006811|ion transport;GO:0045795|positive regulation of cell volume;GO:0070634|transepithelial ammonium transport;GO:0030321|transepithelial chloride transport;","GO:0016324|apical plasma membrane;GO:0070062|extracellular exosome;GO:1903561|extracellular vesicle;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0005886|plasma membrane;","GO:0008519|ammonium transmembrane transporter activity;GO:0019901|protein kinase binding;GO:0008511|sodium:potassium:chloride symporter activity;","K10951","SLC12A2, NKCC1; solute carrier family 12 (sodium/potassium/chloride transporter), member 2"]
["bta_circ_0004731",0,11,7,10.2297482396934,10,21,19,-1.86859397796943,0.0493816897361922,0.476348344536443,"down","yes","NC_037334.1:26432073..26453197:-","gene9759","gi|329664638|ref|NP_001192929.1|",1789,0,"protein PRRC1 [Bos taurus]","gi|329664637|ref|NM_001206000.1|",2144,0,"Bos taurus proline-rich coiled-coil 1 (PRRC1), mRNA","Q96M27",651,0,"Protein PRRC1",".",".",".",".","pfam01931","NTPase_I-T","Protein of unknown function DUF84. The function of this prokaryotic protein family is unknown.",".","GO:0005794|Golgi apparatus;",".",".","."]
["bta_circ_0004751",0,0,0,2.56100278226782,7,0,6,-4.60942945594271,0.0192647998069559,"NA","down","yes","NC_037334.1:2735442..2736286:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0004766",3,13,11,3.51872962644859,0,0,0,5.13905329951121,0.00643039983531282,"NA","up","yes","NC_037334.1:2737998..2743433:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0004783",0,0,0,1.8002607092477,2,5,4,-4.28092738813632,0.0312947669187869,"NA","down","yes","NC_037334.1:2793554..2867239:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0004875",0,0,0,2.13986739815184,4,3,5,-4.53327704300237,0.0204663413835395,"NA","down","yes","NC_037334.1:44617835..44642116:+","gene10130","gi|166795319|ref|NP_001107664.1|",4105,0,"heat shock 70 kDa protein 4 [Bos taurus]","gi|274317530|ref|NM_001114192.2|",4839,0,"Bos taurus heat shock protein family A (Hsp70) member 4 (HSPA4), mRNA","P34932",1553,0,"Heat shock 70 kDa protein 4","YBR169c",449,{"v":3e-138,"d":"3.00E-138"},"COG0443","pfam00012","HSP70","Hsp70 protein. Hsp70 chaperones help to fold many proteins. Hsp70 assisted folding involves repeated cycles of substrate binding and release. Hsp70 activity is ATP dependent. Hsp70 proteins are made up of two regions: the amino terminus is the ATPase domain and the carboxyl terminus is the substrate binding region.","GO:0051131|chaperone-mediated protein complex assembly;GO:0045040|protein import into mitochondrial outer membrane;GO:0006986|response to unfolded protein;","GO:0005829|cytosol;GO:0070062|extracellular exosome;","GO:0005524|ATP binding;","K09489","HSPA4; heat shock 70kDa protein 4"]
["bta_circ_0004883",13,45,16,12.583959371035,0,9,7,1.91879829834698,0.0388215897918011,0.439730132358439,"up","yes","NC_037334.1:45676307..45676607:-","gene10137","gi|440910465|gb|ELR60261.1|",1496,0,"Voltage-dependent anion-selective channel protein 1, partial [Bos mutus]","gi|528956632|ref|XM_005209335.1|",1804,0,"PREDICTED: Bos taurus voltage dependent anion channel 1 (VDAC1), transcript variant X3, mRNA","Q9TT15",577,0,"Voltage-dependent anion-selective channel protein 1",".",".",".",".","pfam01459","Porin_3","Eukaryotic porin.","GO:0006820|anion transport;GO:0006915|apoptotic process;GO:0001662|behavioral fear response;GO:0007612|learning;GO:2000378|negative regulation of reactive oxygen species metabolic process;GO:0007270|neuron-neuron synaptic transmission;GO:1903146|regulation of mitophagy;","GO:0016020|membrane;GO:0045121|membrane raft;GO:0005741|mitochondrial outer membrane;GO:0005757|mitochondrial permeability transition pore complex;GO:0043209|myelin sheath;GO:0005886|plasma membrane;","GO:0000166|nucleotide binding;GO:0015288|porin activity;GO:0008308|voltage-gated anion channel activity;","K05862","VDAC1; voltage-dependent anion channel protein 1"]
["bta_circ_0004895",35,80,32,24.5193484592117,0,7,9,2.97092205200749,0.000170255971170454,0.0175282576033582,"up","yes","NC_037334.1:46847798..46848546:-","gene10165","gi|741933626|ref|XP_010805609.1|",1434,0,"PREDICTED: core histone macro-H2A.1 isoform X4 [Bos taurus]","gi|741933625|ref|XM_010807307.1|",1226,0,"PREDICTED: Bos taurus H2A histone family, member Y (H2AFY), transcript variant X5, mRNA","O75367",526,{"v":2e-171,"d":"2.00E-171"},"Core histone macro-H2A.1","YBL003c",140,{"v":1e-36,"d":"1.00E-36"},"COG5262","pfam01661","Macro","Macro domain. This domain is an ADP-ribose binding module. It is found in a number of otherwise unrelated proteins. It is found at the C-terminus of the macro-H2A histone protein. This domain is found in the non-structural proteins of several types of ssRNA viruses such as NSP3 from alphaviruses. This domain is also found on its own in a family of proteins from bacteria, archaebacteria, and eukaryotes.","GO:0006342|chromatin silencing;GO:0007549|dosage compensation;GO:0071169|establishment of protein localization to chromatin;GO:1902750|negative regulation of cell cycle G2/M phase transition;GO:0045814|negative regulation of gene expression, epigenetic;GO:0061086|negative regulation of histone H3-K27 methylation;GO:0051572|negative regulation of histone H3-K4 methylation;GO:0033128|negative regulation of histone phosphorylation;GO:0071901|negative regulation of protein serine/threonine kinase activity;GO:1902883|negative regulation of response to oxidative stress;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:1901837|negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter;GO:0006334|nucleosome assembly;GO:0045815|positive regulation of gene expression, epigenetic;GO:0045618|positive regulation of keratinocyte differentiation;GO:0034184|positive regulation of maintenance of mitotic sister chromatid cohesion;GO:1902884|positive regulation of response to oxidative stress;GO:0040029|regulation of gene expression, epigenetic;GO:0019216|regulation of lipid metabolic process;GO:1902882|regulation of response to oxidative stress;","GO:0001740|Barr body;GO:0000793|condensed chromosome;GO:0070062|extracellular exosome;GO:0000790|nuclear chromatin;GO:0000228|nuclear chromosome;GO:0000784|nuclear chromosome, telomeric region;GO:0005730|nucleolus;GO:0000786|nucleosome;GO:0005634|nucleus;GO:0005721|pericentric heterochromatin;GO:0001739|sex chromatin;","GO:0031490|chromatin DNA binding;GO:0001046|core promoter sequence-specific DNA binding;GO:0003677|DNA binding;GO:0010385|double-stranded methylated DNA binding;GO:0019899|enzyme binding;GO:0031492|nucleosomal DNA binding;GO:0046982|protein heterodimerization activity;GO:0019901|protein kinase binding;GO:0030291|protein serine/threonine kinase inhibitor activity;GO:0000182|rDNA binding;GO:0000979|RNA polymerase II core promoter sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0044212|transcription regulatory region DNA binding;","K11251","H2A; histone H2A"]
["bta_circ_0004902",0,0,0,1.70759571048176,3,8,0,-4.01580330599944,0.04893592088949,"NA","down","yes","NC_037334.1:47588762..47616420:+","gene10178","gi|440909355|gb|ELR59268.1|",2022,0,"Mothers against decapentaplegic-like protein 5, partial [Bos mutus]","gi|999844017|ref|NM_001077107.3|",6863,0,"Bos taurus SMAD family member 5 (SMAD5), mRNA","Q5R6H7",777,0,"Mothers against decapentaplegic homolog 5",".",".",".",".","pfam03166","MH2","MH2 domain. This is the MH2 (MAD homology 2) domain found at the carboxy terminus of MAD related proteins such as Smads. This domain is separated from the MH1 domain by a non-conserved linker region. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers. Unlike MH1, MH2 does not bind DNA. The well-studied MH2 domain of Smad4 is composed of five alpha helices and three loops enclosing a beta sandwich. Smads are involved in the propagation of TGF-beta signals by direct association with the TGF-beta receptor kinase which phosphorylates the last two Ser of a conserved 'SSXS' motif located at the C-terminus of MH2.","GO:0030509|BMP signaling pathway;GO:0060348|bone development;GO:0060048|cardiac muscle contraction;GO:0051216|cartilage development;GO:0071407|cellular response to organic cyclic compound;GO:0009880|embryonic pattern specification;GO:0030218|erythrocyte differentiation;GO:0007281|germ cell development;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0002051|osteoblast fate commitment;GO:0045669|positive regulation of osteoblast differentiation;GO:1901522|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus;GO:0006468|protein phosphorylation;GO:0060395|SMAD protein signal transduction;GO:0006351|transcription, DNA-templated;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0001657|ureteric bud development;","GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;","GO:0017151|DEAD/H-box RNA helicase binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0031625|ubiquitin protein ligase binding;","K16790","SMAD5; mothers against decapentaplegic homolog 5"]
["bta_circ_0004953",3,22,37,8.76834961471423,2,5,0,2.60208870456239,0.0187246908807081,0.329128306374723,"up","yes","NC_037334.1:57211075..57215136:+","gene10353","gi|139948524|ref|NP_001077222.1|",3243,0,"putative E3 ubiquitin-protein ligase SH3RF2 [Bos taurus]","gi|982932257|ref|XM_005209539.3|",5327,0,"PREDICTED: Bos taurus SH3 domain containing ring finger 2 (SH3RF2), transcript variant X1, mRNA","Q8TEC5",1082,0,"Putative E3 ubiquitin-protein ligase SH3RF2",".",".",".",".","pfam07653","SH3_2","Variant SH3 domain. SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.","GO:0010923|negative regulation of phosphatase activity;GO:0016567|protein ubiquitination;","GO:0005654|nucleoplasm;","GO:0046872|metal ion binding;GO:0019902|phosphatase binding;GO:0008157|protein phosphatase 1 binding;GO:0004864|protein phosphatase inhibitor activity;GO:0016740|transferase activity;","K12171","SH3RF, POSH; E3 ubiquitin-protein ligase SH3RF [EC:2.3.2.27]"]
["bta_circ_0004965",0,0,0,1.94675349229052,0,8,5,-4.23838801604544,0.0352098039621202,"NA","down","yes","NC_037334.1:58601701..58603470:-","gene10367","gi|528957212|ref|XP_005209627.1|",2984,0,"PREDICTED: dihydropyrimidinase-related protein 3 isoform X1 [Bos taurus]","gi|982932300|ref|XM_005209570.3|",4018,0,"PREDICTED: Bos taurus dihydropyrimidinase like 3 (DPYSL3), transcript variant X1, mRNA","Q14195",1135,0,"Dihydropyrimidinase-related protein 3","PA0441",422,{"v":1e-132,"d":"1.00E-132"},"COG0044","pfam01979","Amidohydro_1","Amidohydrolase family. This family of enzymes are a a large metal dependent hydrolase superfamily. The family includes Adenine deaminase EC:3.5.4.2 that hydrolyses adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisation as a purine and also as a nitrogen source. This family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases, EC:3.5.1.25 These enzymes catalyse the reaction N-acetyl-D-glucosamine 6-phosphate + H2O <=> D-glucosamine 6-phosphate + acetate. This family includes the catalytic domain of urease alpha subunit. Dihydroorotases (EC:3.5.2.3) are also included.","GO:0051764|actin crosslink formation;GO:0051017|actin filament bundle assembly;GO:0071345|cellular response to cytokine stimulus;GO:0030336|negative regulation of cell migration;GO:0010977|negative regulation of neuron projection development;GO:0048666|neuron development;GO:0051491|positive regulation of filopodium assembly;GO:0010976|positive regulation of neuron projection development;GO:0051260|protein homooligomerization;GO:0048678|response to axon injury;","GO:0044297|cell body;GO:0005829|cytosol;GO:0070382|exocytic vesicle;GO:0005615|extracellular space;GO:0031941|filamentous actin;GO:0030426|growth cone;GO:0030027|lamellipodium;","GO:0035374|chondroitin sulfate binding;GO:0031005|filamin binding;GO:0016810|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0017124|SH3 domain binding;",".","."]
["bta_circ_0004967",0,0,0,2.10188712643445,3,3,6,-4.50496343640721,0.0215461636731791,"NA","down","yes","NC_037334.1:58601701..58610294:-","gene10367","gi|528957212|ref|XP_005209627.1|",2984,0,"PREDICTED: dihydropyrimidinase-related protein 3 isoform X1 [Bos taurus]","gi|982932300|ref|XM_005209570.3|",4018,0,"PREDICTED: Bos taurus dihydropyrimidinase like 3 (DPYSL3), transcript variant X1, mRNA","Q14195",1135,0,"Dihydropyrimidinase-related protein 3","PA0441",422,{"v":1e-132,"d":"1.00E-132"},"COG0044","pfam01979","Amidohydro_1","Amidohydrolase family. This family of enzymes are a a large metal dependent hydrolase superfamily. The family includes Adenine deaminase EC:3.5.4.2 that hydrolyses adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisation as a purine and also as a nitrogen source. This family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases, EC:3.5.1.25 These enzymes catalyse the reaction N-acetyl-D-glucosamine 6-phosphate + H2O <=> D-glucosamine 6-phosphate + acetate. This family includes the catalytic domain of urease alpha subunit. Dihydroorotases (EC:3.5.2.3) are also included.","GO:0051764|actin crosslink formation;GO:0051017|actin filament bundle assembly;GO:0071345|cellular response to cytokine stimulus;GO:0030336|negative regulation of cell migration;GO:0010977|negative regulation of neuron projection development;GO:0048666|neuron development;GO:0051491|positive regulation of filopodium assembly;GO:0010976|positive regulation of neuron projection development;GO:0051260|protein homooligomerization;GO:0048678|response to axon injury;","GO:0044297|cell body;GO:0005829|cytosol;GO:0070382|exocytic vesicle;GO:0005615|extracellular space;GO:0031941|filamentous actin;GO:0030426|growth cone;GO:0030027|lamellipodium;","GO:0035374|chondroitin sulfate binding;GO:0031005|filamin binding;GO:0016810|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0017124|SH3 domain binding;",".","."]
["bta_circ_0004978",82,426,236,147.456391948479,79,139,98,0.843521742162904,0.0315470085765689,0.428634275476763,"up","yes","NC_037334.1:61853686..61857125:+","gene10431","gi|300797717|ref|NP_001179290.1|",4398,0,"bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 [Bos taurus]","gi|803216887|ref|XM_012113416.1|",6553,0,"PREDICTED: Ovis aries musimon N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 (NDST1), transcript variant X11, mRNA","P52848",1677,0,"Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1",".",".",".",".","pfam12062","HSNSD","heparan sulfate-N-deacetylase. This family of proteins is are heparan sulfate N-deacetylase enzymes. This protein is found in eukaryotes. This proteinenzyme is often found associated with pfam00685.","GO:0035904|aorta development;GO:0003279|cardiac septum development;GO:0060976|coronary vasculature development;GO:0048702|embryonic neurocranium morphogenesis;GO:0048703|embryonic viscerocranium morphogenesis;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0030900|forebrain development;GO:0006024|glycosaminoglycan biosynthetic process;GO:0015012|heparan sulfate proteoglycan biosynthetic process;GO:0015014|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process;GO:0030210|heparin biosynthetic process;GO:0006954|inflammatory response;GO:0030901|midbrain development;GO:0043410|positive regulation of MAPK cascade;GO:0045880|positive regulation of smoothened signaling pathway;GO:0006477|protein sulfation;GO:0007585|respiratory gaseous exchange;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0015016|[heparan sulfate]-glucosamine N-sulfotransferase activity;GO:0042328|heparan sulfate N-acetylglucosaminyltransferase activity;GO:0050119|N-acetylglucosamine deacetylase activity;","K02576","NDST1; heparan sulfate N-deacetylase/N-sulfotransferase NDST1 [EC:3.1.1.- 2.8.2.-]"]
["bta_circ_0004979",4,42,9,7.38778488417963,0,4,3,2.35346059147537,0.0389344824378636,0.439730132358439,"up","yes","NC_037334.1:61874329..61878207:+","gene10431","gi|300797717|ref|NP_001179290.1|",4398,0,"bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 [Bos taurus]","gi|803216887|ref|XM_012113416.1|",6553,0,"PREDICTED: Ovis aries musimon N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 (NDST1), transcript variant X11, mRNA","P52848",1677,0,"Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1",".",".",".",".","pfam12062","HSNSD","heparan sulfate-N-deacetylase. This family of proteins is are heparan sulfate N-deacetylase enzymes. This protein is found in eukaryotes. This proteinenzyme is often found associated with pfam00685.","GO:0035904|aorta development;GO:0003279|cardiac septum development;GO:0060976|coronary vasculature development;GO:0048702|embryonic neurocranium morphogenesis;GO:0048703|embryonic viscerocranium morphogenesis;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0030900|forebrain development;GO:0006024|glycosaminoglycan biosynthetic process;GO:0015012|heparan sulfate proteoglycan biosynthetic process;GO:0015014|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process;GO:0030210|heparin biosynthetic process;GO:0006954|inflammatory response;GO:0030901|midbrain development;GO:0043410|positive regulation of MAPK cascade;GO:0045880|positive regulation of smoothened signaling pathway;GO:0006477|protein sulfation;GO:0007585|respiratory gaseous exchange;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0015016|[heparan sulfate]-glucosamine N-sulfotransferase activity;GO:0042328|heparan sulfate N-acetylglucosaminyltransferase activity;GO:0050119|N-acetylglucosamine deacetylase activity;","K02576","NDST1; heparan sulfate N-deacetylase/N-sulfotransferase NDST1 [EC:3.1.1.- 2.8.2.-]"]
["bta_circ_0005001",0,0,0,1.95539434339163,5,0,5,-4.1983195597115,0.0374776767062138,"NA","down","yes","NC_037334.1:66130786..66158778:+","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0005050",7,27,8,6.64880230307914,3,0,2,2.37478566826088,0.0437912864258969,0.456494092506297,"up","yes","NC_037334.1:83426963..83432176:+","gene10610","gi|296485061|tpg|DAA27176.1|",16459,0,"TPA: versican core protein precursor [Bos taurus]","gi|31341650|ref|NM_181035.2|",10258,0,"Bos taurus versican (VCAN), mRNA","P81282",6324,0,"Versican core protein",".",".",".",".","pfam00193","Xlink","Extracellular link domain.","GO:0007155|cell adhesion;GO:0007417|central nervous system development;GO:0001501|skeletal system development;","GO:0005576|extracellular region;","GO:0005509|calcium ion binding;GO:0030246|carbohydrate binding;GO:0005201|extracellular matrix structural constituent;GO:0005540|hyaluronic acid binding;","K06793","VCAN, CSPG2; versican core protein"]
["bta_circ_0005064",0,9,12,2.38024699824961,0,0,0,4.4474674911947,0.0253923782915581,"NA","up","yes","NC_037334.1:88279194..88349404:-","gene10636","gi|742237277|ref|XP_010830210.1|",2334,0,"PREDICTED: myocyte-specific enhancer factor 2C isoform X2 [Bison bison bison]","gi|742237276|ref|XM_010831908.1|",6148,0,"PREDICTED: Bison bison bison myocyte enhancer factor 2C (MEF2C), transcript variant X6, mRNA","A4UTP7",863,0,"Myocyte-specific enhancer factor 2C","YPL089c",93.2,{"v":4e-18,"d":"4.00E-18"},"COG5068","pfam12347","HJURP_C","Holliday junction regulator protein family C-terminal repeat. Although this family is conserved in the Holliday junction regulator, HJURP, proteins in higher eukaryotes, alongside an Scm3, pfam10384, family, its exact function is not known. The C-terminal region of Scm3 proteins has been evolving rapidly, and this short repeat at the C-terminal end can be present in up to two copies in the higher eukaryotes.","GO:0001782|B cell homeostasis;GO:0042100|B cell proliferation;GO:0050853|B cell receptor signaling pathway;GO:0001568|blood vessel development;GO:0001974|blood vessel remodeling;GO:0003211|cardiac ventricle formation;GO:0035051|cardiocyte differentiation;GO:0071277|cellular response to calcium ion;GO:0035690|cellular response to drug;GO:0071498|cellular response to fluid shear stress;GO:0071222|cellular response to lipopolysaccharide;GO:0071374|cellular response to parathyroid hormone stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0035984|cellular response to trichostatin A;GO:0002062|chondrocyte differentiation;GO:0001958|endochondral ossification;GO:2001013|epithelial cell proliferation involved in renal tubule morphogenesis;GO:0002467|germinal center formation;GO:0072102|glomerulus morphogenesis;GO:0007507|heart development;GO:0001947|heart looping;GO:0006959|humoral immune response;GO:0007611|learning or memory;GO:0000165|MAPK cascade;GO:0030318|melanocyte differentiation;GO:0007521|muscle cell fate determination;GO:0010629|negative regulation of gene expression;GO:0043524|negative regulation of neuron apoptotic process;GO:0030279|negative regulation of ossification;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0072160|nephron tubule epithelial cell differentiation;GO:0014033|neural crest cell differentiation;GO:0048666|neuron development;GO:0030182|neuron differentiation;GO:0001649|osteoblast differentiation;GO:0003151|outflow tract morphogenesis;GO:0030220|platelet formation;GO:0010694|positive regulation of alkaline phosphatase activity;GO:0030890|positive regulation of B cell proliferation;GO:2000987|positive regulation of behavioral fear response;GO:0030501|positive regulation of bone mineralization;GO:2000727|positive regulation of cardiac muscle cell differentiation;GO:0060045|positive regulation of cardiac muscle cell proliferation;GO:0010628|positive regulation of gene expression;GO:2000111|positive regulation of macrophage apoptotic process;GO:0045663|positive regulation of myoblast differentiation;GO:0045666|positive regulation of neuron differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0090073|positive regulation of protein homodimerization activity;GO:2001016|positive regulation of skeletal muscle cell differentiation;GO:0048643|positive regulation of skeletal muscle tissue development;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0003138|primary heart field specification;GO:0002634|regulation of germinal center formation;GO:0045652|regulation of megakaryocyte differentiation;GO:0060025|regulation of synaptic activity;GO:0061333|renal tubule morphogenesis;GO:0003139|secondary heart field specification;GO:0003185|sinoatrial valve morphogenesis;GO:0007519|skeletal muscle tissue development;GO:0051145|smooth muscle cell differentiation;GO:0055012|ventricular cardiac muscle cell differentiation;","GO:0005737|cytoplasm;GO:0016607|nuclear speck;GO:0005634|nucleus;GO:0032991|macromolecular complex;GO:0016528|sarcoplasm;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046983|protein dimerization activity;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0000983|transcription factor activity, RNA polymerase II core promoter sequence-specific;GO:0044212|transcription regulatory region DNA binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K04454","MEF2C; MADS-box transcription enhancer factor 2C"]
["bta_circ_0005090",6,21,17,21.6154295747279,36,36,18,-1.35299676295771,0.046041222750236,0.460838535120418,"down","yes","NC_037334.1:94831634..94835695:-","gene10671","gi|742237414|ref|XP_010830244.1|",8171,0,"PREDICTED: tetratricopeptide repeat protein 37 isoform X1 [Bison bison bison]","gi|982985773|ref|XM_015464381.1|",5758,0,"PREDICTED: Bos taurus tetratricopeptide repeat domain 37 (TTC37), transcript variant X1, mRNA","Q6PGP7",2888,0,"Tetratricopeptide repeat protein 37",".",".",".",".","pfam13414","TPR_11","TPR repeat.","GO:0043928|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0055087|Ski complex;GO:0035327|transcriptionally active chromatin;",".","K12600","SKI3, TTC37; superkiller protein 3"]
["bta_circ_0005101",3,5,7,10.9670771699172,6,28,21,-1.90878592399497,0.0345110283211418,0.439730132358439,"down","yes","NC_037334.1:95041858..95080705:+","gene10677","gi|297477546|ref|XP_002689442.1|",3228,0,"PREDICTED: rho-related BTB domain-containing protein 3 isoform X1 [Bos taurus]","gi|982985779|ref|XM_015464384.1|",5236,0,"PREDICTED: Bos taurus Rho-related BTB domain containing 3 (RHOBTB3), transcript variant X1, mRNA","O94955",1212,0,"Rho-related BTB domain-containing protein 3",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0008584|male gonad development;GO:0042147|retrograde transport, endosome to Golgi;","GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0032588|trans-Golgi network membrane;","GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0003924|GTPase activity;GO:0017137|Rab GTPase binding;","K07869","RHOBTB3; Rho-related BTB domain-containing protein 3"]
["bta_circ_0005103",0,0,0,2.43285296423748,0,9,7,-4.5807405475612,0.0201496839050166,"NA","down","yes","NC_037334.1:95051692..95072423:+","gene10677","gi|297477546|ref|XP_002689442.1|",3228,0,"PREDICTED: rho-related BTB domain-containing protein 3 isoform X1 [Bos taurus]","gi|982985779|ref|XM_015464384.1|",5236,0,"PREDICTED: Bos taurus Rho-related BTB domain containing 3 (RHOBTB3), transcript variant X1, mRNA","O94955",1212,0,"Rho-related BTB domain-containing protein 3",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0008584|male gonad development;GO:0042147|retrograde transport, endosome to Golgi;","GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0032588|trans-Golgi network membrane;","GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0003924|GTPase activity;GO:0017137|Rab GTPase binding;","K07869","RHOBTB3; Rho-related BTB domain-containing protein 3"]
["bta_circ_0005200",0,0,0,1.61578765448749,3,2,4,-4.09373904510496,0.0418526227388098,"NA","down","yes","NC_037335.1:17204326..17234466:-","gene10915","gi|329664886|ref|NP_001192704.1|",2423,0,"intraflagellar transport protein 74 homolog [Bos taurus]","gi|982933016|ref|XM_010807734.2|",2812,0,"PREDICTED: Bos taurus intraflagellar transport 74 (IFT74), transcript variant X1, mRNA","Q8BKE9",867,0,"Intraflagellar transport protein 74 homolog",".",".",".",".","pfam01576","Myosin_tail_1","Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.","GO:0060271|cilium morphogenesis;GO:0007368|determination of left/right symmetry;GO:0008544|epidermis development;GO:0007507|heart development;GO:0042073|intraciliary transport;GO:0035735|intraciliary transport involved in cilium morphogenesis;GO:0003334|keratinocyte development;GO:0050680|negative regulation of epithelial cell proliferation;GO:0007219|Notch signaling pathway;GO:0033630|positive regulation of cell adhesion mediated by integrin;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;","GO:0005813|centrosome;GO:0005929|cilium;GO:0031410|cytoplasmic vesicle;GO:0030992|intraciliary transport particle B;GO:0005634|nucleus;","GO:0048487|beta-tubulin binding;GO:0003682|chromatin binding;",".","."]
["bta_circ_0005207",0,2,3,9.91683449474374,12,31,15,-3.59953329214815,0.000597047716142921,0.0445109366310688,"down","yes","NC_037335.1:2076017..2077361:+","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0005208",0,0,0,5.34538030587319,2,29,6,-5.84284848475067,0.00123967481569202,"NA","down","yes","NC_037335.1:2076020..2077361:+","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0005219",5,26,19,7.27205583314973,3,2,0,2.65611248437637,0.0192774236241783,0.333714374080912,"up","yes","NC_037335.1:23999465..24000172:+","gene11024","gi|300796317|ref|NP_001179478.1|",1817,0,"protein AF-9 [Bos taurus]","gi|982933051|ref|XM_005209892.3|",6085,0,"PREDICTED: Bos taurus myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3 (MLLT3), transcript variant X1, mRNA","A2AM29",697,0,"Protein AF-9","YNL107w",85.1,{"v":1e-16,"d":"1.00E-16"},"COG5033","pfam03366","YEATS","YEATS family. We have named this family the YEATS family, after `YNK7', `ENL', `AF-9', and `TFIIF small subunit'. This family also contains the GAS41 protein. All these proteins are thought to have a transcription stimulatory activity","GO:0009952|anterior/posterior pattern specification;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0045893|positive regulation of transcription, DNA-templated;GO:2000096|positive regulation of Wnt signaling pathway, planar cell polarity pathway;GO:0007379|segment specification;GO:0006351|transcription, DNA-templated;","GO:0005694|chromosome;GO:0008023|transcription elongation factor complex;","GO:0003682|chromatin binding;GO:0042393|histone binding;GO:0070577|lysine-acetylated histone binding;","K15187","MLLT1_3, ENL, AF9; YEATS domain-containing protein 1/3"]
["bta_circ_0005233",8,0,5,2.99060246971074,0,0,0,4.63797948579638,0.0185276693965288,"NA","up","yes","NC_037335.1:27011185..27050041:-","gene11046","gi|300794616|ref|NP_001179650.1|",6789,0,"centlein [Bos taurus]","gi|742190883|ref|XM_010857100.1|",5019,0,"PREDICTED: Bison bison bison centlein, centrosomal protein (CNTLN), mRNA","Q9NXG0",2068,0,"Centlein",".",".",".",".","pfam02463","SMC_N","RecF/RecN/SMC N terminal domain. This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics.   This family also includes the RecF and RecN proteins that are involved in DNA metabolizm and recombination.","GO:0010457|centriole-centriole cohesion;GO:0033365|protein localization to organelle;","GO:0005814|centriole;GO:0005813|centrosome;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005654|nucleoplasm;","GO:0030674|protein binding, bridging;GO:0019904|protein domain specific binding;GO:0019901|protein kinase binding;","K16467","CNTLN; centlein"]
["bta_circ_0005234",4,4,3,1.94028432813278,0,0,0,4.21716164477447,0.0353430233042855,"NA","up","yes","NC_037335.1:27011185..27083882:-","gene11046","gi|300794616|ref|NP_001179650.1|",6789,0,"centlein [Bos taurus]","gi|742190883|ref|XM_010857100.1|",5019,0,"PREDICTED: Bison bison bison centlein, centrosomal protein (CNTLN), mRNA","Q9NXG0",2068,0,"Centlein",".",".",".",".","pfam02463","SMC_N","RecF/RecN/SMC N terminal domain. This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics.   This family also includes the RecF and RecN proteins that are involved in DNA metabolizm and recombination.","GO:0010457|centriole-centriole cohesion;GO:0033365|protein localization to organelle;","GO:0005814|centriole;GO:0005813|centrosome;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005654|nucleoplasm;","GO:0030674|protein binding, bridging;GO:0019904|protein domain specific binding;GO:0019901|protein kinase binding;","K16467","CNTLN; centlein"]
["bta_circ_0005239",466,2423,464,656.034828844599,387,484,461,0.892396678653105,0.0459463618006022,0.460838535120418,"up","yes","NC_037335.1:27926054..27928023:+","gene11048","gi|982933151|ref|XP_015327920.1|",4144,0,"PREDICTED: zinc finger protein basonuclin-2 isoform X5 [Bos taurus]","gi|982986096|ref|XM_015464467.1|",11953,0,"PREDICTED: Bos taurus basonuclin 2 (BNC2), transcript variant X6, mRNA","Q6ZN30",1563,0,"Zinc finger protein basonuclin-2",".",".",".",".","pfam13894","zf-C2H2_4","C2H2-type zinc finger. This family contains a number of divergent C2H2 type zinc fingers.","GO:0003416|endochondral bone growth;GO:0060485|mesenchyme development;GO:0060021|palate development;GO:0043586|tongue development;GO:0006351|transcription, DNA-templated;","GO:0005654|nucleoplasm;","GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;",".","."]
["bta_circ_0005262",0,3,0,4.48674609319482,7,11,7,-3.15059411596278,0.0242863123809849,"NA","down","yes","NC_037335.1:31106147..31141741:+","gene11068","gi|741935366|ref|XP_010806106.1|",10487,0,"PREDICTED: multiple PDZ domain protein isoform X1 [Bos taurus]","gi|982933194|ref|XM_010807804.2|",10771,0,"PREDICTED: Bos taurus multiple PDZ domain protein (MPDZ), transcript variant X1, mRNA","O75970",3521,0,"Multiple PDZ domain protein",".",".",".",".","pfam09045","L27_2","L27_2. The L27_2 domain is a protein-protein interaction domain capable of organizing scaffold proteins into supramolecular assemblies by formation of heteromeric L27_2 domain complexes. L27_2 domain-mediated protein assemblies have been shown to play essential roles in cellular processes including asymmetric cell division, establishment and maintenance of cell polarity, and clustering of receptors and ion channels. Members of this family form specific heterotetrameric complexes, in which each domain contains three alpha-helices. The two N-terminal helices of each L27_2 domain pack together to form a tight, four-helix bundle in the heterodimer, whilst the third helix of each L27_2 domain forms another four-helix bundle that assembles the two units of the heterodimer into a tetramer.","GO:0007155|cell adhesion;GO:0016032|viral process;","GO:0016324|apical plasma membrane;GO:0016327|apicolateral plasma membrane;GO:0005923|bicellular tight junction;GO:0005737|cytoplasm;GO:0031410|cytoplasmic vesicle;GO:0030425|dendrite;GO:0014069|postsynaptic density;GO:0045211|postsynaptic membrane;GO:0043220|Schmidt-Lanterman incisure;","GO:0008022|protein C-terminus binding;","K06095","MPDZ, MUPP1, Patj; multiple PDZ domain protein"]
["bta_circ_0005327",0,0,8,9.03550355508037,18,18,10,-2.65939782035181,0.0214827440240869,0.357850317976361,"down","yes","NC_037335.1:40361503..40369366:+","gene11128","gi|742205748|ref|XP_010859005.1|",4062,0,"PREDICTED: zinc finger protein GLIS3 isoform X1 [Bison bison bison]","gi|982986214|ref|XM_015464501.1|",6617,0,"PREDICTED: Bos taurus GLIS family zinc finger 3 (GLIS3), mRNA","Q8NEA6",1101,0,"Zinc finger protein GLIS3",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0006366|transcription from RNA polymerase II promoter;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K09232","GLIS1_3; zinc finger protein GLIS1/3"]
["bta_circ_0005328",12,22,25,29.2728925753449,41,36,39,-1.20992728528701,0.0450498404251169,0.456494092506297,"down","yes","NC_037335.1:40368241..40369366:+","gene11128","gi|742205748|ref|XP_010859005.1|",4062,0,"PREDICTED: zinc finger protein GLIS3 isoform X1 [Bison bison bison]","gi|982986214|ref|XM_015464501.1|",6617,0,"PREDICTED: Bos taurus GLIS family zinc finger 3 (GLIS3), mRNA","Q8NEA6",1101,0,"Zinc finger protein GLIS3",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0006366|transcription from RNA polymerase II promoter;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K09232","GLIS1_3; zinc finger protein GLIS1/3"]
["bta_circ_0005340",0,0,0,2.5768502948273,5,6,4,-4.82823513443173,0.0118094435002445,"NA","down","yes","NC_037335.1:42007965..42013050:+","gene11137","gi|741935532|ref|XP_010806156.1|",3083,0,"PREDICTED: pumilio homolog 3 isoform X1 [Bos taurus]","gi|982933347|ref|XM_010807854.2|",1834,0,"PREDICTED: Bos taurus pumilio RNA binding family member 3 (PUM3), transcript variant X1, mRNA","Q15397",1072,0,"Pumilio homolog 3",".",".",".",".","pfam08144","CPL","CPL (NUC119) domain. This C terminal domain is fund in Penguin-like proteins associated with Pumilio like repeats.","GO:0010835|regulation of protein ADP-ribosylation;GO:0006417|regulation of translation;","GO:0005694|chromosome;GO:0005783|endoplasmic reticulum;GO:0005730|nucleolus;GO:0005654|nucleoplasm;","GO:0003677|DNA binding;GO:0003729|mRNA binding;GO:0003723|RNA binding;","K14844","PUF6; pumilio homology domain family member 6"]
["bta_circ_0005358",2,0,0,5.30029038410386,10,10,7,-3.0796040318435,0.0236872076589784,"NA","down","yes","NC_037335.1:44431834..44442762:+","gene11156","gi|156121315|ref|NP_001095805.1|",2944,0,"phosphoglucomutase-like protein 5 [Bos taurus]","gi|156121314|ref|NM_001102335.1|",3105,0,"Bos taurus phosphoglucomutase 5 (PGM5), mRNA","Q8BZF8",1127,0,"Phosphoglucomutase-like protein 5","SMc03925",515,{"v":4e-170,"d":"4.00E-170"},"COG0033","pfam02880","PGM_PMM_III","Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III.","GO:0005975|carbohydrate metabolic process;GO:0007155|cell adhesion;","GO:0005913|cell-cell adherens junction;GO:0030055|cell-substrate junction;GO:0043034|costamere;GO:0009898|cytoplasmic side of plasma membrane;GO:0016010|dystrophin-associated glycoprotein complex;GO:0005925|focal adhesion;GO:0014704|intercalated disc;GO:0042383|sarcolemma;GO:0005914|spot adherens junction;GO:0001725|stress fiber;GO:0030018|Z disc;","GO:0000287|magnesium ion binding;","K15636","PGM5; phosphoglucomutase-like protein 5"]
["bta_circ_0005379",0,0,0,2.98377667606511,4,12,3,-5.04103973198193,0.00778356224778047,"NA","down","yes","NC_037335.1:46583942..46587573:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0005429",0,0,0,1.85965664530163,0,10,3,-4.15964776646341,0.0397893226465806,"NA","down","yes","NC_037335.1:53371824..53406187:+","gene11218","gi|555961906|ref|XP_005893047.1|",15485,0,"PREDICTED: vacuolar protein sorting-associated protein 13A isoform X4 [Bos mutus]","gi|594102845|ref|XM_006074409.1|",9723,0,"PREDICTED: Bubalus bubalis vacuolar protein sorting 13 homolog A (S. cerevisiae) (VPS13A), transcript variant X4, mRNA","Q96RL7",5145,0,"Vacuolar protein sorting-associated protein 13A","YLL040c",224,{"v":4e-57,"d":"4.00E-57"},"COG5043","pfam06650","DUF1162","Protein of unknown function (DUF1162). This family represents a conserved region within several hypothetical eukaryotic proteins. Family members might be vacuolar protein sorting related-proteins.","GO:0006914|autophagy;GO:0006895|Golgi to endosome transport;GO:0007626|locomotory behavior;GO:0007399|nervous system development;GO:0008104|protein localization;GO:0015031|protein transport;GO:0035176|social behavior;","GO:0005829|cytosol;GO:0031045|dense core granule;GO:0005622|intracellular;",".","K19525","VPS13A_C; vacuolar protein sorting-associated protein 13A/C"]
["bta_circ_0005447",0,8,8,1.77762092389993,0,0,0,4.01962512969595,0.0489208005174351,"NA","up","yes","NC_037335.1:59575435..59578971:+","gene11258","gi|982933577|ref|XP_015328008.1|",10308,0,"PREDICTED: protein unc-13 homolog B isoform X2 [Bos taurus]","gi|982933576|ref|XM_015472522.1|",7322,0,"PREDICTED: Bos taurus unc-13 homolog B (C. elegans) (UNC13B), transcript variant X2, mRNA","Q62769",2467,0,"Protein unc-13 homolog B",".",".",".",".","pfam06292","DUF1041","Domain of Unknown Function (DUF1041). This family consists of several eukaryotic domains of unknown function. Members of this family are often found in tandem repeats and co-occur with pfam00168, pfam00130 and pfam00169 domains.","GO:0071333|cellular response to glucose stimulus;GO:0007268|synaptic transmission;GO:0035556|intracellular signal transduction;GO:0045921|positive regulation of exocytosis;GO:0097151|positive regulation of inhibitory postsynaptic potential;GO:0050714|positive regulation of protein secretion;GO:0010808|positive regulation of synaptic vesicle priming;GO:0061669|spontaneous neurotransmitter secretion;GO:0016082|synaptic vesicle priming;","GO:0030054|cell junction;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0048786|presynaptic active zone;GO:0097060|synaptic membrane;GO:0043195|terminal bouton;","GO:0005509|calcium ion binding;GO:0005516|calmodulin binding;GO:0019992|diacylglycerol binding;GO:0005543|phospholipid binding;GO:0019905|syntaxin binding;GO:0017075|syntaxin-1 binding;","K15293","UNC13, MUNC13; protein unc-13"]
["bta_circ_0005460",0,26,4,2.98749597101874,0,0,0,4.7541545457952,0.0150162711128622,"NA","up","yes","NC_037335.1:60661138..60666834:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0005482",0,0,3,4.83906315814902,8,10,8,-3.03055920399556,0.0269336178220594,"NA","down","yes","NC_037335.1:62888176..62900883:-","gene11357","gi|556749142|ref|XP_005970004.1|",1013,{"v":9e-128,"d":"9.00E-128"},"PREDICTED: DNA repair protein complementing XP-A cells isoform X2 [Pantholops hodgsonii]","gi|982933710|ref|XR_001500856.1|",1992,0,"PREDICTED: Bos taurus xeroderma pigmentosum, complementation group A (XPA), transcript variant X1, misc_RNA","P23025",296,{"v":1e-91,"d":"1.00E-91"},"DNA repair protein complementing XP-A cells","SPBC649.03",69.7,{"v":4e-12,"d":"4.00E-12"},"COG5145","pfam05181","XPA_C","XPA protein C-terminus.","GO:0006284|base-excision repair;GO:0006281|DNA repair;GO:0070911|global genome nucleotide-excision repair;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0035264|multicellular organism growth;GO:1901255|nucleotide-excision repair involved in interstrand cross-link repair;GO:0000715|nucleotide-excision repair, DNA damage recognition;GO:0033683|nucleotide-excision repair, DNA incision;GO:0006296|nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006294|nucleotide-excision repair, preincision complex assembly;GO:0006293|nucleotide-excision repair, preincision complex stabilization;GO:0034504|protein localization to nucleus;GO:0010996|response to auditory stimulus;GO:0006979|response to oxidative stress;GO:0009636|response to toxic substance;GO:0006283|transcription-coupled nucleotide-excision repair;GO:0009650|UV protection;GO:0070914|UV-damage excision repair;","GO:0005737|cytoplasm;GO:0045171|intercellular bridge;GO:0005654|nucleoplasm;GO:0000110|nucleotide-excision repair factor 1 complex;GO:0005634|nucleus;","GO:0003684|damaged DNA binding;GO:0046872|metal ion binding;GO:0019904|protein domain specific binding;GO:0042803|protein homodimerization activity;","K10847","XPA; DNA-repair protein complementing XP-A cells"]
["bta_circ_0005514",7,3,0,2.3481773377565,0,0,0,4.27672816498056,0.0335944436717201,"NA","up","yes","NC_037335.1:69007756..69010725:-","gene11416","gi|296484619|tpg|DAA26734.1|",2374,0,"TPA: GDNF family receptor alpha-2 precursor [Bos taurus]","gi|113205971|ref|NM_001015595.2|",2039,0,"Bos taurus GDNF family receptor alpha 2 (GFRA2), mRNA","Q5E9X0",917,0,"GDNF family receptor alpha-2",".",".",".",".","pfam02351","GDNF","GDNF/GAS1 domain. This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.",".","GO:0031225|anchored component of membrane;GO:0005886|plasma membrane;","GO:0038023|signaling receptor activity;",".","."]
["bta_circ_0005526",2,5,11,2.4610008380636,0,0,0,4.6053559553232,0.0185618699054126,"NA","up","yes","NC_037335.1:69806203..69813594:+","gene11438","gi|528959148|ref|XP_005210311.1|",2491,0,"PREDICTED: serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [Bos taurus]","gi|982933873|ref|XM_010808040.2|",4797,0,"PREDICTED: Bos taurus protein phosphatase 3, catalytic subunit, gamma isozyme (PPP3CC), transcript variant X4, mRNA","P48454",862,0,"Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform","SPBC1346.01c",594,0,"COG0639","pfam00149","Metallophos","Calcineurin-like phosphoesterase. This family includes a diverse range of phosphoesterases, including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD or yeast MRE11. The most conserved regions in this superfamily centre around the metal chelating residues.","GO:0007420|brain development;GO:0033173|calcineurin-NFAT signaling cascade;GO:0006470|protein dephosphorylation;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0005516|calmodulin binding;GO:0033192|calmodulin-dependent protein phosphatase activity;GO:0046872|metal ion binding;","K04348","PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]"]
["bta_circ_0005554",93,210,187,103.617537943788,51,69,70,1.11832597681208,0.00646748015863295,0.201992718953344,"up","yes","NC_037335.1:72763885..72764994:-","gene11476","gi|426220043|ref|XP_004004227.1|",1963,0,"PREDICTED: BTB/POZ domain-containing protein KCTD9 isoform X1 [Ovis aries]","gi|742119255|ref|XM_010840166.1|",3110,0,"PREDICTED: Bison bison bison potassium channel tetramerization domain containing 9 (KCTD9), transcript variant X2, mRNA","Q7L273",749,0,"BTB/POZ domain-containing protein KCTD9","MA3328",114,{"v":2e-26,"d":"2.00E-26"},"COG1357","pfam02214","BTB_2","BTB/POZ domain. In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.","GO:0035556|intracellular signal transduction;GO:0051260|protein homooligomerization;GO:0016567|protein ubiquitination;","GO:0005622|intracellular;","GO:0097602|cullin family protein binding;GO:0042802|identical protein binding;GO:0043621|protein self-association;",".","."]
["bta_circ_0005614",51,83,44,38.9022666752616,21,11,25,1.42479890838138,0.0229200630613644,0.37540285105053,"up","yes","NC_037335.1:80155602..80161721:+","gene11577",".",".",".",".","gi|965868578|ref|XR_001438171.1|",2407,0,"PREDICTED: Ovis aries musimon uncharacterized LOC105607140 (LOC105607140), transcript variant X6, ncRNA",".",".",".",".",".",".",".",".","pfam05072","Herpes_UL43","Herpesvirus UL43 protein. UL43 genes are expressed with true-late (gamma2) kinetics and have been identified as a virion tegument component.",".",".",".",".","."]
["bta_circ_0005636",0,0,0,2.64488708198234,8,3,3,-4.82203371141228,0.0121415618583372,"NA","down","yes","NC_037335.1:82661118..82672623:+","gene11597","gi|635377446|sp|A3KMX0.3|ER6L2_BOVIN",8319,0,"RecName: Full=DNA excision repair protein ERCC-6-like 2","gi|432134241|ref|NM_001082606.2|",5718,0,"Bos taurus excision repair cross-complementation group 6 like 2 (ERCC6L2), mRNA","A3KMX0",3209,0,"DNA excision repair protein ERCC-6-like 2",".",".",".",".","pfam00176","SNF2_N","SNF2 family N-terminal domain. This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1).","GO:0006281|DNA repair;","GO:0005815|microtubule organizing center;GO:0005739|mitochondrion;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0003677|DNA binding;GO:0004386|helicase activity;",".","."]
["bta_circ_0005654",0,5,0,5.68771490053966,8,13,10,-2.88342374292177,0.0248167717674767,0.383893430686201,"down","yes","NC_037335.1:85498481..85522034:+","gene11645","gi|741882520|ref|XP_010797088.1|",3130,0,"PREDICTED: zinc finger protein 169 isoform X3 [Bos taurus]","gi|982986750|ref|XM_010798786.2|",2456,0,"PREDICTED: Bos taurus zinc finger protein 169 (ZNF169), transcript variant X4, mRNA","Q14929",921,0,"Zinc finger protein 169",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["bta_circ_0005670",0,7,9,1.8090339476539,0,0,0,4.04254352497548,0.0473631419442961,"NA","up","yes","NC_037335.1:88760782..88763705:-","gene11667","gi|741882560|ref|XP_010797131.1|",3367,0,"PREDICTED: selenocysteine insertion sequence-binding protein 2 isoform X5 [Bos taurus]","gi|982986780|ref|XM_010798829.2|",2969,0,"PREDICTED: Bos taurus SECIS binding protein 2 (SECISBP2), transcript variant X5, mRNA","Q96T21",902,0,"Selenocysteine insertion sequence-binding protein 2",".",".",".",".","pfam01248","Ribosomal_L7Ae","Ribosomal protein L7Ae/L30e/S12e/Gadd45 family. This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118.","GO:2000623|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0048666|neuron development;GO:0001514|selenocysteine incorporation;GO:0021756|striatum development;","GO:0005739|mitochondrion;GO:0005634|nucleus;","GO:0003730|mRNA 3'-UTR binding;GO:0043021|ribonucleoprotein complex binding;GO:0003723|RNA binding;GO:0035368|selenocysteine insertion sequence binding;","K19539","SECISBP2, SBP2; selenocysteine insertion sequence-binding protein 2"]
["bta_circ_0005775",0,9,11,2.25343917862888,0,0,0,4.3686904924198,0.0288713874591071,"NA","up","yes","NC_037336.1:10406485..10406978:+","gene11967","gi|982987233|ref|XP_015320207.1|",2001,0,"PREDICTED: LOW QUALITY PROTEIN: opioid growth factor receptor-like protein 1 isoform X2 [Bos taurus]","gi|982987232|ref|XM_015464721.1|",7729,0,"PREDICTED: Bos taurus opioid growth factor receptor-like 1 (OGFRL1), transcript variant X2, mRNA","Q5TC84",578,0,"Opioid growth factor receptor-like protein 1",".",".",".",".","pfam04664","OGFr_N","Opioid growth factor receptor (OGFr) conserved region. Opioid peptides act as growth factors in neural and non-neural cells and tissues, in addition to serving in neurotransmission/neuromodulation in the nervous system. The Opioid growth factor receptor is an integral membrane protein associated with the nucleus. The conserved region is situated at the N-terminus of the member proteins with a series of imperfect repeats lying immediately to its C-terminus.",".","GO:0016020|membrane;","GO:0038023|signaling receptor activity;",".","."]
["bta_circ_0005783",0,0,0,20.3644150423237,0,104,37,-5.21163063439187,0.0105890926252262,0.260154752906126,"down","yes","NC_037336.1:12069056..12070194:+","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0005788",0,0,0,1.57223923099305,3,3,3,-4.06401171109411,0.0436473399698098,"NA","down","yes","NC_037336.1:12518301..12542313:+","gene11972","gi|803278924|ref|XP_011999134.1|",4019,0,"PREDICTED: potassium voltage-gated channel subfamily KQT member 5 isoform X2 [Ovis aries musimon]","gi|803278923|ref|XM_012143744.1|",4251,0,"PREDICTED: Ovis aries musimon potassium channel, voltage gated KQT-like subfamily Q, member 5 (KCNQ5), transcript variant X2, mRNA","Q9NR82",1320,0,"Potassium voltage-gated channel subfamily KQT member 5","all4633",83.2,{"v":5e-16,"d":"5.00E-16"},"COG1226","pfam03520","KCNQ_channel","KCNQ voltage-gated potassium channel. This family matches to the C-terminal tail of KCNQ type potassium channels.","GO:0071805|potassium ion transmembrane transport;GO:0034765|regulation of ion transmembrane transport;","GO:0030118|clathrin coat;GO:0016021|integral component of membrane;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;GO:0008076|voltage-gated potassium channel complex;","GO:0005249|voltage-gated potassium channel activity;","K04930","KCNQ5; potassium voltage-gated channel KQT-like subfamily member 5"]
["bta_circ_0005801",526,1840,1600,774.904192615768,306,688,478,1.13595009777658,0.000567751404920077,0.0442135215692891,"up","yes","NC_037336.1:15276392..15278547:+","gene12000","gi|528960256|ref|XP_005210725.1|",5516,0,"PREDICTED: sentrin-specific protease 6 isoform X1 [Bos taurus]","gi|742184111|ref|XM_010855270.1|",5908,0,"PREDICTED: Bison bison bison SUMO1/sentrin specific peptidase 6 (SENP6), mRNA","Q9GZR1",1734,0,"Sentrin-specific protease 6","SPAC17A5.07c",91.7,{"v":1e-17,"d":"1.00E-17"},"COG5160","pfam02902","Peptidase_C48","Ulp1 protease family, C-terminal catalytic domain. This domain contains the catalytic triad Cys-His-Asn.","GO:0016926|protein desumoylation;GO:0070646|protein modification by small protein removal;GO:0016925|protein sumoylation;GO:0090234|regulation of kinetochore assembly;GO:0090169|regulation of spindle assembly;","GO:0005829|cytosol;GO:0005654|nucleoplasm;","GO:0070139|SUMO-specific endopeptidase activity;","K08595","SENP6; sentrin-specific protease 6 [EC:3.4.22.68]"]
["bta_circ_0005810",0,13,7,2.12778708361301,0,0,0,4.28835122207948,0.0328053942737072,"NA","up","yes","NC_037336.1:15293330..15314456:+","gene12000","gi|528960256|ref|XP_005210725.1|",5516,0,"PREDICTED: sentrin-specific protease 6 isoform X1 [Bos taurus]","gi|742184111|ref|XM_010855270.1|",5908,0,"PREDICTED: Bison bison bison SUMO1/sentrin specific peptidase 6 (SENP6), mRNA","Q9GZR1",1734,0,"Sentrin-specific protease 6","SPAC17A5.07c",91.7,{"v":1e-17,"d":"1.00E-17"},"COG5160","pfam02902","Peptidase_C48","Ulp1 protease family, C-terminal catalytic domain. This domain contains the catalytic triad Cys-His-Asn.","GO:0016926|protein desumoylation;GO:0070646|protein modification by small protein removal;GO:0016925|protein sumoylation;GO:0090234|regulation of kinetochore assembly;GO:0090169|regulation of spindle assembly;","GO:0005829|cytosol;GO:0005654|nucleoplasm;","GO:0070139|SUMO-specific endopeptidase activity;","K08595","SENP6; sentrin-specific protease 6 [EC:3.4.22.68]"]
["bta_circ_0005847",0,0,0,6.39804668216867,22,2,8,-6.03589763983106,0.000759000916780412,0.0492512590431825,"down","yes","NC_037336.1:24250207..24255116:+","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0005878",14,12,24,9.01830831553293,0,0,4,3.25891878235668,0.00574056500939053,0.19277034630468,"up","yes","NC_037336.1:27892318..28008812:+","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0005902",0,6,13,11.9361550787599,16,26,16,-1.92865154324471,0.0375130042039678,0.439730132358439,"down","yes","NC_037336.1:32358716..32398246:+","gene12121","gi|528960475|ref|XP_002690127.3|",4063,0,"PREDICTED: centrosomal protein of 85 kDa-like isoform X2 [Bos taurus]","gi|982987477|ref|XM_015464770.1|",7087,0,"PREDICTED: Bos taurus centrosomal protein 85kDa-like (CEP85L), transcript variant X2, mRNA","Q5SZL2",1393,0,"Centrosomal protein of 85 kDa-like",".",".",".",".","pfam02463","SMC_N","RecF/RecN/SMC N terminal domain. This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics.   This family also includes the RecF and RecN proteins that are involved in DNA metabolizm and recombination.",".","GO:0005813|centrosome;GO:0005737|cytoplasm;",".","K16766","CEP85; centrosomal protein CEP85"]
["bta_circ_0005903",0,0,0,2.318772301135,4,7,3,-4.66833102957672,0.016041234801345,"NA","down","yes","NC_037336.1:32358716..32441549:+","gene12121","gi|528960475|ref|XP_002690127.3|",4063,0,"PREDICTED: centrosomal protein of 85 kDa-like isoform X2 [Bos taurus]","gi|982987477|ref|XM_015464770.1|",7087,0,"PREDICTED: Bos taurus centrosomal protein 85kDa-like (CEP85L), transcript variant X2, mRNA","Q5SZL2",1393,0,"Centrosomal protein of 85 kDa-like",".",".",".",".","pfam02463","SMC_N","RecF/RecN/SMC N terminal domain. This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics.   This family also includes the RecF and RecN proteins that are involved in DNA metabolizm and recombination.",".","GO:0005813|centrosome;GO:0005737|cytoplasm;",".","K16766","CEP85; centrosomal protein CEP85"]
["bta_circ_0005971",0,0,0,4.19499355381748,8,12,5,-5.5509954433831,0.00241265132733121,"NA","down","yes","NC_037336.1:40933470..40952206:-","gene12211","gi|742189243|ref|XP_010854995.1|",1250,0,"PREDICTED: transmembrane protein FLJ37396 [Bison bison bison]","gi|742189242|ref|XM_010856693.1|",1209,0,"PREDICTED: Bison bison bison uncharacterized LOC105000705 (LOC105000705), mRNA",".",".",".",".",".",".",".",".","pfam15082","DUF4549","Domain of unknown function (DUF4549). This family of proteins is found in eukaryotes. Proteins in this family are typically between 143 and 1871 amino acids in length. The human member of this family is C6orf183.",".",".",".",".","."]
["bta_circ_0006017",28,90,58,33.1396869948311,12,36,9,1.38821382288827,0.0215173641706415,0.357850317976361,"up","yes","NC_037336.1:50306491..50311257:+","gene12288","gi|329664042|ref|NP_001193110.1|",2373,0,"ubiquitin carboxyl-terminal hydrolase 45 [Bos taurus]","gi|742096208|ref|XM_010834741.1|",1472,0,"PREDICTED: Bison bison bison ubiquitin specific peptidase 45 (USP45), transcript variant X2, mRNA","Q70EL2",769,0,"Ubiquitin carboxyl-terminal hydrolase 45",".",".",".",".","pfam00443","UCH","Ubiquitin carboxyl-terminal hydrolase.","GO:0006281|DNA repair;GO:0070911|global genome nucleotide-excision repair;GO:0016579|protein deubiquitination;GO:0006511|ubiquitin-dependent protein catabolic process;","GO:0005737|cytoplasm;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0004843|ubiquitin-specific protease activity;GO:0008270|zinc ion binding;","K11844","USP16_45; ubiquitin carboxyl-terminal hydrolase 16/45 [EC:3.4.19.12]"]
["bta_circ_0006093",0,0,0,2.00686652316582,4,2,5,-4.41997672785254,0.024978322722976,"NA","down","yes","NC_037336.1:67158489..67164809:+","gene12407","gi|742095761|ref|XP_010832946.1|",16245,0,"PREDICTED: laminin subunit alpha-2 isoform X1 [Bison bison bison]","gi|742095764|ref|XM_010834645.1|",9527,0,"PREDICTED: Bison bison bison laminin, alpha 2 (LAMA2), transcript variant X2, mRNA","P24043",5798,0,"Laminin subunit alpha-2",".",".",".",".","pfam00055","Laminin_N","Laminin N-terminal (Domain VI).","GO:0007411|axon guidance;GO:0007155|cell adhesion;GO:0030198|extracellular matrix organization;GO:0007517|muscle organ development;GO:0032224|positive regulation of synaptic transmission, cholinergic;GO:0030155|regulation of cell adhesion;GO:0030334|regulation of cell migration;GO:0045995|regulation of embryonic development;GO:0014037|Schwann cell differentiation;","GO:0005605|basal lamina;GO:0005604|basement membrane;GO:0043197|dendritic spine;GO:0005576|extracellular region;GO:0042383|sarcolemma;","GO:0005102|receptor binding;GO:0005198|structural molecule activity;","K05637","LAMA1_2; laminin, alpha 1/2"]
["bta_circ_0006145",26,30,23,17.7359096931899,12,5,6,1.58860760641283,0.046269340822525,0.460987626075111,"up","yes","NC_037336.1:69799939..69815551:+","gene12426","gi|741938121|ref|XP_010806874.1|",4285,0,"PREDICTED: ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [Bos taurus]","gi|982935233|ref|XM_010808572.2|",4370,0,"PREDICTED: Bos taurus ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), transcript variant X1, mRNA","P22413",1438,0,"Ectonucleotide pyrophosphatase/phosphodiesterase family member 1","SPBC725.05c",173,{"v":2e-44,"d":"2.00E-44"},"COG1524","pfam01663","Phosphodiest","Type I phosphodiesterase / nucleotide pyrophosphatase. This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyse the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars. Also in this family is ATX an autotaxin, tumor cell motility-stimulating protein which exhibits type I phosphodiesterases activity. The alignment encompasses the active site. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum.","GO:0050427|3'-phosphoadenosine 5'-phosphosulfate metabolic process;GO:0046034|ATP metabolic process;GO:0031214|biomineral tissue development;GO:0030643|cellular phosphate ion homeostasis;GO:0032869|cellular response to insulin stimulus;GO:0006091|generation of precursor metabolites and energy;GO:0006955|immune response;GO:0030505|inorganic diphosphate transport;GO:0030308|negative regulation of cell growth;GO:0045599|negative regulation of fat cell differentiation;GO:0046325|negative regulation of glucose import;GO:0045719|negative regulation of glycogen biosynthetic process;GO:0046627|negative regulation of insulin receptor signaling pathway;GO:0031953|negative regulation of protein autophosphorylation;GO:0090305|nucleic acid phosphodiester bond hydrolysis;GO:0009143|nucleoside triphosphate catabolic process;GO:0006796|phosphate-containing compound metabolic process;GO:0030500|regulation of bone mineralization;GO:0006771|riboflavin metabolic process;GO:0030730|sequestering of triglyceride;","GO:0016323|basolateral plasma membrane;GO:0009986|cell surface;GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0005887|integral component of plasma membrane;GO:0005765|lysosomal membrane;GO:0005886|plasma membrane;","GO:0050656|3'-phosphoadenosine 5'-phosphosulfate binding;GO:0005524|ATP binding;GO:0005509|calcium ion binding;GO:0004527|exonuclease activity;GO:0005158|insulin receptor binding;GO:0035529|NADH pyrophosphatase activity;GO:0003676|nucleic acid binding;GO:0047429|nucleoside-triphosphate diphosphatase activity;GO:0004551|nucleotide diphosphatase activity;GO:0004528|phosphodiesterase I activity;GO:0030247|polysaccharide binding;GO:0042803|protein homodimerization activity;GO:0005044|scavenger receptor activity;GO:0008270|zinc ion binding;","K01513","ENPP1_3; ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3 [EC:3.1.4.1 3.6.1.9]"]
["bta_circ_0006147",0,0,0,1.95539434339163,5,0,5,-4.1983195597115,0.0374776767062138,"NA","down","yes","NC_037336.1:69911924..69960228:+","gene12428",".",".",".",".","gi|982987817|ref|XR_001497166.1|",2417,0,"PREDICTED: Bos taurus uncharacterized LOC101904601 (LOC101904601), transcript variant X4, ncRNA",".",".",".",".",".",".",".",".","pfam10325","7TM_GPCR_Srz","Serpentine type 7TM GPCR chemoreceptor Srz. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srz is a solo families amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srz appear to be under strong adaptive evolutionary pressure.",".",".",".",".","."]
["bta_circ_0006155",0,0,0,2.612474962042,6,2,6,-4.80782363209924,0.0124732510412119,"NA","down","yes","NC_037336.1:71568435..71568776:+","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0006174",0,0,0,1.68075174231848,0,6,5,-4.00796222908903,0.0493796644707521,"NA","down","yes","NC_037336.1:73371110..73478869:-","gene12498","gi|594070898|ref|XP_006059325.1|",5752,0,"PREDICTED: jouberin isoform X1 [Bubalus bubalis]","gi|594070897|ref|XM_006059263.1|",4530,0,"PREDICTED: Bubalus bubalis Abelson helper integration site 1 (AHI1), transcript variant X1, mRNA","Q8N157",1778,0,"Jouberin",".",".",".",".","pfam00018","SH3_1","SH3 domain. SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.","GO:0034613|cellular protein localization;GO:0007417|central nervous system development;GO:0060271|cilium morphogenesis;GO:0035844|cloaca development;GO:0001947|heart looping;GO:0030902|hindbrain development;GO:0070121|Kupffer's vesicle development;GO:0070986|left/right axis specification;GO:0001738|morphogenesis of a polarized epithelium;GO:0043066|negative regulation of apoptotic process;GO:0071599|otic vesicle development;GO:0035845|photoreceptor cell outer segment organization;GO:0030862|positive regulation of polarized epithelial cell differentiation;GO:0002092|positive regulation of receptor internalization;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0039023|pronephric duct morphogenesis;GO:0039008|pronephric nephron tubule morphogenesis;GO:0050795|regulation of behavior;GO:0010842|retina layer formation;GO:0065001|specification of axis polarity;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0016192|vesicle-mediated transport;","GO:0005912|adherens junction;GO:0005911|cell-cell junction;GO:0005814|centriole;GO:0005813|centrosome;GO:0036064|ciliary basal body;GO:0005929|cilium;GO:0005829|cytosol;GO:0036038|TCTN-B9D complex;","GO:0042802|identical protein binding;","K16740","AHI1; jouberin"]
["bta_circ_0006196",0,0,0,2.38445348378735,7,0,5,-4.49811675786419,0.0233006917722457,"NA","down","yes","NC_037336.1:75089911..75094536:-","gene12516","gi|296483981|tpg|DAA26096.1|",2240,0,"TPA: interferon gamma receptor 1 [Bos taurus]","gi|982935300|ref|XM_010808608.2|",2266,0,"PREDICTED: Bos taurus interferon gamma receptor 1 (IFNGR1), transcript variant X1, mRNA","P15260",462,{"v":8e-153,"d":"8.00E-153"},"Interferon gamma receptor 1",".",".",".",".","pfam07140","IFNGR1","Interferon gamma receptor (IFNGR1). This family consists of several eukaryotic and viral interferon gamma receptor proteins. Molecular interactions among cytokines and cytokine receptors in eukaryotes form the basis of many cell-signaling pathways relevant to immune function. Human interferon-gamma (IFN-gamma) signals through a multimeric receptor complex consisting of two different but structurally related transmembrane chains: the high-affinity receptor-binding subunit (IFN-gammaRalpha) and a species specific accessory factor (AF-1 or IFN-gammaRbeta). The vaccinia viral interferon gamma receptor has been shown to be secreted from infected cells during early infection. The structure has been halved such that the N-terminus of this family is now represented by Tissue_fac pfam01108.","GO:0060333|interferon-gamma-mediated signaling pathway;GO:0060334|regulation of interferon-gamma-mediated signaling pathway;GO:0009615|response to virus;GO:0007165|signal transduction;","GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0019955|cytokine binding;GO:0004906|interferon-gamma receptor activity;","K05132","IFNGR1, CD119; interferon gamma receptor 1"]
["bta_circ_0006234",0,0,0,1.61578765448749,3,2,4,-4.09373904510496,0.0418526227388098,"NA","down","yes","NC_037336.1:82102994..82131905:+","gene12570","gi|514239922|ref|NP_001265490.1|",17036,0,"utrophin [Bos taurus]","gi|982935396|ref|XM_010808642.2|",12518,0,"PREDICTED: Bos taurus utrophin (UTRN), transcript variant X4, mRNA","P46939",6043,0,"Utrophin","ECU09g0290",148,{"v":2e-35,"d":"2.00E-35"},"COG5069","pfam09068","EF-hand_2","EF hand. Members of this family adopt a helix-loop-helix motif, as per other EF hand domains. However, since they do not contain the canonical pattern of calcium binding residues found in many EF hand domains, they do not bind calcium ions. The main function of this domain is the provision of specificity in beta-dystroglycan recognition, though in dystrophin it serves an additional role: stabilisation of the WW domain (pfam00397), enhancing dystroglycan binding.","GO:0006936|muscle contraction;GO:0007517|muscle organ development;GO:0007528|neuromuscular junction development;GO:0001954|positive regulation of cell-matrix adhesion;GO:2000649|regulation of sodium ion transmembrane transporter activity;GO:0014894|response to denervation involved in regulation of muscle adaptation;","GO:0030054|cell junction;GO:0030864|cortical actin cytoskeleton;GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0016010|dystrophin-associated glycoprotein complex;GO:0070062|extracellular exosome;GO:0030175|filopodium;GO:0031527|filopodium membrane;GO:0030426|growth cone;GO:0016020|membrane;GO:0031594|neuromuscular junction;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0045211|postsynaptic membrane;GO:0032991|macromolecular complex;GO:0042383|sarcolemma;","GO:0003779|actin binding;GO:0051015|actin filament binding;GO:0005178|integrin binding;GO:0019901|protein kinase binding;GO:0017166|vinculin binding;GO:0008270|zinc ion binding;",".","."]
["bta_circ_0006246",0,3,7,9.2202254294922,20,7,16,-2.47017342297201,0.0203278094885735,0.346052945781857,"down","yes","NC_037336.1:83074573..83076622:-","gene12575","gi|329664022|ref|NP_001192596.1|",3953,0,"F-box only protein 30 [Bos taurus]","gi|850485237|gb|CP011893.1|",3551,0,"Ovis canadensis canadensis isolate 43U chromosome 8 sequence","Q8TB52",1399,0,"F-box only protein 30",".",".",".",".","pfam00646","F-box","F-box domain. This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.","GO:0043687|post-translational protein modification;GO:0000209|protein polyubiquitination;","GO:0005829|cytosol;","GO:0061630|ubiquitin protein ligase activity;GO:0004842|ubiquitin-protein transferase activity;GO:0008270|zinc ion binding;","K10307","FBXO30; F-box protein 30"]
["bta_circ_0006316",0,0,0,3.83718374785117,8,4,9,-5.39628203859233,0.00353807116457546,"NA","down","yes","NC_037336.1:91453729..91498324:+","gene12660","gi|594102754|ref|XP_006074428.1|",3129,0,"PREDICTED: LOW QUALITY PROTEIN: T-lymphoma invasion and metastasis-inducing protein 2 [Bubalus bubalis]","gi|982988124|ref|XM_015464871.1|",5050,0,"PREDICTED: Bos taurus SR-related CTD-associated factor 8 (SCAF8), transcript variant X4, mRNA","Q9UPN6",1120,0,"Protein SCAF8",".",".",".",".","pfam04818","CTD_bind","RNA polymerase II-binding domain. This domain binds to the phosphorylated C-terminal domain (CTD) of RNA polymerase II.","GO:0006397|mRNA processing;GO:0008380|RNA splicing;","GO:0016363|nuclear matrix;GO:0005654|nucleoplasm;GO:0005681|spliceosomal complex;","GO:0003723|RNA binding;GO:0043175|RNA polymerase core enzyme binding;","K13191","RBM16, SCAF8; RNA-binding protein 16"]
["bta_circ_0006323",5,0,7,2.36050684459954,0,0,0,4.32610343612718,0.0310271414588432,"NA","up","yes","NC_037336.1:91711312..91724037:+","gene12662","gi|982935533|ref|XP_015328402.1|",8402,0,"PREDICTED: LOW QUALITY PROTEIN: T-lymphoma invasion and metastasis-inducing protein 2 [Bos taurus]","gi|982988133|ref|XM_010799033.2|",6785,0,"PREDICTED: Bos taurus T-cell lymphoma invasion and metastasis 2 (TIAM2), mRNA","Q8IVF5",2787,0,"T-lymphoma invasion and metastasis-inducing protein 2",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0007186|G-protein coupled receptor signaling pathway;GO:0035556|intracellular signal transduction;GO:0043065|positive regulation of apoptotic process;GO:0019216|regulation of lipid metabolic process;GO:0035023|regulation of Rho protein signal transduction;GO:0051056|regulation of small GTPase mediated signal transduction;","GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0030175|filopodium;GO:0030426|growth cone;GO:0030027|lamellipodium;GO:0016020|membrane;","GO:0005096|GTPase activator activity;GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005089|Rho guanyl-nucleotide exchange factor activity;","K16847","TIAM2; T-lymphoma invasion and metastasis-inducing protein 2"]
["bta_circ_0006337",9,90,72,26.0334724635239,13,15,5,1.82470145228712,0.00989162593915066,0.250500751472732,"up","yes","NC_037336.1:93668123..93716277:+","gene12672","gi|742123649|ref|XP_010839160.1|",7665,0,"PREDICTED: AT-rich interactive domain-containing protein 1B isoform X1 [Bison bison bison]","gi|742123648|ref|XM_010840858.1|",6796,0,"PREDICTED: Bison bison bison AT rich interactive domain 1B (SWI1-like) (ARID1B), transcript variant X1, mRNA","E9Q4N7",2748,0,"AT-rich interactive domain-containing protein 1B",".",".",".",".","pfam12031","DUF3518","Domain of unknown function (DUF3518). This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 260 amino acids in length. This domain is found associated with pfam01388.","GO:0006338|chromatin remodeling;GO:0097026|dendritic cell dendrite assembly;GO:0060996|dendritic spine development;GO:0007270|neuron-neuron synaptic transmission;GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0071565|nBAF complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0016514|SWI/SNF complex;","GO:0003677|DNA binding;","K11653","ARID1; AT-rich interactive domain-containing protein 1"]
["bta_circ_0006338",5,187,85,35.1103262219482,4,22,7,2.49016055836984,0.00123177005920925,0.0682842786669333,"up","yes","NC_037336.1:93668123..93745630:+","gene12672","gi|742123649|ref|XP_010839160.1|",7665,0,"PREDICTED: AT-rich interactive domain-containing protein 1B isoform X1 [Bison bison bison]","gi|742123648|ref|XM_010840858.1|",6796,0,"PREDICTED: Bison bison bison AT rich interactive domain 1B (SWI1-like) (ARID1B), transcript variant X1, mRNA","E9Q4N7",2748,0,"AT-rich interactive domain-containing protein 1B",".",".",".",".","pfam12031","DUF3518","Domain of unknown function (DUF3518). This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 260 amino acids in length. This domain is found associated with pfam01388.","GO:0006338|chromatin remodeling;GO:0097026|dendritic cell dendrite assembly;GO:0060996|dendritic spine development;GO:0007270|neuron-neuron synaptic transmission;GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0071565|nBAF complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0016514|SWI/SNF complex;","GO:0003677|DNA binding;","K11653","ARID1; AT-rich interactive domain-containing protein 1"]
["bta_circ_0006384",3,6,4,1.96331131803615,0,0,0,4.27164283785198,0.0323845272611295,"NA","up","yes","NC_037336.1:98111827..98148059:-","gene12724","gi|742104506|ref|XP_010835036.1|",2292,0,"PREDICTED: E3 ubiquitin-protein ligase parkin isoform X6 [Bison bison bison]","gi|926701296|ref|XM_005684988.2|",2970,0,"PREDICTED: Capra hircus parkin RBR E3 ubiquitin protein ligase (PARK2), mRNA","O60260",759,0,"E3 ubiquitin-protein ligase parkin","SPAC1805.12c_1",54.3,{"v":1e-07,"d":"1.00E-07"},"COG5272","pfam00240","ubiquitin","Ubiquitin family. This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) Nedd8, Elongin B, Rub1, and Parkin. A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites.","GO:0008344|adult locomotory behavior;GO:0070842|aggresome assembly;GO:0000422|mitophagy;GO:0044257|cellular protein catabolic process;GO:0044267|cellular protein metabolic process;GO:1903351|cellular response to dopamine;GO:0071287|cellular response to manganese ion;GO:0097237|cellular response to toxic substance;GO:0034620|cellular response to unfolded protein;GO:0007417|central nervous system development;GO:0042417|dopamine metabolic process;GO:0051583|dopamine uptake involved in synaptic transmission;GO:0036503|ERAD pathway;GO:0010994|free ubiquitin chain polymerization;GO:0007612|learning;GO:0016236|macroautophagy;GO:0000266|mitochondrial fission;GO:0007005|mitochondrion organization;GO:0000423|macromitophagy;GO:0044828|negative regulation by host of viral genome replication;GO:0032232|negative regulation of actin filament bundle assembly;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0060548|negative regulation of cell death;GO:1902236|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1903382|negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway;GO:1903542|negative regulation of exosomal secretion;GO:0010629|negative regulation of gene expression;GO:0033132|negative regulation of glucokinase activity;GO:0046676|negative regulation of insulin secretion;GO:1902254|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator;GO:0046329|negative regulation of JNK cascade;GO:0010637|negative regulation of mitochondrial fusion;GO:0043524|negative regulation of neuron apoptotic process;GO:1901215|negative regulation of neuron death;GO:1903202|negative regulation of oxidative stress-induced cell death;GO:1903377|negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway;GO:1902283|negative regulation of primary amine oxidase activity;GO:0001933|negative regulation of protein phosphorylation;GO:2000378|negative regulation of reactive oxygen species metabolic process;GO:0090201|negative regulation of release of cytochrome c from mitochondria;GO:1904049|negative regulation of spontaneous neurotransmitter secretion;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0070050|neuron cellular homeostasis;GO:0042415|norepinephrine metabolic process;GO:0061734|parkin-mediated mitophagy in response to mitochondrial depolarization;GO:1903599|positive regulation of mitophagy;GO:1903861|positive regulation of dendrite extension;GO:0043388|positive regulation of DNA binding;GO:0010628|positive regulation of gene expression;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0090141|positive regulation of mitochondrial fission;GO:0010636|positive regulation of mitochondrial fusion;GO:0098779|mitophagy in response to mitochondrial depolarization;GO:0051582|positive regulation of neurotransmitter uptake;GO:1901800|positive regulation of proteasomal protein catabolic process;GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032092|positive regulation of protein binding;GO:0045732|positive regulation of protein catabolic process;GO:1902530|positive regulation of protein linear polyubiquitination;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:1903265|positive regulation of tumor necrosis factor-mediated signaling pathway;GO:0010498|proteasomal protein catabolic process;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051865|protein autoubiquitination;GO:0031648|protein destabilization;GO:0016579|protein deubiquitination;GO:0070979|protein K11-linked ubiquitination;GO:0044314|protein K27-linked ubiquitination;GO:0035519|protein K29-linked ubiquitination;GO:0070936|protein K48-linked ubiquitination;GO:0085020|protein K6-linked ubiquitination;GO:0070534|protein K63-linked ubiquitination;GO:0070585|protein localization to mitochondrion;GO:0006513|protein monoubiquitination;GO:0000209|protein polyubiquitination;GO:0050821|protein stabilization;GO:0016567|protein ubiquitination;GO:0010506|regulation of autophagy;GO:0060828|regulation of canonical Wnt signaling pathway;GO:1900407|regulation of cellular response to oxidative stress;GO:0042053|regulation of dopamine metabolic process;GO:0014059|regulation of dopamine secretion;GO:0010906|regulation of glucose metabolic process;GO:0032368|regulation of lipid transport;GO:0051881|regulation of mitochondrial membrane potential;GO:0010821|regulation of mitochondrion organization;GO:0031647|regulation of protein stability;GO:1903214|regulation of protein targeting to mitochondrion;GO:0031396|regulation of protein ubiquitination;GO:2000377|regulation of reactive oxygen species metabolic process;GO:1902803|regulation of synaptic vesicle transport;GO:0034976|response to endoplasmic reticulum stress;GO:0006979|response to oxidative stress;GO:0001964|startle response;GO:0035249|synaptic transmission, glutamatergic;GO:0006351|transcription, DNA-templated;GO:0006511|ubiquitin-dependent protein catabolic process;GO:0055069|zinc ion homeostasis;","GO:0016235|aggresome;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0097413|Lewy body;GO:0005739|mitochondrion;GO:0043005|neuron projection;GO:0016607|nuclear speck;GO:0005634|nucleus;GO:1990452|Parkin-FBXW7-Cul1 ubiquitin ligase complex;GO:0048471|perinuclear region of cytoplasm;GO:0098793|presynapse;GO:0000151|ubiquitin ligase complex;","GO:0003779|actin binding;GO:0008013|beta-catenin binding;GO:0051087|chaperone binding;GO:0097602|cullin family protein binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0019899|enzyme binding;GO:1990444|F-box domain binding;GO:0001664|G-protein coupled receptor binding;GO:0031072|heat shock protein binding;GO:0042826|histone deacetylase binding;GO:0030544|Hsp70 protein binding;GO:0042802|identical protein binding;GO:0019900|kinase binding;GO:0030165|PDZ domain binding;GO:0043274|phospholipase binding;GO:0019901|protein kinase binding;GO:0017124|SH3 domain binding;GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0015631|tubulin binding;GO:0043130|ubiquitin binding;GO:0031624|ubiquitin conjugating enzyme binding;GO:0061630|ubiquitin protein ligase activity;GO:0031625|ubiquitin protein ligase binding;GO:0004842|ubiquitin-protein transferase activity;GO:1990381|ubiquitin-specific protease binding;GO:0008270|zinc ion binding;","K04556","PARK2; parkin [EC:2.3.2.27]"]
["bta_circ_0006420",4,7,11,3.2409312726989,0,0,0,5.00277925700721,0.008567983814284,"NA","up","yes","NC_037337.1:101086075..101090112:-","gene14216","gi|528967206|ref|XP_005212203.1|",1930,0,"PREDICTED: forkhead box protein N3 isoform X1 [Bos taurus]","gi|982937882|ref|XM_005212147.3|",7856,0,"PREDICTED: Bos taurus forkhead box N3 (FOXN3), transcript variant X4, mRNA","Q33BP8",716,0,"Forkhead box protein N3","SPBC16G5.15c",102,{"v":5e-21,"d":"5.00E-21"},"COG5025","pfam00250","Fork_head","Fork head domain.","GO:0007049|cell cycle;GO:0030154|cell differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;","K09407","FOXN; forkhead box protein N"]
["bta_circ_0006424",0,0,0,1.74086477319377,4,0,5,-4.01986307890338,0.0486117283269939,"NA","down","yes","NC_037337.1:101238997..101243081:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0006449",22,101,114,42.2526132918398,13,35,24,1.36750630000472,0.0139539289531565,0.298906981742218,"up","yes","NC_037337.1:10488330..10499191:-","gene12912","gi|982936116|ref|XP_015328528.1|",1612,0,"PREDICTED: homer protein homolog 1 isoform X2 [Bos taurus]","gi|982936115|ref|XM_015473042.1|",6224,0,"PREDICTED: Bos taurus homer scaffolding protein 1 (HOMER1), transcript variant X2, mRNA","Q2KJ56",574,0,"Homer protein homolog 1",".",".",".",".","pfam00568","WH1","WH1 domain. WASp Homology domain 1 (WH1) domain. WASP is the protein that is defective in Wiskott-Aldrich syndrome (WAS). The majority of point mutations occur within the amino- terminal WH1 domain. The metabotropic glutamate receptors mGluR1alpha and mGluR5 bind a protein called homer, which is a WH1 domain homologue. A subset of WH1 domains has been termed a \"EVH1\" domain and appear to bind a polyproline motif.","GO:0048148|behavioral response to cocaine;GO:0048875|chemical homeostasis within a tissue;GO:0051928|positive regulation of calcium ion transport;GO:0090279|regulation of calcium ion import;GO:2001257|regulation of cation channel activity;GO:2001256|regulation of store-operated calcium entry;GO:0051592|response to calcium ion;GO:0003009|skeletal muscle contraction;GO:0048741|skeletal muscle fiber development;","GO:0045177|apical part of cell;GO:0030424|axon;GO:0030054|cell junction;GO:0043034|costamere;GO:0014069|postsynaptic density;GO:0045211|postsynaptic membrane;GO:0030018|Z disc;","GO:0035256|G-protein coupled glutamate receptor binding;GO:0044325|ion channel binding;","K15010","HOMER; homer"]
["bta_circ_0006453",4,20,13,18.128801473131,22,40,19,-1.43001545727616,0.0429869424095007,0.456494092506297,"down","yes","NC_037337.1:10618645..10667454:+","gene12913","gi|114052222|ref|NP_001039826.1|",2578,0,"poly(A) RNA polymerase GLD2 [Bos taurus]","gi|942096705|ref|XM_005909462.2|",2811,0,"PREDICTED: Bos mutus PAP associated domain containing 4 (PAPD4), transcript variant X1, mRNA","Q2HJ44",997,0,"Poly(A) RNA polymerase GLD2","SPAC821.04c",125,{"v":7e-29,"d":"7.00E-29"},"COG5260","pfam03828","PAP_assoc","Cid1 family poly A polymerase. This domain is found in poly(A) polymerases and has been shown to have polynucleotide adenylyltransferase activity. Proteins in this family have been located to both the nucleus and the cytoplasm.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0071044|histone mRNA catabolic process;GO:0006397|mRNA processing;GO:0043631|RNA polyadenylation;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0046872|metal ion binding;GO:0004652|polynucleotide adenylyltransferase activity;","K14079","PAPD4, GLD2; poly(A) RNA polymerase GLD2 [EC:2.7.7.19]"]
["bta_circ_0006455",0,0,0,2.13986739815184,4,3,5,-4.53327704300237,0.0204663413835395,"NA","down","yes","NC_037337.1:10637915..10657947:+","gene12913","gi|114052222|ref|NP_001039826.1|",2578,0,"poly(A) RNA polymerase GLD2 [Bos taurus]","gi|942096705|ref|XM_005909462.2|",2811,0,"PREDICTED: Bos mutus PAP associated domain containing 4 (PAPD4), transcript variant X1, mRNA","Q2HJ44",997,0,"Poly(A) RNA polymerase GLD2","SPAC821.04c",125,{"v":7e-29,"d":"7.00E-29"},"COG5260","pfam03828","PAP_assoc","Cid1 family poly A polymerase. This domain is found in poly(A) polymerases and has been shown to have polynucleotide adenylyltransferase activity. Proteins in this family have been located to both the nucleus and the cytoplasm.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0071044|histone mRNA catabolic process;GO:0006397|mRNA processing;GO:0043631|RNA polyadenylation;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0046872|metal ion binding;GO:0004652|polynucleotide adenylyltransferase activity;","K14079","PAPD4, GLD2; poly(A) RNA polymerase GLD2 [EC:2.7.7.19]"]
["bta_circ_0006470",5,0,5,2.10689120535808,0,0,0,4.14934328614932,0.0406319064516502,"NA","up","yes","NC_037337.1:11540660..11542556:+","gene12924","gi|741939063|ref|XP_010807159.1|",2386,0,"PREDICTED: ERO1-like protein alpha isoform X1 [Bos taurus]","gi|982935909|ref|XM_010808857.2|",4866,0,"PREDICTED: Bos taurus endoplasmic reticulum oxidoreductase alpha (ERO1A), transcript variant X1, mRNA","A5PJN2",917,0,"ERO1-like protein alpha","SPCC1450.14c",223,{"v":1e-60,"d":"1.00E-60"},"COG5061","pfam04137","ERO1","Endoplasmic Reticulum Oxidoreductin 1 (ERO1). Members of this family are required for the formation of disulphide bonds in the ER.","GO:0019471|4-hydroxyproline metabolic process;GO:0050873|brown fat cell differentiation;GO:0045454|cell redox homeostasis;GO:0006464|cellular protein modification process;GO:0051085|chaperone mediated protein folding requiring cofactor;GO:0030968|endoplasmic reticulum unfolded protein response;GO:0030198|extracellular matrix organization;GO:0070059|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0034975|protein folding in endoplasmic reticulum;GO:0022417|protein maturation by protein folding;GO:0051209|release of sequestered calcium ion into cytosol;GO:0034976|response to endoplasmic reticulum stress;","GO:0005789|endoplasmic reticulum membrane;","GO:0016671|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor;GO:0003756|protein disulfide isomerase activity;GO:0015035|protein disulfide oxidoreductase activity;","K10950","ERO1L; ERO1-like protein alpha [EC:1.8.4.-]"]
["bta_circ_0006492",0,0,0,1.5286908074986,3,4,2,-4.02030426064568,0.0465919556406166,"NA","down","yes","NC_037337.1:12387508..12397514:-","gene12949","gi|803087186|ref|XP_012036133.1|",3869,0,"PREDICTED: dipeptidyl peptidase 8 isoform X2 [Ovis aries]","gi|982936126|ref|XM_015473043.1|",4599,0,"PREDICTED: Bos taurus dipeptidyl-peptidase 8 (DPP8), transcript variant X4, mRNA","Q6V1X1",1459,0,"Dipeptidyl peptidase 8","CC2154",162,{"v":2e-39,"d":"2.00E-39"},"COG1506","pfam00930","DPPIV_N","Dipeptidyl peptidase IV (DPP IV) N-terminal region. This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.","GO:0006955|immune response;GO:0006508|proteolysis;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0008239|dipeptidyl-peptidase activity;GO:0008236|serine-type peptidase activity;","K08655","DPP8; dipeptidyl-peptidase 8 [EC:3.4.14.5]"]
["bta_circ_0006496",8,2,0,2.54735296334062,0,0,0,4.3693593976774,0.029188187348442,"NA","up","yes","NC_037337.1:12567236..12567656:-","gene12953","gi|528962007|ref|XP_005211381.1|",9574,0,"PREDICTED: C-myc promoter-binding protein isoform X3 [Bos taurus]","gi|982936033|ref|XM_005211324.3|",9984,0,"PREDICTED: Bos taurus DENN/MADD domain containing 4A (DENND4A), transcript variant X5, mRNA","Q7Z401",3343,0,"C-myc promoter-binding protein",".",".",".",".","pfam02141","DENN","DENN (AEX-3) domain. DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.","GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005829|cytosol;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0017112|Rab guanyl-nucleotide exchange factor activity;",".","."]
["bta_circ_0006518",0,0,0,2.08518267110329,6,6,0,-4.31749837143554,0.0311397764847497,"NA","down","yes","NC_037337.1:14983399..14988547:+","gene12991","gi|528961931|ref|XP_005211347.1|",3363,0,"PREDICTED: E3 SUMO-protein ligase PIAS1 isoform X1 [Bos taurus]","gi|741939168|ref|XM_005211290.2|",5838,0,"PREDICTED: Bos taurus protein inhibitor of activated STAT 1 (PIAS1), transcript variant X1, mRNA","O75925",1167,0,"E3 SUMO-protein ligase PIAS1",".",".",".",".","pfam14324","PINIT","PINIT domain. The PINIT domain is a protein domain that is found in PIAS proteins. The PINIT domain is about 180 amino acids in length.","GO:0030521|androgen receptor signaling pathway;GO:0045444|fat cell differentiation;GO:0000082|G1/S transition of mitotic cell cycle;GO:0007259|JAK-STAT cascade;GO:0043066|negative regulation of apoptotic process;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0033235|positive regulation of protein sumoylation;GO:0051152|positive regulation of smooth muscle cell differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0016925|protein sumoylation;GO:0065004|protein-DNA complex assembly;GO:0042127|regulation of cell proliferation;GO:0060334|regulation of interferon-gamma-mediated signaling pathway;GO:0007283|spermatogenesis;GO:0006351|transcription, DNA-templated;GO:0008542|visual learning;","GO:0016607|nuclear speck;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0016605|PML body;","GO:0050681|androgen receptor binding;GO:0003677|DNA binding;GO:0019899|enzyme binding;GO:0008022|protein C-terminus binding;GO:0019904|protein domain specific binding;GO:0061665|SUMO ligase activity;GO:0019789|SUMO transferase activity;GO:0003713|transcription coactivator activity;GO:0003714|transcription corepressor activity;GO:0031625|ubiquitin protein ligase binding;GO:0008270|zinc ion binding;","K04706","PIAS1; E3 SUMO-protein ligase PIAS1"]
["bta_circ_0006527",0,0,0,2.89196862007085,4,6,7,-5.00375018593977,0.00830382959612892,"NA","down","yes","NC_037337.1:17550198..17568063:-","gene13018","gi|296483588|tpg|DAA25703.1|",6952,0,"TPA: uveal autoantigen with coiled-coil domains and ankyrin repeats protein [Bos taurus]","gi|31342589|ref|NM_174209.2|",4709,0,"Bos taurus uveal autoantigen with coiled-coil domains and ankyrin repeats (UACA), mRNA","Q8HYY4",2668,0,"Uveal autoantigen with coiled-coil domains and ankyrin repeats protein","all2748",94.7,{"v":2e-19,"d":"2.00E-19"},"COG0666","pfam01576","Myosin_tail_1","Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.","GO:0097190|apoptotic signaling pathway;GO:1901222|regulation of NIK/NF-kappaB signaling;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005634|nucleus;",".",".","."]
["bta_circ_0006532",0,0,0,2.69635926175653,7,5,3,-4.87507136906767,0.0108505701935841,"NA","down","yes","NC_037337.1:17558090..17568063:-","gene13018","gi|296483588|tpg|DAA25703.1|",6952,0,"TPA: uveal autoantigen with coiled-coil domains and ankyrin repeats protein [Bos taurus]","gi|31342589|ref|NM_174209.2|",4709,0,"Bos taurus uveal autoantigen with coiled-coil domains and ankyrin repeats (UACA), mRNA","Q8HYY4",2668,0,"Uveal autoantigen with coiled-coil domains and ankyrin repeats protein","all2748",94.7,{"v":2e-19,"d":"2.00E-19"},"COG0666","pfam01576","Myosin_tail_1","Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.","GO:0097190|apoptotic signaling pathway;GO:1901222|regulation of NIK/NF-kappaB signaling;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005634|nucleus;",".",".","."]
["bta_circ_0006559",24,38,29,19.4118789012618,7,12,11,1.44496024585459,0.0401086776217555,0.442423270501201,"up","yes","NC_037337.1:19001909..19002819:-","gene13026","gi|742094995|ref|XP_010832771.1|",12770,0,"PREDICTED: unconventional myosin-IXa isoform X9 [Bison bison bison]","gi|965827029|ref|XM_012129087.2|",10958,0,"PREDICTED: Ovis aries musimon myosin IXA (MYO9A), transcript variant X23, mRNA","B2RTY4",4372,0,"Unconventional myosin-IXa","SPCC1919.10c",394,{"v":2e-110,"d":"2.00E-110"},"COG5022","pfam00063","Myosin_head","Myosin head (motor domain).","GO:0034329|cell junction assembly;GO:0045198|establishment of epithelial cell apical/basal polarity;GO:0035556|intracellular signal transduction;GO:0007018|microtubule-based movement;GO:0051056|regulation of small GTPase mediated signal transduction;GO:0007601|visual perception;","GO:0005829|cytosol;GO:0016021|integral component of membrane;GO:0016461|unconventional myosin complex;","GO:0003779|actin binding;GO:0005524|ATP binding;GO:0005096|GTPase activator activity;GO:0046872|metal ion binding;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;","K10360","MYO9; myosin IX"]
["bta_circ_0006578",32,603,205,130.28092291806,35,134,68,1.2968853799081,0.0221311489716728,0.365248428066845,"up","yes","NC_037337.1:20063680..20079638:+","gene13041","gi|741884106|ref|XP_010808326.1|",7320,0,"PREDICTED: neogenin isoform X2 [Bos taurus]","gi|982988664|ref|XM_010810024.2|",5215,0,"PREDICTED: Bos taurus neogenin 1 (NEO1), transcript variant X2, mRNA","Q92859",2642,0,"Neogenin",".",".",".",".","pfam06583","Neogenin_C","Neogenin C-terminus. This family represents the C-terminus of eukaryotic neogenin precursor proteins, which contains several potential phosphorylation sites. Neogenin is a member of the N-CAM family of cell adhesion molecules (and therefore contains multiple copies of pfam00047 and pfam00041) and is closely related to the DCC tumor suppressor gene product - these proteins may play an integral role in regulating differentiation programmes and/or cell migration events within many adult and embryonic tissues.","GO:0007411|axon guidance;GO:0007155|cell adhesion;GO:0055072|iron ion homeostasis;GO:0030513|positive regulation of BMP signaling pathway;","GO:0005794|Golgi apparatus;GO:0005887|integral component of plasma membrane;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0098797|plasma membrane protein complex;","GO:0039706|co-receptor binding;GO:0038023|signaling receptor activity;","K06766","NEO1; neogenin"]
["bta_circ_0006598",0,0,0,14.2910777102032,26,31,26,-7.2683574097926,{"v":1.08255766151095e-05,"d":"1.08E-05"},0.00212771787653334,"down","yes","NC_037337.1:21493019..21518315:+","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0006600",0,2,5,6.90717979989124,10,15,11,-2.54234625332788,0.0237907972085038,0.375453490305658,"down","yes","NC_037337.1:21495458..21496530:+","gene13101","gi|41386711|ref|NP_777152.1|",9177,0,"myosin-7 [Bos taurus]","gi|41386710|ref|NM_174727.1|",5906,0,"Bos taurus myosin, heavy chain 7, cardiac muscle, beta (MYH7), mRNA","Q9BE39",3539,0,"Myosin-7","SPCC645.05c",768,0,"COG5022","pfam01576","Myosin_tail_1","Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.","GO:0007018|microtubule-based movement;","GO:0030016|myofibril;GO:0032982|myosin filament;GO:0030017|sarcomere;","GO:0051015|actin filament binding;GO:0005524|ATP binding;GO:0005516|calmodulin binding;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;","K17751","MYH6_7; myosin heavy chain 6/7"]
["bta_circ_0006606",10,0,2,3.19931985375033,0,0,0,4.68349574607743,0.0173091911847967,"NA","up","yes","NC_037337.1:21503178..21529819:+","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0006607",0,0,0,2.23253239691779,3,0,9,-4.39637119607584,0.0276427456196113,"NA","down","yes","NC_037337.1:21503787..21532718:+","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0006731",0,4,0,5.63894122749139,14,5,9,-3.12561683653797,0.0191651960678741,"NA","down","yes","NC_037337.1:43177987..43214396:-","gene13598","gi|155371911|ref|NP_001094560.1|",2327,0,"L-2-hydroxyglutarate dehydrogenase, mitochondrial precursor [Bos taurus]","gi|155371910|ref|NM_001101090.1|",3265,0,"Bos taurus L-2-hydroxyglutarate dehydrogenase (L2HGDH), mRNA","A7MBI3",902,0,"L-2-hydroxyglutarate dehydrogenase, mitochondrial","alr2826",334,{"v":6e-103,"d":"6.00E-103"},"COG0579","pfam01266","DAO","FAD dependent oxidoreductase. This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.","GO:0044267|cellular protein metabolic process;","GO:0016021|integral component of membrane;GO:0005739|mitochondrion;","GO:0047545|2-hydroxyglutarate dehydrogenase activity;","K00109","E1.1.99.2; 2-hydroxyglutarate dehydrogenase [EC:1.1.99.2]"]
["bta_circ_0006779",3,22,0,2.98239677342144,0,0,0,4.70503893640175,0.0164710551661022,"NA","up","yes","NC_037337.1:47004327..47007762:-","gene13654","gi|830074122|ref|XP_012584089.1|",914,{"v":8e-113,"d":"8.00E-113"},"PREDICTED: tropomyosin alpha-1 chain isoform X6 [Condylura cristata]","gi|850484816|gb|CP011892.1|",1002,0,"Ovis canadensis canadensis isolate 43U chromosome 7 sequence","Q63610",187,{"v":4e-52,"d":"4.00E-52"},"Tropomyosin alpha-3 chain",".",".",".",".","pfam00261","Tropomyosin","Tropomyosin.","GO:0007015|actin filament organization;GO:0007420|brain development;GO:0006936|muscle contraction;","GO:0005884|actin filament;GO:0005903|brush border;GO:0005862|muscle thin filament tropomyosin;","GO:0051015|actin filament binding;GO:0008307|structural constituent of muscle;","K09290","TPM3; tropomyosin 3"]
["bta_circ_0006815",6,5,6,3.00524342576351,0,0,0,4.85333659551062,0.0116024658646809,"NA","up","yes","NC_037337.1:48944579..49055340:+","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0006829",8,11,0,3.40590612614148,0,0,0,4.86243711169298,0.0122187742523383,"NA","up","yes","NC_037337.1:50867791..50869245:-","gene13688","gi|528910572|ref|XP_005193713.1|",1850,0,"PREDICTED: protein FAM81A isoform X1 [Bos taurus]","gi|982989424|ref|XM_005193656.3|",3300,0,"PREDICTED: Bos taurus family with sequence similarity 81 member A (FAM81A), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam12128","DUF3584","Protein of unknown function (DUF3584). This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.",".",".",".",".","."]
["bta_circ_0006839",45,186,113,67.2661289086207,40,46,41,1.04644894673889,0.021404225893497,0.357850317976361,"up","yes","NC_037337.1:51360123..51364223:+","gene13694","gi|982989432|ref|XP_015320565.1|",2494,0,"PREDICTED: LOW QUALITY PROTEIN: SAFB-like transcription modulator isoform X2 [Bos taurus]","gi|742104858|ref|XM_010836819.1|",4086,0,"PREDICTED: Bison bison bison SAFB-like, transcription modulator (SLTM), transcript variant X2, mRNA","Q9NWH9",911,0,"SAFB-like transcription modulator",".",".",".",".","pfam14259","RRM_6","RNA recognition motif (a.k.a. RRM, RBD, or RNP domain).","GO:0006915|apoptotic process;GO:0050684|regulation of mRNA processing;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0006351|transcription, DNA-templated;","GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003690|double-stranded DNA binding;GO:0003723|RNA binding;GO:0043565|sequence-specific DNA binding;",".","."]
["bta_circ_0006850",5,5,0,1.94982608658825,0,0,0,4.04273317719192,0.047352037077062,"NA","up","yes","NC_037337.1:52294320..52296744:+","gene13707","gi|297479648|ref|XP_002690901.1|",2765,0,"PREDICTED: retinal dehydrogenase 2 [Bos taurus]","gi|982989436|ref|XM_015465080.1|",3527,0,"PREDICTED: Bos taurus aldehyde dehydrogenase 1 family member A2 (ALDH1A2), mRNA","O94788",1065,0,"Retinal dehydrogenase 2","SPAC9E9.09c",556,0,"COG1012","pfam00171","Aldedh","Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.","GO:0042904|9-cis-retinoic acid biosynthetic process;GO:0001568|blood vessel development;GO:0048738|cardiac muscle tissue development;GO:0071300|cellular response to retinoic acid;GO:0009855|determination of bilateral symmetry;GO:0031076|embryonic camera-type eye development;GO:0048566|embryonic digestive tract development;GO:0035115|embryonic forelimb morphogenesis;GO:0060324|face development;GO:0003007|heart morphogenesis;GO:0030902|hindbrain development;GO:0001822|kidney development;GO:0001889|liver development;GO:0030324|lung development;GO:0007494|midgut development;GO:0016331|morphogenesis of embryonic epithelium;GO:0008285|negative regulation of cell proliferation;GO:0014032|neural crest cell development;GO:0021915|neural tube development;GO:0030182|neuron differentiation;GO:0031016|pancreas development;GO:0021983|pituitary gland development;GO:0043065|positive regulation of apoptotic process;GO:0008284|positive regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0009954|proximal/distal pattern formation;GO:0001936|regulation of endothelial cell proliferation;GO:0034097|response to cytokine;GO:0032355|response to estradiol;GO:0033189|response to vitamin A;GO:0042574|retinal metabolic process;GO:0042573|retinoic acid metabolic process;GO:0090242|retinoic acid receptor signaling pathway involved in somitogenesis;GO:0042572|retinol metabolic process;GO:0035799|ureter maturation;GO:0006776|vitamin A metabolic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0048471|perinuclear region of cytoplasm;","GO:0004028|3-chloroallyl aldehyde dehydrogenase activity;GO:0004029|aldehyde dehydrogenase (NAD) activity;GO:0016918|retinal binding;GO:0001758|retinal dehydrogenase activity;","K07249","E1.2.1.36; retinal dehydrogenase [EC:1.2.1.36]"]
["bta_circ_0006853",20,33,29,16.7273839606793,9,9,5,1.60719237166792,0.0326048669848197,0.428634275476763,"up","yes","NC_037337.1:53070727..53073155:-","gene13713","gi|118150880|ref|NP_001071353.1|",3024,0,"transcription factor 12 [Bos taurus]","gi|982936879|ref|XM_010809243.2|",4438,0,"PREDICTED: Bos taurus transcription factor 12 (TCF12), transcript variant X1, mRNA","Q99081",1155,0,"Transcription factor 12",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0006955|immune response;GO:0007517|muscle organ development;GO:0045666|positive regulation of neuron differentiation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:1902036|regulation of hematopoietic stem cell differentiation;GO:0006357|regulation of transcription from RNA polymerase II promoter;","GO:0005737|cytoplasm;GO:0043231|intracellular membrane-bounded organelle;GO:0000790|nuclear chromatin;GO:0016607|nuclear speck;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0090575|RNA polymerase II transcription factor complex;","GO:0043425|bHLH transcription factor binding;GO:0035497|cAMP response element binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0070888|E-box binding;GO:0035326|enhancer binding;GO:0071837|HMG box domain binding;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0046332|SMAD binding;GO:0008134|transcription factor binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K15603","TCF4_12; transcription factor 4/12"]
["bta_circ_0006885",0,18,4,2.22433760408464,0,0,0,4.33850725071785,0.0304381007961976,"NA","up","yes","NC_037337.1:5466543..5474845:-","gene12859","gi|528961781|ref|XP_005211286.1|",1957,0,"PREDICTED: histamine H2 receptor isoform X3 [Bos taurus]","gi|982988452|ref|XM_015464945.1|",2668,0,"PREDICTED: Bos taurus histamine receptor H2 (HRH2), transcript variant X5, mRNA","P17124",572,0,"Histamine H2 receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001697|histamine-induced gastric acid secretion;GO:0006955|immune response;GO:0045907|positive regulation of vasoconstriction;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0004969|histamine receptor activity;","K04150","HRH2; histamine receptor H2"]
["bta_circ_0006918",0,0,0,2.18341582164629,4,2,6,-4.54572681100706,0.0201516520610762,"NA","down","yes","NC_037337.1:60226175..60234098:+","gene13785","gi|528966518|ref|XP_005211944.1|",6429,0,"PREDICTED: probable phospholipid-transporting ATPase IM isoform X1 [Bos taurus]","gi|982989649|ref|XM_015465120.1|",5536,0,"PREDICTED: Bos taurus ATPase, class I, type 8B, member 4 (ATP8B4), transcript variant X2, mRNA","Q8TF62",2289,0,"Probable phospholipid-transporting ATPase IM","YAL026c",796,0,"COG0474","pfam13246","Hydrolase_like2","Putative hydrolase of sodium-potassium ATPase alpha subunit. This is a putative hydrolase of the sodium-potassium ATPase alpha subunit.","GO:0007030|Golgi organization;GO:0043312|neutrophil degranulation;","GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;GO:0035579|specific granule membrane;GO:0070821|tertiary granule membrane;","GO:0005524|ATP binding;GO:0000287|magnesium ion binding;GO:0004012|phospholipid-translocating ATPase activity;","K01530","E3.6.3.1; phospholipid-translocating ATPase [EC:3.6.3.1]"]
["bta_circ_0006921",3,0,8,1.89817382131849,0,0,0,4.02213731614572,0.0488771785368658,"NA","up","yes","NC_037337.1:60702315..60707681:-","gene13790","gi|528966417|ref|XP_005211904.1|",1281,{"v":7e-170,"d":"7.00E-170"},"PREDICTED: DTW domain-containing protein 1 isoform X2 [Bos taurus]","gi|982937247|ref|XM_015473193.1|",1906,0,"PREDICTED: Bos taurus DTW domain containing 1 (DTWD1), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam03942","DTW","DTW domain. This presumed domain is found in bacterial and eukaryotic proteins. Its function is unknown. The domain contains multiple conserved motifs including a DTXW motif that this domain has been named after.",".",".",".",".","."]
["bta_circ_0006951",4,25,26,8.05480716298308,0,5,3,2.31311862638713,0.0324229237255322,0.428634275476763,"up","yes","NC_037337.1:68068507..68070990:+","gene13873","gi|528966386|ref|XP_005211889.1|",5692,0,"PREDICTED: kinectin isoform X1 [Bos taurus]","gi|741940727|ref|XM_010809358.1|",4860,0,"PREDICTED: Bos taurus kinectin 1 (KTN1), transcript variant X2, mRNA","Q86UP2",2004,0,"Kinectin",".",".",".",".","pfam02463","SMC_N","RecF/RecN/SMC N terminal domain. This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics.   This family also includes the RecF and RecN proteins that are involved in DNA metabolizm and recombination.","GO:0044267|cellular protein metabolic process;GO:0007018|microtubule-based movement;GO:0043687|post-translational protein modification;","GO:0005783|endoplasmic reticulum;GO:0005788|endoplasmic reticulum lumen;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;","GO:0045296|cadherin binding;GO:0019894|kinesin binding;GO:0003723|RNA binding;","K17975","KTN1; kinectin"]
["bta_circ_0006964",0,0,0,4.65175360514816,12,5,8,-5.66964594923365,0.00182451676545439,"NA","down","yes","NC_037337.1:69631650..69655795:-","gene13884","gi|300794420|ref|NP_001179640.1|",3669,0,"exocyst complex component 5 [Bos taurus]","gi|982937220|ref|XM_015473190.1|",5510,0,"PREDICTED: Bos taurus exocyst complex component 5 (EXOC5), transcript variant X1, mRNA","O00471",1390,0,"Exocyst complex component 5",".",".",".",".","pfam07393","Sec10","Exocyst complex component Sec10. This family contains the Sec10 component (approximately 650 residues long) of the eukaryotic exocyst complex, which specifically affects the synthesis and delivery of secretory and basolateral plasma membrane proteins.","GO:0006887|exocytosis;GO:0006893|Golgi to plasma membrane transport;GO:0006892|post-Golgi vesicle-mediated transport;GO:0015031|protein transport;GO:0048278|vesicle docking;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0000145|exocyst;GO:0030496|midbody;","GO:0047485|protein N-terminus binding;GO:0017160|Ral GTPase binding;",".","."]
["bta_circ_0006983",0,0,0,2.19133957792603,3,5,5,-4.58425690713011,0.0186590915750957,"NA","down","yes","NC_037337.1:72976684..72989829:+","gene13930","gi|594038643|ref|XP_006043933.1|",1251,{"v":6e-168,"d":"6.00E-168"},"PREDICTED: CDK-activating kinase assembly factor MAT1 isoform X2 [Bubalus bubalis]","gi|982937561|ref|XR_236196.3|",1514,0,"PREDICTED: Bos taurus MNAT CDK-activating kinase assembly factor 1 (MNAT1), transcript variant X1, misc_RNA","P51948",414,{"v":4e-158,"d":"4.00E-158"},"CDK-activating kinase assembly factor MAT1","SPBC776.18c",135,{"v":8e-35,"d":"8.00E-35"},"COG5220","pfam06391","MAT1","CDK-activating kinase assembly factor MAT1. MAT1 is an assembly/targeting factor for cyclin-dependent kinase-activating kinase (CAK), which interacts with the transcription factor TFIIH. The domain found to the N-terminal side of this domain is a C3HC4 RING finger.","GO:0006370|7-methylguanosine mRNA capping;GO:0007512|adult heart development;GO:0008283|cell proliferation;GO:0006281|DNA repair;GO:0000082|G1/S transition of mitotic cell cycle;GO:0043066|negative regulation of apoptotic process;GO:0006294|nucleotide-excision repair, preincision complex assembly;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0006468|protein phosphorylation;GO:0065003|macromolecular complex assembly;GO:0000079|regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0051592|response to calcium ion;GO:0006363|termination of RNA polymerase I transcription;GO:0006366|transcription from RNA polymerase II promoter;GO:0006368|transcription elongation from RNA polymerase II promoter;GO:0006361|transcription initiation from RNA polymerase I promoter;GO:0006367|transcription initiation from RNA polymerase II promoter;GO:0006283|transcription-coupled nucleotide-excision repair;GO:0021591|ventricular system development;","GO:0005829|cytosol;GO:0005675|holo TFIIH complex;GO:0005654|nucleoplasm;","GO:0061575|cyclin-dependent protein serine/threonine kinase activator activity;GO:0047485|protein N-terminus binding;GO:0008270|zinc ion binding;","K10842","MNAT1; CDK-activating kinase assembly factor MAT1"]
["bta_circ_0007028",0,0,0,1.99030191578497,0,7,6,-4.27148943016322,0.0334416442708374,"NA","down","yes","NC_037337.1:79185632..79220274:+","gene13997","gi|329664248|ref|NP_001192880.1|",3388,0,"MAGUK p55 subfamily member 5 [Bos taurus]","gi|329664247|ref|NM_001205951.1|",6598,0,"Bos taurus membrane protein, palmitoylated 5 (MPP5), mRNA","Q8N3R9",1290,0,"MAGUK p55 subfamily member 5","YDR454c",124,{"v":2e-30,"d":"2.00E-30"},"COG0194","pfam00625","Guanylate_kin","Guanylate kinase.","GO:0070830|bicellular tight junction assembly;GO:0090162|establishment of epithelial cell polarity;GO:0002011|morphogenesis of an epithelial sheet;GO:0032288|myelin assembly;GO:0032287|peripheral nervous system myelin maintenance;GO:0035750|protein localization to myelin sheath abaxonal region;GO:0072659|protein localization to plasma membrane;","GO:0005923|bicellular tight junction;GO:0005913|cell-cell adherens junction;GO:0005737|cytoplasm;GO:0012505|endomembrane system;GO:0070062|extracellular exosome;GO:0043219|lateral loop;GO:0035749|myelin sheath adaxonal region;GO:0005886|plasma membrane;GO:0032991|macromolecular complex;GO:0043220|Schmidt-Lanterman incisure;","GO:0019904|protein domain specific binding;","K06091","MPP5, PALS1; MAGUK p55 subfamily member 5"]
["bta_circ_0007029",0,0,8,9.71885089502297,9,35,12,-2.78356433156838,0.0148649146666246,0.298906981742218,"down","yes","NC_037337.1:79185632..79230004:+","gene13997","gi|329664248|ref|NP_001192880.1|",3388,0,"MAGUK p55 subfamily member 5 [Bos taurus]","gi|329664247|ref|NM_001205951.1|",6598,0,"Bos taurus membrane protein, palmitoylated 5 (MPP5), mRNA","Q8N3R9",1290,0,"MAGUK p55 subfamily member 5","YDR454c",124,{"v":2e-30,"d":"2.00E-30"},"COG0194","pfam00625","Guanylate_kin","Guanylate kinase.","GO:0070830|bicellular tight junction assembly;GO:0090162|establishment of epithelial cell polarity;GO:0002011|morphogenesis of an epithelial sheet;GO:0032288|myelin assembly;GO:0032287|peripheral nervous system myelin maintenance;GO:0035750|protein localization to myelin sheath abaxonal region;GO:0072659|protein localization to plasma membrane;","GO:0005923|bicellular tight junction;GO:0005913|cell-cell adherens junction;GO:0005737|cytoplasm;GO:0012505|endomembrane system;GO:0070062|extracellular exosome;GO:0043219|lateral loop;GO:0035749|myelin sheath adaxonal region;GO:0005886|plasma membrane;GO:0032991|macromolecular complex;GO:0043220|Schmidt-Lanterman incisure;","GO:0019904|protein domain specific binding;","K06091","MPP5, PALS1; MAGUK p55 subfamily member 5"]
["bta_circ_0007032",0,0,0,2.85634395285614,3,10,5,-4.98641282107461,0.00865596644331714,"NA","down","yes","NC_037337.1:79191716..79212041:+","gene13997","gi|329664248|ref|NP_001192880.1|",3388,0,"MAGUK p55 subfamily member 5 [Bos taurus]","gi|329664247|ref|NM_001205951.1|",6598,0,"Bos taurus membrane protein, palmitoylated 5 (MPP5), mRNA","Q8N3R9",1290,0,"MAGUK p55 subfamily member 5","YDR454c",124,{"v":2e-30,"d":"2.00E-30"},"COG0194","pfam00625","Guanylate_kin","Guanylate kinase.","GO:0070830|bicellular tight junction assembly;GO:0090162|establishment of epithelial cell polarity;GO:0002011|morphogenesis of an epithelial sheet;GO:0032288|myelin assembly;GO:0032287|peripheral nervous system myelin maintenance;GO:0035750|protein localization to myelin sheath abaxonal region;GO:0072659|protein localization to plasma membrane;","GO:0005923|bicellular tight junction;GO:0005913|cell-cell adherens junction;GO:0005737|cytoplasm;GO:0012505|endomembrane system;GO:0070062|extracellular exosome;GO:0043219|lateral loop;GO:0035749|myelin sheath adaxonal region;GO:0005886|plasma membrane;GO:0032991|macromolecular complex;GO:0043220|Schmidt-Lanterman incisure;","GO:0019904|protein domain specific binding;","K06091","MPP5, PALS1; MAGUK p55 subfamily member 5"]
["bta_circ_0007084",6,0,6,2.52826944642969,0,0,0,4.41461388887891,0.0269418276607691,"NA","up","yes","NC_037337.1:83482310..83519543:+","gene14059","gi|528967073|ref|XP_005212157.1|",2872,0,"PREDICTED: regulator of G-protein signaling 6 isoform X1 [Bos taurus]","gi|982990032|ref|XM_015465212.1|",3000,0,"PREDICTED: Bos taurus regulator of G-protein signaling 6 (RGS6), transcript variant X4, mRNA","P49758",941,0,"Regulator of G-protein signaling 6",".",".",".",".","pfam00615","RGS","Regulator of G protein signaling domain. RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.","GO:0007186|G-protein coupled receptor signaling pathway;GO:0035556|intracellular signal transduction;GO:0009968|negative regulation of signal transduction;GO:0043547|positive regulation of GTPase activity;GO:0008277|regulation of G-protein coupled receptor protein signaling pathway;","GO:0005829|cytosol;GO:0019898|extrinsic component of membrane;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0005096|GTPase activator activity;","K16449","RGS; regulator of G-protein signaling"]
["bta_circ_0007089",0,0,0,2.46290947967513,2,6,7,-4.75153323868241,0.0138104914034392,"NA","down","yes","NC_037337.1:84528781..84529722:-","gene14065","gi|426233626|ref|XP_004010816.1|",3293,0,"PREDICTED: zinc finger FYVE domain-containing protein 1 isoform X1 [Ovis aries]","gi|982937575|ref|XM_010809489.2|",3256,0,"PREDICTED: Bos taurus zinc finger, FYVE domain containing 1 (ZFYVE1), transcript variant X2, mRNA","Q9HBF4",1251,0,"Zinc finger FYVE domain-containing protein 1",".",".",".",".","pfam01363","FYVE","FYVE zinc finger. The FYVE zinc finger is named after four proteins that it has been found in: Fab1, YOTB/ZK632.12, Vac1, and EEA1. The FYVE finger has been shown to bind two Zn++ ions. The FYVE finger has eight potential zinc coordinating cysteine positions. Many members of this family also include two histidines in a motif R+HHC+XCG, where + represents a charged residue and X any residue. We have included members which do not conserve these histidine residues but are clearly related.","GO:0009267|cellular response to starvation;GO:0016236|macroautophagy;GO:0010923|negative regulation of phosphatase activity;","GO:0005776|autophagosome;GO:0005783|endoplasmic reticulum;GO:0044233|ER-mitochondrion membrane contact site;GO:0097629|extrinsic component of omegasome membrane;GO:0005795|Golgi stack;GO:1990462|omegasome;GO:0048471|perinuclear region of cytoplasm;GO:0000407|pre-autophagosomal structure;","GO:0005545|1-phosphatidylinositol binding;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325|phosphatidylinositol-3,4-bisphosphate binding;GO:0008270|zinc ion binding;","K17603","ZFYVE1; zinc finger FYVE domain-containing protein 1"]
["bta_circ_0007171",27,51,63,27.3814473382628,9,15,15,1.61857404488037,0.00890322060650104,0.24677901219558,"up","yes","NC_037338.1:101757040..101762410:-","gene15498","gi|594055954|ref|XP_006052192.1|",4504,0,"PREDICTED: rap guanine nucleotide exchange factor 1-like isoform X1 [Bubalus bubalis]","gi|982939851|ref|XM_015473640.1|",3153,0,"PREDICTED: Bos taurus Rap guanine nucleotide exchange factor 1 (RAPGEF1), transcript variant X19, mRNA","Q13905",1056,0,"Rap guanine nucleotide exchange factor 1",".",".",".",".","pfam00617","RasGEF","RasGEF domain. Guanine nucleotide exchange factor for Ras-like small GTPases.","GO:0000186|activation of MAPKK activity;GO:0001568|blood vessel development;GO:0098609|cell-cell adhesion;GO:0071320|cellular response to cAMP;GO:1990090|cellular response to nerve growth factor stimulus;GO:0019221|cytokine-mediated signaling pathway;GO:0061028|establishment of endothelial barrier;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:2000178|negative regulation of neural precursor cell proliferation;GO:0051898|negative regulation of protein kinase B signaling;GO:0046580|negative regulation of Ras protein signal transduction;GO:0038180|nerve growth factor signaling pathway;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0043547|positive regulation of GTPase activity;GO:0010976|positive regulation of neuron projection development;GO:0032486|Rap protein signal transduction;GO:1901888|regulation of cell junction assembly;GO:0046328|regulation of JNK cascade;GO:0007165|signal transduction;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005769|early endosome;GO:0005768|endosome;GO:0048471|perinuclear region of cytoplasm;GO:0030670|phagocytic vesicle membrane;GO:0032991|macromolecular complex;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0017034|Rap guanyl-nucleotide exchange factor activity;GO:0017124|SH3 domain binding;","K06277","RAPGEF1, GRF2; Rap guanine nucleotide exchange factor 1"]
["bta_circ_0007184",0,0,0,3.14447846198609,6,6,6,-5.12619574570499,0.00640122907609796,"NA","down","yes","NC_037338.1:102361303..102374858:-","gene15505","gi|742189572|ref|XP_010855080.1|",13802,0,"PREDICTED: probable helicase senataxin isoform X1 [Bison bison bison]","gi|982991376|ref|XM_015465520.1|",10607,0,"PREDICTED: Bos taurus senataxin (SETX), mRNA","Q7Z333",3996,0,"Probable helicase senataxin","SPAC6G9.10c",267,{"v":1e-70,"d":"1.00E-70"},"COG1112","pfam13087","AAA_12","AAA domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.","GO:0006974|cellular response to DNA damage stimulus;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0070301|cellular response to hydrogen peroxide;GO:0034599|cellular response to oxidative stress;GO:0071300|cellular response to retinoic acid;GO:0007623|circadian rhythm;GO:0006310|DNA recombination;GO:0006353|DNA-templated transcription, termination;GO:0006302|double-strand break repair;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0000165|MAPK cascade;GO:0006376|mRNA splice site selection;GO:0043066|negative regulation of apoptotic process;GO:2000144|positive regulation of DNA-templated transcription, initiation;GO:0060566|positive regulation of DNA-templated transcription, termination;GO:0010976|positive regulation of neuron projection development;GO:0033120|positive regulation of RNA splicing;GO:2000806|positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0043491|protein kinase B signaling;GO:0006396|RNA processing;GO:0007283|spermatogenesis;GO:0006369|termination of RNA polymerase II transcription;","GO:0030424|axon;GO:0000781|chromosome, telomeric region;GO:0005737|cytoplasm;GO:0030426|growth cone;GO:0045171|intercellular bridge;GO:0016604|nuclear body;GO:0000228|nuclear chromosome;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0003677|DNA binding;GO:0003678|DNA helicase activity;GO:0042802|identical protein binding;GO:0001147|transcription termination site sequence-specific DNA binding;","K10706","SETX, ALS4; senataxin [EC:3.6.4.-]"]
["bta_circ_0007193",12,33,21,39.6906929348367,32,73,78,-1.68528139779622,0.00235677793619625,0.108411785065027,"down","yes","NC_037338.1:103422207..103423378:-","gene15532","gi|741944288|ref|XP_010808697.1|",7733,0,"PREDICTED: calmodulin-regulated spectrin-associated protein 1 isoform X1 [Bos taurus]","gi|982939756|ref|XM_010810395.2|",6363,0,"PREDICTED: Bos taurus calmodulin regulated spectrin associated protein 1 (CAMSAP1), transcript variant X1, mRNA","Q5T5Y3",2281,0,"Calmodulin-regulated spectrin-associated protein 1",".",".",".",".","pfam08683","CAMSAP_CKK","Microtubule-binding calmodulin-regulated spectrin-associated. This is the C-terminal domain of a family of eumetazoan proteins collectively defined as calmodulin-regulated spectrin-associated, or CAMSAP, proteins. CAMSAP proteins carry an N-terminal region that includes the CH domain, a central region including a predicted coiled-coil and this C-terminal, or CKK, domain - defined as being present in CAMSAP, KIAA1078 and KIAA1543, The C-terminal domain is the part of the CAMSAP proteins that binds to microtubules. The domain appears to act by producing inhibition of neurite extension, probably by blocking microtubule function. CKK represents a domain that has evolved with the metazoa. The structure of a murine hypothetical protein from RIKEN cDNA has shown the domain to adopt a mainly beta barrel structure with an associated alpha-helical hairpin.","GO:0007010|cytoskeleton organization;GO:0000226|microtubule cytoskeleton organization;GO:0031175|neuron projection development;GO:0022604|regulation of cell morphogenesis;GO:0031113|regulation of microtubule polymerization;","GO:0005737|cytoplasm;GO:0005874|microtubule;","GO:0005516|calmodulin binding;GO:0008017|microtubule binding;GO:0051011|microtubule minus-end binding;GO:0030507|spectrin binding;","K17493","CAMSAP; calmodulin-regulated spectrin-associated protein"]
["bta_circ_0007194",0,6,13,2.22087043027005,0,0,0,4.33421308505599,0.030571871631996,"NA","up","yes","NC_037338.1:10424929..10436840:-","gene14431","gi|594041888|ref|XP_006045485.1|",1728,0,"PREDICTED: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Bubalus bubalis]","gi|402693352|ref|NM_001075755.2|",1640,0,"Bos taurus methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (MTHFD2), mRNA","Q0P5C2",666,0,"Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial","BS_folD",249,{"v":5e-77,"d":"5.00E-77"},"COG0190","pfam02882","THF_DHG_CYH_C","Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain.","GO:0006730|one-carbon metabolic process;GO:0046653|tetrahydrofolate metabolic process;","GO:0005739|mitochondrion;","GO:0000287|magnesium ion binding;GO:0004477|methenyltetrahydrofolate cyclohydrolase activity;GO:0004487|methylenetetrahydrofolate dehydrogenase (NAD+) activity;GO:0004488|methylenetetrahydrofolate dehydrogenase (NADP+) activity;GO:0042301|phosphate ion binding;","K13403","MTHFD2; methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.15 3.5.4.9]"]
["bta_circ_0007212",0,8,25,4.19935560742437,0,2,0,3.14364057618116,0.0466212460967768,"NA","up","yes","NC_037338.1:106638949..106652953:+","gene15673","gi|149642797|ref|NP_001092511.1|",6097,0,"histone-lysine N-methyltransferase EHMT1 [Bos taurus]","gi|149642796|ref|NM_001099041.1|",4369,0,"Bos taurus euchromatic histone-lysine N-methyltransferase 1 (EHMT1), mRNA","Q9H9B1",2085,0,"Histone-lysine N-methyltransferase EHMT1","SPBC428.08c",143,{"v":2e-34,"d":"2.00E-34"},"COG2940","pfam05033","Pre-SET","Pre-SET motif. This protein motif is a zinc binding motif. It contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains.","GO:0006325|chromatin organization;GO:0006306|DNA methylation;GO:0009790|embryo development;GO:0016571|histone methylation;GO:0070317|negative regulation of G0 to G1 transition;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0018027|peptidyl-lysine dimethylation;GO:0018026|peptidyl-lysine monomethylation;GO:0060992|response to fungicide;","GO:0005694|chromosome;GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0070742|C2H2 zinc finger domain binding;GO:0046976|histone methyltransferase activity (H3-K27 specific);GO:0046974|histone methyltransferase activity (H3-K9 specific);GO:0018024|histone-lysine N-methyltransferase activity;GO:0008168|methyltransferase activity;GO:0002039|p53 binding;GO:0016279|protein-lysine N-methyltransferase activity;GO:0008270|zinc ion binding;","K11420","EHMT; euchromatic histone-lysine N-methyltransferase [EC:2.1.1.43]"]
["bta_circ_0007218",16,168,72,35.6614764579442,7,15,13,2.32669593060569,0.000239853872872576,0.0225462640500222,"up","yes","NC_037338.1:106649994..106657077:+","gene15673","gi|149642797|ref|NP_001092511.1|",6097,0,"histone-lysine N-methyltransferase EHMT1 [Bos taurus]","gi|149642796|ref|NM_001099041.1|",4369,0,"Bos taurus euchromatic histone-lysine N-methyltransferase 1 (EHMT1), mRNA","Q9H9B1",2085,0,"Histone-lysine N-methyltransferase EHMT1","SPBC428.08c",143,{"v":2e-34,"d":"2.00E-34"},"COG2940","pfam05033","Pre-SET","Pre-SET motif. This protein motif is a zinc binding motif. It contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains.","GO:0006325|chromatin organization;GO:0006306|DNA methylation;GO:0009790|embryo development;GO:0016571|histone methylation;GO:0070317|negative regulation of G0 to G1 transition;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0018027|peptidyl-lysine dimethylation;GO:0018026|peptidyl-lysine monomethylation;GO:0060992|response to fungicide;","GO:0005694|chromosome;GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0070742|C2H2 zinc finger domain binding;GO:0046976|histone methyltransferase activity (H3-K27 specific);GO:0046974|histone methyltransferase activity (H3-K9 specific);GO:0018024|histone-lysine N-methyltransferase activity;GO:0008168|methyltransferase activity;GO:0002039|p53 binding;GO:0016279|protein-lysine N-methyltransferase activity;GO:0008270|zinc ion binding;","K11420","EHMT; euchromatic histone-lysine N-methyltransferase [EC:2.1.1.43]"]
["bta_circ_0007262",12,30,30,13.2258930170922,4,7,7,1.68646243267333,0.0349748260564763,0.439730132358439,"up","yes","NC_037338.1:13048482..13051370:-","gene14469","gi|156523092|ref|NP_001095960.1|",10680,0,"dysferlin [Bos taurus]","gi|402745129|ref|NM_001102490.2|",6990,0,"Bos taurus dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) (DYSF), mRNA","A6QQP7",4119,0,"Dysferlin",".",".",".",".","pfam08150","FerB","FerB (NUC096) domain. This is central domain B in proteins of the Ferlin family.","GO:0006906|vesicle fusion;","GO:0030659|cytoplasmic vesicle membrane;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;GO:0042383|sarcolemma;","GO:0005509|calcium ion binding;GO:0005543|phospholipid binding;","K18261","DYSF; dysferlin"]
["bta_circ_0007265",9,24,18,47.5953531783001,82,85,65,-2.45510155599406,{"v":3.46809758320013e-06,"d":"3.47E-06"},0.000937253371859835,"down","yes","NC_037338.1:13162077..13167647:-","gene14472","gi|803237576|ref|XP_011978911.1|",8614,0,"PREDICTED: zinc finger protein 638 isoform X2 [Ovis aries musimon]","gi|300794827|ref|NM_001192476.1|",5900,0,"Bos taurus zinc finger protein 638 (ZNF638), mRNA","Q14966",2672,0,"Zinc finger protein 638",".",".",".",".","pfam14259","RRM_6","RNA recognition motif (a.k.a. RRM, RBD, or RNP domain).","GO:0006355|regulation of transcription, DNA-templated;GO:0008380|RNA splicing;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0043231|intracellular membrane-bounded organelle;GO:0016607|nuclear speck;GO:0005654|nucleoplasm;","GO:0003690|double-stranded DNA binding;GO:0003723|RNA binding;GO:0008270|zinc ion binding;",".","."]
["bta_circ_0007268",0,3,0,4.25008376383906,3,17,6,-3.06994796384518,0.0332932208157808,"NA","down","yes","NC_037338.1:13162077..13188546:-","gene14472","gi|803237576|ref|XP_011978911.1|",8614,0,"PREDICTED: zinc finger protein 638 isoform X2 [Ovis aries musimon]","gi|300794827|ref|NM_001192476.1|",5900,0,"Bos taurus zinc finger protein 638 (ZNF638), mRNA","Q14966",2672,0,"Zinc finger protein 638",".",".",".",".","pfam14259","RRM_6","RNA recognition motif (a.k.a. RRM, RBD, or RNP domain).","GO:0006355|regulation of transcription, DNA-templated;GO:0008380|RNA splicing;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0043231|intracellular membrane-bounded organelle;GO:0016607|nuclear speck;GO:0005654|nucleoplasm;","GO:0003690|double-stranded DNA binding;GO:0003723|RNA binding;GO:0008270|zinc ion binding;",".","."]
["bta_circ_0007307",0,16,19,20.0784759058871,27,38,30,-1.87146788685509,0.0166686551844934,0.308013953067305,"down","yes","NC_037338.1:14902219..14914837:+","gene14502","gi|426223849|ref|XP_004006086.1|",964,{"v":1e-114,"d":"1.00E-114"},"PREDICTED: protein YIPF4 [Ovis aries]","gi|850480667|gb|CP011888.1|",5994,0,"Ovis canadensis canadensis isolate 43U chromosome 3 sequence","Q9BSR8",362,{"v":2e-111,"d":"2.00E-111"},"Protein YIPF4",".",".",".",".","pfam04893","Yip1","Yip1 domain. The Yip1 integral membrane domain contains four transmembrane alpha helices. The domain is characterized by the motifs DLYGP and GY. The Yip1 protein is a golgi protein involved in vesicular transport that interacts with GTPases.",".","GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0005886|plasma membrane;",".",".","."]
["bta_circ_0007322",0,13,9,2.38140272285447,0,0,0,4.4545707609125,0.0250818000638939,"NA","up","yes","NC_037338.1:153295..160777:-","gene14255","gi|296482845|tpg|DAA24960.1|",4518,0,"TPA: suppressor of sable-like [Bos taurus]","gi|982990254|ref|XM_582657.8|",9444,0,"PREDICTED: Bos taurus zinc finger CCCH-type containing 6 (ZC3H6), mRNA","P61129",1437,0,"Zinc finger CCCH domain-containing protein 6","SPAC227.08c",53.1,{"v":2e-06,"d":"2.00E-06"},"COG5084","pfam00642","zf-CCCH","Zinc finger C-x8-C-x5-C-x3-H type (and similar).",".",".","GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;",".","."]
["bta_circ_0007327",0,0,0,3.19038248998323,6,9,4,-5.14839595329827,0.00612135411860774,"NA","down","yes","NC_037338.1:15774098..15800558:+","gene14507","gi|926703802|ref|XP_013822980.1|",8386,0,"PREDICTED: latent-transforming growth factor beta-binding protein 1 [Capra hircus]","gi|926703801|ref|XM_013967526.1|",5499,0,"PREDICTED: Capra hircus latent transforming growth factor beta binding protein 1 (LTBP1), mRNA","Q14766",3053,0,"Latent-transforming growth factor beta-binding protein 1",".",".",".",".","pfam00683","TB","TB domain. This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.","GO:0035904|aorta development;GO:0044267|cellular protein metabolic process;GO:0060976|coronary vasculature development;GO:0043687|post-translational protein modification;GO:0035583|sequestering of TGFbeta in extracellular matrix;GO:0003281|ventricular septum development;","GO:0005788|endoplasmic reticulum lumen;GO:0031012|extracellular matrix;GO:0005576|extracellular region;GO:0001527|microfibril;GO:0032991|macromolecular complex;","GO:0005509|calcium ion binding;GO:0050436|microfibril binding;GO:0050431|transforming growth factor beta binding;GO:0005024|transforming growth factor beta-activated receptor activity;","K19559","LTBP1; latent transforming growth factor beta binding protein 1"]
["bta_circ_0007330",0,0,0,2.22931984964342,4,5,4,-4.60929273841918,0.017816584444644,"NA","down","yes","NC_037338.1:15779367..15800558:+","gene14507","gi|926703802|ref|XP_013822980.1|",8386,0,"PREDICTED: latent-transforming growth factor beta-binding protein 1 [Capra hircus]","gi|926703801|ref|XM_013967526.1|",5499,0,"PREDICTED: Capra hircus latent transforming growth factor beta binding protein 1 (LTBP1), mRNA","Q14766",3053,0,"Latent-transforming growth factor beta-binding protein 1",".",".",".",".","pfam00683","TB","TB domain. This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.","GO:0035904|aorta development;GO:0044267|cellular protein metabolic process;GO:0060976|coronary vasculature development;GO:0043687|post-translational protein modification;GO:0035583|sequestering of TGFbeta in extracellular matrix;GO:0003281|ventricular septum development;","GO:0005788|endoplasmic reticulum lumen;GO:0031012|extracellular matrix;GO:0005576|extracellular region;GO:0001527|microfibril;GO:0032991|macromolecular complex;","GO:0005509|calcium ion binding;GO:0050436|microfibril binding;GO:0050431|transforming growth factor beta binding;GO:0005024|transforming growth factor beta-activated receptor activity;","K19559","LTBP1; latent transforming growth factor beta binding protein 1"]
["bta_circ_0007332",5,8,19,20.1832783021526,31,27,30,-1.69334486441403,0.0194486637993501,0.333714374080912,"down","yes","NC_037338.1:15784705..15800558:+","gene14507","gi|926703802|ref|XP_013822980.1|",8386,0,"PREDICTED: latent-transforming growth factor beta-binding protein 1 [Capra hircus]","gi|926703801|ref|XM_013967526.1|",5499,0,"PREDICTED: Capra hircus latent transforming growth factor beta binding protein 1 (LTBP1), mRNA","Q14766",3053,0,"Latent-transforming growth factor beta-binding protein 1",".",".",".",".","pfam00683","TB","TB domain. This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.","GO:0035904|aorta development;GO:0044267|cellular protein metabolic process;GO:0060976|coronary vasculature development;GO:0043687|post-translational protein modification;GO:0035583|sequestering of TGFbeta in extracellular matrix;GO:0003281|ventricular septum development;","GO:0005788|endoplasmic reticulum lumen;GO:0031012|extracellular matrix;GO:0005576|extracellular region;GO:0001527|microfibril;GO:0032991|macromolecular complex;","GO:0005509|calcium ion binding;GO:0050436|microfibril binding;GO:0050431|transforming growth factor beta binding;GO:0005024|transforming growth factor beta-activated receptor activity;","K19559","LTBP1; latent transforming growth factor beta binding protein 1"]
["bta_circ_0007334",0,0,0,1.81682531662855,6,0,3,-4.07202804938129,0.0451988578118341,"NA","down","yes","NC_037338.1:15800439..15823261:+","gene14507","gi|926703802|ref|XP_013822980.1|",8386,0,"PREDICTED: latent-transforming growth factor beta-binding protein 1 [Capra hircus]","gi|926703801|ref|XM_013967526.1|",5499,0,"PREDICTED: Capra hircus latent transforming growth factor beta binding protein 1 (LTBP1), mRNA","Q14766",3053,0,"Latent-transforming growth factor beta-binding protein 1",".",".",".",".","pfam00683","TB","TB domain. This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.","GO:0035904|aorta development;GO:0044267|cellular protein metabolic process;GO:0060976|coronary vasculature development;GO:0043687|post-translational protein modification;GO:0035583|sequestering of TGFbeta in extracellular matrix;GO:0003281|ventricular septum development;","GO:0005788|endoplasmic reticulum lumen;GO:0031012|extracellular matrix;GO:0005576|extracellular region;GO:0001527|microfibril;GO:0032991|macromolecular complex;","GO:0005509|calcium ion binding;GO:0050436|microfibril binding;GO:0050431|transforming growth factor beta binding;GO:0005024|transforming growth factor beta-activated receptor activity;","K19559","LTBP1; latent transforming growth factor beta binding protein 1"]
["bta_circ_0007338",0,2,0,3.4603451724259,7,4,7,-3.20020236046003,0.0373078981376408,"NA","down","yes","NC_037338.1:18854667..18908268:+","gene14519","gi|328802685|ref|NP_001192227.1|",5207,0,"cysteine-rich motor neuron 1 protein precursor [Bos taurus]","gi|328802684|ref|NM_001205298.1|",5469,0,"Bos taurus cysteine rich transmembrane BMP regulator 1 (chordin-like) (CRIM1), mRNA","Q9JLL0",1825,0,"Cysteine-rich motor neuron 1 protein",".",".",".",".","pfam00093","VWC","von Willebrand factor type C domain. The high cutoff was used to prevent overlap with pfam00094.","GO:0001558|regulation of cell growth;","GO:0005576|extracellular region;GO:0016021|integral component of membrane;","GO:0005520|insulin-like growth factor binding;GO:0030165|PDZ domain binding;GO:0004867|serine-type endopeptidase inhibitor activity;",".","."]
["bta_circ_0007370",0,0,0,1.72430016581292,0,5,6,-4.0436666411325,0.0469482969777028,"NA","down","yes","NC_037338.1:21571080..21594658:-","gene14563","gi|803257192|ref|XP_011988487.1|",4508,0,"PREDICTED: mitogen-activated protein kinase kinase kinase kinase 3 isoform X2 [Ovis aries musimon]","gi|965834964|ref|XM_012133097.2|",4076,0,"PREDICTED: Ovis aries musimon mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3), transcript variant X2, mRNA","Q8IVH8",1659,0,"Mitogen-activated protein kinase kinase kinase kinase 3",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0035556|intracellular signal transduction;GO:0007254|JNK cascade;GO:0006468|protein phosphorylation;GO:0042981|regulation of apoptotic process;GO:0007346|regulation of mitotic cell cycle;GO:0034612|response to tumor necrosis factor;GO:0009411|response to UV;","GO:0005737|cytoplasm;","GO:0005524|ATP binding;GO:0008349|MAP kinase kinase kinase kinase activity;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;","K04406","MAP4K3, GLK; mitogen-activated protein kinase kinase kinase kinase 3 [EC:2.7.11.1]"]
["bta_circ_0007407",0,0,0,2.25630366575701,0,9,6,-4.46621002659337,0.0244722623883128,"NA","down","yes","NC_037338.1:27973554..27976396:-","gene14626","gi|741942668|ref|XP_005212665.2|",4868,0,"PREDICTED: S1 RNA-binding domain-containing protein 1 isoform X1 [Bos taurus]","gi|982938686|ref|XM_005212608.3|",3249,0,"PREDICTED: Bos taurus S1 RNA binding domain 1 (SRBD1), transcript variant X1, mRNA","Q8N5C6",1683,0,"S1 RNA-binding domain-containing protein 1","CAC2842",431,{"v":4e-133,"d":"4.00E-133"},"COG2183","pfam09371","Tex_N","Tex-like protein N-terminal domain. This presumed domain is found at the N-terminus of Bordetella pertussis tex. This protein defines a novel family of prokaryotic transcriptional accessory factors.","GO:0006139|nucleobase-containing compound metabolic process;",".","GO:0003723|RNA binding;",".","."]
["bta_circ_0007408",4,11,8,13.3104702427545,16,26,18,-1.59091179434153,0.0425274284099713,0.456494092506297,"down","yes","NC_037338.1:27973554..27995478:-","gene14626","gi|741942668|ref|XP_005212665.2|",4868,0,"PREDICTED: S1 RNA-binding domain-containing protein 1 isoform X1 [Bos taurus]","gi|982938686|ref|XM_005212608.3|",3249,0,"PREDICTED: Bos taurus S1 RNA binding domain 1 (SRBD1), transcript variant X1, mRNA","Q8N5C6",1683,0,"S1 RNA-binding domain-containing protein 1","CAC2842",431,{"v":4e-133,"d":"4.00E-133"},"COG2183","pfam09371","Tex_N","Tex-like protein N-terminal domain. This presumed domain is found at the N-terminus of Bordetella pertussis tex. This protein defines a novel family of prokaryotic transcriptional accessory factors.","GO:0006139|nucleobase-containing compound metabolic process;",".","GO:0003723|RNA binding;",".","."]
["bta_circ_0007412",0,0,2,5.14131447892401,10,10,8,-3.62618770122581,0.00891594664157572,"NA","down","yes","NC_037338.1:27973554..28035043:-","gene14626","gi|741942668|ref|XP_005212665.2|",4868,0,"PREDICTED: S1 RNA-binding domain-containing protein 1 isoform X1 [Bos taurus]","gi|982938686|ref|XM_005212608.3|",3249,0,"PREDICTED: Bos taurus S1 RNA binding domain 1 (SRBD1), transcript variant X1, mRNA","Q8N5C6",1683,0,"S1 RNA-binding domain-containing protein 1","CAC2842",431,{"v":4e-133,"d":"4.00E-133"},"COG2183","pfam09371","Tex_N","Tex-like protein N-terminal domain. This presumed domain is found at the N-terminus of Bordetella pertussis tex. This protein defines a novel family of prokaryotic transcriptional accessory factors.","GO:0006139|nucleobase-containing compound metabolic process;",".","GO:0003723|RNA binding;",".","."]
["bta_circ_0007413",8,0,5,2.99060246971074,0,0,0,4.63797948579638,0.0185276693965288,"NA","up","yes","NC_037338.1:27991449..27999032:-","gene14626","gi|741942668|ref|XP_005212665.2|",4868,0,"PREDICTED: S1 RNA-binding domain-containing protein 1 isoform X1 [Bos taurus]","gi|982938686|ref|XM_005212608.3|",3249,0,"PREDICTED: Bos taurus S1 RNA binding domain 1 (SRBD1), transcript variant X1, mRNA","Q8N5C6",1683,0,"S1 RNA-binding domain-containing protein 1","CAC2842",431,{"v":4e-133,"d":"4.00E-133"},"COG2183","pfam09371","Tex_N","Tex-like protein N-terminal domain. This presumed domain is found at the N-terminus of Bordetella pertussis tex. This protein defines a novel family of prokaryotic transcriptional accessory factors.","GO:0006139|nucleobase-containing compound metabolic process;",".","GO:0003723|RNA binding;",".","."]
["bta_circ_0007437",0,0,0,2.51980996327606,7,5,2,-4.76013171023181,0.0136379613199816,"NA","down","yes","NC_037338.1:3136703..3142760:-","gene14323","gi|297480081|ref|XP_002691187.1|",7927,0,"PREDICTED: transmembrane protein 131 isoform X1 [Bos taurus]","gi|982990330|ref|XM_613474.9|",6949,0,"PREDICTED: Bos taurus transmembrane protein 131 (TMEM131), transcript variant X1, mRNA","Q92545",2339,0,"Transmembrane protein 131",".",".",".",".","pfam12371","DUF3651","Protein of unknown function (DUF3651). This domain family is found in eukaryotes, and is approximately 70 amino acids in length. This family is frequently annotated as a membrane protein but there is little associated literature to back this up.",".","GO:0016021|integral component of membrane;GO:0016020|membrane;",".",".","."]
["bta_circ_0007443",0,0,0,1.68075174231848,0,6,5,-4.00796222908903,0.0493796644707521,"NA","down","yes","NC_037338.1:3159058..3171873:-","gene14323","gi|297480081|ref|XP_002691187.1|",7927,0,"PREDICTED: transmembrane protein 131 isoform X1 [Bos taurus]","gi|982990330|ref|XM_613474.9|",6949,0,"PREDICTED: Bos taurus transmembrane protein 131 (TMEM131), transcript variant X1, mRNA","Q92545",2339,0,"Transmembrane protein 131",".",".",".",".","pfam12371","DUF3651","Protein of unknown function (DUF3651). This domain family is found in eukaryotes, and is approximately 70 amino acids in length. This family is frequently annotated as a membrane protein but there is little associated literature to back this up.",".","GO:0016021|integral component of membrane;GO:0016020|membrane;",".",".","."]
["bta_circ_0007457",0,8,11,2.15804438276212,0,0,0,4.30297250407281,0.0320618534870216,"NA","up","yes","NC_037338.1:36440785..36444372:-","gene14672","gi|440894597|gb|ELR47008.1|",2766,0,"Ankyrin repeat and SOCS box protein 3, partial [Bos mutus]","gi|982938800|ref|XM_015473453.1|",3195,0,"PREDICTED: Bos taurus ankyrin repeat and SOCS box containing 3 (ASB3), transcript variant X1, mRNA","Q08DV6",1061,0,"Ankyrin repeat and SOCS box protein 3","all2748",125,{"v":2e-29,"d":"2.00E-29"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0035556|intracellular signal transduction;","GO:0005737|cytoplasm;GO:0005634|nucleus;GO:0000151|ubiquitin ligase complex;","GO:0031625|ubiquitin protein ligase binding;GO:0004842|ubiquitin-protein transferase activity;","K10325","ASB3; ankyrin repeat and SOCS box protein 3"]
["bta_circ_0007502",7,7,0,2.72975652122355,0,0,0,4.5327682276156,0.0220981318468649,"NA","up","yes","NC_037338.1:40858218..40877018:-","gene14714","gi|528968453|ref|XP_005212726.1|",1831,0,"PREDICTED: E3 ubiquitin-protein ligase FANCL isoform X1 [Bos taurus]","gi|528968456|ref|XM_005212671.1|",1634,0,"PREDICTED: Bos taurus Fanconi anemia complementation group L (FANCL), transcript variant X6, mRNA","Q9NW38",598,0,"E3 ubiquitin-protein ligase FANCL",".",".",".",".","pfam09765","WD-3","WD-repeat region. This entry is of a region of approximately 100 residues containing three WD repeats and six cysteine residues possibly as three cystine-bridges. These regions are contained within the Fancl protein in humans which is the putative E3 ubiquitin ligase subunit of the FA complex (Fanconi anaemia). Eight subunits of the Fanconi anaemia gene products form a multisubunit nuclear complex which is required for mono-ubiquitination of a downstream FA protein, FANCD2. The WD repeats are required for interaction with other subunits of the FA complex.","GO:0006974|cellular response to DNA damage stimulus;GO:0006281|DNA repair;GO:0007276|gamete generation;GO:0036297|interstrand cross-link repair;GO:0006513|protein monoubiquitination;GO:0042127|regulation of cell proliferation;","GO:0005737|cytoplasm;GO:0043240|Fanconi anaemia nuclear complex;GO:0043231|intracellular membrane-bounded organelle;GO:0016604|nuclear body;GO:0005635|nuclear envelope;GO:0005654|nucleoplasm;","GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;GO:0031625|ubiquitin protein ligase binding;GO:0004842|ubiquitin-protein transferase activity;","K10606","FANCL, PHF9; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]"]
["bta_circ_0007506",0,7,7,8.92422974483229,10,26,10,-1.99890724992486,0.0467613103234552,0.462817047279631,"down","yes","NC_037338.1:4255174..4281420:-","gene14335","gi|982990364|ref|XP_015320774.1|",3656,0,"PREDICTED: testis-specific gene 10 protein isoform X5 [Bos taurus]","gi|555960383|ref|XM_005892234.1|",3005,0,"PREDICTED: Bos mutus testis specific, 10 (TSGA10), transcript variant X1, mRNA","Q6NY15",1321,0,"Testis-specific gene 10 protein",".",".",".",".","pfam10174","Cast","RIM-binding protein of the cytomatrix active zone. This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.","GO:0030031|cell projection assembly;GO:0007283|spermatogenesis;","GO:0005737|cytoplasm;GO:0031514|motile cilium;GO:0043005|neuron projection;GO:0031965|nuclear membrane;","GO:0005198|structural molecule activity;",".","."]
["bta_circ_0007528",7,3,0,2.3481773377565,0,0,0,4.27672816498056,0.0335944436717201,"NA","up","yes","NC_037338.1:44723413..44724754:-","gene14749","gi|803212232|ref|XP_011966528.1|",1588,0,"PREDICTED: LIM and senescent cell antigen-like-containing domain protein 1 isoform X5 [Ovis aries musimon]","gi|803037321|ref|XM_012170496.1|",3251,0,"PREDICTED: Ovis aries LIM and senescent cell antigen-like domains 1 (LIMS1), transcript variant X3, mRNA","P48059",589,0,"LIM and senescent cell antigen-like-containing domain protein 1",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0007569|cell aging;GO:0034329|cell junction assembly;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0045184|establishment of protein localization;GO:0045892|negative regulation of transcription, DNA-templated;GO:0010811|positive regulation of cell-substrate adhesion;GO:0051894|positive regulation of focal adhesion assembly;GO:0010628|positive regulation of gene expression;GO:0043547|positive regulation of GTPase activity;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1900026|positive regulation of substrate adhesion-dependent cell spreading;GO:0033209|tumor necrosis factor-mediated signaling pathway;","GO:0005911|cell-cell junction;GO:0005829|cytosol;GO:0005925|focal adhesion;GO:0048471|perinuclear region of cytoplasm;GO:0005886|plasma membrane;","GO:0019901|protein kinase binding;GO:0008270|zinc ion binding;",".","."]
["bta_circ_0007595",0,0,0,1.91741407167424,4,0,6,-4.16963927659347,0.0391396333547559,"NA","down","yes","NC_037338.1:61329417..61332260:+","gene14921","gi|297480441|ref|XP_002691425.1|",5777,0,"PREDICTED: EH domain-binding protein 1 isoform X1 [Bos taurus]","gi|982990764|ref|XM_015465385.1|",5112,0,"PREDICTED: Bos taurus EH domain binding protein 1 (EHBP1), transcript variant X1, mRNA","Q8NDI1",2070,0,"EH domain-binding protein 1","SPAC15A10.08",92,{"v":7e-18,"d":"7.00E-18"},"COG5069","pfam12130","DUF3585","Protein of unknown function (DUF3585). This domain is found in eukaryotes. This domain is typically between 135 and 149 amino acids in length and is found associated with pfam00307.","GO:0006897|endocytosis;GO:0015031|protein transport;","GO:0005829|cytosol;GO:0005768|endosome;GO:0005886|plasma membrane;",".",".","."]
["bta_circ_0007621",0,0,0,2.13429924637479,5,4,3,-4.52916034763703,0.0206074271801596,"NA","down","yes","NC_037338.1:66891426..66929893:+","gene14967","gi|528968965|ref|XP_005212902.1|",2424,0,"PREDICTED: aprataxin and PNK-like factor isoform X1 [Bos taurus]","gi|982939149|ref|XM_005212845.3|",4612,0,"PREDICTED: Bos taurus aprataxin and PNKP like factor (APLF), transcript variant X1, mRNA","A0JNH9",875,0,"Aprataxin and PNK-like factor",".",".",".",".","pfam10283","zf-CCHH","Zinc-finger (CX5CX6HX5H) motif. This domain is a zinc-finger motif that in humans is part of the APLF, aprataxin- and PNK-like forkead association domain-containing protein. The ZnF is highly conserved both in primary sequence and in the spacing between the putative zinc coordinating residues and is configured CX5CX6HX5H. Many of the proteins containing the APLF-like ZnF are involved in DNA strand break repair and/or contain domains implicated in DNA metabolizm.","GO:0006974|cellular response to DNA damage stimulus;GO:0006302|double-strand break repair;GO:0000012|single strand break repair;","GO:0005829|cytosol;GO:0005634|nucleus;","GO:0008408|3'-5' exonuclease activity;GO:0003906|DNA-(apurinic or apyrimidinic site) lyase activity;GO:0004520|endodeoxyribonuclease activity;GO:0046872|metal ion binding;GO:0000166|nucleotide binding;","K13295","APLF; aprataxin and PNK-like factor [EC:4.2.99.18]"]
["bta_circ_0007655",0,12,5,10.4491143569403,13,19,19,-2.02771963907092,0.0327949418087965,0.428634275476763,"down","yes","NC_037338.1:70987493..70993232:-","gene15015","gi|50513466|pdb|1S70|A",1756,0,"Chain A, Complex Between Protein Ser/thr Phosphatase-1 (delta) And The Myosin Phosphatase Targeting Subunit 1 (mypt1)","gi|742122836|ref|XM_010840669.1|",3897,0,"PREDICTED: Bison bison bison protein phosphatase 1, catalytic subunit, beta isozyme (PPP1CB), mRNA","P62142",679,0,"Serine/threonine-protein phosphatase PP1-beta catalytic subunit",".",".",".",".","pfam00149","Metallophos","Calcineurin-like phosphoesterase. This family includes a diverse range of phosphoesterases, including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD or yeast MRE11. The most conserved regions in this superfamily centre around the metal chelating residues.","GO:0007049|cell cycle;GO:0051301|cell division;GO:0032922|circadian regulation of gene expression;GO:0043153|entrainment of circadian clock by photoperiod;GO:0005977|glycogen metabolic process;GO:0006470|protein dephosphorylation;GO:0030155|regulation of cell adhesion;GO:0042752|regulation of circadian rhythm;GO:0005979|regulation of glycogen biosynthetic process;GO:0005981|regulation of glycogen catabolic process;","GO:0005829|cytosol;GO:0042587|glycogen granule;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0000164|protein phosphatase type 1 complex;GO:0072357|PTW/PP1 phosphatase complex;","GO:0046872|metal ion binding;GO:0017018|myosin phosphatase activity;GO:0050115|myosin-light-chain-phosphatase activity;GO:0016791|phosphatase activity;GO:0004721|phosphoprotein phosphatase activity;GO:0004722|protein serine/threonine phosphatase activity;","K06269","PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]"]
["bta_circ_0007764",0,12,7,2.03239228774625,0,0,0,4.22081392140897,0.0364064624479583,"NA","up","yes","NC_037338.1:86294718..86301851:-","gene15201","gi|528969192|ref|XP_005213004.1|",9476,0,"PREDICTED: protein GREB1 isoform X1 [Bos taurus]","gi|982939306|ref|XM_010810181.2|",7472,0,"PREDICTED: Bos taurus growth regulation by estrogen in breast cancer 1 (GREB1), transcript variant X3, mRNA","Q4ZG55",3365,0,"Protein GREB1",".",".",".",".","pfam14655","RAB3GAP2_N","Rab3 GTPase-activating protein regulatory subunit N-terminus. This family includes the N-terminus of the Rab3 GTPase-activating protein non-catalytic subunit. Rab3 GTPase-activating protein is a GTPase activating protein with specificity for Rab3 subfamily.",".","GO:0070062|extracellular exosome;GO:0016021|integral component of membrane;GO:0005654|nucleoplasm;",".",".","."]
["bta_circ_0007792",0,17,3,2.00213498859715,0,0,0,4.17724129383596,0.0390786685008019,"NA","up","yes","NC_037338.1:92519544..92521950:+","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0007802",0,17,10,14.1077781565391,15,19,31,-1.76170191005619,0.0447743021742177,0.456494092506297,"down","yes","NC_037338.1:94123536..94175392:+","gene15323","gi|329299101|ref|NP_001178338.2|",5193,0,"rab GTPase-activating protein 1 [Bos taurus]","gi|982939633|ref|XM_010810342.2|",6356,0,"PREDICTED: Bos taurus RAB GTPase activating protein 1 (RABGAP1), transcript variant X1, mRNA","Q5RAN1",1978,0,"Rab GTPase-activating protein 1",".",".",".",".","pfam00566","RabGAP-TBC","Rab-GTPase-TBC domain. Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.","GO:0007049|cell cycle;","GO:0005829|cytosol;GO:0005815|microtubule organizing center;","GO:0005096|GTPase activator activity;",".","."]
["bta_circ_0007830",0,0,0,2.16920681876812,0,11,4,-4.40085959308298,0.027329477758447,"NA","down","yes","NC_037338.1:95741617..95754323:-","gene15343","gi|741886438|ref|XP_010816578.1|",2282,0,"PREDICTED: nuclear receptor subfamily 6 group A member 1 isoform X1 [Bos taurus]","gi|982991247|ref|XM_010818276.2|",6726,0,"PREDICTED: Bos taurus nuclear receptor subfamily 6 group A member 1 (NR6A1), transcript variant X1, mRNA","A0P8Z4",864,0,"Nuclear receptor subfamily 6 group A member 1",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0030154|cell differentiation;GO:0030518|intracellular steroid hormone receptor signaling pathway;GO:0007275|multicellular organismal development;GO:0007283|spermatogenesis;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0004879|RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0003707|steroid hormone receptor activity;GO:0008270|zinc ion binding;","K08561","NR6A1, GCNF; germ cell nuclear factor"]
["bta_circ_0007857",8,5,9,3.97480772752747,0,0,0,5.24155334484173,0.00518287502198698,"NA","up","yes","NC_037339.1:11111355..11115645:-","gene15714","gi|528970949|ref|XP_005213688.1|",1674,0,"PREDICTED: protein SGT1 homolog isoform X1 [Bos taurus]","gi|982940539|ref|XM_005213631.3|",1910,0,"PREDICTED: Bos taurus SGT1 homolog, MIS12 kinetochore complex assembly cochaperone (SUGT1), transcript variant X1, mRNA","Q2KIK0",647,0,"Protein SGT1 homolog","SPBC36.12c",116,{"v":4e-27,"d":"4.00E-27"},"COG5091","pfam05002","SGS","SGS domain. This domain was thought to be unique to the SGT1-like proteins, but is also found in calcyclin binding proteins.",".","GO:0005737|cytoplasm;GO:0005634|nucleus;",".","K12795","SUGT1, SGT1; suppressor of G2 allele of SKP1"]
["bta_circ_0007954",0,0,0,2.99798567894327,8,3,5,-5.01940668902779,0.00814909018585748,"NA","down","yes","NC_037339.1:19037675..19051461:+","gene15810","gi|219804562|ref|NP_001137333.1|",3710,0,"histone-lysine N-methyltransferase SETDB2 [Bos taurus]","gi|982940457|ref|XM_005213601.3|",6137,0,"PREDICTED: Bos taurus SET domain, bifurcated 2 (SETDB2), transcript variant X2, mRNA","Q96T68",1127,0,"Histone-lysine N-methyltransferase SETDB2","SPBC428.08c",69.3,{"v":7e-11,"d":"7.00E-11"},"COG2940","pfam05033","Pre-SET","Pre-SET motif. This protein motif is a zinc binding motif. It contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains.","GO:0051301|cell division;GO:0007059|chromosome segregation;GO:0001947|heart looping;GO:0051567|histone H3-K9 methylation;GO:0070986|left/right axis specification;GO:0000278|mitotic cell cycle;GO:0045892|negative regulation of transcription, DNA-templated;","GO:0005694|chromosome;GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046974|histone methyltransferase activity (H3-K9 specific);GO:0018024|histone-lysine N-methyltransferase activity;GO:0008270|zinc ion binding;","K18494","SETDB2; histone-lysine N-methyltransferase SETDB2 [EC:2.1.1.43]"]
["bta_circ_0008023",7,159,83,38.4257335064948,12,33,21,1.36086153620791,0.0414110933553015,0.454470983929755,"up","yes","NC_037339.1:28760535..28771876:-","gene15916","gi|741945182|ref|XP_010808979.1|",14816,0,"PREDICTED: protein furry homolog isoform X9 [Bos taurus]","gi|982940422|ref|XM_010810677.2|",10642,0,"PREDICTED: Bos taurus FRY microtubule binding protein (FRY), transcript variant X9, mRNA","Q5TBA9",5382,0,"Protein furry homolog",".",".",".",".","pfam14222","MOR2-PAG1_N","Cell morphogenesis N-terminal. This family is the conserved N-terminal region of proteins that are involved in cell morphogenesis.","GO:0090527|actin filament reorganization;GO:0000902|cell morphogenesis;GO:1904428|negative regulation of tubulin deacetylation;GO:0031175|neuron projection development;","GO:0005938|cell cortex;GO:0005815|microtubule organizing center;GO:0030427|site of polarized growth;GO:0000922|spindle pole;","GO:0004857|enzyme inhibitor activity;",".","."]
["bta_circ_0008066",0,3,3,7.92219556255153,13,15,14,-3.0309197787455,0.00507359275879493,0.179821435155978,"down","yes","NC_037339.1:34457321..34488085:-","gene15992","gi|528971464|ref|XP_005213864.1|",1909,0,"PREDICTED: tumor necrosis factor receptor superfamily member 19 isoform X1 [Bos taurus]","gi|982941108|ref|XM_010810804.2|",5000,0,"PREDICTED: Bos taurus tumor necrosis factor receptor superfamily member 19 (TNFRSF19), transcript variant X3, mRNA","Q9NS68",530,{"v":3e-171,"d":"3.00E-171"},"Tumor necrosis factor receptor superfamily member 19",".",".",".",".","pfam00020","TNFR_c6","TNFR/NGFR cysteine-rich region.","GO:0006915|apoptotic process;GO:0001942|hair follicle development;GO:0007254|JNK cascade;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0046330|positive regulation of JNK cascade;GO:0009888|tissue development;","GO:0016021|integral component of membrane;GO:0005622|intracellular;GO:0005886|plasma membrane;","GO:0005031|tumor necrosis factor-activated receptor activity;","K05155","TNFRSF19, TROY; tumor necrosis factor receptor superfamily member 19"]
["bta_circ_0008067",0,0,5,7.7803972080459,10,23,11,-3.09974978928748,0.00938188445556432,0.247890543832493,"down","yes","NC_037339.1:34468016..34488085:-","gene15992","gi|528971464|ref|XP_005213864.1|",1909,0,"PREDICTED: tumor necrosis factor receptor superfamily member 19 isoform X1 [Bos taurus]","gi|982941108|ref|XM_010810804.2|",5000,0,"PREDICTED: Bos taurus tumor necrosis factor receptor superfamily member 19 (TNFRSF19), transcript variant X3, mRNA","Q9NS68",530,{"v":3e-171,"d":"3.00E-171"},"Tumor necrosis factor receptor superfamily member 19",".",".",".",".","pfam00020","TNFR_c6","TNFR/NGFR cysteine-rich region.","GO:0006915|apoptotic process;GO:0001942|hair follicle development;GO:0007254|JNK cascade;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0046330|positive regulation of JNK cascade;GO:0009888|tissue development;","GO:0016021|integral component of membrane;GO:0005622|intracellular;GO:0005886|plasma membrane;","GO:0005031|tumor necrosis factor-activated receptor activity;","K05155","TNFRSF19, TROY; tumor necrosis factor receptor superfamily member 19"]
["bta_circ_0008082",0,5,18,15.2575383949208,17,40,20,-2.00106825717352,0.0261222077092135,0.394938552918319,"down","yes","NC_037339.1:35750598..35786285:+","gene16011","gi|329755281|ref|NP_001092359.2|",5842,0,"exportin-4 [Bos taurus]","gi|329755280|ref|NM_001098889.2|",4673,0,"Bos taurus exportin 4 (XPO4), mRNA","Q9C0E2",2174,0,"Exportin-4",".",".",".",".","pfam08902","DUF1848","Domain of unknown function (DUF1848). This family of proteins are functionally uncharacterized. The C-terminus contains a cluster of cysteines that are similar to the iron-sulfur cluster found at the N-terminus of pfam04055.","GO:0046827|positive regulation of protein export from nucleus;GO:0015031|protein transport;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005643|nuclear pore;GO:0005654|nucleoplasm;","GO:0005049|nuclear export signal receptor activity;GO:0008536|Ran GTPase binding;",".","."]
["bta_circ_0008084",2,3,13,14.1025579735084,28,18,18,-2.07971277205805,0.0179952802061538,0.321535502526484,"down","yes","NC_037339.1:35755223..35755754:+","gene16011","gi|329755281|ref|NP_001092359.2|",5842,0,"exportin-4 [Bos taurus]","gi|329755280|ref|NM_001098889.2|",4673,0,"Bos taurus exportin 4 (XPO4), mRNA","Q9C0E2",2174,0,"Exportin-4",".",".",".",".","pfam08902","DUF1848","Domain of unknown function (DUF1848). This family of proteins are functionally uncharacterized. The C-terminus contains a cluster of cysteines that are similar to the iron-sulfur cluster found at the N-terminus of pfam04055.","GO:0046827|positive regulation of protein export from nucleus;GO:0015031|protein transport;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005643|nuclear pore;GO:0005654|nucleoplasm;","GO:0005049|nuclear export signal receptor activity;GO:0008536|Ran GTPase binding;",".","."]
["bta_circ_0008120",0,0,0,1.72665577031561,0,9,3,-4.04584832567136,0.0469265519757059,"NA","down","yes","NC_037339.1:50843635..50873294:+","gene16072","gi|528912750|ref|XP_005194220.1|",8534,0,"PREDICTED: LIM domain only protein 7 isoform X1 [Bos taurus]","gi|982992025|ref|XM_005194163.3|",6400,0,"PREDICTED: Bos taurus LIM domain 7 (LMO7), transcript variant X14, mRNA","Q8WWI1",1717,0,"LIM domain only protein 7","ECU03g1150",51.6,{"v":4e-06,"d":"4.00E-06"},"COG5199","pfam00307","CH","Calponin homology (CH) domain. The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.","GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0043687|post-translational protein modification;GO:0000209|protein polyubiquitination;GO:0016567|protein ubiquitination;GO:0030155|regulation of cell adhesion;GO:0023051|regulation of signaling;","GO:0016324|apical plasma membrane;GO:0009986|cell surface;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005925|focal adhesion;GO:0005635|nuclear envelope;GO:0005634|nucleus;GO:0000151|ubiquitin ligase complex;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0004842|ubiquitin-protein transferase activity;","K06084","LMO7, FBXO20; F-box protein 20"]
["bta_circ_0008141",0,0,0,2.25630366575701,0,9,6,-4.46621002659337,0.0244722623883128,"NA","down","yes","NC_037339.1:54444102..54479913:-","gene16098","gi|742183332|ref|XP_010853420.1|",3296,0,"PREDICTED: RNA-binding protein 26 isoform X7 [Bison bison bison]","gi|742183290|ref|XM_010855108.1|",7248,0,"PREDICTED: Bison bison bison RNA binding motif protein 26 (RBM26), transcript variant X1, mRNA","Q5T8P6",997,0,"RNA-binding protein 26",".",".",".",".","pfam14259","RRM_6","RNA recognition motif (a.k.a. RRM, RBD, or RNP domain).","GO:0006397|mRNA processing;GO:0010923|negative regulation of phosphatase activity;",".","GO:0046872|metal ion binding;GO:0003723|RNA binding;","K13192","RBM26; RNA-binding protein 26"]
["bta_circ_0008174",7,4,0,2.44357213362326,0,0,0,4.34770900971504,0.0300129176662062,"NA","up","yes","NC_037339.1:77016322..77084656:+","gene16232","gi|742234945|ref|XP_010829791.1|",3783,0,"PREDICTED: propionyl-CoA carboxylase alpha chain, mitochondrial [Bison bison bison]","gi|742234944|ref|XM_010831489.1|",2466,0,"PREDICTED: Bison bison bison propionyl CoA carboxylase, alpha polypeptide (PCCA), mRNA","P05165",1310,0,"Propionyl-CoA carboxylase alpha chain, mitochondrial","BMEI0800",674,0,"COG4770","pfam02786","CPSase_L_D2","Carbamoyl-phosphate synthase L chain, ATP binding domain. Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. This important enzyme initiates both the urea cycle and the biosynthesis of arginine and/or pyrimidines. The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a heterodimer of a small and large chain. The small chain promotes the hydrolysis of glutamine to ammonia, which is used by the large chain to synthesize carbamoyl phosphate. See pfam00988. The small chain has a GATase domain in the carboxyl terminus. See pfam00117. The ATP binding domain (this one) has an ATP-grasp fold.","GO:0006768|biotin metabolic process;","GO:0005829|cytosol;GO:0005759|mitochondrial matrix;","GO:0005524|ATP binding;GO:0009374|biotin binding;GO:0019899|enzyme binding;GO:0046872|metal ion binding;GO:0004658|propionyl-CoA carboxylase activity;","K01965","PCCA, pccA; propionyl-CoA carboxylase alpha chain [EC:6.4.1.3]"]
["bta_circ_0008181",0,0,0,3.01704573877713,5,4,8,-5.05196529111133,0.00755061838677449,"NA","down","yes","NC_037339.1:79039770..79048475:+","gene16251","gi|803228794|ref|XP_011974669.1|",2676,0,"PREDICTED: basic immunoglobulin-like variable motif-containing protein isoform X3 [Ovis aries musimon]","gi|355390310|ref|NM_001206453.2|",3646,0,"Bos taurus basic, immunoglobulin-like variable motif containing (BIVM), mRNA","Q86UB2",913,0,"Basic immunoglobulin-like variable motif-containing protein",".",".",".",".","pfam11882","DUF3402","Domain of unknown function (DUF3402). This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 350 to 473 amino acids in length. This domain is found associated with pfam07923.",".","GO:0005737|cytoplasm;GO:0005615|extracellular space;GO:0005634|nucleus;",".",".","."]
["bta_circ_0008226",0,8,7,12.3929814237115,14,25,25,-2.43749345553601,0.00654000477647276,0.201992718953344,"down","yes","NC_037340.1:12169842..12183760:-","gene16437","gi|122692573|ref|NP_001073743.1|",1785,0,"cell division cycle protein 123 homolog [Bos taurus]","gi|402746477|ref|NM_001080274.2|",1507,0,"Bos taurus cell division cycle 123 (CDC123), mRNA","Q2YDG3",692,0,"Cell division cycle protein 123 homolog",".",".",".",".","pfam07065","D123","D123. This family contains a number of eukaryotic D123 proteins approximately 330 residues long. It has been shown that mutated variants of D123 exhibit temperature-dependent differences in their degradation rate. D123 proteins are regulators of eIF2, the central regulator of translational initiation.","GO:0007050|cell cycle arrest;GO:0051301|cell division;GO:0006417|regulation of translation;","GO:0005737|cytoplasm;",".",".","."]
["bta_circ_0008252",0,0,0,1.66725983426168,2,4,4,-4.16017843985758,0.0378064165505335,"NA","down","yes","NC_037340.1:17025879..17028879:+","gene16473","gi|300797120|ref|NP_001179006.1|",3686,0,"protein kinase C theta type [Bos taurus]","gi|982942174|ref|XM_005214142.3|",3326,0,"PREDICTED: Bos taurus protein kinase C, theta (PRKCQ), transcript variant X2, mRNA","Q04759",1374,0,"Protein kinase C theta type",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0007411|axon guidance;GO:0060326|cell chemotaxis;GO:0038095|Fc-epsilon receptor signaling pathway;GO:0006954|inflammatory response;GO:0035556|intracellular signal transduction;GO:0006509|membrane protein ectodomain proteolysis;GO:0046627|negative regulation of insulin receptor signaling pathway;GO:0070233|negative regulation of T cell apoptotic process;GO:0018105|peptidyl-serine phosphorylation;GO:0030168|platelet activation;GO:0032740|positive regulation of interleukin-17 production;GO:0045086|positive regulation of interleukin-2 biosynthetic process;GO:0032753|positive regulation of interleukin-4 production;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0050870|positive regulation of T cell activation;GO:0042102|positive regulation of T cell proliferation;GO:2000318|positive regulation of T-helper 17 type immune response;GO:2000570|positive regulation of T-helper 2 cell activation;GO:0051973|positive regulation of telomerase activity;GO:1904355|positive regulation of telomere capping;GO:0032212|positive regulation of telomere maintenance via telomerase;GO:0001558|regulation of cell growth;GO:0045652|regulation of megakaryocyte differentiation;GO:0090330|regulation of platelet aggregation;GO:0006355|regulation of transcription, DNA-templated;GO:0050852|T cell receptor signaling pathway;","GO:0016235|aggresome;GO:0005829|cytosol;GO:0001772|immunological synapse;GO:0005622|intracellular;GO:0005815|microtubule organizing center;GO:0005886|plasma membrane;","GO:0005524|ATP binding;GO:0046872|metal ion binding;GO:0004672|protein kinase activity;GO:0004697|protein kinase C activity;GO:0004674|protein serine/threonine kinase activity;","K18052","PRKCQ; novel protein kinase C theta type [EC:2.7.11.13]"]
["bta_circ_0008255",0,0,0,3.83953935235386,8,8,6,-5.42056452758404,0.00329222114067051,"NA","down","yes","NC_037340.1:17027420..17032314:+","gene16473","gi|300797120|ref|NP_001179006.1|",3686,0,"protein kinase C theta type [Bos taurus]","gi|982942174|ref|XM_005214142.3|",3326,0,"PREDICTED: Bos taurus protein kinase C, theta (PRKCQ), transcript variant X2, mRNA","Q04759",1374,0,"Protein kinase C theta type",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0007411|axon guidance;GO:0060326|cell chemotaxis;GO:0038095|Fc-epsilon receptor signaling pathway;GO:0006954|inflammatory response;GO:0035556|intracellular signal transduction;GO:0006509|membrane protein ectodomain proteolysis;GO:0046627|negative regulation of insulin receptor signaling pathway;GO:0070233|negative regulation of T cell apoptotic process;GO:0018105|peptidyl-serine phosphorylation;GO:0030168|platelet activation;GO:0032740|positive regulation of interleukin-17 production;GO:0045086|positive regulation of interleukin-2 biosynthetic process;GO:0032753|positive regulation of interleukin-4 production;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0050870|positive regulation of T cell activation;GO:0042102|positive regulation of T cell proliferation;GO:2000318|positive regulation of T-helper 17 type immune response;GO:2000570|positive regulation of T-helper 2 cell activation;GO:0051973|positive regulation of telomerase activity;GO:1904355|positive regulation of telomere capping;GO:0032212|positive regulation of telomere maintenance via telomerase;GO:0001558|regulation of cell growth;GO:0045652|regulation of megakaryocyte differentiation;GO:0090330|regulation of platelet aggregation;GO:0006355|regulation of transcription, DNA-templated;GO:0050852|T cell receptor signaling pathway;","GO:0016235|aggresome;GO:0005829|cytosol;GO:0001772|immunological synapse;GO:0005622|intracellular;GO:0005815|microtubule organizing center;GO:0005886|plasma membrane;","GO:0005524|ATP binding;GO:0046872|metal ion binding;GO:0004672|protein kinase activity;GO:0004697|protein kinase C activity;GO:0004674|protein serine/threonine kinase activity;","K18052","PRKCQ; novel protein kinase C theta type [EC:2.7.11.13]"]
["bta_circ_0008262",8,4,8,4.01860686201202,0,2,0,3.07582945576535,0.0405347255849311,"NA","up","yes","NC_037340.1:17690390..17690736:-","gene16484","gi|982942254|ref|XP_015329476.1|",8482,0,"PREDICTED: ankyrin repeat domain-containing protein 26 isoform X1 [Bos taurus]","gi|982942253|ref|XM_015473990.1|",6137,0,"PREDICTED: Bos taurus ankyrin repeat domain 26 (ANKRD26), transcript variant X1, mRNA","Q9UPS8",2217,0,"Ankyrin repeat domain-containing protein 26","all2748",68.9,{"v":7e-11,"d":"7.00E-11"},"COG0666","pfam14915","CCDC144C","CCDC144C protein coiled-coil region. This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.","GO:0045599|negative regulation of fat cell differentiation;","GO:0005813|centrosome;",".",".","."]
["bta_circ_0008276",4,14,10,3.78188702414551,0,0,0,5.23931117885526,0.00513935958600228,"NA","up","yes","NC_037340.1:18340688..18349412:+","gene16498","gi|555989372|ref|XP_005906516.1|",3462,0,"PREDICTED: cullin-2 isoform X2 [Bos mutus]","gi|982942278|ref|XM_005214225.3|",2367,0,"PREDICTED: Bos taurus cullin 2 (CUL2), transcript variant X2, mRNA","Q5RCF3",1332,0,"Cullin-2","SPAC17G6.12",359,{"v":7e-106,"d":"7.00E-106"},"COG5647","pfam00888","Cullin","Cullin family.","GO:0016567|protein ubiquitination;GO:0006511|ubiquitin-dependent protein catabolic process;","GO:0031462|Cul2-RING ubiquitin ligase complex;GO:0005654|nucleoplasm;","GO:0031625|ubiquitin protein ligase binding;","K03870","CUL2; cullin 2"]
["bta_circ_0008427",0,0,0,2.6615915373135,5,0,9,-4.67020720476382,0.017337064296852,"NA","down","yes","NC_037340.1:35226054..35227495:-","gene16636","gi|358414990|ref|XP_588743.5|",2938,0,"PREDICTED: poly(A) RNA polymerase, mitochondrial [Bos taurus]","gi|850488330|gb|CP011898.1|",2730,0,"Ovis canadensis canadensis isolate 43U chromosome 13 sequence","Q9NVV4",917,0,"Poly(A) RNA polymerase, mitochondrial","SPBC1685.06",80.9,{"v":2e-14,"d":"2.00E-14"},"COG5260","pfam03828","PAP_assoc","Cid1 family poly A polymerase. This domain is found in poly(A) polymerases and has been shown to have polynucleotide adenylyltransferase activity. Proteins in this family have been located to both the nucleus and the cytoplasm.","GO:0071044|histone mRNA catabolic process;GO:0006378|mRNA polyadenylation;GO:0006351|transcription, DNA-templated;","GO:0043231|intracellular membrane-bounded organelle;GO:0005739|mitochondrion;","GO:0005524|ATP binding;GO:0042802|identical protein binding;GO:0000287|magnesium ion binding;GO:0030145|manganese ion binding;GO:0004652|polynucleotide adenylyltransferase activity;GO:0042803|protein homodimerization activity;GO:0003723|RNA binding;GO:0002134|UTP binding;","K18060","MTPAP; poly(A) RNA polymerase, mitochondrial [EC:2.7.7.19]"]
["bta_circ_0008456",0,0,7,7.5479133753404,10,22,9,-2.57373986635807,0.0328894269295769,0.428634275476763,"down","yes","NC_037340.1:40626445..40663217:+","gene16710","gi|440911591|gb|ELR61240.1|",4697,0,"5'-3' exoribonuclease 2, partial [Bos mutus]","gi|982942517|ref|XM_010811235.2|",3491,0,"PREDICTED: Bos taurus 5'-3' exoribonuclease 2 (XRN2), transcript variant X2, mRNA","Q9H0D6",1750,0,"5'-3' exoribonuclease 2","SPAC26A3.12c",423,{"v":2e-128,"d":"2.00E-128"},"COG5049","pfam03159","XRN_N","XRN 5'-3' exonuclease N-terminus. This family aligns residues towards the N-terminus of several proteins with multiple functions. The members of this family all appear to possess 5'-3' exonuclease activity EC:3.1.11.-. Thus, the aligned region may be necessary for 5' to 3' exonuclease function. The family also contains several Xrn1 and Xrn2 proteins. The 5'-3' exoribonucleases Xrn1p and Xrn2p/Rat1p function in the degradation and processing of several classes of RNA in Saccharomyces cerevisiae. Xrn1p is the main enzyme catalyzing cytoplasmic mRNA degradation in multiple decay pathways, whereas Xrn2p/Rat1p functions in the processing of rRNAs and small nucleolar RNAs (snoRNAs) in the nucleus.","GO:0000738|DNA catabolic process, exonucleolytic;GO:0006353|DNA-templated transcription, termination;GO:0021766|hippocampus development;GO:0006397|mRNA processing;GO:0030182|neuron differentiation;GO:0006355|regulation of transcription, DNA-templated;GO:0060041|retina development in camera-type eye;GO:0006401|RNA catabolic process;GO:0016070|RNA metabolic process;GO:0006396|RNA processing;GO:0006364|rRNA processing;GO:0007283|spermatogenesis;","GO:0016235|aggresome;GO:0016020|membrane;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0000175|3'-5'-exoribonuclease activity;GO:0008409|5'-3' exonuclease activity;GO:0004534|5'-3' exoribonuclease activity;GO:0046872|metal ion binding;GO:0004518|nuclease activity;GO:0003723|RNA binding;GO:0001147|transcription termination site sequence-specific DNA binding;","K12619","XRN2, RAT1; 5'-3' exoribonuclease 2 [EC:3.1.13.-]"]
["bta_circ_0008457",6,6,0,2.3397913039059,0,0,0,4.30951355641776,0.0317929327404115,"NA","up","yes","NC_037340.1:40660962..40663217:+","gene16710","gi|440911591|gb|ELR61240.1|",4697,0,"5'-3' exoribonuclease 2, partial [Bos mutus]","gi|982942517|ref|XM_010811235.2|",3491,0,"PREDICTED: Bos taurus 5'-3' exoribonuclease 2 (XRN2), transcript variant X2, mRNA","Q9H0D6",1750,0,"5'-3' exoribonuclease 2","SPAC26A3.12c",423,{"v":2e-128,"d":"2.00E-128"},"COG5049","pfam03159","XRN_N","XRN 5'-3' exonuclease N-terminus. This family aligns residues towards the N-terminus of several proteins with multiple functions. The members of this family all appear to possess 5'-3' exonuclease activity EC:3.1.11.-. Thus, the aligned region may be necessary for 5' to 3' exonuclease function. The family also contains several Xrn1 and Xrn2 proteins. The 5'-3' exoribonucleases Xrn1p and Xrn2p/Rat1p function in the degradation and processing of several classes of RNA in Saccharomyces cerevisiae. Xrn1p is the main enzyme catalyzing cytoplasmic mRNA degradation in multiple decay pathways, whereas Xrn2p/Rat1p functions in the processing of rRNAs and small nucleolar RNAs (snoRNAs) in the nucleus.","GO:0000738|DNA catabolic process, exonucleolytic;GO:0006353|DNA-templated transcription, termination;GO:0021766|hippocampus development;GO:0006397|mRNA processing;GO:0030182|neuron differentiation;GO:0006355|regulation of transcription, DNA-templated;GO:0060041|retina development in camera-type eye;GO:0006401|RNA catabolic process;GO:0016070|RNA metabolic process;GO:0006396|RNA processing;GO:0006364|rRNA processing;GO:0007283|spermatogenesis;","GO:0016235|aggresome;GO:0016020|membrane;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0000175|3'-5'-exoribonuclease activity;GO:0008409|5'-3' exonuclease activity;GO:0004534|5'-3' exoribonuclease activity;GO:0046872|metal ion binding;GO:0004518|nuclease activity;GO:0003723|RNA binding;GO:0001147|transcription termination site sequence-specific DNA binding;","K12619","XRN2, RAT1; 5'-3' exoribonuclease 2 [EC:3.1.13.-]"]
["bta_circ_0008471",0,0,0,3.58146135866155,7,9,5,-5.32084487395537,0.00415570358303686,"NA","down","yes","NC_037340.1:42993495..43017146:-","gene16754","gi|741888318|ref|XP_010820809.1|",13955,0,"PREDICTED: protein FAM208B isoform X1 [Bos taurus]","gi|982992987|ref|XM_010822507.2|",10030,0,"PREDICTED: Bos taurus family with sequence similarity 208 member B (FAM208B), transcript variant X1, mRNA","Q5VWN6",1845,0,"Protein FAM208B",".",".",".",".","pfam12509","DUF3715","Protein of unknown function (DUF3715). This domain family is found in eukaryotes, and is approximately 170 amino acids in length.",".","GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005634|nucleus;",".",".","."]
["bta_circ_0008502",8,33,39,40.0450665368397,39,72,66,-1.45313111605667,0.00816485486031253,0.232268634315733,"down","yes","NC_037340.1:46840954..46897518:-","gene16823","gi|528973208|ref|XP_005214501.1|",3090,0,"PREDICTED: zinc finger MYND domain-containing protein 11 isoform X1 [Bos taurus]","gi|982942749|ref|XM_005214444.3|",4149,0,"PREDICTED: Bos taurus zinc finger, MYND-type containing 11 (ZMYND11), transcript variant X1, mRNA","Q15326",1136,0,"Zinc finger MYND domain-containing protein 11",".",".",".",".","pfam00855","PWWP","PWWP domain. The PWWP domain is named after a conserved Pro-Trp-Trp-Pro motif. The domain binds to Histone-4 methylated at lysine-20, H4K20me, suggesting that it is methyl-lysine recognition motif. Removal of two conserved aromatic residues in a hydrophobic cavity created by this domain within the full-length protein, Pdp1, abolishes the interaction o f the protein with H4K20me3. In fission yeast, Set9 is the sole enzyme that catalyses all three states of H4K20me, and Set9-mediated H4K20me is required for efficient recruitment of checkpoint protein Crb2 to sites of DNA damage. The methylation of H4K20 is involved in a diverse array of cellular processes, such as organizing higher-order chromatin, maintaining genome stability, and regulating cell-cycle progression.","GO:0007049|cell cycle;GO:0008283|cell proliferation;GO:0006325|chromatin organization;GO:0051607|defense response to virus;GO:2001237|negative regulation of extrinsic apoptotic signaling pathway;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0046329|negative regulation of JNK cascade;GO:0034243|regulation of transcription elongation from RNA polymerase II promoter;GO:0006351|transcription, DNA-templated;GO:0016032|viral process;","GO:0005694|chromosome;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003682|chromatin binding;GO:0003690|double-stranded DNA binding;GO:0042393|histone binding;GO:0035064|methylated histone binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0003712|transcription cofactor activity;GO:0003714|transcription corepressor activity;GO:0008270|zinc ion binding;",".","."]
["bta_circ_0008516",19,36,47,19.8787170206271,10,10,8,1.57931689185263,0.0233210759111076,0.375453490305658,"up","yes","NC_037340.1:47736943..47755248:-","gene16838","gi|297481642|ref|XP_002692410.1|",3088,0,"PREDICTED: glycerophosphocholine phosphodiesterase GPCPD1 isoform X2 [Bos taurus]","gi|982993210|ref|XM_015466072.1|",3616,0,"PREDICTED: Bos taurus glycerophosphocholine phosphodiesterase 1 (GPCPD1), transcript variant X2, mRNA","Q9NPB8",1171,0,"Glycerophosphocholine phosphodiesterase GPCPD1","YPL110c_3",150,{"v":1e-37,"d":"1.00E-37"},"COG0584","pfam03009","GDPD","Glycerophosphoryl diester phosphodiesterase family. Escherichia coli has two sequence related isozymes of glycerophosphoryl diester phosphodiesterase (GDPD) - periplasmic and cytosolic. This family also includes agrocinopine synthase, the similarity to GDPD has been noted. This family appears to have weak but not significant matches to mammalian phospholipase C pfam00388, which suggests that this family may adopt a TIM barrel fold.","GO:0030643|cellular phosphate ion homeostasis;GO:0046475|glycerophospholipid catabolic process;GO:0007519|skeletal muscle tissue development;","GO:0005829|cytosol;","GO:0047389|glycerophosphocholine phosphodiesterase activity;GO:0008889|glycerophosphodiester phosphodiesterase activity;GO:2001070|starch binding;","K18695","GPCPD1; glycerophosphocholine phosphodiesterase GPCPD1 [EC:3.1.4.2]"]
["bta_circ_0008527",58,138,174,61.969298505386,12,32,16,2.38851853636897,{"v":2.14345514477886e-06,"d":"2.14E-06"},0.00077235833716865,"up","yes","NC_037340.1:47746753..47755248:-","gene16838","gi|297481642|ref|XP_002692410.1|",3088,0,"PREDICTED: glycerophosphocholine phosphodiesterase GPCPD1 isoform X2 [Bos taurus]","gi|982993210|ref|XM_015466072.1|",3616,0,"PREDICTED: Bos taurus glycerophosphocholine phosphodiesterase 1 (GPCPD1), transcript variant X2, mRNA","Q9NPB8",1171,0,"Glycerophosphocholine phosphodiesterase GPCPD1","YPL110c_3",150,{"v":1e-37,"d":"1.00E-37"},"COG0584","pfam03009","GDPD","Glycerophosphoryl diester phosphodiesterase family. Escherichia coli has two sequence related isozymes of glycerophosphoryl diester phosphodiesterase (GDPD) - periplasmic and cytosolic. This family also includes agrocinopine synthase, the similarity to GDPD has been noted. This family appears to have weak but not significant matches to mammalian phospholipase C pfam00388, which suggests that this family may adopt a TIM barrel fold.","GO:0030643|cellular phosphate ion homeostasis;GO:0046475|glycerophospholipid catabolic process;GO:0007519|skeletal muscle tissue development;","GO:0005829|cytosol;","GO:0047389|glycerophosphocholine phosphodiesterase activity;GO:0008889|glycerophosphodiester phosphodiesterase activity;GO:2001070|starch binding;","K18695","GPCPD1; glycerophosphocholine phosphodiesterase GPCPD1 [EC:3.1.4.2]"]
["bta_circ_0008533",0,0,0,1.8247490729083,5,3,2,-4.27181087690298,0.0318362362598168,"NA","down","yes","NC_037340.1:51280189..51291810:-","gene16864","gi|821424089|ref|XP_004285337.2|",2032,0,"PREDICTED: LOW QUALITY PROTEIN: pantothenate kinase 2, mitochondrial [Orcinus orca]","gi|594099743|ref|XM_006072934.1|",1764,0,"PREDICTED: Bubalus bubalis pantothenate kinase 2 (PANK2), transcript variant X1, mRNA","Q9BZ23",780,0,"Pantothenate kinase 2, mitochondrial","SPBC4B4.01c",160,{"v":5e-42,"d":"5.00E-42"},"COG5146","pfam03630","Fumble","Fumble. Fumble is required for cell division in Drosophila. Mutants lacking fumble exhibit abnormalities in bipolar spindle organisation, chromosome segregation, and contractile ring formation. Analyses have demonstrated that encodes three protein isoforms, all of which contain a domain with high similarity to the pantothenate kinases of A. nidulans and mouse. A role of fumble in membrane synthesis has been proposed.","GO:0009060|aerobic respiration;GO:0015937|coenzyme A biosynthetic process;GO:0009108|coenzyme biosynthetic process;GO:0070584|mitochondrion morphogenesis;GO:0015939|pantothenate metabolic process;GO:0016310|phosphorylation;GO:1904251|regulation of bile acid metabolic process;GO:0019217|regulation of fatty acid metabolic process;GO:0051881|regulation of mitochondrial membrane potential;GO:0090207|regulation of triglyceride metabolic process;GO:0007286|spermatid development;","GO:0005829|cytosol;GO:0005758|mitochondrial intermembrane space;GO:0005739|mitochondrion;","GO:0005524|ATP binding;GO:0004594|pantothenate kinase activity;","K09680","coaW; type II pantothenate kinase [EC:2.7.1.33]"]
["bta_circ_0008610",0,10,15,2.85606525297856,0,0,0,4.71005612205467,0.016108392241297,"NA","up","yes","NC_037340.1:63842829..63858390:+","gene17183","gi|741947935|ref|XP_010809731.1|",4212,0,"PREDICTED: E3 ubiquitin-protein ligase Itchy homolog isoform X1 [Bos taurus]","gi|982943002|ref|XM_010811429.2|",6224,0,"PREDICTED: Bos taurus itchy E3 ubiquitin protein ligase (ITCH), transcript variant X1, mRNA","Q96J02",1572,0,"E3 ubiquitin-protein ligase Itchy homolog","SPAC11G7.02",578,0,"COG5021","pfam00632","HECT","HECT-domain (ubiquitin-transferase). The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.","GO:0006915|apoptotic process;GO:0051607|defense response to virus;GO:0006954|inflammatory response;GO:0045087|innate immune response;GO:0046642|negative regulation of alpha-beta T cell proliferation;GO:0043066|negative regulation of apoptotic process;GO:0050687|negative regulation of defense response to virus;GO:0046329|negative regulation of JNK cascade;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032480|negative regulation of type I interferon production;GO:0007219|Notch signaling pathway;GO:0070423|nucleotide-binding oligomerization domain containing signaling pathway;GO:0045732|positive regulation of protein catabolic process;GO:2000646|positive regulation of receptor catabolic process;GO:0002669|positive regulation of T cell anergy;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051865|protein autoubiquitination;GO:0035519|protein K29-linked ubiquitination;GO:0070936|protein K48-linked ubiquitination;GO:0070534|protein K63-linked ubiquitination;GO:0016567|protein ubiquitination;GO:0001558|regulation of cell growth;GO:1902036|regulation of hematopoietic stem cell differentiation;GO:0090085|regulation of protein deubiquitination;GO:0006511|ubiquitin-dependent protein catabolic process;GO:0046718|viral entry into host cell;","GO:0005938|cell cortex;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0031901|early endosome membrane;GO:0070062|extracellular exosome;GO:0043231|intracellular membrane-bounded organelle;GO:0016020|membrane;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0032991|macromolecular complex;","GO:1990763|arrestin family protein binding;GO:0045236|CXCR chemokine receptor binding;GO:0016874|ligase activity;GO:0043021|ribonucleoprotein complex binding;GO:0061630|ubiquitin protein ligase activity;GO:0044389|ubiquitin-like protein ligase binding;GO:0019787|ubiquitin-like protein transferase activity;GO:0004842|ubiquitin-protein transferase activity;","K05632","AIP4, ITCH; atrophin-1 interacting protein 4 [EC:2.3.2.26]"]
["bta_circ_0008672",0,42,14,5.78189090109423,0,0,0,5.69869295737872,0.0019471543801258,0.0915162558659127,"up","yes","NC_037340.1:72632910..72633690:-","gene17325","gi|803276278|ref|XP_011997820.1|",2192,0,"PREDICTED: junctophilin-2 isoform X2 [Ovis aries musimon]","gi|982993813|ref|XM_015466184.1|",4319,0,"PREDICTED: Bos taurus junctophilin 2 (JPH2), transcript variant X2, mRNA","Q9BR39",768,0,"Junctophilin-2",".",".",".",".","pfam02493","MORN","MORN repeat. The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22).  #=GF CC   A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesised to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.","GO:0055074|calcium ion homeostasis;GO:0060402|calcium ion transport into cytosol;GO:0060316|positive regulation of ryanodine-sensitive calcium-release channel activity;GO:0055024|regulation of cardiac muscle tissue development;GO:0060314|regulation of ryanodine-sensitive calcium-release channel activity;","GO:0016021|integral component of membrane;GO:0030314|junctional membrane complex;GO:0014701|junctional sarcoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0030018|Z disc;","GO:0015278|calcium-release channel activity;GO:0070300|phosphatidic acid binding;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0080025|phosphatidylinositol-3,5-bisphosphate binding;GO:0032266|phosphatidylinositol-3-phosphate binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0070273|phosphatidylinositol-4-phosphate binding;GO:0010314|phosphatidylinositol-5-phosphate binding;GO:0001786|phosphatidylserine binding;","K19530","JPH; junctophilin"]
["bta_circ_0008726",8,92,54,24.4817775884863,6,10,22,1.44909025585688,0.0468810977586675,0.462817047279631,"up","yes","NC_037340.1:79359790..79364576:-","gene17507","gi|528914212|ref|XP_005192574.1|",4166,0,"PREDICTED: nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [Bos taurus]","gi|982993975|ref|XM_005192517.3|",7168,0,"PREDICTED: Bos taurus nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (NFATC2), transcript variant X1, mRNA","Q13469",1469,0,"Nuclear factor of activated T-cells, cytoplasmic 2",".",".",".",".","pfam00554","RHD","Rel homology domain (RHD). Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See pfam01833) that binds to DNA.","GO:0050853|B cell receptor signaling pathway;GO:0033173|calcineurin-NFAT signaling cascade;GO:0016477|cell migration;GO:0006974|cellular response to DNA damage stimulus;GO:0001816|cytokine production;GO:0038095|Fc-epsilon receptor signaling pathway;GO:0014904|myotube cell development;GO:0030890|positive regulation of B cell proliferation;GO:1901741|positive regulation of myoblast fusion;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045589|regulation of regulatory T cell differentiation;GO:0006355|regulation of transcription, DNA-templated;GO:0042493|response to drug;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0000790|nuclear chromatin;GO:0044798|nuclear transcription factor complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003682|chromatin binding;GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0019902|phosphatase binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0008134|transcription factor binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K17332","NFATC2, NFAT1, NFATP; nuclear factor of activated T-cells, cytoplasmic 2"]
["bta_circ_0008746",0,2,15,2.09290688604446,0,0,0,4.20020598240513,0.0379121484653457,"NA","up","yes","NC_037340.1:81962930..81987468:+","gene17525","gi|115495301|ref|NP_001069407.1|",1657,0,"docking protein 5 [Bos taurus]","gi|402745435|ref|NM_001075939.2|",1740,0,"Bos taurus docking protein 5 (DOK5), mRNA","Q9P104",616,0,"Docking protein 5",".",".",".",".","pfam02174","IRS","PTB domain (IRS-1 type).","GO:0007411|axon guidance;GO:0000165|MAPK cascade;GO:0051386|regulation of neurotrophin TRK receptor signaling pathway;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;","GO:0005829|cytosol;",".",".","."]
["bta_circ_0008769",0,0,0,10.4340523356085,26,2,26,-6.70739345233946,0.000103276493194069,0.011751777804504,"down","yes","NC_037341.1:13589843..13607754:+","gene17741","gi|742105846|ref|XP_010835324.1|",131,{"v":8e-06,"d":"8.00E-06"},"PREDICTED: F-box only protein 36 isoform X3 [Bison bison bison]","gi|850485665|gb|CP011894.1|",915,0,"Ovis canadensis canadensis isolate 43U chromosome 9 sequence",".",".",".",".",".",".",".",".","pfam14351","DUF4401","Domain of unknown function (DUF4401). This family of proteins is found in bacteria. Proteins in this family are typically between 357 and 735 amino acids in length. The family is found in association with pfam09925. There is a single completely conserved residue K that may be functionally important.",".",".",".",".","."]
["bta_circ_0008773",0,0,0,7.37024562606259,22,4,12,-6.27719740039875,0.000361759483914749,0.0320783530662825,"down","yes","NC_037341.1:13607698..13610983:+","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0008795",0,0,0,2.5633583867705,7,4,3,-4.79255214395397,0.0127644381316561,"NA","down","yes","NC_037341.1:16668656..16689165:-","gene17787","gi|528975642|ref|XP_005215415.1|",5401,0,"PREDICTED: TBC1 domain family member 31 isoform X1 [Bos taurus]","gi|982944509|ref|XM_005215358.3|",3556,0,"PREDICTED: Bos taurus TBC1 domain family member 31 (TBC1D31), transcript variant X1, mRNA","Q29RL0",2078,0,"TBC1 domain family member 31",".",".",".",".","pfam00566","RabGAP-TBC","Rab-GTPase-TBC domain. Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.",".","GO:0005813|centrosome;",".",".","."]
["bta_circ_0008814",0,5,16,2.50589909326547,0,0,0,4.49745362006738,0.0234809421946761,"NA","up","yes","NC_037341.1:24770502..24777430:-","gene17870","gi|528914687|ref|XP_005194563.1|",4848,0,"PREDICTED: protein FAN [Bos taurus]","gi|982994415|ref|XM_005194506.3|",3470,0,"PREDICTED: Bos taurus neutral sphingomyelinase activation associated factor (NSMAF), mRNA","Q92636",1673,0,"Protein FAN",".",".",".",".","pfam02138","Beach","Beige/BEACH domain.","GO:0006672|ceramide metabolic process;GO:0043065|positive regulation of apoptotic process;GO:2000304|positive regulation of ceramide biosynthetic process;GO:0007165|signal transduction;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0016230|sphingomyelin phosphodiesterase activator activity;","K18953","NSMAF, FAN; factor associated with neutral sphingomyelinase activation"]
["bta_circ_0008856",6,3,15,24.5001341775772,37,47,36,-2.36800292338264,0.00120705083880711,0.0682842786669333,"down","yes","NC_037341.1:30111362..30112247:-","gene17901","gi|528914710|ref|XP_005194568.1|",2463,0,"PREDICTED: high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X2 [Bos taurus]","gi|982994437|ref|XM_005194511.3|",3116,0,"PREDICTED: Bos taurus phosphodiesterase 7A (PDE7A), transcript variant X2, mRNA","P70453",900,0,"High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A",".",".",".",".","pfam00233","PDEase_I","3'5'-cyclic nucleotide phosphodiesterase.","GO:0006198|cAMP catabolic process;GO:0007165|signal transduction;",".","GO:0004115|3',5'-cyclic-AMP phosphodiesterase activity;GO:0004112|cyclic-nucleotide phosphodiesterase activity;GO:0046872|metal ion binding;","K18436","PDE7; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 [EC:3.1.4.53]"]
["bta_circ_0008871",0,0,0,2.48504223883304,5,0,8,-4.56715505942473,0.0207324903978148,"NA","down","yes","NC_037341.1:31241335..31248244:+","gene17931","gi|296480611|tpg|DAA22726.1|",3417,0,"TPA: centrosome and spindle pole associated protein 1 [Bos taurus]","gi|742159197|ref|XM_010848454.1|",4117,0,"PREDICTED: Bison bison bison centrosome and spindle pole associated protein 1 (CSPP1), transcript variant X3, mRNA","Q1MSJ5",1140,0,"Centrosome and spindle pole-associated protein 1",".",".",".",".","pfam13654","AAA_32","AAA domain. This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.","GO:0051781|positive regulation of cell division;GO:0032467|positive regulation of cytokinesis;","GO:0005813|centrosome;GO:0005737|cytoplasm;GO:0005874|microtubule;GO:0005819|spindle;GO:0000922|spindle pole;",".","K16771","CSPP1; centrosome and spindle pole-associated protein 1"]
["bta_circ_0008906",18,47,42,47.1067426527916,58,74,55,-1.07128092175915,0.0305942102836867,0.428634275476763,"down","yes","NC_037341.1:33545264..33568943:-","gene17940","gi|741889646|ref|XP_010823630.1|",4115,0,"PREDICTED: solute carrier organic anion transporter family member 5A1 isoform X1 [Bos taurus]","gi|982994470|ref|XM_010825328.2|",9118,0,"PREDICTED: Bos taurus solute carrier organic anion transporter family member 5A1 (SLCO5A1), transcript variant X1, mRNA","Q9H2Y9",1386,0,"Solute carrier organic anion transporter family member 5A1",".",".",".",".","pfam03137","OATP","Organic Anion Transporter Polypeptide (OATP) family. This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.","GO:0043252|sodium-independent organic anion transport;","GO:0005887|integral component of plasma membrane;","GO:0015347|sodium-independent organic anion transmembrane transporter activity;","K14356","SLCO5A; solute carrier organic anion transporter family, member 5A"]
["bta_circ_0008925",13,66,49,22.518782485309,9,20,9,1.37436168557529,0.0374194395386831,0.439730132358439,"up","yes","NC_037341.1:34871509..34908751:-","gene17953","gi|742154069|ref|XP_010845262.1|",2669,0,"PREDICTED: eyes absent homolog 1 isoform X1 [Bison bison bison]","gi|742154088|ref|XM_010846965.1|",3918,0,"PREDICTED: Bison bison bison EYA transcriptional coactivator and phosphatase 1 (EYA1), transcript variant X6, mRNA","Q99502",1009,0,"Eyes absent homolog 1",".",".",".",".","pfam07223","DUF1421","Protein of unknown function (DUF1421). This family represents a conserved region approximately 350 residues long within a number of plant proteins of unknown function.","GO:0009653|anatomical structure morphogenesis;GO:0035909|aorta morphogenesis;GO:0001658|branching involved in ureteric bud morphogenesis;GO:0030154|cell differentiation;GO:0090103|cochlea morphogenesis;GO:0006302|double-strand break repair;GO:0048704|embryonic skeletal system morphogenesis;GO:0016576|histone dephosphorylation;GO:0007501|mesodermal cell fate specification;GO:0001656|metanephros development;GO:0042474|middle ear morphogenesis;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:0048665|neuron fate specification;GO:0071600|otic vesicle morphogenesis;GO:0042473|outer ear morphogenesis;GO:0003151|outflow tract morphogenesis;GO:0007389|pattern specification process;GO:0060037|pharyngeal system development;GO:0045739|positive regulation of DNA repair;GO:0050679|positive regulation of epithelial cell proliferation;GO:0072513|positive regulation of secondary heart field cardioblast proliferation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0016925|protein sumoylation;GO:0045664|regulation of neuron differentiation;GO:0010212|response to ionizing radiation;GO:0048752|semicircular canal morphogenesis;GO:0007605|sensory perception of sound;GO:0014706|striated muscle tissue development;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0032993|protein-DNA complex;","GO:0046872|metal ion binding;GO:0004725|protein tyrosine phosphatase activity;GO:0003723|RNA binding;","K15616","EYA1; eyes absent homolog 1 [EC:3.1.3.48]"]
["bta_circ_0008926",7,48,41,13.9007580636534,3,8,2,2.41244984252934,0.00498561328078043,0.179648265217455,"up","yes","NC_037341.1:34908083..34908751:-","gene17953","gi|742154069|ref|XP_010845262.1|",2669,0,"PREDICTED: eyes absent homolog 1 isoform X1 [Bison bison bison]","gi|742154088|ref|XM_010846965.1|",3918,0,"PREDICTED: Bison bison bison EYA transcriptional coactivator and phosphatase 1 (EYA1), transcript variant X6, mRNA","Q99502",1009,0,"Eyes absent homolog 1",".",".",".",".","pfam07223","DUF1421","Protein of unknown function (DUF1421). This family represents a conserved region approximately 350 residues long within a number of plant proteins of unknown function.","GO:0009653|anatomical structure morphogenesis;GO:0035909|aorta morphogenesis;GO:0001658|branching involved in ureteric bud morphogenesis;GO:0030154|cell differentiation;GO:0090103|cochlea morphogenesis;GO:0006302|double-strand break repair;GO:0048704|embryonic skeletal system morphogenesis;GO:0016576|histone dephosphorylation;GO:0007501|mesodermal cell fate specification;GO:0001656|metanephros development;GO:0042474|middle ear morphogenesis;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:0048665|neuron fate specification;GO:0071600|otic vesicle morphogenesis;GO:0042473|outer ear morphogenesis;GO:0003151|outflow tract morphogenesis;GO:0007389|pattern specification process;GO:0060037|pharyngeal system development;GO:0045739|positive regulation of DNA repair;GO:0050679|positive regulation of epithelial cell proliferation;GO:0072513|positive regulation of secondary heart field cardioblast proliferation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0016925|protein sumoylation;GO:0045664|regulation of neuron differentiation;GO:0010212|response to ionizing radiation;GO:0048752|semicircular canal morphogenesis;GO:0007605|sensory perception of sound;GO:0014706|striated muscle tissue development;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0032993|protein-DNA complex;","GO:0046872|metal ion binding;GO:0004725|protein tyrosine phosphatase activity;GO:0003723|RNA binding;","K15616","EYA1; eyes absent homolog 1 [EC:3.1.3.48]"]
["bta_circ_0008932",0,0,0,1.73765222591941,5,5,0,-4.03466302515196,0.0475458789136191,"NA","down","yes","NC_037341.1:36897156..37023436:-","gene17970","gi|803105073|ref|XP_012039250.1|",2477,0,"PREDICTED: double-stranded RNA-binding protein Staufen homolog 2 isoform X1 [Ovis aries]","gi|850485665|gb|CP011894.1|",2623,0,"Ovis canadensis canadensis isolate 43U chromosome 9 sequence","Q9NUL3",919,0,"Double-stranded RNA-binding protein Staufen homolog 2",".",".",".",".","pfam00035","dsrm","Double-stranded RNA binding motif. Sequences gathered for seed by HMM_iterative_training Putative motif shared by proteins that bind to dsRNA. At least some DSRM proteins seem to bind to specific RNA targets. Exemplified by Staufen, which is involved in localisation of at least five different mRNAs in the early Drosophila embryo. Also by interferon-induced protein kinase in humans, which is part of the cellular response to dsRNA.",".","GO:0005783|endoplasmic reticulum;GO:0016020|membrane;GO:0005874|microtubule;GO:0005730|nucleolus;","GO:0003725|double-stranded RNA binding;GO:0003723|RNA binding;","K17597","STAU; double-stranded RNA-binding protein Staufen"]
["bta_circ_0008967",0,0,0,3.66299005387339,8,8,5,-5.34829288724436,0.00390795176449086,"NA","down","yes","NC_037341.1:43679271..43680159:+","gene18021","gi|803291832|ref|XP_012005571.1|",3619,0,"PREDICTED: zinc finger and BTB domain-containing protein 10 [Ovis aries musimon]","gi|965875048|ref|XM_012150181.2|",6853,0,"PREDICTED: Ovis aries musimon zinc finger and BTB domain containing 10 (ZBTB10), mRNA","Q96DT7",1301,0,"Zinc finger and BTB domain-containing protein 10",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005654|nucleoplasm;","GO:0003677|DNA binding;GO:0046872|metal ion binding;","K10497","ZBTB10, RINZF; zinc finger and BTB domain-containing protein 10"]
["bta_circ_0008986",0,6,3,7.42857781729785,11,19,9,-2.41627684983213,0.0250365280882305,0.383893430686201,"down","yes","NC_037341.1:55961485..55992656:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0009030",0,0,0,1.88735755623659,2,3,6,-4.33623089289243,0.0287104921867047,"NA","down","yes","NC_037341.1:64747461..64823484:-","gene18162","gi|528976363|ref|XP_005215691.1|",20880,0,"PREDICTED: vacuolar protein sorting-associated protein 13B isoform X1 [Bos taurus]","gi|982994697|ref|XM_015466383.1|",6759,0,"PREDICTED: Bos taurus vacuolar protein sorting 13 homolog B (yeast) (VPS13B), transcript variant X7, mRNA","Q7Z7G8",7374,0,"Vacuolar protein sorting-associated protein 13B","SPBC31F10.18c",76.3,{"v":1e-12,"d":"1.00E-12"},"COG5043","pfam12624","Chorein_N","N-terminal region of Chorein, a TM vesicle-mediated sorter. Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.","GO:0015031|protein transport;",".",".","K19526","VPS13B; vacuolar protein sorting-associated protein 13B"]
["bta_circ_0009050",41,103,78,44.3452709119112,14,24,36,1.31451235181257,0.0147353536020498,0.298906981742218,"up","yes","NC_037341.1:65561545..65562382:+","gene18172","gi|118601812|ref|NP_001073075.1|",2424,0,"serine/threonine-protein kinase 3 [Bos taurus]","gi|402746847|ref|NM_001079607.2|",2802,0,"Bos taurus serine/threonine kinase 3 (STK3), mRNA","Q13188",933,0,"Serine/threonine-protein kinase 3",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006915|apoptotic process;GO:0060706|cell differentiation involved in embryonic placenta development;GO:0007417|central nervous system development;GO:0003157|endocardium development;GO:0097284|hepatocyte apoptotic process;GO:0035329|hippo signaling;GO:0035556|intracellular signal transduction;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0008285|negative regulation of cell proliferation;GO:0046621|negative regulation of organ growth;GO:0001841|neural tube formation;GO:0043065|positive regulation of apoptotic process;GO:0051091|positive regulation of sequence-specific DNA binding transcription factor activity;GO:1902043|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0045600|positive regulation of fat cell differentiation;GO:0046330|positive regulation of JNK cascade;GO:0032092|positive regulation of protein binding;GO:0051897|positive regulation of protein kinase B signaling;GO:0060215|primitive hemopoiesis;GO:0006468|protein phosphorylation;GO:0050821|protein stabilization;GO:0042981|regulation of apoptotic process;GO:0060800|regulation of cell differentiation involved in embryonic placenta development;GO:0007346|regulation of mitotic cell cycle;GO:0007165|signal transduction;GO:0023014|signal transduction by protein phosphorylation;GO:0031098|stress-activated protein kinase signaling cascade;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005634|nucleus;GO:0032991|macromolecular complex;","GO:0005524|ATP binding;GO:0042802|identical protein binding;GO:0000287|magnesium ion binding;GO:0046983|protein dimerization activity;GO:0004672|protein kinase activity;GO:0043539|protein serine/threonine kinase activator activity;GO:0004674|protein serine/threonine kinase activity;","K04412","STK3, MST2; serine/threonine kinase 3"]
["bta_circ_0009084",0,0,0,2.05598309843732,3,0,8,-4.27243182799033,0.033574852292125,"NA","down","yes","NC_037341.1:69807952..69811910:+","gene18217","gi|329664140|ref|NP_001192355.1|",8338,0,"protein virilizer homolog [Bos taurus]","gi|329664139|ref|NM_001205426.1|",6473,0,"Bos taurus KIAA1429 ortholog (KIAA1429), mRNA","Q69YN4",3156,0,"Protein virilizer homolog",".",".",".",".","pfam14923","CCDC142","Coiled-coil protein 142. The function of this coiled-coil domain-containing family is not known. It is found in eukaryotes.","GO:0080009|mRNA methylation;GO:0006397|mRNA processing;GO:0008380|RNA splicing;","GO:0005829|cytosol;GO:0016604|nuclear body;GO:0016607|nuclear speck;GO:0005654|nucleoplasm;","GO:0003723|RNA binding;",".","."]
["bta_circ_0009110",0,7,13,2.31626522613681,0,0,0,4.40014024707569,0.0274785861624929,"NA","up","yes","NC_037341.1:73093699..73105548:-","gene18234","gi|300798072|ref|NP_001180075.1|",3288,0,"anion exchange transporter [Bos taurus]","gi|982945150|ref|XM_005215678.3|",5359,0,"PREDICTED: Bos taurus solute carrier family 26 (anion exchanger), member 7 (SLC26A7), transcript variant X3, mRNA","Q8TE54",1117,0,"Anion exchange transporter","aq_1268",145,{"v":9e-35,"d":"9.00E-35"},"COG0659","pfam00916","Sulfate_transp","Sulfate transporter family. Mutations in human SLC26A2 lead to several human diseases.","GO:0006820|anion transport;GO:0015701|bicarbonate transport;GO:0006821|chloride transport;GO:0001696|gastric acid secretion;GO:0006811|ion transport;GO:0019532|oxalate transport;GO:0051453|regulation of intracellular pH;GO:0042391|regulation of membrane potential;GO:0008272|sulfate transport;","GO:0016323|basolateral plasma membrane;GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;GO:0055038|recycling endosome membrane;","GO:0015301|anion:anion antiporter activity;GO:0015106|bicarbonate transmembrane transporter activity;GO:0005254|chloride channel activity;GO:0019531|oxalate transmembrane transporter activity;GO:0008271|secondary active sulfate transmembrane transporter activity;GO:0015116|sulfate transmembrane transporter activity;","K13962","SLC26A7, SUT2; solute carrier family 26 (anion exchange transporter), member 7"]
["bta_circ_0009171",0,0,0,2.49532159961546,4,7,4,-4.78430278746016,0.0128644720471839,"NA","down","yes","NC_037341.1:81010964..81024505:-","gene18306","gi|982945121|ref|XP_015330019.1|",5193,0,"PREDICTED: ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X1 [Bos taurus]","gi|982945120|ref|XM_015474533.1|",3463,0,"PREDICTED: Bos taurus ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2), transcript variant X1, mRNA","A1A4K5",1784,0,"Ectonucleotide pyrophosphatase/phosphodiesterase family member 2","XF2599",169,{"v":9e-44,"d":"9.00E-44"},"COG1524","pfam01663","Phosphodiest","Type I phosphodiesterase / nucleotide pyrophosphatase. This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyse the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars. Also in this family is ATX an autotaxin, tumor cell motility-stimulating protein which exhibits type I phosphodiesterases activity. The alignment encompasses the active site. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum.","GO:0006935|chemotaxis;GO:0006955|immune response;GO:0034638|phosphatidylcholine catabolic process;GO:0009395|phospholipid catabolic process;GO:0010634|positive regulation of epithelial cell migration;GO:2000394|positive regulation of lamellipodium morphogenesis;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0045765|regulation of angiogenesis;","GO:0005615|extracellular space;","GO:0047391|alkylglycerophosphoethanolamine phosphodiesterase activity;GO:0005509|calcium ion binding;GO:0004622|lysophospholipase activity;GO:0003676|nucleic acid binding;GO:0004551|nucleotide diphosphatase activity;GO:0004528|phosphodiesterase I activity;GO:0030247|polysaccharide binding;GO:0005044|scavenger receptor activity;GO:0008270|zinc ion binding;","K01122","ENPP2; ectonucleotide pyrophosphatase/phosphodiesterase family member 2 [EC:3.1.4.39]"]
["bta_circ_0009218",0,0,0,2.40908169539826,3,0,10,-4.50988474799719,0.0229660254457117,"NA","down","yes","NC_037342.1:15244092..15253204:+","gene18442","gi|803311476|ref|XP_012014063.1|",2456,0,"PREDICTED: sestrin-3 isoform X1 [Ovis aries musimon]","gi|982994907|ref|XM_594021.7|",9192,0,"PREDICTED: Bos taurus sestrin 3 (SESN3), mRNA","P58005",938,0,"Sestrin-3",".",".",".",".","pfam04636","PA26","PA26 p53-induced protein (sestrin). PA26 is a p53-inducible protein. Its function is unknown. It has similarity to pfam04636 in its N-terminus.","GO:0034198|cellular response to amino acid starvation;GO:0071230|cellular response to amino acid stimulus;GO:0042149|cellular response to glucose starvation;GO:0042593|glucose homeostasis;GO:1904262|negative regulation of TORC1 signaling;GO:0046626|regulation of insulin receptor signaling pathway;GO:0051896|regulation of protein kinase B signaling;GO:1901031|regulation of response to reactive oxygen species;GO:0032868|response to insulin;GO:0038203|TORC2 signaling;","GO:0005737|cytoplasm;GO:0005634|nucleus;GO:0031932|TORC2 complex;","GO:0016491|oxidoreductase activity;","K10141","SESN; sestrin"]
["bta_circ_0009268",0,0,0,1.84145352823946,2,0,8,-4.09373446956485,0.0439610261947129,"NA","down","yes","NC_037342.1:24586798..24591107:+","gene18544","gi|82697379|ref|NP_001032553.1|",3441,0,"zinc finger and BTB domain-containing protein 16 [Bos taurus]","gi|982945555|ref|XM_005215850.3|",7736,0,"PREDICTED: Bos taurus zinc finger and BTB domain containing 16 (ZBTB16), transcript variant X2, mRNA","Q05516",1282,0,"Zinc finger and BTB domain-containing protein 16",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0009952|anterior/posterior pattern specification;GO:0006915|apoptotic process;GO:0051216|cartilage development;GO:0007417|central nervous system development;GO:0042733|embryonic digit morphogenesis;GO:0035116|embryonic hindlimb morphogenesis;GO:0009880|embryonic pattern specification;GO:0035136|forelimb morphogenesis;GO:0030097|hemopoiesis;GO:0048133|male germ-line stem cell asymmetric division;GO:0001823|mesonephros development;GO:0030099|myeloid cell differentiation;GO:0008285|negative regulation of cell proliferation;GO:0045638|negative regulation of myeloid cell differentiation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0043065|positive regulation of apoptotic process;GO:0061036|positive regulation of cartilage development;GO:0032332|positive regulation of chondrocyte differentiation;GO:0045600|positive regulation of fat cell differentiation;GO:0051138|positive regulation of NK T cell differentiation;GO:0045778|positive regulation of ossification;GO:0045893|positive regulation of transcription, DNA-templated;GO:0043687|post-translational protein modification;GO:0034504|protein localization to nucleus;GO:0016567|protein ubiquitination;GO:0006351|transcription, DNA-templated;","GO:0005829|cytosol;GO:0016604|nuclear body;GO:0016607|nuclear speck;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0016605|PML body;GO:0032991|macromolecular complex;GO:0017053|transcriptional repressor complex;","GO:0003677|DNA binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0008022|protein C-terminus binding;GO:0019904|protein domain specific binding;GO:0042803|protein homodimerization activity;GO:0000980|RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001206|transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding;","K10055","ZBTB16, PLZF; zinc finger and BTB domain-containing protein 16"]
["bta_circ_0009274",5,20,20,28.4080034041672,48,20,54,-1.84684946367905,0.00679930721192749,0.207043692847708,"down","yes","NC_037342.1:24586798..24716038:+","gene18544","gi|82697379|ref|NP_001032553.1|",3441,0,"zinc finger and BTB domain-containing protein 16 [Bos taurus]","gi|982945555|ref|XM_005215850.3|",7736,0,"PREDICTED: Bos taurus zinc finger and BTB domain containing 16 (ZBTB16), transcript variant X2, mRNA","Q05516",1282,0,"Zinc finger and BTB domain-containing protein 16",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0009952|anterior/posterior pattern specification;GO:0006915|apoptotic process;GO:0051216|cartilage development;GO:0007417|central nervous system development;GO:0042733|embryonic digit morphogenesis;GO:0035116|embryonic hindlimb morphogenesis;GO:0009880|embryonic pattern specification;GO:0035136|forelimb morphogenesis;GO:0030097|hemopoiesis;GO:0048133|male germ-line stem cell asymmetric division;GO:0001823|mesonephros development;GO:0030099|myeloid cell differentiation;GO:0008285|negative regulation of cell proliferation;GO:0045638|negative regulation of myeloid cell differentiation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0043065|positive regulation of apoptotic process;GO:0061036|positive regulation of cartilage development;GO:0032332|positive regulation of chondrocyte differentiation;GO:0045600|positive regulation of fat cell differentiation;GO:0051138|positive regulation of NK T cell differentiation;GO:0045778|positive regulation of ossification;GO:0045893|positive regulation of transcription, DNA-templated;GO:0043687|post-translational protein modification;GO:0034504|protein localization to nucleus;GO:0016567|protein ubiquitination;GO:0006351|transcription, DNA-templated;","GO:0005829|cytosol;GO:0016604|nuclear body;GO:0016607|nuclear speck;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0016605|PML body;GO:0032991|macromolecular complex;GO:0017053|transcriptional repressor complex;","GO:0003677|DNA binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0008022|protein C-terminus binding;GO:0019904|protein domain specific binding;GO:0042803|protein homodimerization activity;GO:0000980|RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001206|transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding;","K10055","ZBTB16, PLZF; zinc finger and BTB domain-containing protein 16"]
["bta_circ_0009306",0,13,27,4.66394347602759,0,0,0,5.39333418849554,0.00402370389441585,"NA","up","yes","NC_037342.1:32140486..32141515:+","gene18668","gi|300795351|ref|NP_001179686.1|",11545,0,"sortilin-related receptor precursor [Bos taurus]","gi|300795350|ref|NM_001192757.1|",10600,0,"Bos taurus sortilin-related receptor, L(DLR class) A repeats containing (SORL1), mRNA","Q92673",4138,0,"Sortilin-related receptor",".",".",".",".","pfam00057","Ldl_recept_a","Low-density lipoprotein receptor domain class A.","GO:0044267|cellular protein metabolic process;GO:0008203|cholesterol metabolic process;GO:0006869|lipid transport;GO:1902430|negative regulation of beta-amyloid formation;GO:1902960|negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;GO:0043407|negative regulation of MAP kinase activity;GO:1902963|negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process;GO:1902997|negative regulation of neurofibrillary tangle assembly;GO:0050768|negative regulation of neurogenesis;GO:1901215|negative regulation of neuron death;GO:0032091|negative regulation of protein binding;GO:0032460|negative regulation of protein oligomerization;GO:1902948|negative regulation of tau-protein kinase activity;GO:1902771|positive regulation of choline O-acetyltransferase activity;GO:1902955|positive regulation of early endosome to recycling endosome transport;GO:2001137|positive regulation of endocytic recycling;GO:1902953|positive regulation of ER to Golgi vesicle-mediated transport;GO:0045732|positive regulation of protein catabolic process;GO:0070863|positive regulation of protein exit from endoplasmic reticulum;GO:1902966|positive regulation of protein localization to early endosome;GO:0006892|post-Golgi vesicle-mediated transport;GO:0034067|protein localization to Golgi apparatus;GO:0051604|protein maturation;GO:0045053|protein retention in Golgi apparatus;GO:0006605|protein targeting;GO:0006622|protein targeting to lysosome;GO:0006898|receptor-mediated endocytosis;GO:0014910|regulation of smooth muscle cell migration;","GO:0005769|early endosome;GO:0005783|endoplasmic reticulum;GO:0005768|endosome;GO:0010008|endosome membrane;GO:0070062|extracellular exosome;GO:0005615|extracellular space;GO:0005794|Golgi apparatus;GO:0031985|Golgi cisterna;GO:0000139|Golgi membrane;GO:0005887|integral component of plasma membrane;GO:0034362|low-density lipoprotein particle;GO:0016020|membrane;GO:0005641|nuclear envelope lumen;GO:0055037|recycling endosome;GO:0005802|trans-Golgi network;","GO:0030306|ADP-ribosylation factor binding;GO:0001540|beta-amyloid binding;GO:0030169|low-density lipoprotein particle binding;GO:0005041|low-density lipoprotein receptor activity;GO:0004888|transmembrane signaling receptor activity;",".","."]
["bta_circ_0009307",0,0,0,1.72665577031561,0,9,3,-4.04584832567136,0.0469265519757059,"NA","down","yes","NC_037342.1:32190612..32191957:+","gene18668","gi|300795351|ref|NP_001179686.1|",11545,0,"sortilin-related receptor precursor [Bos taurus]","gi|300795350|ref|NM_001192757.1|",10600,0,"Bos taurus sortilin-related receptor, L(DLR class) A repeats containing (SORL1), mRNA","Q92673",4138,0,"Sortilin-related receptor",".",".",".",".","pfam00057","Ldl_recept_a","Low-density lipoprotein receptor domain class A.","GO:0044267|cellular protein metabolic process;GO:0008203|cholesterol metabolic process;GO:0006869|lipid transport;GO:1902430|negative regulation of beta-amyloid formation;GO:1902960|negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;GO:0043407|negative regulation of MAP kinase activity;GO:1902963|negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process;GO:1902997|negative regulation of neurofibrillary tangle assembly;GO:0050768|negative regulation of neurogenesis;GO:1901215|negative regulation of neuron death;GO:0032091|negative regulation of protein binding;GO:0032460|negative regulation of protein oligomerization;GO:1902948|negative regulation of tau-protein kinase activity;GO:1902771|positive regulation of choline O-acetyltransferase activity;GO:1902955|positive regulation of early endosome to recycling endosome transport;GO:2001137|positive regulation of endocytic recycling;GO:1902953|positive regulation of ER to Golgi vesicle-mediated transport;GO:0045732|positive regulation of protein catabolic process;GO:0070863|positive regulation of protein exit from endoplasmic reticulum;GO:1902966|positive regulation of protein localization to early endosome;GO:0006892|post-Golgi vesicle-mediated transport;GO:0034067|protein localization to Golgi apparatus;GO:0051604|protein maturation;GO:0045053|protein retention in Golgi apparatus;GO:0006605|protein targeting;GO:0006622|protein targeting to lysosome;GO:0006898|receptor-mediated endocytosis;GO:0014910|regulation of smooth muscle cell migration;","GO:0005769|early endosome;GO:0005783|endoplasmic reticulum;GO:0005768|endosome;GO:0010008|endosome membrane;GO:0070062|extracellular exosome;GO:0005615|extracellular space;GO:0005794|Golgi apparatus;GO:0031985|Golgi cisterna;GO:0000139|Golgi membrane;GO:0005887|integral component of plasma membrane;GO:0034362|low-density lipoprotein particle;GO:0016020|membrane;GO:0005641|nuclear envelope lumen;GO:0055037|recycling endosome;GO:0005802|trans-Golgi network;","GO:0030306|ADP-ribosylation factor binding;GO:0001540|beta-amyloid binding;GO:0030169|low-density lipoprotein particle binding;GO:0005041|low-density lipoprotein receptor activity;GO:0004888|transmembrane signaling receptor activity;",".","."]
["bta_circ_0009347",0,0,0,1.86829749640274,5,2,3,-4.30257014286107,0.0303276557516136,"NA","down","yes","NC_037342.1:37898596..37911590:+","gene18723","gi|742231047|ref|XP_010828872.1|",2358,0,"PREDICTED: vitamin D 25-hydroxylase isoform X4 [Bison bison bison]","gi|742231046|ref|XM_010830570.1|",3217,0,"PREDICTED: Bison bison bison vitamin D 25-hydroxylase (LOC104981447), transcript variant X4, mRNA","Q6VVX0",850,0,"Vitamin D 25-hydroxylase",".",".",".",".","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0010164|response to cesium ion;GO:0010212|response to ionizing radiation;GO:0042359|vitamin D metabolic process;GO:0006766|vitamin metabolic process;","GO:0005789|endoplasmic reticulum membrane;GO:0031090|organelle membrane;","GO:0020037|heme binding;GO:0005506|iron ion binding;GO:0016705|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0008395|steroid hydroxylase activity;GO:0030343|vitamin D3 25-hydroxylase activity;","K07419","CYP2R1; vitamin D 25-hydroxylase [EC:1.14.13.159]"]
["bta_circ_0009366",19,50,34,56.8356571866867,78,77,86,-1.51071270123113,0.00191294300374778,0.0915162558659127,"down","yes","NC_037342.1:38431604..38443663:+","gene18729","gi|593715096|ref|XP_007104022.1|",903,{"v":7e-115,"d":"7.00E-115"},"PREDICTED: ras-related protein R-Ras2-like isoform X2 [Physeter catodon]","gi|982945769|ref|XM_010812454.2|",1959,0,"PREDICTED: Bos taurus related RAS viral (r-ras) oncogene homolog 2 (RRAS2), transcript variant X2, mRNA","P62071",351,{"v":1e-115,"d":"1.00E-115"},"Ras-related protein R-Ras2","SPAC17H9.09c",197,{"v":2e-57,"d":"2.00E-57"},"COG1100","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0009987|cellular process;GO:0030335|positive regulation of cell migration;GO:0007265|Ras protein signal transduction;GO:1901214|regulation of neuron death;","GO:0005622|intracellular;GO:0005886|plasma membrane;","GO:0005525|GTP binding;GO:0003924|GTPase activity;","K07830","RRAS2, TC21; Ras-related protein R-Ras2"]
["bta_circ_0009376",4,4,7,2.4475156066157,0,0,0,4.57522916784658,0.019476474446213,"NA","up","yes","NC_037342.1:39927177..39936566:-","gene18744","gi|635015109|ref|XP_008004664.1|",2552,0,"PREDICTED: transcriptional enhancer factor TEF-1 isoform X5 [Chlorocebus sabaeus]","gi|982995116|ref|XM_005194599.3|",9336,0,"PREDICTED: Bos taurus TEA domain transcription factor 1 (TEAD1), transcript variant X1, mRNA","P28347",821,0,"Transcriptional enhancer factor TEF-1",".",".",".",".","pfam01285","TEA","TEA/ATTS domain family.","GO:0048568|embryonic organ development;GO:0035329|hippo signaling;GO:1902895|positive regulation of pri-miRNA transcription from RNA polymerase II promoter;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0065003|macromolecular complex assembly;GO:0006367|transcription initiation from RNA polymerase II promoter;","GO:0005654|nucleoplasm;GO:0071148|TEAD-1-YAP complex;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046982|protein heterodimerization activity;GO:0000987|core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001085|RNA polymerase II transcription factor binding;GO:0043565|sequence-specific DNA binding;GO:0001223|transcription coactivator binding;GO:0000982|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001134|transcription factor activity, transcription factor recruiting;","K09448","TEAD; transcriptional enhancer factor"]
["bta_circ_0009427",12,0,21,6.19780926944595,0,0,0,4.59492440398398,0.0249056623450919,0.383893430686201,"up","yes","NC_037342.1:51369428..51403148:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0009481",35,132,87,162.986253815834,231,307,219,-1.90471881070951,{"v":4.39607517210909e-07,"d":"4.40E-07"},0.000190086290441997,"down","yes","NC_037342.1:63908514..63909612:+","gene19383","gi|741952474|ref|XP_010811034.1|",5958,0,"PREDICTED: homeodomain-interacting protein kinase 3 isoform X2 [Bos taurus]","gi|982946537|ref|XM_005216299.3|",7627,0,"PREDICTED: Bos taurus homeodomain interacting protein kinase 3 (HIPK3), transcript variant X3, mRNA","Q9H422",2160,0,"Homeodomain-interacting protein kinase 3",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006915|apoptotic process;GO:0009299|mRNA transcription;GO:0043066|negative regulation of apoptotic process;GO:0043508|negative regulation of JUN kinase activity;GO:0018105|peptidyl-serine phosphorylation;GO:0018107|peptidyl-threonine phosphorylation;GO:0006468|protein phosphorylation;GO:0006355|regulation of transcription, DNA-templated;","GO:0005829|cytosol;GO:0016604|nuclear body;GO:0016605|PML body;","GO:0005524|ATP binding;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;","K08826","HIPK; homeodomain interacting protein kinase [EC:2.7.11.1]"]
["bta_circ_0009583",20,85,102,80.3179538566487,81,134,103,-0.959235111412679,0.0362058670643499,0.439730132358439,"down","yes","NC_037343.1:12470914..12478370:+","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0009586",0,0,0,1.84380913274215,2,4,5,-4.31211229141759,0.0297781947833084,"NA","down","yes","NC_037343.1:12470914..12520522:+","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0009597",0,8,10,2.03123656314139,0,0,0,4.21514809347415,0.0367195670272668,"NA","up","yes","NC_037343.1:12867479..12872745:+","gene20050",".",".",".",".","gi|982996153|ref|XR_001498191.1|",389,0,"PREDICTED: Bos taurus uncharacterized LOC107133222 (LOC107133222), ncRNA",".",".",".",".",".",".",".",".","pfam13112","DUF3965","Protein of unknown function (DUF3965). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 380 amino acids in length.",".",".",".",".","."]
["bta_circ_0009612",0,12,10,2.41281574660844,0,0,0,4.47312626907796,0.0243145513564689,"NA","up","yes","NC_037343.1:18832669..18834752:+","gene20067","gi|982947635|ref|XP_015330531.1|",3790,0,"PREDICTED: BTB/POZ domain-containing protein KCTD3 isoform X1 [Bos taurus]","gi|328802670|ref|NM_001191424.1|",7081,0,"Bos taurus potassium channel tetramerization domain containing 3 (KCTD3), mRNA","Q9Y597",1423,0,"BTB/POZ domain-containing protein KCTD3",".",".",".",".","pfam02214","BTB_2","BTB/POZ domain. In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.","GO:0051260|protein homooligomerization;","GO:0005886|plasma membrane;",".",".","."]
["bta_circ_0009625",5,2,3,2.04406515785015,0,0,0,4.24968904471892,0.0337640998241779,"NA","up","yes","NC_037343.1:23506620..23507399:-","gene20090","gi|343183370|ref|NP_001230249.1|",7609,0,"bifunctional glutamate/proline--tRNA ligase [Bos taurus]","gi|343183369|ref|NM_001243320.1|",4857,0,"Bos taurus glutamyl-prolyl-tRNA synthetase (EPRS), mRNA","P07814",2750,0,"Bifunctional glutamate/proline--tRNA ligase","SPBC19C7.06_2",598,0,"COG0442","pfam00749","tRNA-synt_1c","tRNA synthetases class I (E and Q), catalytic domain. Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only glutamyl and glutaminyl tRNA synthetases. In some organisms, a single glutamyl-tRNA synthetase aminoacylates both tRNA(Glu) and tRNA(Gln).","GO:0032869|cellular response to insulin stimulus;GO:0071346|cellular response to interferon-gamma;GO:0006424|glutamyl-tRNA aminoacylation;GO:0044539|long-chain fatty acid import;GO:0017148|negative regulation of translation;GO:0006433|prolyl-tRNA aminoacylation;GO:0065003|macromolecular complex assembly;GO:0006418|tRNA aminoacylation for protein translation;","GO:0017101|aminoacyl-tRNA synthetase multienzyme complex;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0097452|GAIT complex;GO:0016020|membrane;GO:0005886|plasma membrane;","GO:0005524|ATP binding;GO:0004818|glutamate-tRNA ligase activity;GO:0051020|GTPase binding;GO:0042802|identical protein binding;GO:0004827|proline-tRNA ligase activity;GO:0042803|protein homodimerization activity;GO:0035613|RNA stem-loop binding;GO:0008270|zinc ion binding;","K14163","EPRS; bifunctional glutamyl/prolyl-tRNA synthetase [EC:6.1.1.17 6.1.1.15]"]
["bta_circ_0009646",0,0,0,3.67091381015313,7,11,4,-5.35266107523491,0.00388509733337305,"NA","down","yes","NC_037343.1:27409092..27422312:-","gene20126","gi|594040844|ref|XP_006044977.1|",4030,0,"PREDICTED: nuclear valosin-containing protein-like isoform X1 [Bubalus bubalis]","gi|594040843|ref|XM_006044915.1|",2398,0,"PREDICTED: Bubalus bubalis nuclear VCP-like (NVL), transcript variant X1, mRNA","O15381",1374,0,"Nuclear valosin-containing protein-like","SPBC16E9.10c",639,0,"COG0464","pfam00004","AAA","ATPase family associated with various cellular activities (AAA). AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.","GO:0051973|positive regulation of telomerase activity;GO:0042254|ribosome biogenesis;","GO:0016020|membrane;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005697|telomerase holoenzyme complex;","GO:0005524|ATP binding;GO:1990275|preribosome binding;GO:0003723|RNA binding;","K14571","RIX7, NVL; ribosome biogenesis ATPase"]
["bta_circ_0009646",0,0,0,3.67091381015313,7,11,4,-5.35266107523491,0.00388509733337305,"NA","down","yes","NC_037343.1:27409092..27422312:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0009651",33,15,19,16.2844374965447,3,9,5,2.15563818418806,0.0140653083702014,0.298906981742218,"up","yes","NC_037343.1:2782140..2787106:+","gene19947","gi|528979229|ref|XP_005216760.1|",6048,0,"PREDICTED: neurofascin isoform X1 [Bos taurus]","gi|982996009|ref|XM_015466689.1|",10154,0,"PREDICTED: Bos taurus neurofascin (NFASC), transcript variant X1, mRNA","O94856",2063,0,"Neurofascin",".",".",".",".","pfam13882","Bravo_FIGEY","Bravo-like intracellular region. This is the very C-terminal intracellular region of neural adhesion molecule L1 proteins that are also known as Bravo or NrCAM. It lies upstream of the IG and Fn3 domains and has the highly conserved motif FIGEY. The function is not known.","GO:0007411|axon guidance;GO:0045162|clustering of voltage-gated sodium channels;GO:0042552|myelination;GO:0043312|neutrophil degranulation;GO:0030913|paranodal junction assembly;GO:0007422|peripheral nervous system development;GO:0071205|protein localization to juxtaparanode region of axon;GO:0002175|protein localization to paranode region of axon;GO:0072659|protein localization to plasma membrane;GO:0050808|synapse organization;GO:0019226|transmission of nerve impulse;","GO:0043194|axon initial segment;GO:0030425|dendrite;GO:0005925|focal adhesion;GO:0016021|integral component of membrane;GO:0005622|intracellular;GO:0043209|myelin sheath;GO:0033268|node of Ranvier;GO:0033010|paranodal junction;GO:0033270|paranode region of axon;GO:0005886|plasma membrane;GO:0097454|Schwann cell microvillus;","GO:0086080|protein binding involved in heterotypic cell-cell adhesion;GO:0019904|protein domain specific binding;","K06757","NFASC; neurofascin"]
["bta_circ_0009652",18,5,10,8.40502942245225,2,3,3,2.15749376970588,0.0490612007599876,0.476348344536443,"up","yes","NC_037343.1:2785772..2787106:+","gene19947","gi|528979229|ref|XP_005216760.1|",6048,0,"PREDICTED: neurofascin isoform X1 [Bos taurus]","gi|982996009|ref|XM_015466689.1|",10154,0,"PREDICTED: Bos taurus neurofascin (NFASC), transcript variant X1, mRNA","O94856",2063,0,"Neurofascin",".",".",".",".","pfam13882","Bravo_FIGEY","Bravo-like intracellular region. This is the very C-terminal intracellular region of neural adhesion molecule L1 proteins that are also known as Bravo or NrCAM. It lies upstream of the IG and Fn3 domains and has the highly conserved motif FIGEY. The function is not known.","GO:0007411|axon guidance;GO:0045162|clustering of voltage-gated sodium channels;GO:0042552|myelination;GO:0043312|neutrophil degranulation;GO:0030913|paranodal junction assembly;GO:0007422|peripheral nervous system development;GO:0071205|protein localization to juxtaparanode region of axon;GO:0002175|protein localization to paranode region of axon;GO:0072659|protein localization to plasma membrane;GO:0050808|synapse organization;GO:0019226|transmission of nerve impulse;","GO:0043194|axon initial segment;GO:0030425|dendrite;GO:0005925|focal adhesion;GO:0016021|integral component of membrane;GO:0005622|intracellular;GO:0043209|myelin sheath;GO:0033268|node of Ranvier;GO:0033010|paranodal junction;GO:0033270|paranode region of axon;GO:0005886|plasma membrane;GO:0097454|Schwann cell microvillus;","GO:0086080|protein binding involved in heterotypic cell-cell adhesion;GO:0019904|protein domain specific binding;","K06757","NFASC; neurofascin"]
["bta_circ_0009668",7,6,0,2.63436172535678,0,0,0,4.47474011165354,0.024372828003812,"NA","up","yes","NC_037343.1:30084572..30153581:-","gene20167","gi|594077546|ref|XP_006062489.1|",9155,0,"PREDICTED: serine/threonine-protein kinase MRCK alpha isoform X2 [Bubalus bubalis]","gi|594077545|ref|XM_006062427.1|",10359,0,"PREDICTED: Bubalus bubalis CDC42 binding protein kinase alpha (DMPK-like) (CDC42BPA), transcript variant X2, mRNA","Q5VT25",3208,0,"Serine/threonine-protein kinase MRCK alpha",".",".",".",".","pfam00780","CNH","CNH domain. Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.","GO:0031532|actin cytoskeleton reorganization;GO:0031032|actomyosin structure organization;GO:0016477|cell migration;GO:0035556|intracellular signal transduction;GO:0006468|protein phosphorylation;","GO:0042641|actomyosin;GO:0031252|cell leading edge;GO:0005911|cell-cell junction;GO:0005737|cytoplasm;GO:0070062|extracellular exosome;GO:0030027|lamellipodium;","GO:0005524|ATP binding;GO:0042802|identical protein binding;GO:0000287|magnesium ion binding;GO:0004674|protein serine/threonine kinase activity;","K16307","CDC42BP; serine/threonine-protein kinase MRCK [EC:2.7.11.1]"]
["bta_circ_0009696",7,2,0,2.25278254188973,0,0,0,4.19772700859067,0.037981578407965,"NA","up","yes","NC_037343.1:33496286..33543770:+","gene20196","gi|944447982|gb|KQL87744.1|",2628,0,"hypothetical protein Y1Q_027250 [Alligator mississippiensis]","gi|741953820|ref|XM_010813110.1|",6874,0,"PREDICTED: Bos taurus v-akt murine thymoma viral oncogene homolog 3 (AKT3), transcript variant X3, mRNA","Q9Y243",1001,0,"RAC-gamma serine/threonine-protein kinase",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0048854|brain morphogenesis;GO:0048873|homeostasis of number of cells within a tissue;GO:0035556|intracellular signal transduction;GO:0000002|mitochondrial genome maintenance;GO:2000773|negative regulation of cellular senescence;GO:0018105|peptidyl-serine phosphorylation;GO:0043536|positive regulation of blood vessel endothelial cell migration;GO:0090050|positive regulation of cell migration involved in sprouting angiogenesis;GO:0045793|positive regulation of cell size;GO:0001938|positive regulation of endothelial cell proliferation;GO:0032008|positive regulation of TOR signaling;GO:0006468|protein phosphorylation;GO:0007165|signal transduction;","GO:0005737|cytoplasm;GO:0005622|intracellular;GO:0016020|membrane;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;","K04456","AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]"]
["bta_circ_0009836",3,5,5,1.99472434179012,0,0,0,4.29414445287599,0.0312407830508962,"NA","up","yes","NC_037343.1:57315244..57364577:-","gene20589","gi|528980207|ref|XP_005217144.1|",3293,0,"PREDICTED: E3 ubiquitin-protein ligase RFWD2 isoform X1 [Bos taurus]","gi|982948127|ref|XM_005217087.3|",2956,0,"PREDICTED: Bos taurus ring finger and WD repeat domain 2, E3 ubiquitin protein ligase (RFWD2), transcript variant X1, mRNA","Q9R1A8",1249,0,"E3 ubiquitin-protein ligase COP1",".",".",".",".","pfam00097","zf-C3HC4","Zinc finger, C3HC4 type (RING finger). The C3HC4 type zinc-finger (RING finger) is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C where X is any amino acid. Many proteins containing a RING finger play a key role in the ubiquitination pathway.","GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010212|response to ionizing radiation;","GO:0031464|Cul4A-RING E3 ubiquitin ligase complex;GO:0000139|Golgi membrane;GO:0016607|nuclear speck;","GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K10143","RFWD2, COP1; E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27]"]
["bta_circ_0009843",0,0,0,3.15240221826584,5,9,5,-5.13704385408897,0.00625664757014425,"NA","down","yes","NC_037343.1:57381336..57389272:-","gene20589","gi|528980207|ref|XP_005217144.1|",3293,0,"PREDICTED: E3 ubiquitin-protein ligase RFWD2 isoform X1 [Bos taurus]","gi|982948127|ref|XM_005217087.3|",2956,0,"PREDICTED: Bos taurus ring finger and WD repeat domain 2, E3 ubiquitin protein ligase (RFWD2), transcript variant X1, mRNA","Q9R1A8",1249,0,"E3 ubiquitin-protein ligase COP1",".",".",".",".","pfam00097","zf-C3HC4","Zinc finger, C3HC4 type (RING finger). The C3HC4 type zinc-finger (RING finger) is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C where X is any amino acid. Many proteins containing a RING finger play a key role in the ubiquitination pathway.","GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010212|response to ionizing radiation;","GO:0031464|Cul4A-RING E3 ubiquitin ligase complex;GO:0000139|Golgi membrane;GO:0016607|nuclear speck;","GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K10143","RFWD2, COP1; E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27]"]
["bta_circ_0009873",7,2,0,2.25278254188973,0,0,0,4.19772700859067,0.037981578407965,"NA","up","yes","NC_037343.1:64987845..65017929:-","gene20677","gi|555962125|ref|XP_005893156.1|",3042,0,"PREDICTED: procollagen galactosyltransferase 2 [Bos mutus]","gi|300796727|ref|NM_001191302.1|",1878,0,"Bos taurus collagen beta(1-O)galactosyltransferase 2 (COLGALT2), mRNA","Q8IYK4",1124,0,"Procollagen galactosyltransferase 2",".",".",".",".","pfam01755","Glyco_transf_25","Glycosyltransferase family 25 (LPS biosynthesis protein). Members of this family belong to Glycosyltransferase family 25 This is a family of glycosyltransferases involved in lipopolysaccharide (LPS) biosynthesis. These enzymes catalyse the transfer of various sugars onto the growing LPS chain during its biosynthesis.",".","GO:0005788|endoplasmic reticulum lumen;","GO:0050211|procollagen galactosyltransferase activity;","K11703","GLT25D; collagen beta-1,O-galactosyltransferase [EC:2.4.1.50]"]
["bta_circ_0009889",4,6,2,2.00426610024558,0,0,0,4.26380265025268,0.0329090557360149,"NA","up","yes","NC_037343.1:65762843..65784440:-","gene20684","gi|741955256|ref|XP_010811859.1|",4584,0,"PREDICTED: ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [Bos taurus]","gi|555962130|ref|XM_005893097.1|",6553,0,"PREDICTED: Bos mutus ER degradation enhancer, mannosidase alpha-like 3 (EDEM3), transcript variant X1, mRNA","Q9BZQ6",1688,0,"ER degradation-enhancing alpha-mannosidase-like protein 3",".",".",".",".","pfam01532","Glyco_hydro_47","Glycosyl hydrolase family 47. Members of this family are alpha-mannosidases that catalyse the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2).","GO:0030968|endoplasmic reticulum unfolded protein response;GO:1904382|mannose trimming involved in glycoprotein ERAD pathway;GO:0006491|N-glycan processing;GO:0006486|protein glycosylation;","GO:0005783|endoplasmic reticulum;GO:0005788|endoplasmic reticulum lumen;GO:0044322|endoplasmic reticulum quality control compartment;GO:0016020|membrane;","GO:0005509|calcium ion binding;GO:0004571|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity;","K10086","EDEM3; ER degradation enhancer, mannosidase alpha-like 3"]
["bta_circ_0009925",2,5,0,32.628396972512,37,94,63,-4.84081856201982,{"v":7.32607154297758e-10,"d":"7.33E-10"},{"v":5.27965555863917e-07,"d":"5.28E-07"},"down","yes","NC_037343.1:69562359..69577209:-","gene20715","gi|466035766|ref|XP_004275294.1|",3726,0,"PREDICTED: prospero homeobox protein 1 [Orcinus orca]","gi|982949016|ref|XM_005217353.3|",8278,0,"PREDICTED: Bos taurus prospero homeobox 1 (PROX1), transcript variant X1, mRNA","Q92786",1387,0,"Prospero homeobox protein 1",".",".",".",".","pfam05044","HPD","Homeo-prospero domain. Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos. It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. Homologues of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain. However, the structure shows that these two regions form a single stable structural domain as defined here. This homeo-prospero domain binds to DNA.","GO:0090425|acinar cell differentiation;GO:0060414|aorta smooth muscle tissue morphogenesis;GO:0055009|atrial cardiac muscle tissue morphogenesis;GO:0007420|brain development;GO:0061114|branching involved in pancreas morphogenesis;GO:0055007|cardiac muscle cell differentiation;GO:0001709|cell fate determination;GO:0021707|cerebellar granule cell differentiation;GO:0007623|circadian rhythm;GO:0021542|dentate gyrus development;GO:0021516|dorsal spinal cord development;GO:0060059|embryonic retina morphogenesis in camera-type eye;GO:0060214|endocardium formation;GO:0002194|hepatocyte cell migration;GO:0070365|hepatocyte differentiation;GO:0072574|hepatocyte proliferation;GO:0001822|kidney development;GO:0002088|lens development in camera-type eye;GO:0070309|lens fiber cell morphogenesis;GO:0001889|liver development;GO:0030324|lung development;GO:0001946|lymphangiogenesis;GO:0060836|lymphatic endothelial cell differentiation;GO:0070858|negative regulation of bile acid biosynthetic process;GO:0008285|negative regulation of cell proliferation;GO:0043433|negative regulation of sequence-specific DNA binding transcription factor activity;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045071|negative regulation of viral genome replication;GO:0021915|neural tube development;GO:0030182|neuron differentiation;GO:0097150|neuronal stem cell population maintenance;GO:0030910|olfactory placode formation;GO:0046619|optic placode formation involved in camera-type eye formation;GO:0043049|otic placode formation;GO:0031016|pancreas development;GO:0045787|positive regulation of cell cycle;GO:1901978|positive regulation of cell cycle checkpoint;GO:0008284|positive regulation of cell proliferation;GO:0045737|positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0010595|positive regulation of endothelial cell migration;GO:0001938|positive regulation of endothelial cell proliferation;GO:2000979|positive regulation of forebrain neuron differentiation;GO:0060421|positive regulation of heart growth;GO:2000179|positive regulation of neural precursor cell proliferation;GO:0060298|positive regulation of sarcomere organization;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0042752|regulation of circadian rhythm;GO:0010468|regulation of gene expression;GO:0060849|regulation of transcription involved in lymphatic endothelial cell fate commitment;GO:0031667|response to nutrient levels;GO:0060042|retina morphogenesis in camera-type eye;GO:0030240|skeletal muscle thin filament assembly;GO:0006351|transcription, DNA-templated;GO:0048845|venous blood vessel morphogenesis;GO:0055010|ventricular cardiac muscle tissue morphogenesis;GO:0055005|ventricular cardiac myofibril assembly;GO:0060412|ventricular septum morphogenesis;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0001046|core promoter sequence-specific DNA binding;GO:0050692|DBD domain binding;GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0050693|LBD domain binding;GO:0016922|ligand-dependent nuclear receptor binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003714|transcription corepressor activity;GO:0003705|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0044212|transcription regulatory region DNA binding;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;",".","."]
["bta_circ_0009926",0,3,0,7.34865819782802,9,20,14,-3.88979421532403,0.00171566034644613,0.0847995482704926,"down","yes","NC_037343.1:69568467..69577209:-","gene20715","gi|466035766|ref|XP_004275294.1|",3726,0,"PREDICTED: prospero homeobox protein 1 [Orcinus orca]","gi|982949016|ref|XM_005217353.3|",8278,0,"PREDICTED: Bos taurus prospero homeobox 1 (PROX1), transcript variant X1, mRNA","Q92786",1387,0,"Prospero homeobox protein 1",".",".",".",".","pfam05044","HPD","Homeo-prospero domain. Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos. It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. Homologues of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain. However, the structure shows that these two regions form a single stable structural domain as defined here. This homeo-prospero domain binds to DNA.","GO:0090425|acinar cell differentiation;GO:0060414|aorta smooth muscle tissue morphogenesis;GO:0055009|atrial cardiac muscle tissue morphogenesis;GO:0007420|brain development;GO:0061114|branching involved in pancreas morphogenesis;GO:0055007|cardiac muscle cell differentiation;GO:0001709|cell fate determination;GO:0021707|cerebellar granule cell differentiation;GO:0007623|circadian rhythm;GO:0021542|dentate gyrus development;GO:0021516|dorsal spinal cord development;GO:0060059|embryonic retina morphogenesis in camera-type eye;GO:0060214|endocardium formation;GO:0002194|hepatocyte cell migration;GO:0070365|hepatocyte differentiation;GO:0072574|hepatocyte proliferation;GO:0001822|kidney development;GO:0002088|lens development in camera-type eye;GO:0070309|lens fiber cell morphogenesis;GO:0001889|liver development;GO:0030324|lung development;GO:0001946|lymphangiogenesis;GO:0060836|lymphatic endothelial cell differentiation;GO:0070858|negative regulation of bile acid biosynthetic process;GO:0008285|negative regulation of cell proliferation;GO:0043433|negative regulation of sequence-specific DNA binding transcription factor activity;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045071|negative regulation of viral genome replication;GO:0021915|neural tube development;GO:0030182|neuron differentiation;GO:0097150|neuronal stem cell population maintenance;GO:0030910|olfactory placode formation;GO:0046619|optic placode formation involved in camera-type eye formation;GO:0043049|otic placode formation;GO:0031016|pancreas development;GO:0045787|positive regulation of cell cycle;GO:1901978|positive regulation of cell cycle checkpoint;GO:0008284|positive regulation of cell proliferation;GO:0045737|positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0010595|positive regulation of endothelial cell migration;GO:0001938|positive regulation of endothelial cell proliferation;GO:2000979|positive regulation of forebrain neuron differentiation;GO:0060421|positive regulation of heart growth;GO:2000179|positive regulation of neural precursor cell proliferation;GO:0060298|positive regulation of sarcomere organization;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0042752|regulation of circadian rhythm;GO:0010468|regulation of gene expression;GO:0060849|regulation of transcription involved in lymphatic endothelial cell fate commitment;GO:0031667|response to nutrient levels;GO:0060042|retina morphogenesis in camera-type eye;GO:0030240|skeletal muscle thin filament assembly;GO:0006351|transcription, DNA-templated;GO:0048845|venous blood vessel morphogenesis;GO:0055010|ventricular cardiac muscle tissue morphogenesis;GO:0055005|ventricular cardiac myofibril assembly;GO:0060412|ventricular septum morphogenesis;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0001046|core promoter sequence-specific DNA binding;GO:0050692|DBD domain binding;GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0050693|LBD domain binding;GO:0016922|ligand-dependent nuclear receptor binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003714|transcription corepressor activity;GO:0003705|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0044212|transcription regulatory region DNA binding;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;",".","."]
["bta_circ_0009978",0,0,0,2.07739876277386,0,5,8,-4.32726746700641,0.0306845383047395,"NA","down","yes","NC_037343.1:76549213..76606729:-","gene20815","gi|803129781|ref|XP_012043252.1|",3656,0,"PREDICTED: DENN domain-containing protein 1B isoform X1 [Ovis aries]","gi|742233370|ref|XM_010831135.1|",7521,0,"PREDICTED: Bison bison bison DENN/MADD domain containing 1B (DENND1B), mRNA","Q6P3S1",1196,0,"DENN domain-containing protein 1B",".",".",".",".","pfam02141","DENN","DENN (AEX-3) domain. DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.","GO:0032456|endocytic recycling;GO:0043547|positive regulation of GTPase activity;GO:0015031|protein transport;GO:0050776|regulation of immune response;GO:0050852|T cell receptor signaling pathway;GO:0035745|T-helper 2 cell cytokine production;","GO:0030136|clathrin-coated vesicle;GO:0005829|cytosol;GO:0016607|nuclear speck;","GO:0017112|Rab guanyl-nucleotide exchange factor activity;",".","."]
["bta_circ_0009996",0,0,0,1.79233695296796,3,2,5,-4.25024607832348,0.0329436429275932,"NA","down","yes","NC_037343.1:79981483..79984401:+","gene20869","gi|594111435|ref|XP_006078535.1|",7432,0,"PREDICTED: LOW QUALITY PROTEIN: lysine-specific demethylase 5B [Bubalus bubalis]","gi|982996922|ref|XM_015466901.1|",5513,0,"PREDICTED: Bos taurus lysine (K)-specific demethylase 5B (KDM5B), transcript variant X1, mRNA","Q9UGL1",2664,0,"Lysine-specific demethylase 5B",".",".",".",".","pfam08429","PLU-1","PLU-1-like protein. Sequences in this family bear similarity to the central region of PLU-1. This is a nuclear protein that may have a role in DNA-binding and transcription, and is closely associated with the malignant phenotype of breast cancer. This region is found in various other Jumonji/ARID domain-containing proteins (see pfam02373, pfam01388).","GO:0060444|branching involved in mammary gland duct morphogenesis;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:1990830|cellular response to leukemia inhibitory factor;GO:0034720|histone H3-K4 demethylation;GO:0070306|lens fiber cell differentiation;GO:0060763|mammary duct terminal end bud growth;GO:0045892|negative regulation of transcription, DNA-templated;GO:0010628|positive regulation of gene expression;GO:0033601|positive regulation of mammary gland epithelial cell proliferation;GO:0009791|post-embryonic development;GO:2000864|regulation of estradiol secretion;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0060992|response to fungicide;GO:0048511|rhythmic process;GO:0007338|single fertilization;GO:0006351|transcription, DNA-templated;GO:0061038|uterus morphogenesis;","GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0051213|dioxygenase activity;GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0042393|histone binding;GO:0032452|histone demethylase activity;GO:0034648|histone demethylase activity (H3-dimethyl-K4 specific);GO:0032453|histone demethylase activity (H3-K4 specific);GO:0034647|histone demethylase activity (H3-trimethyl-K4 specific);GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;GO:0003714|transcription corepressor activity;GO:0008270|zinc ion binding;","K11446","KDM5, JARID1; histone demethylase JARID1 [EC:1.14.11.-]"]
["bta_circ_0010055",0,0,0,18.937123315624,46,35,25,-7.62121816099578,{"v":2.78947264615467e-06,"d":"2.79E-06"},0.000861548551569484,"down","yes","NC_037344.1:12787267..12792351:-","gene21007","gi|440896595|gb|ELR48487.1|",2019,0,"Mothers against decapentaplegic-like protein 1, partial [Bos mutus]","gi|982949669|ref|XM_010813715.2|",3018,0,"PREDICTED: Bos taurus SMAD family member 1 (SMAD1), transcript variant X1, mRNA","Q1JQA2",780,0,"Mothers against decapentaplegic homolog 1",".",".",".",".","pfam03166","MH2","MH2 domain. This is the MH2 (MAD homology 2) domain found at the carboxy terminus of MAD related proteins such as Smads. This domain is separated from the MH1 domain by a non-conserved linker region. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers. Unlike MH1, MH2 does not bind DNA. The well-studied MH2 domain of Smad4 is composed of five alpha helices and three loops enclosing a beta sandwich. Smads are involved in the propagation of TGF-beta signals by direct association with the TGF-beta receptor kinase which phosphorylates the last two Ser of a conserved 'SSXS' motif located at the C-terminus of MH2.","GO:0030509|BMP signaling pathway;GO:0060348|bone development;GO:0060038|cardiac muscle cell proliferation;GO:0051216|cartilage development;GO:0071407|cellular response to organic cyclic compound;GO:0007276|gamete generation;GO:0030902|hindbrain development;GO:0042592|homeostatic process;GO:0006954|inflammatory response;GO:0000165|MAPK cascade;GO:0001710|mesodermal cell fate commitment;GO:0030901|midbrain development;GO:0008285|negative regulation of cell proliferation;GO:0002051|osteoblast fate commitment;GO:0061036|positive regulation of cartilage development;GO:0045669|positive regulation of osteoblast differentiation;GO:1902895|positive regulation of pri-miRNA transcription from RNA polymerase II promoter;GO:1903672|positive regulation of sprouting angiogenesis;GO:1901522|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus;GO:0007183|SMAD protein complex assembly;GO:0060395|SMAD protein signal transduction;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0001657|ureteric bud development;","GO:0005737|cytoplasm;GO:0005637|nuclear inner membrane;GO:0005667|transcription factor complex;","GO:0070410|co-SMAD binding;GO:0017151|DEAD/H-box RNA helicase binding;GO:0070411|I-SMAD binding;GO:0046872|metal ion binding;GO:0070878|primary miRNA binding;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;GO:0019901|protein kinase binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K04676","SMAD1; mothers against decapentaplegic homolog 1"]
["bta_circ_0010080",0,0,0,2.29971224130114,7,6,0,-4.46429387034213,0.0245757870630113,"NA","down","yes","NC_037344.1:18165655..18190227:+","gene21054","gi|528917897|ref|XP_594035.6|",2143,0,"PREDICTED: histone-lysine N-methyltransferase SETD7 [Bos taurus]","gi|982997661|ref|XM_594035.8|",7197,0,"PREDICTED: Bos taurus SET domain containing (lysine methyltransferase) 7 (SETD7), mRNA","Q8WTS6",732,0,"Histone-lysine N-methyltransferase SETD7","slr1485",62.4,{"v":8e-09,"d":"8.00E-09"},"COG4642","pfam00856","SET","SET domain. SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.","GO:0006974|cellular response to DNA damage stimulus;GO:0006325|chromatin organization;GO:0070828|heterochromatin organization;GO:0018027|peptidyl-lysine dimethylation;GO:0018026|peptidyl-lysine monomethylation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0051570|regulation of histone H3-K9 methylation;GO:0045471|response to ethanol;GO:0006351|transcription, DNA-templated;","GO:0005694|chromosome;GO:0005730|nucleolus;GO:0005654|nucleoplasm;","GO:0003682|chromatin binding;GO:0018024|histone-lysine N-methyltransferase activity;GO:0002039|p53 binding;GO:0016279|protein-lysine N-methyltransferase activity;","K11431","SETD7; histone-lysine N-methyltransferase SETD7 [EC:2.1.1.43]"]
["bta_circ_0010102",5,9,16,4.75933300894503,0,3,0,2.90075388335664,0.0357438334960258,"NA","up","yes","NC_037344.1:28960133..28964464:-","gene21097","gi|741955859|ref|XP_010812032.1|",4278,0,"PREDICTED: protein Jade-1 isoform X1 [Bos taurus]","gi|982949751|ref|XM_005217547.3|",5655,0,"PREDICTED: Bos taurus jade family PHD finger 1 (JADE1), transcript variant X4, mRNA","Q6IE81",1558,0,"Protein Jade-1","YPR031w",182,{"v":3e-46,"d":"3.00E-46"},"COG5141","pfam13832","zf-HC5HC2H_2","PHD-zinc-finger like domain.","GO:0006915|apoptotic process;GO:0043966|histone H3 acetylation;GO:0043983|histone H4-K12 acetylation;GO:0043981|histone H4-K5 acetylation;GO:0043982|histone H4-K8 acetylation;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0030308|negative regulation of cell growth;GO:2000134|negative regulation of G1/S transition of mitotic cell cycle;","GO:0036064|ciliary basal body;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0000123|histone acetyltransferase complex;GO:0016607|nuclear speck;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0046872|metal ion binding;GO:0001105|RNA polymerase II transcription coactivator activity;","K11347","PHF17, JADE1; protein Jade-1"]
["bta_circ_0010103",0,19,4,2.3197323999514,0,0,0,4.39858686244125,0.0276509523291347,"NA","up","yes","NC_037344.1:28964253..28971164:-","gene21097","gi|741955859|ref|XP_010812032.1|",4278,0,"PREDICTED: protein Jade-1 isoform X1 [Bos taurus]","gi|982949751|ref|XM_005217547.3|",5655,0,"PREDICTED: Bos taurus jade family PHD finger 1 (JADE1), transcript variant X4, mRNA","Q6IE81",1558,0,"Protein Jade-1","YPR031w",182,{"v":3e-46,"d":"3.00E-46"},"COG5141","pfam13832","zf-HC5HC2H_2","PHD-zinc-finger like domain.","GO:0006915|apoptotic process;GO:0043966|histone H3 acetylation;GO:0043983|histone H4-K12 acetylation;GO:0043981|histone H4-K5 acetylation;GO:0043982|histone H4-K8 acetylation;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0030308|negative regulation of cell growth;GO:2000134|negative regulation of G1/S transition of mitotic cell cycle;","GO:0036064|ciliary basal body;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0000123|histone acetyltransferase complex;GO:0016607|nuclear speck;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0046872|metal ion binding;GO:0001105|RNA polymerase II transcription coactivator activity;","K11347","PHF17, JADE1; protein Jade-1"]
["bta_circ_0010114",0,0,0,3.89821819358642,0,24,4,-5.25505477823735,0.00559125207193673,"NA","down","yes","NC_037344.1:29640220..29653374:-","gene21108","gi|741955994|ref|XP_010812067.1|",4486,0,"PREDICTED: la-related protein 1B isoform X1 [Bos taurus]","gi|982997698|ref|XM_010823303.2|",4970,0,"PREDICTED: Bos taurus La ribonucleoprotein domain family member 1B (LARP1B), transcript variant X1, mRNA","Q659C4",1439,0,"La-related protein 1B","SPAC1527.03",82.4,{"v":4e-15,"d":"4.00E-15"},"COG5193","pfam05383","La","La domain. This presumed domain is found at the N-terminus of La RNA-binding proteins as well as other proteins. The function of this region is uncertain.",".","GO:0005634|nucleus;","GO:0003723|RNA binding;","K18757","LARP1; la-related protein 1"]
["bta_circ_0010121",0,7,0,7.56704014292109,14,20,7,-2.87612201824209,0.0162506669959973,0.304581839036667,"down","yes","NC_037344.1:29714326..29721659:-","gene21111","gi|803242868|ref|XP_011981510.1|",2512,0,"PREDICTED: uncharacterized protein C4orf29 homolog isoform X1 [Ovis aries musimon]","gi|982949771|ref|XM_005217561.3|",3274,0,"PREDICTED: Bos taurus abhydrolase domain containing 18 (ABHD18), transcript variant X1, mRNA","Q8C1A9",900,0,"Protein ABHD18",".",".",".",".","pfam09752","DUF2048","Uncharacterized conserved protein (DUF2048). The proteins in this family are conserved from plants to vertebrates. The function is unknown.",".","GO:0005576|extracellular region;",".",".","."]
["bta_circ_0010122",0,0,0,1.85965664530163,0,10,3,-4.15964776646341,0.0397893226465806,"NA","down","yes","NC_037344.1:29718030..29727437:-","gene21111","gi|803242868|ref|XP_011981510.1|",2512,0,"PREDICTED: uncharacterized protein C4orf29 homolog isoform X1 [Ovis aries musimon]","gi|982949771|ref|XM_005217561.3|",3274,0,"PREDICTED: Bos taurus abhydrolase domain containing 18 (ABHD18), transcript variant X1, mRNA","Q8C1A9",900,0,"Protein ABHD18",".",".",".",".","pfam09752","DUF2048","Uncharacterized conserved protein (DUF2048). The proteins in this family are conserved from plants to vertebrates. The function is unknown.",".","GO:0005576|extracellular region;",".",".","."]
["bta_circ_0010146",53,145,109,65.7679728962706,36,62,37,0.928222865382454,0.037977743949082,0.439730132358439,"up","yes","NC_037344.1:39753819..39758277:-","gene21157","gi|982949925|ref|XP_015330892.1|",7714,0,"PREDICTED: rap guanine nucleotide exchange factor 2 isoform X1 [Bos taurus]","gi|982949924|ref|XM_015475406.1|",7020,0,"PREDICTED: Bos taurus Rap guanine nucleotide exchange factor 2 (RAPGEF2), transcript variant X1, mRNA","F1MSG6",2619,0,"Rap guanine nucleotide exchange factor 2",".",".",".",".","pfam00617","RasGEF","RasGEF domain. Guanine nucleotide exchange factor for Ras-like small GTPases.","GO:0071880|adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0001568|blood vessel development;GO:0031547|brain-derived neurotrophic factor receptor signaling pathway;GO:0019933|cAMP-mediated signaling;GO:0071320|cellular response to cAMP;GO:0071321|cellular response to cGMP;GO:1990090|cellular response to nerve growth factor stimulus;GO:0061028|establishment of endothelial barrier;GO:0090557|establishment of endothelial intestinal barrier;GO:0021884|forebrain neuron development;GO:0007186|G-protein coupled receptor signaling pathway;GO:0030033|microvillus assembly;GO:0008285|negative regulation of cell proliferation;GO:0050774|negative regulation of dendrite morphogenesis;GO:0048022|negative regulation of melanin biosynthetic process;GO:0038180|nerve growth factor signaling pathway;GO:0001764|neuron migration;GO:0031175|neuron projection development;GO:0007218|neuropeptide signaling pathway;GO:2000481|positive regulation of cAMP-dependent protein kinase activity;GO:0043950|positive regulation of cAMP-mediated signaling;GO:2000670|positive regulation of dendritic cell apoptotic process;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0043547|positive regulation of GTPase activity;GO:2001224|positive regulation of neuron migration;GO:0010976|positive regulation of neuron projection development;GO:0032092|positive regulation of protein binding;GO:0045860|positive regulation of protein kinase activity;GO:2001214|positive regulation of vasculogenesis;GO:0072659|protein localization to plasma membrane;GO:0032486|Rap protein signal transduction;GO:1901888|regulation of cell junction assembly;GO:0021591|ventricular system development;","GO:0016324|apical plasma membrane;GO:0005923|bicellular tight junction;GO:0005911|cell-cell junction;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0030139|endocytic vesicle;GO:0005770|late endosome;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0048471|perinuclear region of cytoplasm;GO:0005886|plasma membrane;GO:0032991|macromolecular complex;GO:0045202|synapse;","GO:0031697|beta-1 adrenergic receptor binding;GO:0030552|cAMP binding;GO:0005096|GTPase activator activity;GO:0030165|PDZ domain binding;GO:0070300|phosphatidic acid binding;GO:0017034|Rap guanyl-nucleotide exchange factor activity;GO:0005088|Ras guanyl-nucleotide exchange factor activity;GO:0050699|WW domain binding;","K08018","RAPGEF2, PDZGEF1; Rap guanine nucleotide exchange factor 2"]
["bta_circ_0010175",0,0,0,1.77884504491116,5,0,4,-4.04923082852261,0.0466318155344839,"NA","down","yes","NC_037344.1:46694631..46696037:+","gene21236","gi|982950144|ref|XP_003587190.4|",5600,0,"PREDICTED: RIMS-binding protein 2 isoform X4 [Bos taurus]","gi|982998001|ref|XM_015467101.1|",6447,0,"PREDICTED: Bos taurus RIMS binding protein 2 (RIMBP2), transcript variant X4, mRNA","O15034",1724,0,"RIMS-binding protein 2",".",".",".",".","pfam14604","SH3_9","Variant SH3 domain.","GO:0010923|negative regulation of phosphatase activity;","GO:0030054|cell junction;GO:0005886|plasma membrane;GO:0045202|synapse;",".","K17591","RIMBP2; RIMS-binding protein 2"]
["bta_circ_0010181",0,0,0,8.44317317295251,13,8,26,-6.50975213374879,0.000167918175769471,0.0175282576033582,"down","yes","NC_037344.1:4771654..4793930:-","gene20946","gi|742123100|ref|XP_010839032.1|",2091,0,"PREDICTED: arfaptin-1 isoform X1 [Bison bison bison]","gi|742123099|ref|XM_010840730.1|",3166,0,"PREDICTED: Bison bison bison ADP-ribosylation factor interacting protein 1 (ARFIP1), transcript variant X1, mRNA","P53367",752,0,"Arfaptin-1",".",".",".",".","pfam06456","Arfaptin","Arfaptin-like domain. Arfaptin interacts with ARF1, a small GTPase involved in vesicle budding at the Golgi complex and immature secretory granules. The structure of arfaptin shows that upon binding to a small GTPase, arfaptin forms an elongated, crescent-shaped dimer of three-helix coiled-coils. The N-terminal region of ICA69 is similar to arfaptin.","GO:0006886|intracellular protein transport;GO:0034315|regulation of Arp2/3 complex-mediated actin nucleation;GO:0050708|regulation of protein secretion;","GO:0005829|cytosol;GO:0000139|Golgi membrane;GO:0032588|trans-Golgi network membrane;","GO:0070273|phosphatidylinositol-4-phosphate binding;GO:0019904|protein domain specific binding;",".","."]
["bta_circ_0010184",0,0,0,2.1319436418721,5,0,6,-4.33330724978825,0.0304337401521948,"NA","down","yes","NC_037344.1:4777988..4793930:-","gene20946","gi|742123100|ref|XP_010839032.1|",2091,0,"PREDICTED: arfaptin-1 isoform X1 [Bison bison bison]","gi|742123099|ref|XM_010840730.1|",3166,0,"PREDICTED: Bison bison bison ADP-ribosylation factor interacting protein 1 (ARFIP1), transcript variant X1, mRNA","P53367",752,0,"Arfaptin-1",".",".",".",".","pfam06456","Arfaptin","Arfaptin-like domain. Arfaptin interacts with ARF1, a small GTPase involved in vesicle budding at the Golgi complex and immature secretory granules. The structure of arfaptin shows that upon binding to a small GTPase, arfaptin forms an elongated, crescent-shaped dimer of three-helix coiled-coils. The N-terminal region of ICA69 is similar to arfaptin.","GO:0006886|intracellular protein transport;GO:0034315|regulation of Arp2/3 complex-mediated actin nucleation;GO:0050708|regulation of protein secretion;","GO:0005829|cytosol;GO:0000139|Golgi membrane;GO:0032588|trans-Golgi network membrane;","GO:0070273|phosphatidylinositol-4-phosphate binding;GO:0019904|protein domain specific binding;",".","."]
["bta_circ_0010237",3,0,2,7.52994528193605,16,5,13,-2.49493990093439,0.0353985741891029,0.439730132358439,"down","yes","NC_037344.1:54068685..54087452:+","gene21342","gi|125630675|ref|NP_001074994.1|",3449,0,"intraflagellar transport protein 81 homolog [Bos taurus]","gi|982950314|ref|XM_010813927.2|",4502,0,"PREDICTED: Bos taurus intraflagellar transport 81 (IFT81), transcript variant X1, mRNA","O35594",1270,0,"Intraflagellar transport protein 81 homolog",".",".",".",".","pfam10174","Cast","RIM-binding protein of the cytomatrix active zone. This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.","GO:0030154|cell differentiation;GO:0060271|cilium morphogenesis;GO:0042073|intraciliary transport;GO:0035735|intraciliary transport involved in cilium morphogenesis;GO:0007275|multicellular organismal development;GO:0007283|spermatogenesis;","GO:0005813|centrosome;GO:0036064|ciliary basal body;GO:0005929|cilium;GO:0030992|intraciliary transport particle B;GO:0097225|sperm midpiece;GO:0097228|sperm principal piece;","GO:0015631|tubulin binding;",".","."]
["bta_circ_0010252",0,0,0,7.54272543449701,24,18,0,-4.96276489859384,0.0139979949833405,0.298906981742218,"down","yes","NC_037344.1:54706781..54710809:-","gene21361","gi|528988521|ref|XP_005217810.1|",867,{"v":3e-115,"d":"3.00E-115"},"PREDICTED: myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [Bos taurus]","gi|942058882|ref|XM_005897404.2|",775,0,"PREDICTED: Bos mutus myosin, light chain 2, regulatory, cardiac, slow (MYL2), transcript variant X2, mRNA","Q3SZE5",336,{"v":1e-115,"d":"1.00E-115"},"Myosin regulatory light chain 2, ventricular/cardiac muscle isoform","ECU03g1570",99,{"v":3e-24,"d":"3.00E-24"},"COG5126","pfam13405","EF-hand_6","EF-hand domain.","GO:0060047|heart contraction;GO:0007507|heart development;GO:0098735|positive regulation of the force of heart contraction;GO:0002026|regulation of the force of heart contraction;","GO:0031672|A band;GO:0016459|myosin complex;","GO:0005509|calcium ion binding;","K10351","MYL2; myosin regulatory light chain 2"]
["bta_circ_0010257",7,15,14,5.66722698780592,0,3,0,3.16916136260102,0.0157610526913103,0.298906981742218,"up","yes","NC_037344.1:55247580..55251092:-","gene21365","gi|528918203|ref|XP_005195101.1|",4539,0,"PREDICTED: ataxin-2 isoform X1 [Bos taurus]","gi|982998231|ref|XM_005195044.3|",4498,0,"PREDICTED: Bos taurus ataxin 2 (ATXN2), transcript variant X1, mRNA","Q99700",1646,0,"Ataxin-2","YGR178c",55.1,{"v":2e-06,"d":"2.00E-06"},"COG5180","pfam14438","SM-ATX","Ataxin 2 SM domain. This SM domain is found in Ataxin-2.","GO:0033962|cytoplasmic mRNA processing body assembly;GO:0002091|negative regulation of receptor internalization;GO:0010603|regulation of cytoplasmic mRNA processing body assembly;GO:0006417|regulation of translation;GO:0016070|RNA metabolic process;GO:0050658|RNA transport;GO:0034063|stress granule assembly;","GO:0005737|cytoplasm;GO:0010494|cytoplasmic stress granule;GO:0005829|cytosol;GO:0005794|Golgi apparatus;GO:0016020|membrane;GO:0048471|perinuclear region of cytoplasm;GO:0005844|polysome;GO:0005802|trans-Golgi network;","GO:0005154|epidermal growth factor receptor binding;GO:0008022|protein C-terminus binding;GO:0003723|RNA binding;",".","."]
["bta_circ_0010292",3,5,4,1.86791652216939,0,0,0,4.19363119892833,0.0365975281349596,"NA","up","yes","NC_037344.1:6107051..6107804:-","gene20962","gi|194674462|ref|XP_607376.4|",4730,0,"PREDICTED: protein FAM160A1 [Bos taurus]","gi|982997492|ref|XM_005194937.3|",4629,0,"PREDICTED: Bos taurus family with sequence similarity 160 member A1 (FAM160A1), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam10257","RAI16-like","Retinoic acid induced 16-like protein. This is the conserved N-terminal 450 residues of a family of proteins described as retinoic acid-induced protein 16-like proteins. The exact function is not known. The proteins are found from worms to humans.",".",".",".",".","."]
["bta_circ_0010301",0,0,0,3.41604836373519,5,7,8,-5.25303129860197,0.00484359414414183,"NA","down","yes","NC_037344.1:6180474..6220503:-","gene20962","gi|194674462|ref|XP_607376.4|",4730,0,"PREDICTED: protein FAM160A1 [Bos taurus]","gi|982997492|ref|XM_005194937.3|",4629,0,"PREDICTED: Bos taurus family with sequence similarity 160 member A1 (FAM160A1), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam10257","RAI16-like","Retinoic acid induced 16-like protein. This is the conserved N-terminal 450 residues of a family of proteins described as retinoic acid-induced protein 16-like proteins. The exact function is not known. The proteins are found from worms to humans.",".",".",".",".","."]
["bta_circ_0010318",11,41,20,11.2899134053423,5,0,3,2.52893111415055,0.0107384574345846,0.26086005588283,"up","yes","NC_037344.1:63038540..63040557:-","gene21497","gi|759107811|ref|XP_011354191.1|",1703,0,"PREDICTED: signal peptide peptidase-like 3 [Pteropus vampyrus]","gi|982998390|ref|XM_615162.6|",2527,0,"PREDICTED: Bos taurus signal peptide peptidase like 3 (SPPL3), mRNA","Q9CUS9",652,0,"Signal peptide peptidase-like 3",".",".",".",".","pfam04258","Peptidase_A22B","Signal peptide peptidase. The members of this family are membrane proteins. In some proteins this region is found associated with pfam02225. This family corresponds with Merops subfamily A22B, the type example of which is signal peptide peptidase. There is a sequence-similarity relationship with pfam01080.","GO:0033619|membrane protein proteolysis;GO:0070886|positive regulation of calcineurin-NFAT signaling cascade;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0032092|positive regulation of protein binding;GO:0035307|positive regulation of protein dephosphorylation;GO:0050852|T cell receptor signaling pathway;","GO:0033116|endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0005794|Golgi apparatus;GO:0030660|Golgi-associated vesicle membrane;GO:0071458|integral component of cytoplasmic side of endoplasmic reticulum membrane;GO:0071556|integral component of lumenal side of endoplasmic reticulum membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0005765|lysosomal membrane;GO:0016020|membrane;GO:0005886|plasma membrane;GO:0005791|rough endoplasmic reticulum;","GO:0042500|aspartic endopeptidase activity, intramembrane cleaving;GO:0042803|protein homodimerization activity;","K09598","SPPL3; signal peptide peptidase-like 3 [EC:3.4.23.-]"]
["bta_circ_0010336",12,157,61,34.8526184739116,9,17,25,1.59044301534011,0.0157060852500455,0.298906981742218,"up","yes","NC_037344.1:63880429..63883569:-","gene21519","gi|329112497|ref|NP_001192262.1|",12944,0,"acetyl-CoA carboxylase 2 [Bos taurus]","gi|329112496|ref|NM_001205333.1|",8900,0,"Bos taurus acetyl-CoA carboxylase beta (ACACB), mRNA","O00763",4406,0,"Acetyl-CoA carboxylase 2","SPAC56E4.04c_3",711,0,"COG4799","pfam08326","ACC_central","Acetyl-CoA carboxylase, central region. The region featured in this family is found in various eukaryotic acetyl-CoA carboxylases, N-terminal to the catalytic domain (pfam01039). This enzyme (EC:6.4.1.2) is involved in the synthesis of long-chain fatty acids, as it catalyses the rate-limiting step in this process.","GO:0006084|acetyl-CoA metabolic process;GO:0006853|carnitine shuttle;GO:0097009|energy homeostasis;GO:0006633|fatty acid biosynthetic process;GO:2001295|malonyl-CoA biosynthetic process;GO:0043086|negative regulation of catalytic activity;GO:0031999|negative regulation of fatty acid beta-oxidation;GO:0010629|negative regulation of gene expression;GO:0031325|positive regulation of cellular metabolic process;GO:0060421|positive regulation of heart growth;GO:0010884|positive regulation of lipid storage;GO:0051289|protein homotetramerization;GO:0045540|regulation of cholesterol biosynthetic process;GO:0010906|regulation of glucose metabolic process;GO:0042493|response to drug;GO:0031667|response to nutrient levels;GO:0014070|response to organic cyclic compound;","GO:0005829|cytosol;GO:0012505|endomembrane system;GO:0005741|mitochondrial outer membrane;GO:0005739|mitochondrion;GO:0005634|nucleus;","GO:0003989|acetyl-CoA carboxylase activity;GO:0005524|ATP binding;GO:0009374|biotin binding;GO:0004075|biotin carboxylase activity;GO:0042802|identical protein binding;GO:0046872|metal ion binding;","K01946","ACACB; acetyl-CoA carboxylase / biotin carboxylase 2 [EC:6.4.1.2 6.3.4.14]"]
["bta_circ_0010363",38,69,66,38.1848581263103,19,32,21,1.085420512028,0.0451848916726862,0.456494092506297,"up","yes","NC_037344.1:68015073..68016763:+","gene21570","gi|555955466|ref|XP_005889891.1|",630,{"v":2e-106,"d":"2.00E-106"},"PREDICTED: iron-sulfur cluster co-chaperone protein HscB, mitochondrial [Bos mutus]","gi|156121324|ref|NM_001102340.1|",778,0,"Bos taurus HscB mitochondrial iron-sulfur cluster co-chaperone (HSCB), mRNA","Q8IWL3",201,{"v":1e-84,"d":"1.00E-84"},"Iron-sulfur cluster co-chaperone protein HscB, mitochondrial","NMA1598",51.2,{"v":5e-10,"d":"5.00E-10"},"COG1076","pfam07743","HSCB_C","HSCB C-terminal oligomerization domain. This domain is the HSCB C-terminal oligomerization domain and is found on co-chaperone proteins.","GO:0016226|iron-sulfur cluster assembly;GO:0051259|protein oligomerization;GO:0097428|protein maturation by iron-sulfur cluster transfer;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005739|mitochondrion;GO:0005634|nucleus;","GO:0001671|ATPase activator activity;GO:0051087|chaperone binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;","K04082","hscB, HSCB, HSC20; molecular chaperone HscB"]
["bta_circ_0010395",0,31,16,22.7098544671205,35,33,33,-1.67417613202762,0.0308949075261781,0.428634275476763,"down","yes","NC_037344.1:9589540..9591304:+","gene20983","gi|741955781|ref|XP_010812014.1|",4829,0,"PREDICTED: mineralocorticoid receptor isoform X1 [Bos taurus]","gi|982949664|ref|XM_010813712.2|",5845,0,"PREDICTED: Bos taurus nuclear receptor subfamily 3 group C member 2 (NR3C2), transcript variant X1, mRNA","P08235",1634,0,"Mineralocorticoid receptor",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0007165|signal transduction;GO:0006367|transcription initiation from RNA polymerase II promoter;","GO:0005829|cytosol;GO:0005789|endoplasmic reticulum membrane;GO:0005654|nucleoplasm;GO:0043235|receptor complex;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0005496|steroid binding;GO:0003707|steroid hormone receptor activity;GO:0008270|zinc ion binding;","K08555","NR3C2, MR; mineralocorticoid receptor"]
["bta_circ_0010399",4,0,9,2.31955206239011,0,0,0,4.31260981594736,0.0317165164285716,"NA","up","yes","NC_037345.1:10059109..10062881:+","gene21914","gi|78369244|ref|NP_001030354.1|",3634,0,"cadherin-13 precursor [Bos taurus]","gi|402745934|ref|NM_001035277.2|",3692,0,"Bos taurus cadherin 13 (CDH13), mRNA","Q3B7N0",1404,0,"Cadherin-13",".",".",".",".","pfam08758","Cadherin_pro","Cadherin prodomain like. Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.","GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;","GO:0031225|anchored component of membrane;GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;GO:0042803|protein homodimerization activity;","K06808","CDH13; cadherin 13, H-cadherin"]
["bta_circ_0010406",0,0,0,1.79233695296796,3,2,5,-4.25024607832348,0.0329436429275932,"NA","down","yes","NC_037345.1:10699690..10701578:-","gene21934","gi|76688614|ref|XP_610037.2|",2359,0,"PREDICTED: TLD domain-containing protein 1 isoform X2 [Bos taurus]","gi|982998975|ref|XM_005195196.3|",3448,0,"PREDICTED: Bos taurus TBC/LysM-associated domain containing 1 (TLDC1), transcript variant X3, mRNA","Q6P9B6",677,0,"TLD domain-containing protein 1",".",".",".",".","pfam07534","TLD","TLD. This domain is predicted to be an enzyme and is often found associated with pfam01476. It's structure consists of a beta-sandwich surrounded by two helices and two one-turn helices.","GO:1903204|negative regulation of oxidative stress-induced neuron death;","GO:0005737|cytoplasm;GO:0005765|lysosomal membrane;GO:0016020|membrane;",".",".","."]
["bta_circ_0010423",4,0,8,2.19274424276938,0,0,0,4.22816508534504,0.0361197254967952,"NA","up","yes","NC_037345.1:14993046..15003117:-","gene22039","gi|114053129|ref|NP_001039723.1|",3983,0,"vacuolar protein sorting-associated protein 35 [Bos taurus]","gi|114053128|ref|NM_001046258.1|",3205,0,"Bos taurus VPS35 retromer complex component (VPS35), mRNA","Q2HJG5",1537,0,"Vacuolar protein sorting-associated protein 35",".",".",".",".","pfam03635","Vps35","Vacuolar protein sorting-associated protein 35. Vacuolar protein sorting-associated protein (Vps) 35 is one of around 50 proteins involved in protein trafficking. In particular, Vps35 assembles into a retromer complex with at least four other proteins Vps5, Vps17, Vps26 and Vps29. Vps35 contains a central region of weaker sequence similarity, thought to indicate the presence of at least three domains.","GO:0006886|intracellular protein transport;GO:0007040|lysosome organization;GO:0043653|mitochondrial fragmentation involved in apoptotic process;GO:1903828|negative regulation of cellular protein localization;GO:0010629|negative regulation of gene expression;GO:0050728|negative regulation of inflammatory response;GO:1902823|negative regulation of late endosome to lysosome transport;GO:1901215|negative regulation of neuron death;GO:0032463|negative regulation of protein homooligomerization;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:1903364|positive regulation of cellular protein catabolic process;GO:1903181|positive regulation of dopamine biosynthetic process;GO:0060161|positive regulation of dopamine receptor signaling pathway;GO:0010628|positive regulation of gene expression;GO:0090326|positive regulation of locomotion involved in locomotory behavior;GO:0090141|positive regulation of mitochondrial fission;GO:0061357|positive regulation of Wnt protein secretion;GO:0031648|protein destabilization;GO:0033365|protein localization to organelle;GO:1902950|regulation of dendritic spine maintenance;GO:2000331|regulation of terminal button organization;GO:0042147|retrograde transport, endosome to Golgi;GO:1990126|retrograde transport, endosome to plasma membrane;GO:0045056|transcytosis;GO:0050882|voluntary musculoskeletal movement;","GO:0005829|cytosol;GO:0005769|early endosome;GO:0005768|endosome;GO:0010008|endosome membrane;GO:0005770|late endosome;GO:0005764|lysosome;GO:0005739|mitochondrion;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0048471|perinuclear region of cytoplasm;GO:0014069|postsynaptic density;GO:0030904|retromer complex;GO:0030906|retromer, cargo-selective complex;GO:0097422|tubular endosome;","GO:0031748|D1 dopamine receptor binding;GO:0008565|protein transporter activity;","K18468","VPS35; vacuolar protein sorting-associated protein 35"]
["bta_circ_0010428",5,2,8,2.67810425595379,0,0,0,4.66505657953826,0.0167317605895706,"NA","up","yes","NC_037345.1:15835078..15858307:-","gene22051","gi|926713672|ref|XP_005692008.2|",3108,0,"PREDICTED: T-cell immunomodulatory protein [Capra hircus]","gi|84370088|ref|NM_001038532.1|",3041,0,"Bos taurus integrin alpha FG-GAP repeat containing 1 (ITFG1), mRNA","Q8TB96",1129,0,"T-cell immunomodulatory protein",".",".",".",".","pfam13517","VCBS","Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella. This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).",".","GO:0070062|extracellular exosome;GO:0016021|integral component of membrane;",".","K17257","ITFG1; integrin alpha FG-GAP repeat containing protein 1"]
["bta_circ_0010462",0,3,6,9.66104577703027,21,7,18,-2.70780760216448,0.0103113203946846,0.256242237854117,"down","yes","NC_037345.1:19137684..19184422:+","gene22083","gi|114051812|ref|NP_001039882.1|",5094,0,"ubiquitin carboxyl-terminal hydrolase CYLD [Bos taurus]","gi|741958393|ref|XM_005218684.2|",7973,0,"PREDICTED: Bos taurus cylindromatosis (turban tumor syndrome) (CYLD), transcript variant X1, mRNA","Q1RMU2",1966,0,"Ubiquitin carboxyl-terminal hydrolase CYLD",".",".",".",".","pfam01302","CAP_GLY","CAP-Gly domain. Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.","GO:0043369|CD4-positive or CD8-positive, alpha-beta T cell lineage commitment;GO:0048872|homeostasis of number of cells;GO:0045087|innate immune response;GO:0070266|necroptotic process;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:1901223|negative regulation of NIK/NF-kappaB signaling;GO:0045581|negative regulation of T cell differentiation;GO:1903829|positive regulation of cellular protein localization;GO:2001238|positive regulation of extrinsic apoptotic signaling pathway;GO:0045582|positive regulation of T cell differentiation;GO:0050862|positive regulation of T cell receptor signaling pathway;GO:0070536|protein K63-linked deubiquitination;GO:1990108|protein linear deubiquitination;GO:0045577|regulation of B cell differentiation;GO:1902017|regulation of cilium assembly;GO:2001242|regulation of intrinsic apoptotic signaling pathway;GO:0070507|regulation of microtubule cytoskeleton organization;GO:0007346|regulation of mitotic cell cycle;GO:0043393|regulation of protein binding;GO:0010803|regulation of tumor necrosis factor-mediated signaling pathway;GO:1901026|ripoptosome assembly involved in necroptotic process;GO:0006511|ubiquitin-dependent protein catabolic process;GO:0016055|Wnt signaling pathway;","GO:0005813|centrosome;GO:0036064|ciliary basal body;GO:0097542|ciliary tip;GO:0005881|cytoplasmic microtubule;GO:0005829|cytosol;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0030496|midbody;GO:0048471|perinuclear region of cytoplasm;GO:0005819|spindle;","GO:1990380|Lys48-specific deubiquitinase activity;GO:0061578|Lys63-specific deubiquitinase activity;GO:0070064|proline-rich region binding;GO:0019901|protein kinase binding;GO:0004843|ubiquitin-specific protease activity;GO:0008270|zinc ion binding;","K08601","CYLD, USLP2; ubiquitin thioesterase CYLD [EC:3.4.19.12]"]
["bta_circ_0010490",0,0,0,2.29735663679846,7,2,3,-4.6010372617248,0.0183616001489675,"NA","down","yes","NC_037345.1:2707744..2723007:-","gene21856","gi|555964607|ref|XP_005894370.1|",972,{"v":3e-117,"d":"3.00E-117"},"PREDICTED: craniofacial development protein 1 isoform X2 [Bos mutus]","gi|926713217|ref|XM_005691802.2|",2983,0,"PREDICTED: Capra hircus Bcnt protein (BCNT), transcript variant X1, mRNA","Q8HXY9",359,{"v":3e-111,"d":"3.00E-111"},"Craniofacial development protein 1",".",".",".",".","pfam07572","BCNT","Bucentaur or craniofacial development. Bucentaur or craniofacial development protein 1 (BCNT) in ruminents has a different domain architecture to that in mouse and human. For this reason it has been used as a model for molecular evolution. Both bovine and human BCNTs are phosphorylated by casein kinase II in vitro.","GO:0007155|cell adhesion;GO:0007275|multicellular organismal development;GO:2000270|negative regulation of fibroblast apoptotic process;GO:0042127|regulation of cell proliferation;GO:0008360|regulation of cell shape;",".",".",".","."]
["bta_circ_0010492",0,0,0,1.8137526173045,0,7,5,-4.12798526052196,0.041548341761854,"NA","down","yes","NC_037345.1:2773067..2784079:-","gene21860","gi|528989972|ref|XP_005218404.1|",2670,0,"PREDICTED: bucentaur-2 isoform X2 [Bos taurus]","gi|22779306|dbj|AB081095.1|",4394,0,"Bos taurus bcnt, h-type bcnt genes, complete and partial cds","O02751",806,0,"Craniofacial development protein 2",".",".",".",".","pfam03372","Exo_endo_phos","Endonuclease/Exonuclease/phosphatase family. This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12 and Nocturnin.",".","GO:0005737|cytoplasm;GO:0005634|nucleus;",".",".","."]
["bta_circ_0010527",5,20,3,16.8251848033432,24,25,26,-1.73509413999859,0.0274378521266158,0.406305728066736,"down","yes","NC_037345.1:43119298..43129442:-","gene22399","gi|528991649|ref|XP_005219099.1|",5353,0,"PREDICTED: ankyrin repeat domain-containing protein 27 isoform X1 [Bos taurus]","gi|156523175|ref|NM_001102532.1|",4527,0,"Bos taurus ankyrin repeat domain 27 (ANKRD27), mRNA","Q96NW4",1843,0,"Ankyrin repeat domain-containing protein 27","all2748",108,{"v":7e-24,"d":"7.00E-24"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0045022|early endosome to late endosome transport;GO:0035646|endosome to melanosome transport;GO:0035544|negative regulation of SNARE complex assembly;GO:0048812|neuron projection morphogenesis;GO:0050775|positive regulation of dendrite morphogenesis;GO:0015031|protein transport;GO:1990126|retrograde transport, endosome to plasma membrane;","GO:0030659|cytoplasmic vesicle membrane;GO:0005829|cytosol;GO:0005769|early endosome;GO:0005770|late endosome;GO:0005764|lysosome;GO:0042470|melanosome;GO:0016020|membrane;GO:0043005|neuron projection;GO:0005886|plasma membrane;GO:0030133|transport vesicle;GO:0097422|tubular endosome;","GO:0005096|GTPase activator activity;GO:0005085|guanyl-nucleotide exchange factor activity;GO:0017137|Rab GTPase binding;GO:0017112|Rab guanyl-nucleotide exchange factor activity;GO:0000149|SNARE binding;",".","."]
["bta_circ_0010570",0,9,9,1.99982353938742,0,0,0,4.19496448463892,0.0378512186280713,"NA","up","yes","NC_037345.1:48311645..48320934:+","gene22584","gi|332205852|ref|NP_001193706.1|",20831,0,"ryanodine receptor 1 [Bos taurus]","gi|332205851|ref|NM_001206777.1|",15201,0,"Bos taurus ryanodine receptor 1 (skeletal) (RYR1), mRNA","Q92736",5582,0,"Ryanodine receptor 2",".",".",".",".","pfam01365","RYDR_ITPR","RIH domain. The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types of calcium channels. This region is found in the ryanodine receptor and the inositol-1,4,5- trisphosphate receptor. This domain may form a binding site for IP3.","GO:0030509|BMP signaling pathway;GO:0006816|calcium ion transport;GO:0060402|calcium ion transport into cytosol;GO:0019722|calcium-mediated signaling;GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0060070|canonical Wnt signaling pathway;GO:0060048|cardiac muscle contraction;GO:0003300|cardiac muscle hypertrophy;GO:0086064|cell communication by electrical coupling involved in cardiac conduction;GO:0006874|cellular calcium ion homeostasis;GO:0071313|cellular response to caffeine;GO:0071872|cellular response to epinephrine stimulus;GO:0005513|detection of calcium ion;GO:0003143|embryonic heart tube morphogenesis;GO:0072599|establishment of protein localization to endoplasmic reticulum;GO:0034220|ion transmembrane transport;GO:0003220|left ventricular cardiac muscle tissue morphogenesis;GO:1901896|positive regulation of calcium-transporting ATPase activity;GO:0010460|positive regulation of heart rate;GO:0051284|positive regulation of sequestering of calcium ion;GO:0098735|positive regulation of the force of heart contraction;GO:0086029|Purkinje myocyte to ventricular cardiac muscle cell signaling;GO:0098910|regulation of atrial cardiac muscle cell action potential;GO:0098904|regulation of AV node cell action potential;GO:1903779|regulation of cardiac conduction;GO:0055117|regulation of cardiac muscle contraction;GO:0010882|regulation of cardiac muscle contraction by calcium ion signaling;GO:0010881|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:0051480|cytosolic calcium ion homeostasis;GO:0002027|regulation of heart rate;GO:0098907|regulation of SA node cell action potential;GO:0098911|regulation of ventricular cardiac muscle cell action potential;GO:0051209|release of sequestered calcium ion into cytosol;GO:0014808|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0031000|response to caffeine;GO:0001666|response to hypoxia;GO:0014850|response to muscle activity;GO:0035994|response to muscle stretch;GO:0051775|response to redox state;GO:0070296|sarcoplasmic reticulum calcium ion transport;GO:0097050|type B pancreatic cell apoptotic process;GO:0086005|ventricular cardiac muscle cell action potential;","GO:0034704|calcium channel complex;GO:0014701|junctional sarcoplasmic reticulum membrane;GO:0016020|membrane;GO:0005886|plasma membrane;GO:0032991|macromolecular complex;GO:0016529|sarcoplasmic reticulum;GO:0033017|sarcoplasmic reticulum membrane;GO:0005790|smooth endoplasmic reticulum;GO:0030018|Z disc;","GO:0005262|calcium channel activity;GO:0005509|calcium ion binding;GO:0048763|calcium-induced calcium release activity;GO:0015278|calcium-release channel activity;GO:0005516|calmodulin binding;GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0044325|ion channel binding;GO:0034236|protein kinase A catalytic subunit binding;GO:0034237|protein kinase A regulatory subunit binding;GO:0043621|protein self-association;GO:0005219|ryanodine-sensitive calcium-release channel activity;GO:0043924|suramin binding;","K04962","RYR2; ryanodine receptor 2"]
["bta_circ_0010601",11,29,8,8.08519327294988,0,8,0,2.38962099049009,0.0448916517001717,0.456494092506297,"up","yes","NC_037345.1:52963342..52963555:-","gene22823","gi|440902292|gb|ELR53099.1|",1981,0,"Creatine kinase M-type, partial [Bos mutus]","gi|402744914|ref|NM_174773.4|",1569,0,"Bos taurus creatine kinase, muscle (CKM), mRNA","Q9XSC6",763,0,"Creatine kinase M-type","CAC3190",89.7,{"v":8e-19,"d":"8.00E-19"},"COG3869","pfam00217","ATP-gua_Ptrans","ATP:guanido phosphotransferase, C-terminal catalytic domain. The substrate binding site is located in the cleft between N and C-terminal domains, but most of the catalytic residues are found in the larger C-terminal domain.","GO:0046314|phosphocreatine biosynthetic process;GO:0009408|response to heat;","GO:0005737|cytoplasm;GO:0005615|extracellular space;","GO:0005524|ATP binding;GO:0004111|creatine kinase activity;","K00933","E2.7.3.2; creatine kinase [EC:2.7.3.2]"]
["bta_circ_0010617",6,148,83,31.0136782233336,6,9,12,2.4701264331469,0.00076973441588402,0.0492512590431825,"up","yes","NC_037345.1:56605695..56607271:+","gene23041","gi|440898033|gb|ELR49615.1|",3645,0,"Myosin-binding protein C, fast-type, partial [Bos mutus]","gi|942082483|ref|XM_005905040.2|",2279,0,"PREDICTED: Bos mutus myosin binding protein C, fast type (MYBPC2), transcript variant X2, mRNA","Q14324",1285,0,"Myosin-binding protein C, fast-type",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007015|actin filament organization;GO:0007155|cell adhesion;GO:0030049|muscle filament sliding;GO:0045214|sarcomere organization;GO:0006941|striated muscle contraction;GO:0071688|striated muscle myosin thick filament assembly;","GO:0005829|cytosol;GO:0031430|M band;GO:0005859|muscle myosin complex;GO:0032982|myosin filament;GO:0030018|Z disc;","GO:0051015|actin filament binding;GO:0051371|muscle alpha-actinin binding;GO:0008307|structural constituent of muscle;GO:0097493|structural molecule activity conferring elasticity;","K12558","MYBPC2; myosin-binding protein C, fast-type"]
["bta_circ_0010628",0,14,20,3.87168353454925,0,0,0,5.14444064290787,0.00688930062644899,"NA","up","yes","NC_037345.1:60321258..60450293:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0010631",0,30,16,4.89076898993454,0,0,0,5.4776204445629,0.00329126474938439,"NA","up","yes","NC_037345.1:60425501..60466990:-","gene23216","gi|982954789|ref|XP_015329944.1|",4639,0,"PREDICTED: zinc finger protein 271 [Bos taurus]","gi|983000600|ref|XM_015467728.1|",3031,0,"PREDICTED: Bos taurus zinc finger protein 271 (LOC618456), mRNA","O43345",803,0,"Zinc finger protein 208",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0008270|zinc ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["bta_circ_0010631",0,30,16,4.89076898993454,0,0,0,5.4776204445629,0.00329126474938439,"NA","up","yes","NC_037345.1:60425501..60466990:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0010634",9,12,0,3.79587134345913,0,0,0,5.01439713851875,0.00909675731858077,"NA","up","yes","NC_037345.1:60652816..60676818:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0010637",0,0,0,3.25855912508858,2,8,10,-5.16100283107439,0.00606258129114422,"NA","down","yes","NC_037345.1:62280244..62281078:+","gene23328","gi|742079867|ref|XP_010847579.1|",636,{"v":7e-78,"d":"7.00E-78"},"PREDICTED: troponin T, slow skeletal muscle, partial [Bison bison bison]","gi|741961220|ref|XM_010815468.1|",975,0,"PREDICTED: Bos taurus troponin T type 1 (skeletal, slow) (TNNT1), transcript variant X2, mRNA","Q8MKH6",248,{"v":1e-78,"d":"1.00E-78"},"Troponin T, slow skeletal muscle",".",".",".",".","pfam00992","Troponin","Troponin. Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). this Pfam contains members of the TnT subunit. Troponin is a complex of three proteins, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). The troponin complex regulates Ca++ induced muscle contraction. This family includes troponin T and troponin I. Troponin I binds to actin and troponin T binds to tropomyosin.","GO:0045932|negative regulation of muscle contraction;GO:0003009|skeletal muscle contraction;GO:0014883|transition between fast and slow fiber;","GO:0005861|troponin complex;","GO:0005523|tropomyosin binding;","K10372","TNNT1; troponin T, slow skeletal muscle"]
["bta_circ_0010689",0,0,0,1.90320506879608,0,9,4,-4.20148622069518,0.0372898688738234,"NA","down","yes","NC_037346.1:13567499..13572017:-","gene23708","gi|528994216|ref|XP_005220032.1|",12327,0,"PREDICTED: acetyl-CoA carboxylase 1 isoform X2 [Bos taurus]","gi|982956017|ref|XM_005219978.3|",8675,0,"PREDICTED: Bos taurus acetyl-CoA carboxylase alpha (ACACA), transcript variant X7, mRNA","Q9TTS3",4704,0,"Acetyl-CoA carboxylase 1","SPAC56E4.04c_3",713,0,"COG4799","pfam08326","ACC_central","Acetyl-CoA carboxylase, central region. The region featured in this family is found in various eukaryotic acetyl-CoA carboxylases, N-terminal to the catalytic domain (pfam01039). This enzyme (EC:6.4.1.2) is involved in the synthesis of long-chain fatty acids, as it catalyses the rate-limiting step in this process.","GO:0006084|acetyl-CoA metabolic process;GO:0006633|fatty acid biosynthetic process;GO:2001295|malonyl-CoA biosynthetic process;GO:0051289|protein homotetramerization;","GO:0005829|cytosol;","GO:0003989|acetyl-CoA carboxylase activity;GO:0005524|ATP binding;GO:0004075|biotin carboxylase activity;GO:0046872|metal ion binding;","K11262","ACACA; acetyl-CoA carboxylase / biotin carboxylase 1 [EC:6.4.1.2 6.3.4.14]"]
["bta_circ_0010704",0,0,0,2.87847671201405,6,4,6,-4.98187454559114,0.00871469745238596,"NA","down","yes","NC_037346.1:14148128..14148829:-","gene23720","gi|329112597|ref|NP_001178374.1|",5581,0,"HEAT repeat-containing protein 6 [Bos taurus]","gi|329112596|ref|NM_001191445.1|",3951,0,"Bos taurus HEAT repeat containing 6 (HEATR6), mRNA","Q6AI08",1881,0,"HEAT repeat-containing protein 6",".",".",".",".","pfam13251","DUF4042","Domain of unknown function (DUF4042). This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is approximately 180 amino acids in length.",".",".","GO:0003723|RNA binding;",".","."]
["bta_circ_0010707",0,0,0,1.95539434339163,5,0,5,-4.1983195597115,0.0374776767062138,"NA","down","yes","NC_037346.1:14561603..14565913:-","gene23741","gi|157786842|ref|NP_001099294.1|",650,{"v":4e-106,"d":"4.00E-106"},"TATA-binding protein-associated factor 2N [Rattus norvegicus]","gi|983001318|ref|XM_005192862.3|",2363,0,"PREDICTED: Bos taurus TATA-box binding protein associated factor 15 (TAF15), mRNA","Q92804",329,{"v":1e-100,"d":"1.00E-100"},"TATA-binding protein-associated factor 2N",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0045893|positive regulation of transcription, DNA-templated;GO:1901796|regulation of signal transduction by p53 class mediator;GO:0006366|transcription from RNA polymerase II promoter;GO:0006367|transcription initiation from RNA polymerase II promoter;","GO:0005737|cytoplasm;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0003723|RNA binding;","K14651","TAF15, NPL3; transcription initiation factor TFIID subunit 15"]
["bta_circ_0010727",0,4,0,5.55419998500519,14,11,4,-3.10790596874195,0.0201383178203539,"NA","down","yes","NC_037346.1:17932961..17937601:-","gene23796","gi|926716025|ref|XP_013827377.1|",3641,0,"PREDICTED: mitochondrial Rho GTPase 1 isoform X2 [Capra hircus]","gi|741962123|ref|XM_010815765.1|",2155,0,"PREDICTED: Bos taurus ras homolog family member T1 (RHOT1), transcript variant X7, mRNA","Q2HJF8",1237,0,"Mitochondrial Rho GTPase 1",".",".",".",".","pfam08356","EF_assoc_2","EF hand associated. This region predominantly appears near EF-hands (pfam00036) in GTP-binding proteins. It is found in all three eukaryotic kingdoms.","GO:0019725|cellular homeostasis;GO:0097345|mitochondrial outer membrane permeabilization;GO:0047497|mitochondrion transport along microtubule;","GO:0031307|integral component of mitochondrial outer membrane;","GO:0005509|calcium ion binding;GO:0005525|GTP binding;GO:0003924|GTPase activity;","K07870","RHOT1, ARHT1; Ras homolog gene family, member T1"]
["bta_circ_0010806",0,0,0,2.42243375550474,8,0,4,-4.51391803084925,0.0227377607129298,"NA","down","yes","NC_037346.1:23410336..23422710:-","gene23974","gi|300794745|ref|NP_001179145.1|",2828,0,"methyltransferase-like protein 16 [Bos taurus]","gi|982956260|ref|XR_813155.2|",6103,0,"PREDICTED: Bos taurus methyltransferase like 16 (METTL16), transcript variant X1, misc_RNA","Q86W50",989,0,"U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase","SPAC27D7.08c",166,{"v":8e-43,"d":"8.00E-43"},"COG3129","pfam05971","Methyltransf_10","Protein of unknown function (DUF890). This family consists of several conserved hypothetical proteins from both eukaryotes and prokaryotes. The function of this family is unknown.","GO:0006402|mRNA catabolic process;GO:0061157|mRNA destabilization;GO:0010608|posttranscriptional regulation of gene expression;GO:0048024|regulation of mRNA splicing, via spliceosome;GO:0070475|rRNA base methylation;","GO:0005634|nucleus;","GO:0052907|23S rRNA (adenine(1618)-N(6))-methyltransferase activity;GO:0016422|mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity;GO:0003723|RNA binding;GO:0035613|RNA stem-loop binding;GO:0030629|U6 snRNA 3'-end binding;","K11393","METT10D; methyltransferase [EC:2.1.1.-]"]
["bta_circ_0010865",0,0,0,138.067165220652,293,0,426,-4.283991755002,0.0435173770893959,0.456494092506297,"down","yes","NC_037346.1:29430476..29532719:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0010867",0,38,4,4.13223352141989,0,0,0,5.19545156873771,0.00633874388598336,"NA","up","yes","NC_037346.1:29459626..29516680:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0010868",2,9,5,2.08173310380628,0,0,0,4.37791457533236,0.0273339300527052,"NA","up","yes","NC_037346.1:29461107..29491471:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0010881",0,0,0,3.18245873370348,7,6,5,-5.13841257911217,0.00624858937234942,"NA","down","yes","NC_037346.1:29493365..29518832:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0010883",0,0,0,6.81774787664191,13,21,7,-6.24126490790835,0.000370933777362193,0.0320783530662825,"down","yes","NC_037346.1:29496025..29523639:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0010924",0,22,12,3.62037934451752,0,0,0,5.05762376461762,0.00823525420059817,"NA","up","yes","NC_037346.1:33748652..33753071:+","gene24306","gi|528995171|ref|XP_005220406.1|",3540,0,"PREDICTED: A-kinase anchor protein 10, mitochondrial isoform X1 [Bos taurus]","gi|982957190|ref|XM_005220349.3|",3795,0,"PREDICTED: Bos taurus A-kinase anchoring protein 10 (AKAP10), transcript variant X1, mRNA","O43572",1252,0,"A-kinase anchor protein 10, mitochondrial",".",".",".",".","pfam00615","RGS","Regulator of G protein signaling domain. RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.","GO:0007596|blood coagulation;GO:0008104|protein localization;GO:0007165|signal transduction;","GO:0005829|cytosol;GO:0005739|mitochondrion;GO:0005886|plasma membrane;GO:0032991|macromolecular complex;","GO:0051018|protein kinase A binding;","K16526","AKAP10; A-kinase anchor protein 10"]
["bta_circ_0010963",0,0,0,1.84145352823946,2,0,8,-4.09373446956485,0.0439610261947129,"NA","down","yes","NC_037346.1:35993494..36007412:-","gene24383","gi|926717431|ref|XP_005693712.2|",1374,0,"PREDICTED: luc7-like protein 3 isoform X2 [Capra hircus]","gi|77736312|ref|NM_001034684.1|",1864,0,"Bos taurus LUC7-like 3 pre-mRNA splicing factor (LUC7L3), mRNA","Q5R8W6",478,{"v":6e-162,"d":"6.00E-162"},"Luc7-like protein 3","SPCC16A11.13",116,{"v":7e-28,"d":"7.00E-28"},"COG5200","pfam03194","LUC7","LUC7 N_terminus. This family contains the N terminal region of several LUC7 protein homologues and only contains eukaryotic proteins. LUC7 has been shown to be a U1 snRNA associated protein with a role in splice site recognition. The family also contains human and mouse LUC7 like (LUC7L) proteins and human cisplatin resistance-associated overexpressed protein (CROP).","GO:0006376|mRNA splice site selection;GO:0008380|RNA splicing;","GO:0016607|nuclear speck;GO:0005634|nucleus;GO:0005685|U1 snRNP;","GO:0003677|DNA binding;GO:0003729|mRNA binding;",".","."]
["bta_circ_0010966",60,84,44,119.47956710836,105,243,189,-1.51054690995826,0.00170436475871554,0.0847995482704926,"down","yes","NC_037346.1:36033438..36034772:+","gene24385","gi|155371947|ref|NP_001094579.1|",1467,0,"ankyrin repeat domain-containing protein 40 [Bos taurus]","gi|155371946|ref|NM_001101109.1|",3638,0,"Bos taurus ankyrin repeat domain 40 (ANKRD40), mRNA",".",".",".",".",".",".",".",".","pfam12796","Ank_2","Ankyrin repeats (3 copies).",".",".",".",".","."]
["bta_circ_0010972",16,21,29,12.0499677561249,4,6,0,2.4938353779616,0.00933117125329207,0.247890543832493,"up","yes","NC_037346.1:36582347..36582947:-","gene24411","gi|705043112|ref|NP_001289593.1|",5208,0,"integrin alpha-3 precursor [Bos taurus]","gi|705043111|ref|NM_001302664.1|",4587,0,"Bos taurus integrin subunit alpha 3 (ITGA3), mRNA","F1MMS9",2010,0,"Integrin alpha-3",".",".",".",".","pfam08441","Integrin_alpha2","Integrin alpha. This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.","GO:0007155|cell adhesion;GO:0097062|dendritic spine maintenance;GO:0035640|exploration behavior;GO:0007229|integrin-mediated signaling pathway;GO:0030324|lung development;GO:0007613|memory;GO:0048333|mesodermal cell differentiation;GO:0035024|negative regulation of Rho protein signal transduction;GO:0072006|nephron development;GO:0001764|neuron migration;GO:1903078|positive regulation of protein localization to plasma membrane;GO:0030510|regulation of BMP signaling pathway;GO:0017015|regulation of transforming growth factor beta receptor signaling pathway;GO:0030111|regulation of Wnt signaling pathway;GO:0097205|renal filtration;GO:0043588|skin development;","GO:0016323|basolateral plasma membrane;GO:0030054|cell junction;GO:0060076|excitatory synapse;GO:0009897|external side of plasma membrane;GO:0031527|filopodium membrane;GO:0034667|integrin alpha3-beta1 complex;GO:0071438|invadopodium membrane;GO:0097060|synaptic membrane;","GO:0046872|metal ion binding;GO:0002020|protease binding;GO:0046982|protein heterodimerization activity;","K06482","ITGA3; integrin alpha 3"]
["bta_circ_0010982",8,225,132,42.7258758458303,0,7,7,3.87820258699243,0.000819489656073,0.0492512590431825,"up","yes","NC_037346.1:42261749..42262227:-","gene24665","gi|961729388|ref|XP_014925091.1|",1073,{"v":1e-140,"d":"1.00E-140"},"PREDICTED: ras-related protein Rab-5C [Acinonyx jubatus]","gi|982957871|ref|XM_005220751.3|",1760,0,"PREDICTED: Bos taurus RAB5C, member RAS oncogene family (RAB5C), transcript variant X2, mRNA","Q58DS9",417,{"v":5e-142,"d":"5.00E-142"},"Ras-related protein Rab-5C",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0048227|plasma membrane to endosome transport;GO:0015031|protein transport;GO:0030100|regulation of endocytosis;","GO:0005769|early endosome;GO:0031901|early endosome membrane;GO:0030139|endocytic vesicle;GO:0005811|lipid particle;GO:0042470|melanosome;GO:0005886|plasma membrane;","GO:0019003|GDP binding;GO:0005525|GTP binding;GO:0003924|GTPase activity;","K07889","RAB5C; Ras-related protein Rab-5C"]
["bta_circ_0010994",8,18,5,18.7534833250588,17,45,25,-1.58376337262581,0.0317414306523854,0.428634275476763,"down","yes","NC_037346.1:44192341..44195755:-","gene24779","gi|528996642|ref|XP_005221017.1|",3371,0,"PREDICTED: G patch domain-containing protein 8 isoform X2 [Bos taurus]","gi|742086656|ref|XM_010832438.1|",5717,0,"PREDICTED: Bison bison bison G patch domain containing 8 (GPATCH8), transcript variant X1, mRNA","Q9UKJ3",1164,0,"G patch domain-containing protein 8",".",".",".",".","pfam12171","zf-C2H2_jaz","Zinc-finger double-stranded RNA-binding. This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localisation.",".",".","GO:0046872|metal ion binding;GO:0003723|RNA binding;",".","."]
["bta_circ_0011009",0,0,0,2.19369518242872,3,9,2,-4.5716114138243,0.0192885541142555,"NA","down","yes","NC_037346.1:46065074..46135877:-","gene24829","gi|359077044|ref|XP_003587505.1|",5207,0,"PREDICTED: KAT8 regulatory NSL complex subunit 1 isoform X1 [Bos taurus]","gi|983002322|ref|XM_015468195.1|",5292,0,"PREDICTED: Bos taurus KAT8 regulatory NSL complex subunit 1 (KANSL1), transcript variant X3, mRNA","Q7Z3B3",1876,0,"KAT8 regulatory NSL complex subunit 1",".",".",".",".","pfam15275","PEHE","PEHE domain. This domain was first identified in drosophila MSL1 (male-specific lethal 1). In drosophila it binds to the histone acetyltransferase males-absent on the first protein (MOF) and to protein male-specific lethal-3 (MSL3).","GO:0043984|histone H4-K16 acetylation;GO:0043981|histone H4-K5 acetylation;GO:0043982|histone H4-K8 acetylation;","GO:0000777|condensed chromosome kinetochore;GO:0000123|histone acetyltransferase complex;GO:0071339|MLL1 complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;",".","K18400","KANSL1; KAT8 regulatory NSL complex subunit 1"]
["bta_circ_0011029",0,19,6,2.57334803919286,0,0,0,4.55995965036394,0.0210539583314445,"NA","up","yes","NC_037346.1:48171643..48173708:-","gene24873","gi|358417501|ref|XP_003583660.1|",8723,0,"PREDICTED: sodium channel protein type 4 subunit alpha isoform X1 [Bos taurus]","gi|983002360|ref|XM_015468204.1|",8033,0,"PREDICTED: Bos taurus sodium channel, voltage gated, type IV alpha subunit (SCN4A), transcript variant X3, mRNA","P35499",3099,0,"Sodium channel protein type 4 subunit alpha",".",".",".",".","pfam06512","Na_trans_assoc","Sodium ion transport-associated. Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.","GO:0086010|membrane depolarization during action potential;GO:0006936|muscle contraction;GO:0019228|neuronal action potential;GO:0034765|regulation of ion transmembrane transport;GO:0006814|sodium ion transport;","GO:0005887|integral component of plasma membrane;GO:0001518|voltage-gated sodium channel complex;","GO:0005244|voltage-gated ion channel activity;GO:0005248|voltage-gated sodium channel activity;","K04837","SCN4A; voltage-gated sodium channel type IV alpha"]
["bta_circ_0011055",33,399,198,92.8264473255112,16,67,43,1.84063092063719,0.000796467705028567,0.0492512590431825,"up","yes","NC_037346.1:50615857..50621220:+","gene24947","gi|505855412|ref|XP_004621117.1|",2055,0,"PREDICTED: casein kinase I isoform delta isoform X1 [Sorex araneus]","gi|586597912|ref|NM_001102080.2|",2212,0,"Bos taurus casein kinase 1 delta (CSNK1D), mRNA","P48730",793,0,"Casein kinase I isoform delta",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:1990090|cellular response to nerve growth factor stimulus;GO:0032922|circadian regulation of gene expression;GO:0048208|COPII vesicle coating;GO:0006897|endocytosis;GO:0000086|G2/M transition of mitotic cell cycle;GO:0007030|Golgi organization;GO:0007020|microtubule nucleation;GO:0018105|peptidyl-serine phosphorylation;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:2000052|positive regulation of non-canonical Wnt signaling pathway;GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0001934|positive regulation of protein phosphorylation;GO:0071539|protein localization to centrosome;GO:0061512|protein localization to cilium;GO:0034067|protein localization to Golgi apparatus;GO:0006468|protein phosphorylation;GO:0008360|regulation of cell shape;GO:0042752|regulation of circadian rhythm;GO:0010389|regulation of G2/M transition of mitotic cell cycle;GO:0051225|spindle assembly;GO:0016055|Wnt signaling pathway;","GO:0005813|centrosome;GO:0005829|cytosol;GO:0033116|endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0005794|Golgi apparatus;GO:0000139|Golgi membrane;GO:0043005|neuron projection;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;GO:0005886|plasma membrane;GO:0005819|spindle;GO:0005876|spindle microtubule;","GO:0005524|ATP binding;GO:0045296|cadherin binding;GO:0042277|peptide binding;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0050321|tau-protein kinase activity;","K08959","CSNK1D; casein kinase 1, delta [EC:2.7.11.1]"]
["bta_circ_0011055",33,399,198,92.8264473255112,16,67,43,1.84063092063719,0.000796467705028567,0.0492512590431825,"up","yes","NC_037346.1:50615857..50621220:+","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0011088",0,0,0,2.38445348378735,7,0,5,-4.49811675786419,0.0233006917722457,"NA","down","yes","NC_037346.1:55403313..55406580:+","gene25094","gi|555992577|ref|XP_005908063.1|",1745,0,"PREDICTED: phosphoribosyl pyrophosphate synthase-associated protein 1 isoform X1 [Bos mutus]","gi|402765712|ref|NM_001076857.2|",1970,0,"Bos taurus phosphoribosyl pyrophosphate synthetase-associated protein 1 (PRPSAP1), mRNA","Q08DW2",674,0,"Phosphoribosyl pyrophosphate synthase-associated protein 1","SPCC1620.06c",251,{"v":4e-76,"d":"4.00E-76"},"COG0462","pfam14572","Pribosyl_synth","Phosphoribosyl synthetase-associated domain. This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.","GO:0009165|nucleotide biosynthetic process;",".","GO:0042802|identical protein binding;GO:0000287|magnesium ion binding;GO:0004749|ribose phosphate diphosphokinase activity;",".","."]
["bta_circ_0011093",7,30,21,27.4679849878566,24,59,39,-1.3467783496613,0.0256140413849463,0.389982799114464,"down","yes","NC_037346.1:5621801..5634257:-","gene23555","gi|742138859|ref|XP_010841929.1|",1106,{"v":2e-141,"d":"2.00E-141"},"PREDICTED: monocyte to macrophage differentiation factor isoform X2 [Bison bison bison]","gi|115497827|ref|NM_001075601.1|",736,0,"Bos taurus monocyte to macrophage differentiation-associated (MMD), mRNA","Q15546",353,{"v":5e-113,"d":"5.00E-113"},"Monocyte to macrophage differentiation factor","YPO0900",67,{"v":2e-11,"d":"2.00E-11"},"COG1272","pfam03006","HlyIII","Haemolysin-III related. Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolizm. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea.","GO:0019835|cytolysis;GO:0045666|positive regulation of neuron differentiation;GO:0045860|positive regulation of protein kinase activity;GO:0032880|regulation of protein localization;","GO:0005794|Golgi apparatus;GO:0005887|integral component of plasma membrane;GO:0031902|late endosome membrane;GO:0005765|lysosomal membrane;GO:0016020|membrane;","GO:0004672|protein kinase activity;GO:0038023|signaling receptor activity;","K11064","MMD; monocyte to macrophage differentiation protein"]
["bta_circ_0011104",6,109,91,32.129861543697,11,31,11,1.4639485879771,0.0364531611025515,0.439730132358439,"up","yes","NC_037346.1:61136786..61146453:-","gene25232","gi|528997643|ref|XP_005221398.1|",1814,0,"PREDICTED: dual specificity mitogen-activated protein kinase kinase 6 isoform X2 [Bos taurus]","gi|982958977|ref|XM_005221341.3|",1620,0,"PREDICTED: Bos taurus mitogen-activated protein kinase kinase 6 (MAP2K6), transcript variant X2, mRNA","Q5E9X2",686,0,"Dual specificity mitogen-activated protein kinase kinase 6",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0032147|activation of protein kinase activity;GO:0006915|apoptotic process;GO:0060048|cardiac muscle contraction;GO:0042981|regulation of apoptotic process;GO:0007346|regulation of mitotic cell cycle;GO:0006355|regulation of transcription, DNA-templated;GO:0023014|signal transduction by protein phosphorylation;GO:0031098|stress-activated protein kinase signaling cascade;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005829|cytosol;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0004708|MAP kinase kinase activity;GO:0019901|protein kinase binding;GO:0004674|protein serine/threonine kinase activity;GO:0004713|protein tyrosine kinase activity;","K04433","MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]"]
["bta_circ_0011127",0,0,0,1.5778073827701,2,2,5,-4.0531980680196,0.0445500379892742,"NA","down","yes","NC_037346.1:6247593..6254722:+","gene23567","gi|27807327|ref|NP_777260.1|",1135,{"v":2e-149,"d":"2.00E-149"},"phosphatidylcholine transfer protein [Bos taurus]","gi|94534910|gb|BC116120.1|",1911,0,"Bos taurus phosphatidylcholine transfer protein, mRNA (cDNA clone MGC:138928 IMAGE:8091568), complete cds","P02720",441,{"v":8e-151,"d":"8.00E-151"},"Phosphatidylcholine transfer protein",".",".",".",".","pfam01852","START","START domain.","GO:0015914|phospholipid transport;","GO:0005829|cytosol;","GO:0031210|phosphatidylcholine binding;GO:0008525|phosphatidylcholine transporter activity;",".","."]
["bta_circ_0011169",11,5,18,6.92843988886616,0,3,3,2.39637628989691,0.0430826513835823,0.456494092506297,"up","yes","NC_037347.1:11415826..11424058:-","gene25426","gi|27807039|ref|NP_777000.1|",3604,0,"phosphatidylinositol 3-kinase regulatory subunit alpha [Bos taurus]","gi|742177553|ref|XM_010853602.1|",6667,0,"PREDICTED: Bison bison bison phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (PIK3R1), transcript variant X3, mRNA","P23727",1392,0,"Phosphatidylinositol 3-kinase regulatory subunit alpha",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0030183|B cell differentiation;GO:0001678|cellular glucose homeostasis;GO:0032869|cellular response to insulin stimulus;GO:0034644|cellular response to UV;GO:0008625|extrinsic apoptotic signaling pathway via death domain receptors;GO:0060396|growth hormone receptor signaling pathway;GO:0008286|insulin receptor signaling pathway;GO:0048009|insulin-like growth factor receptor signaling pathway;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0043066|negative regulation of apoptotic process;GO:0001953|negative regulation of cell-matrix adhesion;GO:0045671|negative regulation of osteoclast differentiation;GO:0014065|phosphatidylinositol 3-kinase signaling;GO:0046854|phosphatidylinositol phosphorylation;GO:0030335|positive regulation of cell migration;GO:1900103|positive regulation of endoplasmic reticulum unfolded protein response;GO:0046326|positive regulation of glucose import;GO:2001275|positive regulation of glucose import in response to insulin stimulus;GO:0042307|positive regulation of protein import into nucleus;GO:1903078|positive regulation of protein localization to plasma membrane;GO:0033120|positive regulation of RNA splicing;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0032760|positive regulation of tumor necrosis factor production;GO:0006606|protein import into nucleus;GO:0006468|protein phosphorylation;GO:0050821|protein stabilization;GO:0046626|regulation of insulin receptor signaling pathway;GO:0043551|regulation of phosphatidylinositol 3-kinase activity;GO:0051492|regulation of stress fiber assembly;GO:0034976|response to endoplasmic reticulum stress;","GO:0005911|cell-cell junction;GO:0005801|cis-Golgi network;GO:0005829|cytosol;GO:0005634|nucleus;GO:1990578|perinuclear endoplasmic reticulum membrane;GO:0005942|phosphatidylinositol 3-kinase complex;GO:0005943|phosphatidylinositol 3-kinase complex, class IA;","GO:0046935|1-phosphatidylinositol-3-kinase regulator activity;GO:0043125|ErbB-3 class receptor binding;GO:0042802|identical protein binding;GO:0043559|insulin binding;GO:0005158|insulin receptor binding;GO:0043560|insulin receptor substrate binding;GO:0005159|insulin-like growth factor receptor binding;GO:0005168|neurotrophin TRKA receptor binding;GO:0043548|phosphatidylinositol 3-kinase binding;GO:0035014|phosphatidylinositol 3-kinase regulator activity;GO:0036312|phosphatidylinositol 3-kinase regulatory subunit binding;GO:0001784|phosphotyrosine binding;GO:0046982|protein heterodimerization activity;GO:0019903|protein phosphatase binding;GO:0008134|transcription factor binding;GO:0005068|transmembrane receptor protein tyrosine kinase adaptor activity;","K02649","PIK3R; phosphoinositide-3-kinase, regulatory subunit"]
["bta_circ_0011183",2,0,0,6.1695449684494,12,8,11,-3.35069246293831,0.011164266756623,0.268190496975767,"down","yes","NC_037347.1:13440871..13473350:-","gene25438","gi|741965456|ref|XP_010815037.1|",924,{"v":2e-108,"d":"2.00E-108"},"PREDICTED: splicing regulatory glutamine/lysine-rich protein 1-like, partial [Bos taurus]","gi|742149029|ref|XM_010845545.1|",8803,0,"PREDICTED: Bison bison bison splicing regulatory glutamine/lysine-rich protein 1 (SREK1), transcript variant X3, mRNA","Q8WXA9",333,{"v":2e-97,"d":"2.00E-97"},"Splicing regulatory glutamine/lysine-rich protein 1",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0006397|mRNA processing;GO:0000381|regulation of alternative mRNA splicing, via spliceosome;GO:0008380|RNA splicing;","GO:0016607|nuclear speck;GO:0005654|nucleoplasm;GO:0005681|spliceosomal complex;","GO:0003723|RNA binding;","K13165","SFRS12; splicing factor, arginine/serine-rich 12"]
["bta_circ_0011191",0,0,0,2.45177317612102,4,8,3,-4.75259222148929,0.0137192945305042,"NA","down","yes","NC_037347.1:13560673..13580089:-","gene25441","gi|528997941|ref|XP_005221508.1|",7329,0,"PREDICTED: protein LAP2 isoform X1 [Bos taurus]","gi|982959267|ref|XM_005221451.3|",6739,0,"PREDICTED: Bos taurus erbb2 interacting protein (ERBB2IP), transcript variant X1, mRNA","Q96RT1",2497,0,"Erbin","alr0124_1",177,{"v":9e-46,"d":"9.00E-46"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0045175|basal protein localization;GO:0007155|cell adhesion;GO:0016049|cell growth;GO:0071356|cellular response to tumor necrosis factor;GO:0007173|epidermal growth factor receptor signaling pathway;GO:0038128|ERBB2 signaling pathway;GO:0045197|establishment or maintenance of epithelial cell apical/basal polarity;GO:0007229|integrin-mediated signaling pathway;GO:0045104|intermediate filament cytoskeleton organization;GO:0071638|negative regulation of monocyte chemotactic protein-1 production;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0070433|negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0006605|protein targeting;GO:0032496|response to lipopolysaccharide;GO:0032495|response to muramyl dipeptide;GO:0007165|signal transduction;","GO:0009925|basal plasma membrane;GO:0005604|basement membrane;GO:0016323|basolateral plasma membrane;GO:0030054|cell junction;GO:0005737|cytoplasm;GO:0030056|hemidesmosome;GO:0031965|nuclear membrane;GO:0016607|nuclear speck;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0005176|ErbB-2 class receptor binding;GO:0005102|receptor binding;GO:0005200|structural constituent of cytoskeleton;","K12796","ERBB2IP, ERBIN; erbb2-interacting protein"]
["bta_circ_0011231",0,0,0,2.1454355499289,3,2,7,-4.51633737100402,0.0212679439946128,"NA","down","yes","NC_037347.1:23222779..23239543:+","gene25519","gi|528922180|ref|XP_600430.6|",4720,0,"PREDICTED: interleukin-6 receptor subunit beta [Bos taurus]","gi|983003071|ref|XM_600430.9|",6976,0,"PREDICTED: Bos taurus interleukin 6 signal transducer (IL6ST), transcript variant X1, mRNA","P40189",1577,0,"Interleukin-6 receptor subunit beta",".",".",".",".","pfam06328","Lep_receptor_Ig","Ig-like C2-type domain. This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.","GO:0070120|ciliary neurotrophic factor-mediated signaling pathway;GO:0019221|cytokine-mediated signaling pathway;GO:0005977|glycogen metabolic process;GO:0070106|interleukin-27-mediated signaling pathway;GO:0070757|interleukin-35-mediated signaling pathway;GO:0070102|interleukin-6-mediated signaling pathway;GO:0048861|leukemia inhibitory factor signaling pathway;GO:0043066|negative regulation of apoptotic process;GO:0070104|negative regulation of interleukin-6-mediated signaling pathway;GO:0038165|oncostatin-M-mediated signaling pathway;GO:0002675|positive regulation of acute inflammatory response;GO:0002821|positive regulation of adaptive immune response;GO:0048711|positive regulation of astrocyte differentiation;GO:0010613|positive regulation of cardiac muscle hypertrophy;GO:0008284|positive regulation of cell proliferation;GO:0045669|positive regulation of osteoblast differentiation;GO:0042102|positive regulation of T cell proliferation;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0008593|regulation of Notch signaling pathway;GO:0034097|response to cytokine;GO:0016032|viral process;","GO:0070110|ciliary neurotrophic factor receptor complex;GO:0030425|dendrite;GO:0009897|external side of plasma membrane;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005896|interleukin-6 receptor complex;GO:0016020|membrane;GO:0043025|neuronal cell body;GO:0005900|oncostatin-M receptor complex;GO:0005886|plasma membrane;","GO:0004897|ciliary neurotrophic factor receptor activity;GO:0005127|ciliary neurotrophic factor receptor binding;GO:0019838|growth factor binding;GO:0019970|interleukin-11 binding;GO:0004921|interleukin-11 receptor activity;GO:0045509|interleukin-27 receptor activity;GO:0042803|protein homodimerization activity;","K05060","IL6ST, GP130; interleukin 6 signal transducer"]
["bta_circ_0011361",3,11,9,13.604458597161,6,31,29,-1.70011433203646,0.0422757822128125,0.456494092506297,"down","yes","NC_037347.1:39432593..39433609:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0011366",0,0,0,1.92533782795398,3,3,5,-4.37422281352943,0.0268609470057404,"NA","down","yes","NC_037347.1:40318018..40322227:-","gene25665","gi|77735697|ref|NP_001029542.1|",3775,0,"threonine--tRNA ligase, cytoplasmic [Bos taurus]","gi|402745353|ref|NM_001034370.2|",2799,0,"Bos taurus threonyl-tRNA synthetase (TARS), mRNA","Q3ZBV8",1458,0,"Threonine--tRNA ligase, cytoplasmic","SPBC25H2.02",816,0,"COG0441","pfam00587","tRNA-synt_2b","tRNA synthetase class II core domain (G, H, P, S and T). Other tRNA synthetase sub-families are too dissimilar to be included. This domain is the core catalytic domain of tRNA synthetases and includes glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases.","GO:0006435|threonyl-tRNA aminoacylation;","GO:0015629|actin cytoskeleton;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0005524|ATP binding;GO:0004829|threonine-tRNA ligase activity;","K01868","TARS, thrS; threonyl-tRNA synthetase [EC:6.1.1.3]"]
["bta_circ_0011373",31,25,13,57.8068534314543,84,86,86,-1.79592206919053,0.00327110593312189,0.136002519757875,"down","yes","NC_037347.1:41585304..41594143:-","gene25676","gi|555951466|ref|XP_005887930.1|",12267,0,"PREDICTED: PDZ domain-containing protein 2 [Bos mutus]","gi|594063685|ref|XM_006055809.1|",10764,0,"PREDICTED: Bubalus bubalis PDZ domain containing 2 (PDZD2), transcript variant X1, mRNA","O15018",3297,0,"PDZ domain-containing protein 2",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0007155|cell adhesion;","GO:0005911|cell-cell junction;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005576|extracellular region;GO:0005634|nucleus;",".",".","."]
["bta_circ_0011389",0,0,0,1.61578765448749,3,2,4,-4.09373904510496,0.0418526227388098,"NA","down","yes","NC_037347.1:4799731..4804703:+","gene25340","gi|76613853|ref|XP_881296.1|",2997,0,"PREDICTED: CREB3 regulatory factor [Bos taurus]","gi|983002936|ref|XM_010824705.2|",8337,0,"PREDICTED: Bos taurus CREB3 regulatory factor (CREBRF), transcript variant X3, mRNA","Q8IUR6",1139,0,"CREB3 regulatory factor",".",".",".",".","pfam00170","bZIP_1","bZIP transcription factor. The Pfam entry includes the basic region and the leucine zipper region.","GO:0030968|endoplasmic reticulum unfolded protein response;GO:0042711|maternal behavior;GO:1900102|negative regulation of endoplasmic reticulum unfolded protein response;GO:1900170|negative regulation of glucocorticoid mediated signaling pathway;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0032388|positive regulation of intracellular transport;GO:1902213|positive regulation of prolactin signaling pathway;GO:0045732|positive regulation of protein catabolic process;GO:0051222|positive regulation of protein transport;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0034976|response to endoplasmic reticulum stress;","GO:0005737|cytoplasm;GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001228|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;",".","."]
["bta_circ_0011430",2,4,9,2.11199040295538,0,0,0,4.38071060963763,0.0272869194316483,"NA","up","yes","NC_037347.1:66451777..66466592:-","gene25790","gi|803286146|ref|XP_012002711.1|",2163,0,"PREDICTED: non-canonical poly(A) RNA polymerase PAPD7 isoform X2 [Ovis aries musimon]","gi|982959721|ref|XM_005221667.3|",3873,0,"PREDICTED: Bos taurus PAP associated domain containing 7 (PAPD7), transcript variant X3, mRNA","Q5XG87",796,0,"Non-canonical poly(A) RNA polymerase PAPD7","SPAC12G12.13c",201,{"v":6e-53,"d":"6.00E-53"},"COG5260","pfam03828","PAP_assoc","Cid1 family poly A polymerase. This domain is found in poly(A) polymerases and has been shown to have polynucleotide adenylyltransferase activity. Proteins in this family have been located to both the nucleus and the cytoplasm.","GO:0006302|double-strand break repair;GO:0007076|mitotic chromosome condensation;GO:0006397|mRNA processing;GO:0042493|response to drug;GO:0007062|sister chromatid cohesion;","GO:0005794|Golgi apparatus;GO:0031965|nuclear membrane;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0046872|metal ion binding;GO:0004652|polynucleotide adenylyltransferase activity;GO:0043221|SMC family protein binding;","K03514","PAPD5_7, TRF4; non-canonical poly(A) RNA polymerase PAPD5/7 [EC:2.7.7.19]"]
["bta_circ_0011441",5,3,8,2.77349905182055,0,0,0,4.73347701399671,0.0146653902257288,"NA","up","yes","NC_037347.1:6765897..6773105:+","gene25365","gi|156120865|ref|NP_001095579.1|",3905,0,"ribosome-releasing factor 2, mitochondrial [Bos taurus]","gi|402745874|ref|NM_001102109.2|",2769,0,"Bos taurus G elongation factor, mitochondrial 2 (GFM2), mRNA","A6QNM2",1506,0,"Ribosome-releasing factor 2, mitochondrial","TM1503",494,{"v":6e-161,"d":"6.00E-161"},"COG0480","pfam00009","GTP_EFTU","Elongation factor Tu GTP binding domain. This domain contains a P-loop motif, also found in several other families such as pfam00071, pfam00025 and pfam00063. Elongation factor Tu consists of three structural domains, this plus two C-terminal beta barrel domains.","GO:0032543|mitochondrial translation;GO:0032790|ribosome disassembly;","GO:0005739|mitochondrion;","GO:0005525|GTP binding;GO:0003924|GTPase activity;","K02355","fusA, GFM, EFG; elongation factor G"]
["bta_circ_0011466",6,82,46,15.4229554923334,0,0,0,7.13181079222929,{"v":1.94543187675238e-05,"d":"1.95E-05"},0.00300430265538475,"up","yes","NC_037348.1:14053504..14053750:-","gene25995","gi|156121009|ref|NP_001095651.1|",2141,0,"chromodomain-helicase-DNA-binding protein 2 [Bos taurus]","gi|156121008|ref|NM_001102181.1|",4895,0,"Bos taurus chromodomain helicase DNA binding protein 2 (CHD2), mRNA","O14647",782,0,"Chromodomain-helicase-DNA-binding protein 2",".",".",".",".","pfam13907","DUF4208","Domain of unknown function (DUF4208). This domain is found at the C-terminus of chromodomain-helicase-DNA-binding proteins. The exact function of the domain is undetermined.","GO:0006974|cellular response to DNA damage stimulus;GO:0006325|chromatin organization;GO:0060218|hematopoietic stem cell differentiation;GO:0007517|muscle organ development;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0006351|transcription, DNA-templated;","GO:0043231|intracellular membrane-bounded organelle;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0004003|ATP-dependent DNA helicase activity;GO:0003677|DNA binding;GO:0042393|histone binding;GO:0003723|RNA binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;",".","."]
["bta_circ_0011482",0,8,8,1.77762092389993,0,0,0,4.01962512969595,0.0489208005174351,"NA","up","yes","NC_037348.1:14131055..14141510:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0011490",3,12,22,20.0001086532454,18,36,37,-1.57363250547382,0.0295587484777936,0.423218637145628,"down","yes","NC_037348.1:16978788..16998885:+","gene26012","gi|742085562|ref|XP_010830477.1|",5305,0,"PREDICTED: cytosolic carboxypeptidase 4 isoform X1 [Bison bison bison]","gi|594099451|ref|XM_006072797.1|",5017,0,"PREDICTED: Bubalus bubalis ATP/GTP binding protein-like 1 (AGBL1), transcript variant X1, mRNA","Q96MI9",1630,0,"Cytosolic carboxypeptidase 4","PA2831",102,{"v":1e-21,"d":"1.00E-21"},"COG2866","pfam00246","Peptidase_M14","Zinc carboxypeptidase.","GO:0035609|C-terminal protein deglutamylation;GO:0035610|protein side chain deglutamylation;","GO:0005829|cytosol;","GO:0004181|metallocarboxypeptidase activity;GO:0015631|tubulin binding;GO:0008270|zinc ion binding;",".","."]
["bta_circ_0011493",5,29,25,29.0148409454336,31,62,38,-1.47564662405153,0.0143954143736324,0.298906981742218,"down","yes","NC_037348.1:16986260..16998885:+","gene26012","gi|742085562|ref|XP_010830477.1|",5305,0,"PREDICTED: cytosolic carboxypeptidase 4 isoform X1 [Bison bison bison]","gi|594099451|ref|XM_006072797.1|",5017,0,"PREDICTED: Bubalus bubalis ATP/GTP binding protein-like 1 (AGBL1), transcript variant X1, mRNA","Q96MI9",1630,0,"Cytosolic carboxypeptidase 4","PA2831",102,{"v":1e-21,"d":"1.00E-21"},"COG2866","pfam00246","Peptidase_M14","Zinc carboxypeptidase.","GO:0035609|C-terminal protein deglutamylation;GO:0035610|protein side chain deglutamylation;","GO:0005829|cytosol;","GO:0004181|metallocarboxypeptidase activity;GO:0015631|tubulin binding;GO:0008270|zinc ion binding;",".","."]
["bta_circ_0011501",0,0,0,2.43828126806422,6,6,2,-4.72105051511155,0.0146412278154451,"NA","down","yes","NC_037348.1:17073976..17083789:+","gene26012","gi|742085562|ref|XP_010830477.1|",5305,0,"PREDICTED: cytosolic carboxypeptidase 4 isoform X1 [Bison bison bison]","gi|594099451|ref|XM_006072797.1|",5017,0,"PREDICTED: Bubalus bubalis ATP/GTP binding protein-like 1 (AGBL1), transcript variant X1, mRNA","Q96MI9",1630,0,"Cytosolic carboxypeptidase 4","PA2831",102,{"v":1e-21,"d":"1.00E-21"},"COG2866","pfam00246","Peptidase_M14","Zinc carboxypeptidase.","GO:0035609|C-terminal protein deglutamylation;GO:0035610|protein side chain deglutamylation;","GO:0005829|cytosol;","GO:0004181|metallocarboxypeptidase activity;GO:0015631|tubulin binding;GO:0008270|zinc ion binding;",".","."]
["bta_circ_0011504",0,0,0,1.72665577031561,0,9,3,-4.04584832567136,0.0469265519757059,"NA","down","yes","NC_037348.1:17095339..17111907:+","gene26012","gi|742085562|ref|XP_010830477.1|",5305,0,"PREDICTED: cytosolic carboxypeptidase 4 isoform X1 [Bison bison bison]","gi|594099451|ref|XM_006072797.1|",5017,0,"PREDICTED: Bubalus bubalis ATP/GTP binding protein-like 1 (AGBL1), transcript variant X1, mRNA","Q96MI9",1630,0,"Cytosolic carboxypeptidase 4","PA2831",102,{"v":1e-21,"d":"1.00E-21"},"COG2866","pfam00246","Peptidase_M14","Zinc carboxypeptidase.","GO:0035609|C-terminal protein deglutamylation;GO:0035610|protein side chain deglutamylation;","GO:0005829|cytosol;","GO:0004181|metallocarboxypeptidase activity;GO:0015631|tubulin binding;GO:0008270|zinc ion binding;",".","."]
["bta_circ_0011505",0,4,3,9.32061529216492,17,21,12,-3.08932608572946,0.00258607014782159,0.114103748154904,"down","yes","NC_037348.1:17095339..17129804:+","gene26012","gi|742085562|ref|XP_010830477.1|",5305,0,"PREDICTED: cytosolic carboxypeptidase 4 isoform X1 [Bison bison bison]","gi|594099451|ref|XM_006072797.1|",5017,0,"PREDICTED: Bubalus bubalis ATP/GTP binding protein-like 1 (AGBL1), transcript variant X1, mRNA","Q96MI9",1630,0,"Cytosolic carboxypeptidase 4","PA2831",102,{"v":1e-21,"d":"1.00E-21"},"COG2866","pfam00246","Peptidase_M14","Zinc carboxypeptidase.","GO:0035609|C-terminal protein deglutamylation;GO:0035610|protein side chain deglutamylation;","GO:0005829|cytosol;","GO:0004181|metallocarboxypeptidase activity;GO:0015631|tubulin binding;GO:0008270|zinc ion binding;",".","."]
["bta_circ_0011507",0,16,14,20.5859030128375,30,59,17,-2.19777844163229,0.00588475617766367,0.19277034630468,"down","yes","NC_037348.1:17098113..17111907:+","gene26012","gi|742085562|ref|XP_010830477.1|",5305,0,"PREDICTED: cytosolic carboxypeptidase 4 isoform X1 [Bison bison bison]","gi|594099451|ref|XM_006072797.1|",5017,0,"PREDICTED: Bubalus bubalis ATP/GTP binding protein-like 1 (AGBL1), transcript variant X1, mRNA","Q96MI9",1630,0,"Cytosolic carboxypeptidase 4","PA2831",102,{"v":1e-21,"d":"1.00E-21"},"COG2866","pfam00246","Peptidase_M14","Zinc carboxypeptidase.","GO:0035609|C-terminal protein deglutamylation;GO:0035610|protein side chain deglutamylation;","GO:0005829|cytosol;","GO:0004181|metallocarboxypeptidase activity;GO:0015631|tubulin binding;GO:0008270|zinc ion binding;",".","."]
["bta_circ_0011510",0,0,0,2.1454355499289,3,2,7,-4.51633737100402,0.0212679439946128,"NA","down","yes","NC_037348.1:17111763..17168013:+","gene26012","gi|742085562|ref|XP_010830477.1|",5305,0,"PREDICTED: cytosolic carboxypeptidase 4 isoform X1 [Bison bison bison]","gi|594099451|ref|XM_006072797.1|",5017,0,"PREDICTED: Bubalus bubalis ATP/GTP binding protein-like 1 (AGBL1), transcript variant X1, mRNA","Q96MI9",1630,0,"Cytosolic carboxypeptidase 4","PA2831",102,{"v":1e-21,"d":"1.00E-21"},"COG2866","pfam00246","Peptidase_M14","Zinc carboxypeptidase.","GO:0035609|C-terminal protein deglutamylation;GO:0035610|protein side chain deglutamylation;","GO:0005829|cytosol;","GO:0004181|metallocarboxypeptidase activity;GO:0015631|tubulin binding;GO:0008270|zinc ion binding;",".","."]
["bta_circ_0011533",0,15,16,34.5763011343943,49,62,70,-2.95763039194466,{"v":1.06967172585705e-05,"d":"1.07E-05"},0.00212771787653334,"down","yes","NC_037348.1:21532707..21536104:+","gene26092","gi|965912202|ref|XP_014946837.1|",687,{"v":1e-78,"d":"1.00E-78"},"PREDICTED: endogenous retrovirus group K member 18 Pol protein-like [Ovis aries musimon]","gi|983003586|ref|XR_229219.3|",4568,0,"PREDICTED: Bos taurus uncharacterized LOC101908359 (LOC101908359), transcript variant X1, ncRNA","P08361",166,{"v":7e-74,"d":"7.00E-74"},"Gag-Pol polyprotein",".",".",".",".","pfam00078","RVT_1","Reverse transcriptase (RNA-dependent DNA polymerase). A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses.","GO:0015074|DNA integration;GO:0006310|DNA recombination;GO:0075713|establishment of integrated proviral latency;GO:0039657|suppression by virus of host gene expression;GO:0046718|viral entry into host cell;GO:0044826|viral genome integration into host DNA;GO:0019068|virion assembly;","GO:0044185|host cell late endosome membrane;GO:0020002|host cell plasma membrane;GO:0072494|host multivesicular body;GO:0016020|membrane;GO:0019013|viral nucleocapsid;","GO:0004190|aspartic-type endopeptidase activity;GO:0003677|DNA binding;GO:0003887|DNA-directed DNA polymerase activity;GO:0003723|RNA binding;GO:0003964|RNA-directed DNA polymerase activity;GO:0004523|RNA-DNA hybrid ribonuclease activity;GO:0039660|structural constituent of virion;GO:0008270|zinc ion binding;",".","."]
["bta_circ_0011543",0,0,0,2.28386472874166,9,0,2,-4.39661891810786,0.0277755604459109,"NA","down","yes","NC_037348.1:22120816..22124053:-","gene26115","gi|926718994|ref|XP_013828404.1|",8635,0,"PREDICTED: ras GTPase-activating-like protein IQGAP1 [Capra hircus]","gi|983003603|ref|XM_015468471.1|",7100,0,"PREDICTED: Bos taurus IQ motif containing GTPase activating protein 1 (IQGAP1), mRNA","P46940",3217,0,"Ras GTPase-activating-like protein IQGAP1","SPAC4F8.13c",361,{"v":1e-100,"d":"1.00E-100"},"COG5261","pfam00616","RasGAP","GTPase-activator protein for Ras-like GTPase. All alpha-helical domain that accelerates the GTPase activity of Ras, thereby \"switching\" it into an \"off\" position.","GO:0071277|cellular response to calcium ion;GO:0071364|cellular response to epidermal growth factor stimulus;GO:0036120|cellular response to platelet-derived growth factor stimulus;GO:0007173|epidermal growth factor receptor signaling pathway;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0072015|glomerular visceral epithelial cell development;GO:0035305|negative regulation of dephosphorylation;GO:1990138|neuron projection extension;GO:0043312|neutrophil degranulation;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:1903829|positive regulation of cellular protein localization;GO:1900006|positive regulation of dendrite development;GO:0051894|positive regulation of focal adhesion assembly;GO:0043406|positive regulation of MAP kinase activity;GO:1900086|positive regulation of peptidyl-tyrosine autophosphorylation;GO:0045860|positive regulation of protein kinase activity;GO:0001817|regulation of cytokine production;GO:0007346|regulation of mitotic cell cycle;GO:1990776|response to angiotensin;GO:0007165|signal transduction;","GO:0005884|actin filament;GO:0030424|axon;GO:0005737|cytoplasm;GO:0036464|cytoplasmic ribonucleoprotein granule;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0005925|focal adhesion;GO:0030426|growth cone;GO:0016328|lateral plasma membrane;GO:0045121|membrane raft;GO:0005874|microtubule;GO:0030496|midbody;GO:0043005|neuron projection;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0001726|ruffle;GO:0030667|secretory granule membrane;GO:0036057|slit diaphragm;","GO:0045296|cadherin binding;GO:0005509|calcium ion binding;GO:0005516|calmodulin binding;GO:0005096|GTPase activator activity;GO:0005095|GTPase inhibitor activity;GO:0051019|mitogen-activated protein kinase binding;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0019904|protein domain specific binding;GO:0019901|protein kinase binding;GO:0019903|protein phosphatase binding;GO:0043539|protein serine/threonine kinase activator activity;GO:0044877|macromolecular complex binding;GO:0048365|Rac GTPase binding;GO:0044548|S100 protein binding;","K16848","IQGAP1; Ras GTPase-activating-like protein IQGAP1"]
["bta_circ_0011573",0,7,9,1.8090339476539,0,0,0,4.04254352497548,0.0473631419442961,"NA","up","yes","NC_037348.1:23043414..23048500:-","gene26140","gi|329664702|ref|NP_001192937.1|",3850,0,"fibronectin type III and SPRY domain-containing protein 2 [Bos taurus]","gi|742124562|ref|XM_010841105.1|",3976,0,"PREDICTED: Bison bison bison fibronectin type III and SPRY domain containing 2 (FSD2), mRNA",".",".",".",".",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.",".",".",".",".","."]
["bta_circ_0011580",0,0,0,3.09300628221191,7,4,6,-5.0844144857054,0.00705037494015986,"NA","down","yes","NC_037348.1:23114317..23119659:-","gene26142","gi|115495969|ref|NP_001068935.1|",1696,0,"homer protein homolog 2 [Bos taurus]","gi|402744222|ref|NM_001075467.2|",1886,0,"Bos taurus homer scaffolding protein 2 (HOMER2), mRNA","Q9NSB8",634,0,"Homer protein homolog 2",".",".",".",".","pfam00568","WH1","WH1 domain. WASp Homology domain 1 (WH1) domain. WASP is the protein that is defective in Wiskott-Aldrich syndrome (WAS). The majority of point mutations occur within the amino- terminal WH1 domain. The metabotropic glutamate receptors mGluR1alpha and mGluR5 bind a protein called homer, which is a WH1 domain homologue. A subset of WH1 domains has been termed a \"EVH1\" domain and appear to bind a polyproline motif.","GO:0048148|behavioral response to cocaine;GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0048875|chemical homeostasis within a tissue;GO:0007216|G-protein coupled glutamate receptor signaling pathway;GO:0070885|negative regulation of calcineurin-NFAT signaling cascade;GO:0032703|negative regulation of interleukin-2 production;GO:0008277|regulation of G-protein coupled receptor protein signaling pathway;GO:0007605|sensory perception of sound;","GO:0045177|apical part of cell;GO:0030054|cell junction;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0030425|dendrite;GO:0043025|neuronal cell body;GO:0014069|postsynaptic density;GO:0045211|postsynaptic membrane;GO:0032426|stereocilium bundle tip;","GO:0003779|actin binding;GO:0035256|G-protein coupled glutamate receptor binding;GO:0030160|GKAP/Homer scaffold activity;GO:0019904|protein domain specific binding;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;","K15010","HOMER; homer"]
["bta_circ_0011614",0,0,0,1.72430016581292,0,5,6,-4.0436666411325,0.0469482969777028,"NA","down","yes","NC_037348.1:25078983..25102759:+","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0011651",0,20,2,2.16151155657671,0,0,0,4.26965331784017,0.034100006943682,"NA","up","yes","NC_037348.1:31392815..31395966:+","gene26268","gi|528999346|ref|XP_005222027.1|",2168,0,"PREDICTED: transmembrane protein C15orf27 homolog isoform X1 [Bos taurus]","gi|982960326|ref|XM_005221973.3|",2979,0,"PREDICTED: Bos taurus transmembrane protein 266 (TMEM266), transcript variant X3, mRNA","Q2M3C6",757,0,"Transmembrane protein 266",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices",".","GO:0005829|cytosol;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;",".",".","."]
["bta_circ_0011664",3,5,3,1.74110870254866,0,0,0,4.083215776457,0.0432719175415306,"NA","up","yes","NC_037348.1:32396978..32527707:-","gene26279","gi|359077797|ref|XP_003587616.1|",8086,0,"PREDICTED: pseudopodium-enriched atypical kinase 1 [Bos taurus]","gi|983003752|ref|XM_015468516.1|",11295,0,"PREDICTED: Bos taurus pseudopodium enriched atypical kinase 1 (PEAK1), transcript variant X4, mRNA","Q9H792",2816,0,"Inactive tyrosine-protein kinase PEAK1",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0016477|cell migration;GO:0048041|focal adhesion assembly;GO:0046777|protein autophosphorylation;GO:0051893|regulation of focal adhesion assembly;GO:0034446|substrate adhesion-dependent cell spreading;","GO:0015629|actin cytoskeleton;GO:0005737|cytoplasm;GO:0005925|focal adhesion;","GO:0005524|ATP binding;GO:0042802|identical protein binding;GO:0004715|non-membrane spanning protein tyrosine kinase activity;","K17538","PEAK1, SGK269; pseudopodium-enriched atypical kinase 1 [EC:2.7.10.2]"]
["bta_circ_0011692",0,11,8,2.06380531150022,0,0,0,4.24363293597368,0.0351448879920331,"NA","up","yes","NC_037348.1:41849526..41875458:-","gene26386","gi|741898456|ref|XP_010823197.1|",10312,0,"PREDICTED: HEAT repeat-containing protein 5A isoform X7 [Bos taurus]","gi|983003862|ref|XM_010824895.2|",7572,0,"PREDICTED: Bos taurus HEAT repeat containing 5A (HEATR5A), transcript variant X11, mRNA",".",".",".",".",".",".",".",".","pfam10345","Cohesin_load","Cohesin loading factor. Cohesin_load is a common cohesin loading factor protein that is conserved in fungi. It is associated with the cohesin complex and is required in G1 for cohesin binding to chromosomes but dispensable in G2 when cohesion has been established. It is referred to as both Ssl3, in pombe, and Scc4, in S.cerevisiae. It complexes with Mis4.",".",".",".",".","."]
["bta_circ_0011722",4,58,55,47.8871465336092,57,63,77,-1.24947396379666,0.0358563289136039,0.439730132358439,"down","yes","NC_037348.1:44574908..44593472:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0011753",0,0,0,1.74878852947352,3,3,4,-4.22854152057912,0.0339591890316316,"NA","down","yes","NC_037348.1:47503841..47521389:+","gene26452","gi|742098589|ref|XP_010833621.1|",2248,0,"PREDICTED: mirror-image polydactyly gene 1 protein isoform X1 [Bison bison bison]","gi|742098592|ref|XM_010835320.1|",2410,0,"PREDICTED: Bison bison bison mirror-image polydactyly 1 (MIPOL1), transcript variant X2, mRNA","Q8TD10",707,0,"Mirror-image polydactyly gene 1 protein",".",".",".",".","pfam05622","HOOK","HOOK protein. This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organisms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas the central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head.",".","GO:0005634|nucleus;","GO:0042802|identical protein binding;",".","."]
["bta_circ_0011759",7,15,25,30.8600911907772,53,46,38,-1.81692605785822,0.00353617923542283,0.144249424660078,"down","yes","NC_037348.1:49057068..49097373:-","gene26459","gi|149692839|ref|XP_001492394.1|",4093,0,"PREDICTED: protein transport protein Sec23A [Equus caballus]","gi|125991941|ref|NM_001081604.1|",4579,0,"Bos taurus Sec23 homolog A, COPII coat complex component (SEC23A), mRNA","A2VDL8",1578,0,"Protein transport protein Sec23A","SPCC31H12.07",869,0,"COG5047","pfam04811","Sec23_trunk","Sec23/Sec24 trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.","GO:0090110|cargo loading into COPII-coated vesicle;GO:0006886|intracellular protein transport;","GO:0030127|COPII vesicle coat;GO:0005829|cytosol;GO:0070971|endoplasmic reticulum exit site;GO:0005789|endoplasmic reticulum membrane;GO:0019898|extrinsic component of membrane;GO:0000139|Golgi membrane;","GO:0008270|zinc ion binding;","K14006","SEC23; protein transport protein SEC23"]
["bta_circ_0011790",6,31,30,35.3084348958528,50,53,51,-1.58214770097381,0.00577671780479371,0.19277034630468,"down","yes","NC_037348.1:55215470..55223783:-","gene26501","gi|329755331|ref|NP_001193326.1|",9541,0,"tumor suppressor p53-binding protein 1 [Bos taurus]","gi|329755330|ref|NM_001206397.1|",6104,0,"Bos taurus tumor protein p53 binding protein 1 (TP53BP1), mRNA","Q12888",3139,0,"TP53-binding protein 1",".",".",".",".","pfam09038","53-BP1_Tudor","tumor suppressor p53-binding protein-1 Tudor. Members of this family consist of ten beta-strands and a carboxy-terminal alpha-helix. The amino-terminal five beta-strands and the C-terminal five beta-strands adopt folds that are identical to each other. This domain is essential for the recruitment of proteins to double stranded breaks in DNA, which is mediated by interaction with methylated Lys 79 of histone H3.","GO:0006974|cellular response to DNA damage stimulus;GO:0071481|cellular response to X-ray;GO:0000077|DNA damage checkpoint;GO:0006303|double-strand break repair via nonhomologous end joining;GO:2000042|negative regulation of double-strand break repair via homologous recombination;GO:0051091|positive regulation of sequence-specific DNA binding transcription factor activity;GO:0045830|positive regulation of isotype switching;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0051260|protein homooligomerization;GO:0006351|transcription, DNA-templated;","GO:0000777|condensed chromosome kinetochore;GO:0005737|cytoplasm;GO:1990391|DNA repair complex;GO:0016604|nuclear body;GO:0000784|nuclear chromosome, telomeric region;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005657|replication fork;GO:0035861|site of double-strand break;","GO:0003684|damaged DNA binding;GO:0035064|methylated histone binding;GO:0002039|p53 binding;GO:0001102|RNA polymerase II activating transcription factor binding;GO:0001104|RNA polymerase II transcription cofactor activity;GO:0042162|telomeric DNA binding;GO:0061649|ubiquitinated histone binding;",".","."]
["bta_circ_0011793",0,7,14,2.44307304575754,0,0,0,4.47578591382337,0.024268449729235,"NA","up","yes","NC_037348.1:56155885..56157255:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0011796",3,12,0,2.02844881475381,0,0,0,4.14410078652328,0.0409651337580724,"NA","up","yes","NC_037348.1:56266298..56267423:+","gene26527","gi|742102611|ref|XP_010834564.1|",175,{"v":2e-12,"d":"2.00E-12"},"PREDICTED: WAS/WASL-interacting protein family member 3-like [Bison bison bison]","gi|983003988|ref|XR_001499026.1|",421,0,"PREDICTED: Bos taurus uncharacterized LOC101909140 (LOC101909140), transcript variant X4, ncRNA",".",".",".",".",".",".",".",".","pfam03040","CemA","CemA family. Members of this family are probable integral membrane proteins. Their molecular function is unknown. CemA proteins are found in the inner envelope membrane of chloroplasts but not in the thylakoid membrane. A cyanobacterial member of this family has been implicated in CO2 transport, but is probably not a CO2 transporter itself. They are predicted to be haem-binding however this has not been proven experimentally.",".",".",".",".","."]
["bta_circ_0011844",6,56,46,15.508544639021,0,10,7,2.20626625675135,0.0141653888649592,0.298906981742218,"up","yes","NC_037348.1:64884148..64887545:+","gene26627","gi|742169784|ref|XP_010849669.1|",4211,0,"PREDICTED: echinoderm microtubule-associated protein-like 1 isoform X1 [Bison bison bison]","gi|742169783|ref|XM_010851367.1|",4000,0,"PREDICTED: Bison bison bison echinoderm microtubule associated protein like 1 (EML1), transcript variant X1, mRNA","O00423",1492,0,"Echinoderm microtubule-associated protein-like 1","all0284_3",82.8,{"v":3e-15,"d":"3.00E-15"},"COG2319","pfam03451","HELP","HELP motif. The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.","GO:0007420|brain development;GO:0002244|hematopoietic progenitor cell differentiation;GO:0000226|microtubule cytoskeleton organization;GO:0007052|mitotic spindle organization;GO:0007405|neuroblast proliferation;","GO:0005829|cytosol;GO:0005874|microtubule;GO:0005875|microtubule associated complex;GO:1990023|mitotic spindle midzone;GO:0097431|mitotic spindle pole;GO:0048471|perinuclear region of cytoplasm;","GO:0005509|calcium ion binding;GO:0008017|microtubule binding;GO:0015631|tubulin binding;","K18595","EML1_2; echinoderm microtubule-associated protein-like 1/2"]
["bta_circ_0011869",0,0,0,2.0828270666006,6,2,3,-4.46039099577153,0.0234028868914369,"NA","down","yes","NC_037348.1:67414790..67434291:+","gene26770","gi|803216047|ref|XP_011968404.1|",1847,0,"PREDICTED: REST corepressor 1 isoform X2 [Ovis aries musimon]","gi|983004144|ref|XM_015468613.1|",4046,0,"PREDICTED: Bos taurus REST corepressor 1 (RCOR1), transcript variant X1, mRNA","Q9UKL0",698,0,"REST corepressor 1",".",".",".",".","pfam01448","ELM2","ELM2 domain. The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in a member from Arabidopsis thaliana. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.","GO:0007596|blood coagulation;GO:0070933|histone H4 deacetylation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;GO:0016032|viral process;","GO:1990391|DNA repair complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005667|transcription factor complex;GO:0017053|transcriptional repressor complex;","GO:0004407|histone deacetylase activity;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003714|transcription corepressor activity;GO:0008134|transcription factor binding;GO:0044212|transcription regulatory region DNA binding;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K11829","RCOR1, COREST; REST corepressor 1"]
["bta_circ_0011896",0,0,0,2.3434005127459,0,7,8,-4.519141485706,0.0223946146918695,"NA","down","yes","NC_037348.1:6887421..6907420:-","gene25955","gi|947300540|ref|XP_014447485.1|",1994,0,"PREDICTED: myocyte-specific enhancer factor 2A isoform X2 [Tupaia chinensis]","gi|402766737|ref|NM_001083638.2|",4947,0,"Bos taurus myocyte enhancer factor 2A (MEF2A), mRNA","A2VDZ3",766,0,"Myocyte-specific enhancer factor 2A","YPL089c",92,{"v":7e-18,"d":"7.00E-18"},"COG5068","pfam12347","HJURP_C","Holliday junction regulator protein family C-terminal repeat. Although this family is conserved in the Holliday junction regulator, HJURP, proteins in higher eukaryotes, alongside an Scm3, pfam10384, family, its exact function is not known. The C-terminal region of Scm3 proteins has been evolving rapidly, and this short repeat at the C-terminal end can be present in up to two copies in the higher eukaryotes.","GO:0006915|apoptotic process;GO:0061337|cardiac conduction;GO:0071277|cellular response to calcium ion;GO:0048813|dendrite morphogenesis;GO:0070375|ERK5 cascade;GO:0000165|MAPK cascade;GO:0000002|mitochondrial genome maintenance;GO:0048311|mitochondrion distribution;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0010613|positive regulation of cardiac muscle hypertrophy;GO:0046326|positive regulation of glucose import;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0055005|ventricular cardiac myofibril assembly;","GO:0005829|cytosol;GO:0000790|nuclear chromatin;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0033613|activating transcription factor binding;GO:0003682|chromatin binding;GO:0035035|histone acetyltransferase binding;GO:0042826|histone deacetylase binding;GO:0046982|protein heterodimerization activity;GO:0019901|protein kinase binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001105|RNA polymerase II transcription coactivator activity;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001085|RNA polymerase II transcription factor binding;GO:0046332|SMAD binding;GO:0003705|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K09260","MEF2A; MADS-box transcription enhancer factor 2A"]
["bta_circ_0011901",13,20,12,8.63020680049751,0,5,4,2.17843265851643,0.0382917661693198,0.439730132358439,"up","yes","NC_037348.1:7286704..7306409:-","gene25956","gi|803313920|ref|XP_012015279.1|",1846,0,"PREDICTED: leucine-rich repeat-containing protein 28 isoform X1 [Ovis aries musimon]","gi|965896079|ref|XR_001035866.2|",3635,0,"PREDICTED: Ovis aries musimon leucine rich repeat containing 28 (LRRC28), transcript variant X6, misc_RNA","Q32KX5",676,0,"Leucine-rich repeat-containing protein 28","MA2301_1",77.8,{"v":2e-14,"d":"2.00E-14"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0007165|signal transduction;",".",".",".","."]
["bta_circ_0011959",0,0,0,2.09075082288034,5,5,2,-4.49180061534247,0.022069364362823,"NA","down","yes","NC_037349.1:15472961..15497890:-","gene27034","gi|156120985|ref|NP_001095639.1|",3305,0,"anoctamin-10 [Bos taurus]","gi|156120984|ref|NM_001102169.1|",2253,0,"Bos taurus anoctamin 10 (ANO10), mRNA","Q9NW15",1194,0,"Anoctamin-10",".",".",".",".","pfam04547","Anoctamin","Calcium-activated chloride channel. The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.","GO:0006812|cation transport;GO:0006821|chloride transport;GO:0034220|ion transmembrane transport;","GO:0016021|integral component of membrane;GO:0005622|intracellular;GO:0016020|membrane;GO:0005886|plasma membrane;","GO:0005227|calcium activated cation channel activity;GO:0005229|intracellular calcium activated chloride channel activity;","K19327","ANO10, TMEM16K; anoctamin-10"]
["bta_circ_0011974",3,4,6,2.02613736554408,0,0,0,4.31201824171982,0.030388303218425,"NA","up","yes","NC_037349.1:1769116..1777782:-","gene26871","gi|741968030|ref|XP_010815732.1|",5609,0,"PREDICTED: sodium bicarbonate cotransporter 3 isoform X2 [Bos taurus]","gi|982961163|ref|XM_015459416.1|",10730,0,"PREDICTED: Bos taurus solute carrier family 4, sodium bicarbonate cotransporter, member 7 (SLC4A7), transcript variant X6, mRNA","Q9R1N3",1964,0,"Sodium bicarbonate cotransporter 3",".",".",".",".","pfam00955","HCO3_cotransp","HCO3- transporter family. This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.","GO:0060117|auditory receptor cell development;GO:0051453|regulation of intracellular pH;","GO:0016324|apical plasma membrane;GO:0016323|basolateral plasma membrane;GO:0031410|cytoplasmic vesicle;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;GO:0032420|stereocilium;GO:0045202|synapse;","GO:0005452|inorganic anion exchanger activity;GO:0008510|sodium:bicarbonate symporter activity;","K13858","SLC4A7; solute carrier family 4 (sodium bicarbonate cotransporter), member 7"]
["bta_circ_0012010",4,9,2,11.0857254670373,21,15,13,-1.90211719329441,0.0374879826944278,0.439730132358439,"down","yes","NC_037349.1:30594647..30646082:+","gene27149","gi|686712106|ref|XP_009237069.1|",2531,0,"PREDICTED: forkhead box protein P1 isoform X2 [Pongo abelii]","gi|742211005|ref|XM_010861998.1|",5430,0,"PREDICTED: Bison bison bison forkhead box P1 (FOXP1), transcript variant X3, mRNA","A4IFD2",969,0,"Forkhead box protein P1","SPBC32H8.11",84.3,{"v":2e-15,"d":"2.00E-15"},"COG5025","pfam00250","Fork_head","Fork head domain.","GO:0009653|anatomical structure morphogenesis;GO:0055007|cardiac muscle cell differentiation;GO:0072358|cardiovascular system development;GO:0030154|cell differentiation;GO:0033152|immunoglobulin V(D)J recombination;GO:0001701|in utero embryonic development;GO:0072619|interleukin-21 secretion;GO:0061140|lung secretory cell differentiation;GO:0008045|motor neuron axon guidance;GO:1901250|negative regulation of lung goblet cell differentiation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:2000727|positive regulation of cardiac muscle cell differentiation;GO:0050679|positive regulation of epithelial cell proliferation;GO:0002639|positive regulation of immunoglobulin production;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0002329|pre-B cell differentiation;GO:0060043|regulation of cardiac muscle cell proliferation;GO:0045214|sarcomere organization;GO:0007519|skeletal muscle tissue development;GO:0048745|smooth muscle tissue development;GO:0061470|T follicular helper cell differentiation;GO:0006351|transcription, DNA-templated;GO:0021517|ventral spinal cord development;","GO:0005634|nucleus;","GO:0003682|chromatin binding;GO:0046872|metal ion binding;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;GO:0043621|protein self-association;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003705|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;","K09409","FOXP; forkhead box protein P"]
["bta_circ_0012014",0,0,5,5.77424777970145,12,10,7,-2.61300125981432,0.0446265486457292,0.456494092506297,"down","yes","NC_037349.1:30601256..30646082:+","gene27149","gi|686712106|ref|XP_009237069.1|",2531,0,"PREDICTED: forkhead box protein P1 isoform X2 [Pongo abelii]","gi|742211005|ref|XM_010861998.1|",5430,0,"PREDICTED: Bison bison bison forkhead box P1 (FOXP1), transcript variant X3, mRNA","A4IFD2",969,0,"Forkhead box protein P1","SPBC32H8.11",84.3,{"v":2e-15,"d":"2.00E-15"},"COG5025","pfam00250","Fork_head","Fork head domain.","GO:0009653|anatomical structure morphogenesis;GO:0055007|cardiac muscle cell differentiation;GO:0072358|cardiovascular system development;GO:0030154|cell differentiation;GO:0033152|immunoglobulin V(D)J recombination;GO:0001701|in utero embryonic development;GO:0072619|interleukin-21 secretion;GO:0061140|lung secretory cell differentiation;GO:0008045|motor neuron axon guidance;GO:1901250|negative regulation of lung goblet cell differentiation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:2000727|positive regulation of cardiac muscle cell differentiation;GO:0050679|positive regulation of epithelial cell proliferation;GO:0002639|positive regulation of immunoglobulin production;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0002329|pre-B cell differentiation;GO:0060043|regulation of cardiac muscle cell proliferation;GO:0045214|sarcomere organization;GO:0007519|skeletal muscle tissue development;GO:0048745|smooth muscle tissue development;GO:0061470|T follicular helper cell differentiation;GO:0006351|transcription, DNA-templated;GO:0021517|ventral spinal cord development;","GO:0005634|nucleus;","GO:0003682|chromatin binding;GO:0046872|metal ion binding;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;GO:0043621|protein self-association;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003705|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;","K09409","FOXP; forkhead box protein P"]
["bta_circ_0012018",8,70,21,15.0775869908363,4,11,6,1.73288686879549,0.0322278290233995,0.428634275476763,"up","yes","NC_037349.1:31646288..31649878:-","gene27157","gi|982961593|ref|XP_015314991.1|",2159,0,"PREDICTED: microphthalmia-associated transcription factor isoform X6 [Bos taurus]","gi|982961598|ref|XM_015459508.1|",4667,0,"PREDICTED: Bos taurus microphthalmia-associated transcription factor (MITF), transcript variant X9, mRNA","O75030",791,0,"Microphthalmia-associated transcription factor",".",".",".",".","pfam11851","DUF3371","Domain of unknown function (DUF3371). This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 125 to 142 amino acids in length.","GO:0046849|bone remodeling;GO:0043010|camera-type eye development;GO:0044336|canonical Wnt signaling pathway involved in negative regulation of apoptotic process;GO:0045165|cell fate commitment;GO:0030318|melanocyte differentiation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0030316|osteoclast differentiation;GO:2000144|positive regulation of DNA-templated transcription, initiation;GO:0010628|positive regulation of gene expression;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0065003|macromolecular complex assembly;GO:0042127|regulation of cell proliferation;GO:0045670|regulation of osteoclast differentiation;GO:2001141|regulation of RNA biosynthetic process;GO:0006355|regulation of transcription, DNA-templated;","GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0032991|macromolecular complex;","GO:0003682|chromatin binding;GO:0070888|E-box binding;GO:0046983|protein dimerization activity;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003705|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001227|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;","K09455","MITF; microphthalmia-associated transcription factor"]
["bta_circ_0012023",2,3,0,5.82006440173586,8,11,10,-2.43577608322928,0.0434837913571025,0.456494092506297,"down","yes","NC_037349.1:34015631..34029892:+","gene27171","gi|741968664|ref|XP_010815925.1|",1796,0,"PREDICTED: succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial isoform X1 [Bos taurus]","gi|982961645|ref|XM_010817623.2|",2173,0,"PREDICTED: Bos taurus succinate-CoA ligase, GDP-forming, beta subunit (SUCLG2), transcript variant X1, mRNA","Q9YI36",505,{"v":7e-171,"d":"7.00E-171"},"Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial (Fragment)","YGR244c",275,{"v":1e-82,"d":"1.00E-82"},"COG0045","pfam08442","ATP-grasp_2","ATP-grasp domain.","GO:0006104|succinyl-CoA metabolic process;GO:0006099|tricarboxylic acid cycle;","GO:0005739|mitochondrion;","GO:0005524|ATP binding;GO:0005525|GTP binding;GO:0046872|metal ion binding;GO:0004776|succinate-CoA ligase (GDP-forming) activity;",".","."]
["bta_circ_0012029",0,0,0,5.2384418321408,10,6,13,-5.85276029076368,0.00112304403837999,"NA","down","yes","NC_037349.1:35183048..35209497:-","gene27178","gi|157074110|ref|NP_001096767.1|",1266,{"v":2e-166,"d":"2.00E-166"},"S-adenosylmethionine mitochondrial carrier protein [Bos taurus]","gi|157074109|ref|NM_001103297.1|",2303,0,"Bos taurus solute carrier family 25 (S-adenosylmethionine carrier), member 26 (SLC25A26), mRNA","A6QR09",492,{"v":6e-168,"d":"6.00E-168"},"S-adenosylmethionine mitochondrial carrier protein",".",".",".",".","pfam00153","Mito_carr","Mitochondrial carrier protein.","GO:0006839|mitochondrial transport;GO:0015805|S-adenosyl-L-methionine transport;","GO:0016021|integral component of membrane;GO:0005743|mitochondrial inner membrane;","GO:0000095|S-adenosyl-L-methionine transmembrane transporter activity;","K15111","SLC25A26; solute carrier family 25 (mitochondrial S-adenosylmethionine transporter), member 26"]
["bta_circ_0012041",0,0,0,2.85077580107909,4,11,3,-4.97519584700708,0.00889663898853273,"NA","down","yes","NC_037349.1:37478684..37486299:-","gene27191","gi|296474960|tpg|DAA17075.1|",3286,0,"TPA: ataxin 7 [Bos taurus]","gi|983004507|ref|XM_015468716.1|",8969,0,"PREDICTED: Bos taurus ataxin 7 (ATXN7), transcript variant X5, mRNA","O15265",1129,0,"Ataxin-7",".",".",".",".","pfam08313","SCA7","SCA7, zinc-binding domain. This domain is found in the protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK. This domain is also found in Ataxin-7, a human protein which in its polyglutamine expanded pathological form, is responsible for the neurodegenerative disease spinocerebellar ataxia 7 (SCA7). Ataxin-7 is an integral component of the mammalian SAGA-like complexes, the TATA-binding protein-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA). This domain is a minimal domain in ataxin-7-like proteins that is required for interaction with TFTC/STAGA subunits and is conserved highly through evolution. The domain contains a conserved Cys(3)His motif that binds zinc, thus indicating this to be a new zinc-binding domain.","GO:0016578|histone deubiquitination;GO:0000226|microtubule cytoskeleton organization;GO:0006997|nucleus organization;GO:0016579|protein deubiquitination;GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;GO:0007601|visual perception;","GO:0005829|cytosol;GO:0015630|microtubule cytoskeleton;GO:0016363|nuclear matrix;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0036459|ubiquitinyl hydrolase activity;","K11318","ATXN7, SCA7; ataxin-7"]
["bta_circ_0012099",0,0,0,2.39237724006709,6,3,4,-4.69085506292848,0.0154410564422098,"NA","down","yes","NC_037349.1:45983334..46007070:-","gene27250","gi|556717267|ref|XP_005954547.1|",5430,0,"PREDICTED: voltage-dependent calcium channel subunit alpha-2/delta-3 [Pantholops hodgsonii]","gi|332164671|ref|NM_001206751.1|",3214,0,"Bos taurus calcium channel, voltage-dependent, alpha 2/delta subunit 3 (CACNA2D3), mRNA","Q8IZS8",2061,0,"Voltage-dependent calcium channel subunit alpha-2/delta-3",".",".",".",".","pfam08399","VWA_N","VWA N-terminal. This domain is found at the N-terminus of proteins containing von Willebrand factor type A (VWA, pfam00092) and Cache (pfam02743) domains. It has been found in vertebrates, Drosophila and C. elegans but has not yet been identified in other eukaryotes. It is probably involved in the function of some voltage-dependent calcium channel subunits.","GO:0034765|regulation of ion transmembrane transport;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0005262|calcium channel activity;GO:0046872|metal ion binding;GO:0005244|voltage-gated ion channel activity;","K04860","CACNA2D3; voltage-dependent calcium channel alpha-2/delta-3"]
["bta_circ_0012101",0,0,0,3.28304748874917,5,6,8,-5.19051253023279,0.00557355816917785,"NA","down","yes","NC_037349.1:46003730..46094668:-","gene27250","gi|556717267|ref|XP_005954547.1|",5430,0,"PREDICTED: voltage-dependent calcium channel subunit alpha-2/delta-3 [Pantholops hodgsonii]","gi|332164671|ref|NM_001206751.1|",3214,0,"Bos taurus calcium channel, voltage-dependent, alpha 2/delta subunit 3 (CACNA2D3), mRNA","Q8IZS8",2061,0,"Voltage-dependent calcium channel subunit alpha-2/delta-3",".",".",".",".","pfam08399","VWA_N","VWA N-terminal. This domain is found at the N-terminus of proteins containing von Willebrand factor type A (VWA, pfam00092) and Cache (pfam02743) domains. It has been found in vertebrates, Drosophila and C. elegans but has not yet been identified in other eukaryotes. It is probably involved in the function of some voltage-dependent calcium channel subunits.","GO:0034765|regulation of ion transmembrane transport;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0005262|calcium channel activity;GO:0046872|metal ion binding;GO:0005244|voltage-gated ion channel activity;","K04860","CACNA2D3; voltage-dependent calcium channel alpha-2/delta-3"]
["bta_circ_0012105",0,0,0,2.96792916350563,6,6,5,-5.03890493498305,0.00770980889133211,"NA","down","yes","NC_037349.1:46077752..46094668:-","gene27250","gi|556717267|ref|XP_005954547.1|",5430,0,"PREDICTED: voltage-dependent calcium channel subunit alpha-2/delta-3 [Pantholops hodgsonii]","gi|332164671|ref|NM_001206751.1|",3214,0,"Bos taurus calcium channel, voltage-dependent, alpha 2/delta subunit 3 (CACNA2D3), mRNA","Q8IZS8",2061,0,"Voltage-dependent calcium channel subunit alpha-2/delta-3",".",".",".",".","pfam08399","VWA_N","VWA N-terminal. This domain is found at the N-terminus of proteins containing von Willebrand factor type A (VWA, pfam00092) and Cache (pfam02743) domains. It has been found in vertebrates, Drosophila and C. elegans but has not yet been identified in other eukaryotes. It is probably involved in the function of some voltage-dependent calcium channel subunits.","GO:0034765|regulation of ion transmembrane transport;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0005262|calcium channel activity;GO:0046872|metal ion binding;GO:0005244|voltage-gated ion channel activity;","K04860","CACNA2D3; voltage-dependent calcium channel alpha-2/delta-3"]
["bta_circ_0012148",0,0,4,5.50023008221653,8,18,5,-2.85077199939416,0.0317663117110909,"NA","down","yes","NC_037349.1:50629477..50629878:-","gene27380","gi|982961761|ref|XP_010815965.2|",4004,0,"PREDICTED: dystroglycan isoform X1 [Bos taurus]","gi|982961763|ref|XM_005222706.3|",5379,0,"PREDICTED: Bos taurus dystroglycan 1 (DAG1), transcript variant X3, mRNA","O18738",1507,0,"Dystroglycan",".",".",".",".","pfam05454","DAG1","Dystroglycan (Dystrophin-associated glycoprotein 1). Dystroglycan is one of the dystrophin-associated glycoproteins, which is encoded by a 5.5 kb transcript in human. The protein product is cleaved into two non-covalently associated subunits, [alpha] (N-terminal) and [beta] (C-terminal). In skeletal muscle the dystroglycan complex works as a transmembrane linkage between the extracellular matrix and the cytoskeleton. [alpha]-dystroglycan is extracellular and binds to merosin ([alpha]-2 laminin) in the basement membrane, while [beta]-dystroglycan is a transmembrane protein and binds to dystrophin, which is a large rod-like cytoskeletal protein, absent in Duchenne muscular dystrophy patients. Dystrophin binds to intracellular actin cables. In this way, the dystroglycan complex, which links the extracellular matrix to the intracellular actin cables, is thought to provide structural integrity in muscle tissues. The dystroglycan complex is also known to serve as an agrin receptor in muscle, where it may regulate agrin-induced acetylcholine receptor clustering at the neuromuscular junction. There is also evidence which suggests the function of dystroglycan as a part of the signal transduction pathway because it is shown that Grb2, a mediator of the Ras-related signal pathway, can interact with the cytoplasmic domain of dystroglycan. In general, aberrant expression of dystrophin-associated protein complex underlies the pathogenesis of Duchenne muscular dystrophy, Becker muscular dystrophy and severe childhood autosomal recessive muscular dystrophy. Interestingly, no genetic disease has been described for either [alpha]- or [beta]-dystroglycan. Dystroglycan is widely distributed in non-muscle tissues as well as in muscle tissues. During epithelial morphogenesis of kidney, the dystroglycan complex is shown to act as a receptor for the basement membrane. Dystroglycan expression in mouse brain and neural retina has also been reported. However, the physiological role of dystroglycan in non-muscle tissues has remained unclear.","GO:0007016|cytoskeletal anchoring at plasma membrane;","GO:0030054|cell junction;GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0016010|dystrophin-associated glycoprotein complex;GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0016020|membrane;GO:0005654|nucleoplasm;GO:0045211|postsynaptic membrane;GO:0042383|sarcolemma;","GO:0005509|calcium ion binding;GO:0043236|laminin binding;","K06265","DAG1; dystroglycan 1"]
["bta_circ_0012179",3,12,5,12.1561761776413,15,14,25,-1.74548792020039,0.0400511664851193,0.442423270501201,"down","yes","NC_037349.1:52249890..52252518:+","gene27457","gi|296474783|tpg|DAA16898.1|",5057,0,"TPA: sterol regulatory element-binding protein cleavage-activating protein [Bos taurus]","gi|156120426|ref|NM_001101889.1|",4288,0,"Bos taurus SREBF chaperone (SCAP), mRNA","A6QM06",1951,0,"Sterol regulatory element-binding protein cleavage-activating protein",".",".",".",".","pfam12349","Sterol-sensing","Sterol-sensing domain of SREBP cleavage-activation. Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.","GO:0008203|cholesterol metabolic process;GO:0032933|SREBP signaling pathway;","GO:0005789|endoplasmic reticulum membrane;GO:0012507|ER to Golgi transport vesicle membrane;GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0015485|cholesterol binding;",".","."]
["bta_circ_0012197",3,6,3,1.83650349841542,0,0,0,4.16634333746389,0.0381921040369018,"NA","up","yes","NC_037349.1:5335081..5364082:-","gene26888","gi|197382899|ref|NP_001095751.2|",2637,0,"acidic amino acid decarboxylase GADL1 [Bos taurus]","gi|982961375|ref|XM_010817523.2|",3508,0,"PREDICTED: Bos taurus glutamate decarboxylase like 1 (GADL1), transcript variant X2, mRNA","A6QM00",1020,0,"Acidic amino acid decarboxylase GADL1","BH2623",216,{"v":2e-59,"d":"2.00E-59"},"COG0076","pfam00282","Pyridoxal_deC","Pyridoxal-dependent decarboxylase conserved domain.","GO:0019752|carboxylic acid metabolic process;",".","GO:0004068|aspartate 1-decarboxylase activity;GO:0030170|pyridoxal phosphate binding;GO:0004782|sulfinoalanine decarboxylase activity;","K18966","GADL1, CSADC, ADC; sulfinoalanine decarboxylase / aspartate 1-decarboxylase [EC:4.1.1.29 4.1.1.11]"]
["bta_circ_0012202",0,0,0,2.16992391358949,6,0,5,-4.35661160125004,0.0293371552158517,"NA","down","yes","NC_037349.1:53585954..53595366:-","gene27507","gi|156120909|ref|NP_001095601.1|",3078,0,"phosphatidylinositide phosphatase SAC1 [Bos taurus]","gi|402745424|ref|NM_001102131.2|",3557,0,"Bos taurus SAC1 suppressor of actin mutations 1-like (yeast) (SACM1L), mRNA","A6QL88",1190,0,"Phosphatidylinositide phosphatase SAC1","SPBC19F5.03",347,{"v":1e-104,"d":"1.00E-104"},"COG5329","pfam02383","Syja_N","SacI homology domain. This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.","GO:0046856|phosphatidylinositol dephosphorylation;","GO:0032281|AMPA glutamate receptor complex;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;","GO:0016791|phosphatase activity;GO:0043812|phosphatidylinositol-4-phosphate phosphatase activity;",".","."]
["bta_circ_0012214",0,18,16,3.74603143953339,0,0,0,5.10546538577549,0.00745547286833665,"NA","up","yes","NC_037349.1:54414531..54418849:-","gene27526","gi|300795567|ref|NP_001178174.1|",5699,0,"plasma membrane calcium-transporting ATPase 2 [Bos taurus]","gi|300795566|ref|NM_001191245.1|",8983,0,"Bos taurus ATPase, Ca++ transporting, plasma membrane 2 (ATP2B2), mRNA","Q9R0K7",2180,0,"Plasma membrane calcium-transporting ATPase 2",".",".",".",".","pfam00122","E1-E2_ATPase","E1-E2 ATPase.","GO:0060088|auditory receptor cell stereocilium organization;GO:1901660|calcium ion export;GO:0006816|calcium ion transport;GO:0000902|cell morphogenesis;GO:0006874|cellular calcium ion homeostasis;GO:0021707|cerebellar granule cell differentiation;GO:0021702|cerebellar Purkinje cell differentiation;GO:0021692|cerebellar Purkinje cell layer morphogenesis;GO:0021549|cerebellum development;GO:0046068|cGMP metabolic process;GO:0090102|cochlea development;GO:0050910|detection of mechanical stimulus involved in sensory perception of sound;GO:0048839|inner ear development;GO:0042472|inner ear morphogenesis;GO:0060113|inner ear receptor cell differentiation;GO:0007595|lactation;GO:0040011|locomotion;GO:0007626|locomotory behavior;GO:0050885|neuromuscular process controlling balance;GO:0030182|neuron differentiation;GO:0006996|organelle organization;GO:0045299|otolith mineralization;GO:0051928|positive regulation of calcium ion transport;GO:0008361|regulation of cell size;GO:0051480|cytosolic calcium ion homeostasis;GO:0048167|regulation of synaptic plasticity;GO:0007605|sensory perception of sound;GO:0042428|serotonin metabolic process;GO:0050808|synapse organization;","GO:0016324|apical plasma membrane;GO:0030054|cell junction;GO:0005929|cilium;GO:0005737|cytoplasm;GO:0030425|dendrite;GO:0005783|endoplasmic reticulum;GO:0005887|integral component of plasma membrane;GO:0045121|membrane raft;GO:0043025|neuronal cell body;GO:0032809|neuronal cell body membrane;GO:0005886|plasma membrane;GO:0098839|postsynaptic density membrane;","GO:0033130|acetylcholine receptor binding;GO:0005524|ATP binding;GO:0005509|calcium ion binding;GO:0030899|calcium-dependent ATPase activity;GO:0005388|calcium-transporting ATPase activity;GO:0005516|calmodulin binding;GO:0035254|glutamate receptor binding;GO:0030165|PDZ domain binding;GO:0008022|protein C-terminus binding;","K05850","ATP2B; Ca2+ transporting ATPase, plasma membrane [EC:3.6.3.8]"]
["bta_circ_0012226",0,0,0,12.3000586995969,20,35,19,-7.06871172852592,{"v":2.29998005494183e-05,"d":"2.30E-05"},0.00310784804924015,"down","yes","NC_037349.1:5620520..5638927:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0012244",169,471,315,349.279841149162,384,462,401,-0.669621909613212,0.0488511619790666,0.476348344536443,"down","yes","NC_037349.1:59616480..59617659:-","gene27622","gi|300794281|ref|NP_001179377.1|",3344,0,"kelch repeat and BTB domain-containing protein 12 [Bos taurus]","gi|982962862|ref|XM_005223171.3|",2987,0,"PREDICTED: Bos taurus kelch repeat and BTB (POZ) domain containing 12 (KBTBD12), transcript variant X2, mRNA","Q3ZCT8",1177,0,"Kelch repeat and BTB domain-containing protein 12",".",".",".",".","pfam07707","BACK","BTB And C-terminal Kelch. This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).","GO:0016567|protein ubiquitination;","GO:0031463|Cul3-RING ubiquitin ligase complex;",".",".","."]
["bta_circ_0012285",3,11,0,1.93305401888705,0,0,0,4.07134956202423,0.045531204242812,"NA","up","yes","NC_037349.1:9698434..9704725:+","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0012335",145,1008,631,233.229806357504,24,24,34,3.90428012575797,{"v":2.22451100713064e-18,"d":"2.22E-18"},{"v":4.80939279741644e-15,"d":"4.81E-15"},"up","yes","NC_037350.1:19219722..19232576:-","gene27977","gi|529002929|ref|XP_005223432.1|",1332,{"v":4e-166,"d":"4.00E-166"},"PREDICTED: chloride intracellular channel protein 5 isoform X1 [Bos taurus]","gi|982963376|ref|XM_005223375.3|",5759,0,"PREDICTED: Bos taurus chloride intracellular channel 5 (CLIC5), transcript variant X1, mRNA","Q9EPT8",494,{"v":2e-159,"d":"2.00E-159"},"Chloride intracellular channel protein 5",".",".",".",".","pfam13409","GST_N_2","Glutathione S-transferase, N-terminal domain. This family is closely related to pfam02798.","GO:0060088|auditory receptor cell stereocilium organization;GO:0002024|diet induced thermogenesis;GO:0050885|neuromuscular process controlling balance;GO:0008104|protein localization;GO:0034765|regulation of ion transmembrane transport;GO:0007605|sensory perception of sound;","GO:0015629|actin cytoskeleton;GO:0034707|chloride channel complex;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005815|microtubule organizing center;GO:0032420|stereocilium;GO:0032421|stereocilium bundle;","GO:0005254|chloride channel activity;GO:0005244|voltage-gated ion channel activity;","K05025","CLIC5; chloride intracellular channel protein 5"]
["bta_circ_0012351",0,0,0,9.38916986764247,12,30,16,-6.70041645143399,{"v":8.47773955063232e-05,"d":"8.48E-05"},0.0101827071713706,"down","yes","NC_037350.1:20461613..20464294:-","gene27993","gi|116004041|ref|NP_001070379.1|",3133,0,"tumor necrosis factor receptor superfamily member 21 [Bos taurus]","gi|116004040|ref|NM_001076911.1|",3556,0,"Bos taurus tumor necrosis factor receptor superfamily member 21 (TNFRSF21), mRNA","O75509",1072,0,"Tumor necrosis factor receptor superfamily member 21",".",".",".",".","pfam00531","Death","Death domain.","GO:0002250|adaptive immune response;GO:0006915|apoptotic process;GO:0097190|apoptotic signaling pathway;GO:0001783|B cell apoptotic process;GO:0071356|cellular response to tumor necrosis factor;GO:0006959|humoral immune response;GO:0006955|immune response;GO:0006954|inflammatory response;GO:0042552|myelination;GO:0030889|negative regulation of B cell proliferation;GO:2001180|negative regulation of interleukin-10 secretion;GO:2000666|negative regulation of interleukin-13 secretion;GO:2000663|negative regulation of interleukin-5 secretion;GO:0031642|negative regulation of myelination;GO:0042130|negative regulation of T cell proliferation;GO:0051402|neuron apoptotic process;GO:0097252|oligodendrocyte apoptotic process;GO:0042981|regulation of apoptotic process;GO:0042127|regulation of cell proliferation;GO:0019216|regulation of lipid metabolic process;GO:0048713|regulation of oligodendrocyte differentiation;GO:0032496|response to lipopolysaccharide;GO:0050852|T cell receptor signaling pathway;","GO:0030424|axon;GO:0005887|integral component of plasma membrane;GO:0031226|intrinsic component of plasma membrane;GO:0005886|plasma membrane;","GO:0005031|tumor necrosis factor-activated receptor activity;","K05157","TNFRSF21, DR6; tumor necrosis factor receptor superfamily member 21"]
["bta_circ_0012366",297,332,350,233.697273542643,78,253,112,1.1967353632396,0.00920967385133436,0.247890543832493,"up","yes","NC_037350.1:27307441..27317952:+","gene28102","gi|27807269|ref|NP_777128.1|",17713,0,"tenascin-X precursor [Bos taurus]","gi|31340694|ref|NM_174703.2|",12437,0,"Bos taurus tenascin XB (TNXB), mRNA","P22105",3197,0,"Tenascin-X",".",".",".",".","pfam00147","Fibrinogen_C","Fibrinogen beta and gamma chains, C-terminal globular domain.","GO:0030036|actin cytoskeleton organization;GO:0007155|cell adhesion;GO:0030199|collagen fibril organization;GO:0032963|collagen metabolic process;GO:0048251|elastic fiber assembly;","GO:0070062|extracellular exosome;GO:0031012|extracellular matrix;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005622|intracellular;","GO:0008201|heparin binding;GO:0005178|integrin binding;","K06252","TN; tenascin"]
["bta_circ_0012374",0,0,0,3.12777400665493,9,9,0,-4.93170873269829,0.0106159855664573,"NA","down","yes","NC_037350.1:27844712..27956766:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0012389",567,305,445,260.127371307443,0,57,0,3.80830588899771,0.038157398519338,0.439730132358439,"up","yes","NC_037350.1:28549136..28720812:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0012393",2277,554,708,814.761192777844,3,3,2,8.51298834674423,{"v":2.17119909624759e-14,"d":"2.17E-14"},{"v":2.34706622304364e-11,"d":"2.35E-11"},"up","yes","NC_037350.1:28570937..28720812:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0012394",21,6,13,9.11304647466054,0,0,4,3.21767816919678,0.00958525673714465,0.247890543832493,"up","yes","NC_037350.1:28571581..28721197:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0012402",43,248,167,86.9634522833922,32,73,73,0.960513918144385,0.0381569702573002,0.439730132358439,"up","yes","NC_037350.1:3019707..3035565:+","gene27663","gi|332634768|ref|NP_001193835.1|",1200,{"v":7e-151,"d":"7.00E-151"},"ras-related protein Rab-23 [Bos taurus]","gi|742159430|ref|XM_010848523.1|",3759,0,"PREDICTED: Bison bison bison RAB23, member RAS oncogene family (RAB23), mRNA","Q9ULC3",445,{"v":3e-144,"d":"3.00E-144"},"Ras-related protein Rab-23",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0000045|autophagosome assembly;GO:0006968|cellular defense response;GO:0060271|cilium morphogenesis;GO:0097094|craniofacial suture morphogenesis;GO:0046039|GTP metabolic process;GO:0042308|negative regulation of protein import into nucleus;GO:0015031|protein transport;","GO:0005776|autophagosome;GO:0030054|cell junction;GO:0005813|centrosome;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0010008|endosome membrane;GO:0045335|phagocytic vesicle;GO:0030670|phagocytic vesicle membrane;GO:0005886|plasma membrane;","GO:0005525|GTP binding;GO:0003924|GTPase activity;","K06234","RAB23; Ras-related protein Rab-23"]
["bta_circ_0012420",0,22,9,3.23995588565533,0,0,0,4.89687523664185,0.0113558932148787,"NA","up","yes","NC_037350.1:32347951..32370843:-","gene28622","gi|982964386|ref|XP_015315446.1|",7082,0,"PREDICTED: leucine-rich repeat-containing protein 16A isoform X3 [Bos taurus]","gi|982964387|ref|XM_015459961.1|",5500,0,"PREDICTED: Bos taurus leucine rich repeat containing 16A (LRRC16A), transcript variant X4, mRNA","Q5VZK9",2303,0,"F-actin-uncapping protein LRRC16A",".",".",".",".","pfam08542","Rep_fac_C","Replication factor C C-terminal domain. This is the C-terminal domain of RFC (replication factor-C) protein of the clamp loader complex which binds to the DNA sliding clamp (proliferating cell nuclear antigen, PCNA). The five modules of RFC assemble into a right-handed spiral, which results in only three of the five RFC subunits (RFC-A, RFC-B and RFC-C) making contact with PCNA, leaving a wedge-shaped gap between RFC-E and the PCNA clamp-loader complex. The C-terminal is vital for the correct orientation of RFC-E with respect to RFC-A.","GO:0051639|actin filament network formation;GO:0007015|actin filament organization;GO:0051638|barbed-end actin filament uncapping;GO:0007596|blood coagulation;GO:0016477|cell migration;GO:0030032|lamellipodium assembly;GO:0044351|macropinocytosis;GO:2000813|negative regulation of barbed-end actin filament capping;GO:0030838|positive regulation of actin filament polymerization;GO:0030335|positive regulation of cell migration;GO:1902745|positive regulation of lamellipodium organization;GO:0051496|positive regulation of stress fiber assembly;GO:1900026|positive regulation of substrate adhesion-dependent cell spreading;GO:0031529|ruffle organization;GO:0046415|urate metabolic process;","GO:0031252|cell leading edge;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0031941|filamentous actin;GO:0030027|lamellipodium;GO:0044354|macropinosome;GO:0016607|nuclear speck;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0044877|macromolecular complex binding;",".","."]
["bta_circ_0012562",32,128,56,40.1072176787798,13,30,26,1.31270578942323,0.016342041317416,0.304581839036667,"up","yes","NC_037350.1:6292848..6303867:-","gene27684","gi|742159520|ref|XP_010846852.1|",3649,0,"PREDICTED: muscular LMNA-interacting protein isoform X4 [Bison bison bison]","gi|742159519|ref|XM_010848550.1|",4542,0,"PREDICTED: Bison bison bison muscular LMNA-interacting protein (MLIP), transcript variant X4, mRNA","A0A096MK47",580,0,"Muscular LMNA-interacting protein",".",".",".",".","pfam15274","MLIP","Muscular LMNA-interacting protein. MLIP is a Muscle-enriched A-type Lamin-interacting Protein, an innovation of amniotes, and is expressed ubiquitously and most abundantly in heart, skeletal, and smooth muscle. MLIP interacts directly and co-localizes with lamin A and C in the nuclear envelope. MLIP also co-localizes with promyelocytic leukemia (PML) bodies within the nucleus. PML, like MLIP, is only found in amniotes, suggesting that a functional link between the nuclear envelope and PML bodies may exist through MLIP.","GO:0010614|negative regulation of cardiac muscle hypertrophy;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;","GO:0005635|nuclear envelope;GO:0005634|nucleus;GO:0016605|PML body;GO:0042383|sarcolemma;",".",".","."]
["bta_circ_0012621",0,0,0,2.1945521252004,2,0,10,-4.3567797800539,0.0295901940501724,"NA","down","yes","NC_037351.1:22167088..22175756:-","gene29016","gi|741972297|ref|XP_010817027.1|",4036,0,"PREDICTED: dystrobrevin alpha isoform X9 [Bos taurus]","gi|982965233|ref|XM_010818725.2|",6340,0,"PREDICTED: Bos taurus dystrobrevin alpha (DTNA), transcript variant X12, mRNA","Q9Y4J8",1423,0,"Dystrobrevin alpha",".",".",".",".","pfam09068","EF-hand_2","EF hand. Members of this family adopt a helix-loop-helix motif, as per other EF hand domains. However, since they do not contain the canonical pattern of calcium binding residues found in many EF hand domains, they do not bind calcium ions. The main function of this domain is the provision of specificity in beta-dystroglycan recognition, though in dystrophin it serves an additional role: stabilisation of the WW domain (pfam00397), enhancing dystroglycan binding.","GO:0007268|synaptic transmission;GO:0007274|neuromuscular synaptic transmission;GO:0007165|signal transduction;GO:0006941|striated muscle contraction;","GO:0030424|axon;GO:0030054|cell junction;GO:0005737|cytoplasm;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0032991|macromolecular complex;GO:0042383|sarcolemma;GO:0045202|synapse;","GO:0030165|PDZ domain binding;GO:0008270|zinc ion binding;",".","."]
["bta_circ_0012634",12,43,21,12.2029905605128,0,9,4,2.255069943651,0.01555726648614,0.298906981742218,"up","yes","NC_037351.1:2393119..2394591:-","gene28920","gi|926722478|ref|XP_013829680.1|",9106,0,"PREDICTED: zinc finger protein 236 [Capra hircus]","gi|983006017|ref|XM_015469075.1|",8022,0,"PREDICTED: Bos taurus zinc finger protein 236 (ZNF236), transcript variant X1, mRNA","Q9UL36",2969,0,"Zinc finger protein 236",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0071333|cellular response to glucose stimulus;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;",".","."]
["bta_circ_0012658",4,9,6,2.79768176632878,0,0,0,4.79304389695936,0.0129730893368289,"NA","up","yes","NC_037351.1:32367824..32369131:+","gene29071","gi|741972511|ref|XP_010817088.1|",5167,0,"PREDICTED: oxysterol-binding protein-related protein 1 isoform X1 [Bos taurus]","gi|983006160|ref|XM_015469103.1|",4549,0,"PREDICTED: Bos taurus oxysterol binding protein like 1A (OSBPL1A), transcript variant X2, mRNA","Q9BXW6",1717,0,"Oxysterol-binding protein-related protein 1",".",".",".",".","pfam01237","Oxysterol_BP","Oxysterol-binding protein.","GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0006699|bile acid biosynthetic process;GO:0008203|cholesterol metabolic process;GO:0016192|vesicle-mediated transport;","GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005770|late endosome;","GO:0015485|cholesterol binding;GO:0005543|phospholipid binding;GO:0015248|sterol transporter activity;",".","."]
["bta_circ_0012782",0,0,0,2.72655562514449,2,4,10,-4.88042851895246,0.010875163564692,"NA","down","yes","NC_037351.1:43505875..43511497:+","gene29211","gi|529005047|ref|XP_005224214.1|",2437,0,"PREDICTED: mRNA cap guanine-N7 methyltransferase isoform X1 [Bos taurus]","gi|942045193|ref|XM_014477174.1|",2110,0,"PREDICTED: Bos mutus RNA (guanine-7-) methyltransferase (RNMT), transcript variant X3, mRNA","Q4R7K1",796,0,"mRNA cap guanine-N7 methyltransferase",".",".",".",".","pfam03291","Pox_MCEL","mRNA capping enzyme. This family of enzymes are related to pfam03919.","GO:0006370|7-methylguanosine mRNA capping;","GO:0005845|mRNA cap binding complex;GO:0005634|nucleus;","GO:0004482|mRNA (guanine-N7-)-methyltransferase activity;GO:0003723|RNA binding;","K00565","RNMT; mRNA (guanine-N7-)-methyltransferase [EC:2.1.1.56]"]
["bta_circ_0012796",6,68,79,71.3841066735754,82,133,101,-1.47748556504138,0.00644210749792724,0.201992718953344,"down","yes","NC_037351.1:46547493..46597798:-","gene29239","gi|594104719|ref|XP_006075336.1|",2732,0,"PREDICTED: E3 SUMO-protein ligase PIAS2 isoform X7 [Bubalus bubalis]","gi|983006481|ref|XM_010825599.2|",3690,0,"PREDICTED: Bos taurus protein inhibitor of activated STAT 2 (PIAS2), transcript variant X8, mRNA","O75928",1022,0,"E3 SUMO-protein ligase PIAS2",".",".",".",".","pfam14324","PINIT","PINIT domain. The PINIT domain is a protein domain that is found in PIAS proteins. The PINIT domain is about 180 amino acids in length.","GO:0030521|androgen receptor signaling pathway;GO:0060766|negative regulation of androgen receptor signaling pathway;GO:0043433|negative regulation of sequence-specific DNA binding transcription factor activity;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0016925|protein sumoylation;GO:0045667|regulation of osteoblast differentiation;GO:0006351|transcription, DNA-templated;","GO:0016607|nuclear speck;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0016605|PML body;","GO:0050681|androgen receptor binding;GO:0003677|DNA binding;GO:0061665|SUMO ligase activity;GO:0019789|SUMO transferase activity;GO:0003713|transcription coactivator activity;GO:0008134|transcription factor binding;GO:0031625|ubiquitin protein ligase binding;GO:0008270|zinc ion binding;","K16063","PIAS2; E3 SUMO-protein ligase PIAS2"]
["bta_circ_0012882",0,0,0,2.29985208925146,0,8,7,-4.49381127010353,0.0233636912660622,"NA","down","yes","NC_037351.1:57626050..57631752:-","gene29336","gi|982965469|ref|XP_015315576.1|",10827,0,"PREDICTED: alpha-protein kinase 2 isoform X3 [Bos taurus]","gi|982965468|ref|XM_015460090.1|",9874,0,"PREDICTED: Bos taurus alpha kinase 2 (ALPK2), transcript variant X3, mRNA","Q86TB3",2112,0,"Alpha-protein kinase 2",".",".",".",".","pfam02816","Alpha_kinase","Alpha-kinase family. This family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases and Elongation Factor-2 kinase and a bifunctional ion channel. This family is known as the alpha-kinase family. The structure of the kinase domain revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.",".","GO:0005737|cytoplasm;","GO:0005524|ATP binding;GO:0004674|protein serine/threonine kinase activity;","K08868","ALPK; alpha-kinase"]
["bta_circ_0012884",3,6,4,1.96331131803615,0,0,0,4.27164283785198,0.0323845272611295,"NA","up","yes","NC_037351.1:57696224..57697943:-","gene29336","gi|982965469|ref|XP_015315576.1|",10827,0,"PREDICTED: alpha-protein kinase 2 isoform X3 [Bos taurus]","gi|982965468|ref|XM_015460090.1|",9874,0,"PREDICTED: Bos taurus alpha kinase 2 (ALPK2), transcript variant X3, mRNA","Q86TB3",2112,0,"Alpha-protein kinase 2",".",".",".",".","pfam02816","Alpha_kinase","Alpha-kinase family. This family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases and Elongation Factor-2 kinase and a bifunctional ion channel. This family is known as the alpha-kinase family. The structure of the kinase domain revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.",".","GO:0005737|cytoplasm;","GO:0005524|ATP binding;GO:0004674|protein serine/threonine kinase activity;","K08868","ALPK; alpha-kinase"]
["bta_circ_0012902",2,4,6,1.7315669440932,0,0,0,4.09418834308396,0.0426398051667653,"NA","up","yes","NC_037351.1:60593012..60598580:-","gene29365","gi|300797485|ref|NP_001179535.1|",4731,0,"GPI ethanolamine phosphate transferase 1 [Bos taurus]","gi|300797484|ref|NM_001192606.1|",4777,0,"Bos taurus phosphatidylinositol glycan anchor biosynthesis class N (PIGN), mRNA","O95427",1484,0,"GPI ethanolamine phosphate transferase 1","YKL165c",543,{"v":4e-170,"d":"4.00E-170"},"COG1524","pfam04987","PigN","Phosphatidylinositolglycan class N (PIG-N). Phosphatidylinositolglycan class N (PIG-N) is a mammalian homologue of the yeast protein MCD4P and is expressed in the endoplasmic reticulum. PIG-N is essential for glycosylphosphatidylinositol anchor synthesis. Glycosylphosphatidylinositol (GPI)-anchored proteins are cell surface-localized proteins that serve many important cellular functions.","GO:0006506|GPI anchor biosynthetic process;GO:0016254|preassembly of GPI anchor in ER membrane;","GO:0005829|cytosol;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0016020|membrane;GO:0005886|plasma membrane;","GO:0051377|mannose-ethanolamine phosphotransferase activity;","K05285","PIGN; phosphatidylinositol glycan, class N [EC:2.7.-.-]"]
["bta_circ_0012945",0,0,0,1.72430016581292,0,5,6,-4.0436666411325,0.0469482969777028,"NA","down","yes","NC_037352.1:10751904..10759543:+","gene29742","gi|116003949|ref|NP_001070330.1|",3845,0,"sorting nexin-29 [Bos taurus]","gi|983007007|ref|XM_015469309.1|",7534,0,"PREDICTED: Bos taurus sorting nexin-29 (LOC104975843), mRNA","Q08DX0",1485,0,"Sorting nexin-29",".",".",".",".","pfam02759","RUN","RUN domain. This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.",".",".","GO:0035091|phosphatidylinositol binding;","K17935","SNX29; sorting nexin-29"]
["bta_circ_0012950",0,23,14,3.96938977962574,0,0,0,5.18796030420761,0.00627183970234761,"NA","up","yes","NC_037352.1:127532..128195:-","gene29404","gi|157427926|ref|NP_001098870.1|",4164,0,"inactive rhomboid protein 1 [Bos taurus]","gi|982965998|ref|XM_015458447.1|",6004,0,"PREDICTED: Bos taurus rhomboid 5 homolog 1 (Drosophila) (RHBDF1), transcript variant X3, mRNA","A7YWH9",1608,0,"Inactive rhomboid protein 1","L173329",62.8,{"v":1e-09,"d":"1.00E-09"},"COG0705","pfam12595","Rhomboid_SP","Rhomboid serine protease. This domain family is found in eukaryotes, and is approximately 210 amino acids in length. The family is found in association with pfam01694. Rhomboid is a seven-transmembrane spanning protein that resides in the Golgi and acts as a serine protease to cleave Spitz.","GO:0016477|cell migration;GO:0008283|cell proliferation;GO:0050709|negative regulation of protein secretion;GO:0015031|protein transport;GO:0006508|proteolysis;GO:0042058|regulation of epidermal growth factor receptor signaling pathway;GO:0061136|regulation of proteasomal protein catabolic process;GO:0050708|regulation of protein secretion;","GO:0005789|endoplasmic reticulum membrane;GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0019838|growth factor binding;",".","."]
["bta_circ_0012978",76,148,59,56.1877700634941,21,26,24,1.81177795038262,0.000836559152679939,0.0492512590431825,"up","yes","NC_037352.1:14429484..14434413:+","gene29776","gi|27806339|ref|NP_776648.1|",7742,0,"multidrug resistance-associated protein 1 [Bos taurus]","gi|742118117|ref|XM_010839896.1|",5871,0,"PREDICTED: Bison bison bison ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (ABCC1), transcript variant X1, mRNA","Q8HXQ5",2961,0,"Multidrug resistance-associated protein 1","YDR135c",993,0,"COG1132","pfam00664","ABC_membrane","ABC transporter transmembrane region. This family represents a unit of six transmembrane helices. Many members of the ABC transporter family (pfam00005) have two such regions.","GO:0006855|drug transmembrane transport;GO:0034775|glutathione transmembrane transport;GO:0042908|xenobiotic transport;","GO:0016323|basolateral plasma membrane;GO:0005887|integral component of plasma membrane;","GO:0005524|ATP binding;GO:0015431|glutathione S-conjugate-exporting ATPase activity;GO:0034634|glutathione transmembrane transporter activity;GO:0008559|xenobiotic-transporting ATPase activity;","K05665","ABCC1; ATP-binding cassette, subfamily C (CFTR/MRP), member 1"]
["bta_circ_0012995",0,0,0,2.46290947967513,2,6,7,-4.75153323868241,0.0138104914034392,"NA","down","yes","NC_037352.1:16906335..16909477:-","gene29793","gi|164420711|ref|NP_001106712.1|",977,{"v":1e-130,"d":"1.00E-130"},"5-demethoxyubiquinone hydroxylase, mitochondrial isoform 1 precursor [Bos taurus]","gi|164420710|ref|NM_001113241.1|",860,0,"Bos taurus coenzyme Q7 homolog, ubiquinone (yeast) (COQ7), transcript variant 1, mRNA","Q2TBW2",380,{"v":4e-132,"d":"4.00E-132"},"5-demethoxyubiquinone hydroxylase, mitochondrial","SPBC337.15c",145,{"v":8e-41,"d":"8.00E-41"},"COG2941","pfam03232","COQ7","Ubiquinone biosynthesis protein COQ7. Members of this family contain two repeats of about 90 amino acids, that contains two conserved motifs. One of these DXEXXH may be part of an enzyme active site.","GO:0006744|ubiquinone biosynthetic process;","GO:0005743|mitochondrial inner membrane;GO:0005634|nucleus;","GO:0046872|metal ion binding;GO:0004497|monooxygenase activity;","K06134","COQ7; ubiquinone biosynthesis monooxygenase Coq7 [EC:1.14.13.-]"]
["bta_circ_0013023",5,5,9,3.09109646317481,0,0,0,4.91223995512006,0.0103190998692465,"NA","up","yes","NC_037352.1:20773920..20778835:-","gene29856","gi|983007021|ref|XP_015324800.1|",5398,0,"PREDICTED: ubiquitin carboxyl-terminal hydrolase 31 isoform X2 [Bos taurus]","gi|983007020|ref|XM_015469314.1|",10588,0,"PREDICTED: Bos taurus ubiquitin specific peptidase 31 (USP31), mRNA","Q70CQ4",1646,0,"Ubiquitin carboxyl-terminal hydrolase 31","SPCC16A11.12c",168,{"v":5e-41,"d":"5.00E-41"},"COG5560","pfam00443","UCH","Ubiquitin carboxyl-terminal hydrolase.","GO:0016579|protein deubiquitination;GO:0006511|ubiquitin-dependent protein catabolic process;","GO:0005634|nucleus;","GO:0004843|ubiquitin-specific protease activity;","K11852","USP31; ubiquitin carboxyl-terminal hydrolase 31 [EC:3.4.19.12]"]
["bta_circ_0013045",0,18,13,3.3656079806712,0,0,0,4.95482133636786,0.010113393254996,"NA","up","yes","NC_037352.1:25938472..25944018:-","gene29913","gi|115495087|ref|NP_001069235.1|",5010,0,"sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [Bos taurus]","gi|115495086|ref|NM_001075767.1|",3491,0,"Bos taurus ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 (ATP2A1), mRNA","Q0VCY0",1904,0,"Sarcoplasmic/endoplasmic reticulum calcium ATPase 1","BH2515",509,{"v":2e-161,"d":"2.00E-161"},"COG0474","pfam00122","E1-E2_ATPase","E1-E2 ATPase.",".","GO:0016021|integral component of membrane;GO:0033017|sarcoplasmic reticulum membrane;","GO:0005524|ATP binding;GO:0005388|calcium-transporting ATPase activity;GO:0046872|metal ion binding;","K05853","ATP2A; Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum [EC:3.6.3.8]"]
["bta_circ_0013047",0,0,0,1.99030191578497,0,7,6,-4.27148943016322,0.0334416442708374,"NA","down","yes","NC_037352.1:26051069..26051812:-","gene29920","gi|529006843|ref|XP_005224902.1|",1979,0,"PREDICTED: battenin isoform X1 [Bos taurus]","gi|742107021|ref|XM_010837267.1|",2445,0,"PREDICTED: Bison bison bison ceroid-lipofuscinosis, neuronal 3 (CLN3), transcript variant X1, mRNA","Q29611",655,0,"Battenin",".",".",".",".","pfam02487","CLN3","CLN3 protein. This is a family of proteins from the CLN3 gene. A missense mutation of glutamic acid (E) to lysine (K) at position 295 in the human protein has been implicated in Juvenile neuronal ceroid lipofuscinosis (Batten disease).","GO:0042987|amyloid precursor protein catabolic process;GO:0015809|arginine transport;GO:0006672|ceramide metabolic process;GO:0006681|galactosylceramide metabolic process;GO:0001575|globoside metabolic process;GO:0006678|glucosylceramide metabolic process;GO:0007042|lysosomal lumen acidification;GO:0035752|lysosomal lumen pH elevation;GO:0043066|negative regulation of apoptotic process;GO:0006898|receptor-mediated endocytosis;GO:0006684|sphingomyelin metabolic process;GO:0007034|vacuolar transport;GO:0047496|vesicle transport along microtubule;","GO:0005901|caveola;GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0000139|Golgi membrane;GO:0005795|Golgi stack;GO:0030176|integral component of endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0005770|late endosome;GO:0005765|lysosomal membrane;GO:0005764|lysosome;GO:0045121|membrane raft;GO:0043005|neuron projection;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0008021|synaptic vesicle;GO:0005802|trans-Golgi network;",".",".","."]
["bta_circ_0013054",0,0,0,1.8137526173045,0,7,5,-4.12798526052196,0.041548341761854,"NA","down","yes","NC_037352.1:27671416..27682286:+","gene30028","gi|116004241|ref|NP_001070479.1|",1541,0,"protein NipSnap homolog 2 [Bos taurus]","gi|116004240|ref|NM_001077011.1|",2012,0,"Bos taurus glioblastoma amplified sequence (GBAS), mRNA","O75323",553,0,"Protein NipSnap homolog 2",".",".",".",".","pfam07978","NIPSNAP","NIPSNAP. Members of this family include many hypothetical proteins. It also includes members of the NIPSNAP family which have putative roles in vesicular transport. This domain is often found in duplicate.","GO:0006754|ATP biosynthetic process;GO:2000984|negative regulation of ATP citrate synthase activity;GO:0006119|oxidative phosphorylation;GO:1901843|positive regulation of high voltage-gated calcium channel activity;","GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0005741|mitochondrial outer membrane;GO:0005739|mitochondrion;",".",".","."]
["bta_circ_0013118",25,19,21,14.4221443163803,4,5,6,2.07607347301437,0.015175568624561,0.298906981742218,"up","yes","NC_037352.1:38003874..38004226:-","gene30291","gi|982967228|ref|XP_015315910.1|",4221,0,"PREDICTED: radial spoke head 10 homolog B isoform X1 [Bos taurus]","gi|982967231|ref|XM_015460426.1|",3113,0,"PREDICTED: Bos taurus radial spoke head 10 homolog B (Chlamydomonas) (RSPH10B), transcript variant X3, mRNA",".",".",".",".","slr1485",98.2,{"v":7e-21,"d":"7.00E-21"},"COG4642","pfam02493","MORN","MORN repeat. The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22).  #=GF CC   A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesised to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.",".",".",".",".","."]
["bta_circ_0013125",0,0,0,2.01479027944556,3,5,4,-4.45669601125322,0.0233234272540108,"NA","down","yes","NC_037352.1:38625522..38660501:+","gene30322","gi|742149827|ref|XP_010844068.1|",4551,0,"PREDICTED: E3 ubiquitin-protein ligase RNF216 isoform X1 [Bison bison bison]","gi|982967398|ref|XM_005225169.3|",5528,0,"PREDICTED: Bos taurus ring finger protein 216 (RNF216), transcript variant X1, mRNA","Q9NWF9",1379,0,"E3 ubiquitin-protein ligase RNF216",".",".",".",".","pfam01485","IBR","IBR domain. The IBR (In Between Ring fingers) domain is often found to occur between pairs of ring fingers (pfam00097). This domain has also been called the C6HC domain and DRIL (for double RING finger linked) domain. Proteins that contain two Ring fingers and an IBR domain (these proteins are also termed RBR family proteins) are thought to exist in all eukaryotic organisms. RBR family members play roles in protein quality control and can indirectly regulate transcription. Evidence suggests that RBR proteins are often parts of cullin-containing ubiquitin ligase complexes. The ubiquitin ligase Parkin is an RBR family protein whose mutations are involved in forms of familial Parkinson's disease.","GO:0006915|apoptotic process;GO:0032480|negative regulation of type I interferon production;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0070936|protein K48-linked ubiquitination;GO:0050691|regulation of defense response to virus by host;GO:0032648|regulation of interferon-beta production;GO:0016032|viral process;","GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K11976","RNF216; TRIAD3; E3 ubiquitin-protein ligase RNF216 [EC:2.3.2.27]"]
["bta_circ_0013137",0,0,0,2.81600807663607,2,6,9,-4.94401306508382,0.00952240439647066,"NA","down","yes","NC_037352.1:39600270..39618880:-","gene30339","gi|983007351|ref|XP_015324899.1|",10205,0,"PREDICTED: LOW QUALITY PROTEIN: protein sidekick-1 isoform X2 [Bos taurus]","gi|983007350|ref|XM_015469413.1|",7323,0,"PREDICTED: Bos taurus sidekick cell adhesion molecule 1 (SDK1), transcript variant X2, mRNA","Q7Z5N4",3526,0,"Protein sidekick-1",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.","GO:0048148|behavioral response to cocaine;GO:0045216|cell-cell junction organization;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0060998|regulation of dendritic spine development;GO:0010842|retina layer formation;GO:0007416|synapse assembly;","GO:0030054|cell junction;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;GO:0045202|synapse;","GO:0042802|identical protein binding;","K16353","SDK; protein sidekick"]
["bta_circ_0013182",0,0,0,1.66169168248462,3,5,2,-4.15120248681258,0.038356152419291,"NA","down","yes","NC_037353.1:10969576..10970999:-","gene30480","gi|157074158|ref|NP_001096793.1|",2061,0,"lysosomal acid lipase/cholesteryl ester hydrolase precursor [Bos taurus]","gi|157074157|ref|NM_001103323.1|",2479,0,"Bos taurus lipase A, lysosomal acid, cholesterol esterase (LIPA), mRNA","Q4R4S5",673,0,"Lysosomal acid lipase/cholesteryl ester hydrolase","SPBC16A3.12c",206,{"v":3e-57,"d":"3.00E-57"},"COG0596","pfam04083","Abhydro_lipase","Partial alpha/beta-hydrolase lipase region. This family corresponds to a N-terminal part of an alpha/beta hydrolase domain.","GO:0016042|lipid catabolic process;","GO:0005764|lysosome;","GO:0004771|sterol esterase activity;",".","."]
["bta_circ_0013185",10,23,18,26.1792493435659,27,55,32,-1.33488233525577,0.0279692032692724,0.411356581416101,"down","yes","NC_037353.1:11272267..11272619:-","gene30490","gi|297490734|ref|XP_002698391.1|",2382,0,"PREDICTED: pantothenate kinase 1 isoform X1 [Bos taurus]","gi|983007649|ref|XM_002703169.4|",3790,0,"PREDICTED: Bos taurus pantothenate kinase 1 (PANK1), transcript variant X1, mRNA","Q8TE04",858,0,"Pantothenate kinase 1","SPBC4B4.01c",167,{"v":2e-43,"d":"2.00E-43"},"COG5146","pfam03630","Fumble","Fumble. Fumble is required for cell division in Drosophila. Mutants lacking fumble exhibit abnormalities in bipolar spindle organisation, chromosome segregation, and contractile ring formation. Analyses have demonstrated that encodes three protein isoforms, all of which contain a domain with high similarity to the pantothenate kinases of A. nidulans and mouse. A role of fumble in membrane synthesis has been proposed.","GO:0015937|coenzyme A biosynthetic process;GO:0009108|coenzyme biosynthetic process;","GO:0071944|cell periphery;GO:0030118|clathrin coat;GO:0005829|cytosol;GO:0005634|nucleus;GO:0055037|recycling endosome;","GO:0005524|ATP binding;GO:0004594|pantothenate kinase activity;","K09680","coaW; type II pantothenate kinase [EC:2.7.1.33]"]
["bta_circ_0013188",7,28,35,10.4584983423382,6,0,0,2.73303864771628,0.0151434945003202,0.298906981742218,"up","yes","NC_037353.1:12514452..12515598:+","gene30500","gi|78369236|ref|NP_001030538.1|",1353,0,"ribonuclease P protein subunit p30 [Bos taurus]","gi|742134156|ref|XM_010842211.1|",1247,0,"PREDICTED: Bison bison bison ribonuclease P/MRP 30kDa subunit (RPP30), mRNA","Q3SZ21",525,0,"Ribonuclease P protein subunit p30","SPAC3A12.04c",139,{"v":1e-36,"d":"1.00E-36"},"COG1603","pfam01876","RNase_P_p30","RNase P subunit p30. This protein is part of the RNase P complex that is involved in tRNA maturation.","GO:0090502|RNA phosphodiester bond hydrolysis, endonucleolytic;GO:0008033|tRNA processing;","GO:0005655|nucleolar ribonuclease P complex;","GO:0004526|ribonuclease P activity;GO:0003723|RNA binding;","K03539","RPP1, RPP30; ribonuclease P/MRP protein subunit RPP1 [EC:3.1.26.5]"]
["bta_circ_0013189",0,0,0,1.87065310090543,5,6,0,-4.15306280682625,0.0400339162609007,"NA","down","yes","NC_037353.1:12540064..12541723:-","gene30501","gi|77735703|ref|NP_001029550.1|",1502,0,"ankyrin repeat domain-containing protein 1 [Bos taurus]","gi|402766900|ref|NM_001034378.2|",1751,0,"Bos taurus ankyrin repeat domain 1 (cardiac muscle) (ANKRD1), mRNA","Q3ZBX7",583,0,"Ankyrin repeat domain-containing protein 1","TVN1399",84.3,{"v":1e-17,"d":"1.00E-17"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0055008|cardiac muscle tissue morphogenesis;GO:0035690|cellular response to drug;GO:0071347|cellular response to interleukin-1;GO:0071222|cellular response to lipopolysaccharide;GO:0071260|cellular response to mechanical stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0071356|cellular response to tumor necrosis factor;GO:0045445|myoblast differentiation;GO:2000279|negative regulation of DNA biosynthetic process;GO:0043065|positive regulation of apoptotic process;GO:0043517|positive regulation of DNA damage response, signal transduction by p53 class mediator;GO:0050714|positive regulation of protein secretion;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0035994|response to muscle stretch;GO:0035914|skeletal muscle cell differentiation;","GO:0005829|cytosol;GO:0001650|fibrillar center;GO:0031674|I band;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0003677|DNA binding;GO:0042826|histone deacetylase binding;GO:0002039|p53 binding;GO:0070412|R-SMAD binding;GO:0061629|RNA polymerase II sequence-specific DNA binding transcription factor binding;GO:0001105|RNA polymerase II transcription coactivator activity;GO:0031432|titin binding;GO:0003712|transcription cofactor activity;GO:0003714|transcription corepressor activity;",".","."]
["bta_circ_0013202",3,3,8,2.18435820891878,0,0,0,4.41164325520006,0.0258946614541736,"NA","up","yes","NC_037353.1:13632714..13655399:-","gene30511","gi|982967871|ref|XP_015316086.1|",2948,0,"PREDICTED: cytoplasmic polyadenylation element-binding protein 3 isoform X1 [Bos taurus]","gi|982967875|ref|XM_005225419.3|",8296,0,"PREDICTED: Bos taurus cytoplasmic polyadenylation element binding protein 3 (CPEB3), transcript variant X5, mRNA","Q7TN99",1115,0,"Cytoplasmic polyadenylation element-binding protein 3",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0061158|3'-UTR-mediated mRNA destabilization;GO:0071230|cellular response to amino acid stimulus;GO:0007616|long-term memory;GO:1900248|negative regulation of cytoplasmic translational elongation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0017148|negative regulation of translation;GO:0060999|positive regulation of dendritic spine development;GO:1900273|positive regulation of long-term synaptic potentiation;GO:1900365|positive regulation of mRNA polyadenylation;GO:1900153|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0060213|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;GO:0045727|positive regulation of translation;GO:0060998|regulation of dendritic spine development;GO:0048167|regulation of synaptic plasticity;GO:0050955|thermoception;","GO:0097440|apical dendrite;GO:0030014|CCR4-NOT complex;GO:0030054|cell junction;GO:0005737|cytoplasm;GO:0030425|dendrite;GO:1990124|messenger ribonucleoprotein complex;GO:0043005|neuron projection;GO:0005634|nucleus;GO:0014069|postsynaptic density;GO:0045211|postsynaptic membrane;GO:0045202|synapse;","GO:0035925|mRNA 3'-UTR AU-rich region binding;GO:0003730|mRNA 3'-UTR binding;GO:0043022|ribosome binding;GO:0003723|RNA binding;GO:0035613|RNA stem-loop binding;GO:0008135|translation factor activity, RNA binding;GO:0000900|translation repressor activity, nucleic acid binding;","K02602","CPEB, ORB; cytoplasmic polyadenylation element-binding protein"]
["bta_circ_0013213",0,0,3,4.79858743397863,14,4,5,-2.97704672493714,0.0359549838205598,"NA","down","yes","NC_037353.1:14278295..14301158:+","gene30518","gi|741975832|ref|XP_010818144.1|",4031,0,"PREDICTED: exocyst complex component 6 isoform X1 [Bos taurus]","gi|982968019|ref|XM_005225489.3|",3478,0,"PREDICTED: Bos taurus exocyst complex component 6 (EXOC6), transcript variant X4, mRNA","E2R766",1480,0,"Exocyst complex component 6",".",".",".",".","pfam04091","Sec15","Exocyst complex subunit Sec15-like.","GO:0015031|protein transport;GO:0006904|vesicle docking involved in exocytosis;","GO:0000145|exocyst;GO:0090543|Flemming body;GO:0030426|growth cone;GO:0048471|perinuclear region of cytoplasm;",".",".","."]
["bta_circ_0013217",2,0,0,5.12695363289776,9,5,11,-2.99146346049108,0.0309953010701943,"NA","down","yes","NC_037353.1:14292891..14321625:+","gene30518","gi|741975832|ref|XP_010818144.1|",4031,0,"PREDICTED: exocyst complex component 6 isoform X1 [Bos taurus]","gi|982968019|ref|XM_005225489.3|",3478,0,"PREDICTED: Bos taurus exocyst complex component 6 (EXOC6), transcript variant X4, mRNA","E2R766",1480,0,"Exocyst complex component 6",".",".",".",".","pfam04091","Sec15","Exocyst complex subunit Sec15-like.","GO:0015031|protein transport;GO:0006904|vesicle docking involved in exocytosis;","GO:0000145|exocyst;GO:0090543|Flemming body;GO:0030426|growth cone;GO:0048471|perinuclear region of cytoplasm;",".",".","."]
["bta_circ_0013219",13,19,58,52.6899755156031,75,58,90,-1.57667529752392,0.00802820063614159,0.231426263671175,"down","yes","NC_037353.1:14295513..14321625:+","gene30518","gi|741975832|ref|XP_010818144.1|",4031,0,"PREDICTED: exocyst complex component 6 isoform X1 [Bos taurus]","gi|982968019|ref|XM_005225489.3|",3478,0,"PREDICTED: Bos taurus exocyst complex component 6 (EXOC6), transcript variant X4, mRNA","E2R766",1480,0,"Exocyst complex component 6",".",".",".",".","pfam04091","Sec15","Exocyst complex subunit Sec15-like.","GO:0015031|protein transport;GO:0006904|vesicle docking involved in exocytosis;","GO:0000145|exocyst;GO:0090543|Flemming body;GO:0030426|growth cone;GO:0048471|perinuclear region of cytoplasm;",".",".","."]
["bta_circ_0013223",0,3,0,4.24287710238068,10,3,8,-3.03759707683606,0.0367098061726043,"NA","down","yes","NC_037353.1:14301049..14321625:+","gene30518","gi|741975832|ref|XP_010818144.1|",4031,0,"PREDICTED: exocyst complex component 6 isoform X1 [Bos taurus]","gi|982968019|ref|XM_005225489.3|",3478,0,"PREDICTED: Bos taurus exocyst complex component 6 (EXOC6), transcript variant X4, mRNA","E2R766",1480,0,"Exocyst complex component 6",".",".",".",".","pfam04091","Sec15","Exocyst complex subunit Sec15-like.","GO:0015031|protein transport;GO:0006904|vesicle docking involved in exocytosis;","GO:0000145|exocyst;GO:0090543|Flemming body;GO:0030426|growth cone;GO:0048471|perinuclear region of cytoplasm;",".",".","."]
["bta_circ_0013240",0,0,0,2.54429832693665,10,3,0,-4.57977817289779,0.0204104684532179,"NA","down","yes","NC_037353.1:16744239..16767260:-","gene30567","gi|555973787|ref|XP_005898889.1|",1680,0,"PREDICTED: PDZ and LIM domain protein 1 [Bos mutus]","gi|148877478|gb|BC146213.1|",1438,0,"Bos taurus PDZ and LIM domain 1, mRNA (cDNA clone MGC:166382 IMAGE:8474203), complete cds","Q5E9E1",651,0,"PDZ and LIM domain protein 1",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0006355|regulation of transcription, DNA-templated;","GO:0005856|cytoskeleton;GO:0005667|transcription factor complex;GO:0030018|Z disc;","GO:0046872|metal ion binding;GO:0003713|transcription coactivator activity;",".","."]
["bta_circ_0013294",0,0,0,3.43189587629468,3,13,6,-5.25530905239905,0.00488458261663114,"NA","down","yes","NC_037353.1:23739573..23741706:-","gene30716","gi|686734359|ref|XP_009244020.1|",1989,0,"PREDICTED: cytosolic purine 5'-nucleotidase isoform X2 [Pongo abelii]","gi|982967892|ref|XM_005225434.3|",1863,0,"PREDICTED: Bos taurus 5'-nucleotidase, cytosolic II (NT5C2), transcript variant X2, mRNA","O46411",769,0,"Cytosolic purine 5'-nucleotidase",".",".",".",".","pfam05761","5_nucleotid","5' nucleotidase family. This family of eukaryotic proteins includes 5' nucleotidase enzymes, such as purine 5'-nucleotidase EC:3.1.3.5.","GO:0046085|adenosine metabolic process;GO:0046040|IMP metabolic process;","GO:0005737|cytoplasm;","GO:0008253|5'-nucleotidase activity;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0000166|nucleotide binding;","K01081","E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5]"]
["bta_circ_0013311",13,35,42,41.0920248432844,57,66,43,-1.16983378663009,0.0294936939617479,0.423218637145628,"down","yes","NC_037353.1:31512402..31513326:+","gene30793","gi|156120535|ref|NP_001095413.1|",2463,0,"leucine-rich repeat protein SHOC-2 [Bos taurus]","gi|982968430|ref|XM_010820029.2|",3987,0,"PREDICTED: Bos taurus SHOC2 leucine-rich repeat scaffold protein (SHOC2), transcript variant X1, mRNA","A6QLV3",953,0,"Leucine-rich repeat protein SHOC-2","alr0124_1",150,{"v":3e-37,"d":"3.00E-37"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0046579|positive regulation of Ras protein signal transduction;GO:0007265|Ras protein signal transduction;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0000164|protein phosphatase type 1 complex;","GO:0008157|protein phosphatase 1 binding;GO:0019903|protein phosphatase binding;GO:0019888|protein phosphatase regulator activity;","K19613","SHOC2, SUR8; leucine-rich repeat protein SHOC2"]
["bta_circ_0013339",0,3,0,4.02277938040577,10,4,6,-2.96149142930815,0.0429991096972016,"NA","down","yes","NC_037353.1:35300502..35310984:+","gene30825","gi|118150992|ref|NP_001071416.1|",3894,0,"protein FAM160B1 [Bos taurus]","gi|118150991|ref|NM_001077948.1|",2839,0,"Bos taurus family with sequence similarity 160 member B1 (FAM160B1), mRNA",".",".",".",".",".",".",".",".","pfam10257","RAI16-like","Retinoic acid induced 16-like protein. This is the conserved N-terminal 450 residues of a family of proteins described as retinoic acid-induced protein 16-like proteins. The exact function is not known. The proteins are found from worms to humans.",".",".",".",".","."]
["bta_circ_0013351",5,13,4,3.22021573200526,0,0,0,4.97958553287288,0.00901192337169794,"NA","up","yes","NC_037353.1:38965855..38970523:-","gene30855","gi|555981873|ref|XP_005902849.1|",1622,0,"PREDICTED: CDK2-associated and cullin domain-containing protein 1 [Bos mutus]","gi|742199749|ref|XM_010859270.1|",7345,0,"PREDICTED: Bison bison bison CDK2-associated, cullin domain 1 (CACUL1), mRNA","Q86Y37",594,0,"CDK2-associated and cullin domain-containing protein 1",".",".",".",".","pfam00888","Cullin","Cullin family.","GO:0000082|G1/S transition of mitotic cell cycle;GO:0008284|positive regulation of cell proliferation;GO:0045860|positive regulation of protein kinase activity;GO:0016567|protein ubiquitination;GO:0006511|ubiquitin-dependent protein catabolic process;","GO:0031461|cullin-RING ubiquitin ligase complex;","GO:0019901|protein kinase binding;GO:0031625|ubiquitin protein ligase binding;",".","."]
["bta_circ_0013376",0,0,0,1.77020419381005,0,8,4,-4.08947018071434,0.0439946082858927,"NA","down","yes","NC_037353.1:41743413..41815676:-","gene30882","gi|741903141|ref|XP_010799128.1|",1851,0,"PREDICTED: arginyl-tRNA--protein transferase 1 isoform X1 [Bos taurus]","gi|742199582|ref|XM_010859230.1|",4725,0,"PREDICTED: Bison bison bison arginyltransferase 1 (ATE1), transcript variant X4, mRNA","O95260",622,0,"Arginyl-tRNA--protein transferase 1","SPAC3C7.07c",114,{"v":3e-25,"d":"3.00E-25"},"COG2935","pfam04377","ATE_C","Arginine-tRNA-protein transferase, C terminus. This family represents the C terminal region of the enzyme arginine-tRNA-protein transferase (EC 2.3.2.8), which catalyses the post-translational conjugation of arginine to the N terminus of a protein. In eukaryotes, this functions as part of the N-end rule pathway of protein degradation by conjugating a destabilizing amino acid to the amino terminal aspartate or glutamate of a protein, targeting the protein for ubiquitin-dependent proteolysis. N terminal cysteine is sometimes modified.","GO:0010498|proteasomal protein catabolic process;GO:0016598|protein arginylation;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0004057|arginyltransferase activity;","K00685","ATE1, ate1; arginine-tRNA-protein transferase [EC:2.3.2.8]"]
["bta_circ_0013404",24,91,77,33.2510775337021,7,19,21,1.68648388017823,0.00438210132605221,0.166212334507454,"up","yes","NC_037353.1:44298453..44307574:-","gene30927","gi|741903267|ref|XP_010799424.1|",1720,0,"PREDICTED: protein FAM53B isoform X1 [Bos taurus]","gi|965785452|ref|XM_012108606.2|",4105,0,"PREDICTED: Ovis aries musimon family with sequence similarity 53 member B (FAM53B), transcript variant X2, mRNA","Q14153",502,{"v":6e-160,"d":"6.00E-160"},"Protein FAM53B",".",".",".",".","pfam15242","FAM53","Family of FAM53. The FAM53 protein family refers to a family of proteins, which bind to a transcriptional regulator that modulates cell proliferation. It is known to be highly important in neural tube development. It is found in eukaryotes and is typically between 303 and 413 amino acids in length.","GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:0060828|regulation of canonical Wnt signaling pathway;GO:0016055|Wnt signaling pathway;","GO:0005634|nucleus;",".",".","."]
["bta_circ_0013421",41,438,227,116.837488658672,15,132,76,1.24964821257038,0.0308544084424541,0.428634275476763,"up","yes","NC_037353.1:46469960..46478981:+","gene30957","gi|529009397|ref|XP_005225929.1|",9477,0,"PREDICTED: dedicator of cytokinesis protein 1 isoform X1 [Bos taurus]","gi|983008182|ref|XM_015469652.1|",6874,0,"PREDICTED: Bos taurus dedicator of cytokinesis 1 (DOCK1), transcript variant X1, mRNA","Q14185",3523,0,"Dedicator of cytokinesis protein 1",".",".",".",".","pfam14429","DOCK-C2","C2 domain in Dock180 and Zizimin proteins. The Dock180/Dock1 and Zizimin proteins are atypical GTP/GDP exchange factors for the small GTPases Rac and Cdc42 and are implicated cell-migration and phagocytosis. Across all Dock180 proteins, two regions are conserved: C-terminus termed CZH2 or DHR2 (or the Dedicator of cytokinesis) whereas CZH1/DHR1 contain a new family of the C2 domain.","GO:0006915|apoptotic process;GO:0007596|blood coagulation;GO:0016477|cell migration;GO:0007010|cytoskeleton organization;GO:0038096|Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0007229|integrin-mediated signaling pathway;GO:0006911|phagocytosis, engulfment;GO:0010634|positive regulation of epithelial cell migration;GO:1900026|positive regulation of substrate adhesion-dependent cell spreading;GO:0007165|signal transduction;GO:0007264|small GTPase mediated signal transduction;GO:0048010|vascular endothelial growth factor receptor signaling pathway;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0032045|guanyl-nucleotide exchange factor complex;GO:0016020|membrane;GO:0016607|nuclear speck;GO:0005634|nucleus;","GO:0005096|GTPase activator activity;GO:0005089|Rho guanyl-nucleotide exchange factor activity;GO:0017124|SH3 domain binding;","K13708","DOCK1; dedicator of cytokinesis protein 1"]
["bta_circ_0013440",0,42,16,6.78760776225469,0,3,2,2.68253742054168,0.0388028328040153,0.439730132358439,"up","yes","NC_037353.1:48954247..48954627:+","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0013559",7,0,8,3.07645550712204,0,0,0,4.70131822607994,0.0165136202118015,"NA","up","yes","NC_037354.1:33394858..33413492:+","gene31323","gi|164450495|ref|NP_001069066.2|",3510,0,"phospholipase DDHD2 [Bos taurus]","gi|164450494|ref|NM_001075598.2|",4308,0,"Bos taurus DDHD domain containing 2 (DDHD2), mRNA","O94830",1249,0,"Phospholipase DDHD2",".",".",".",".","pfam02862","DDHD","DDHD domain. The DDHD domain is 180 residues long and contains four conserved residues that may form a metal binding site. The domain is named after these four residues. This pattern of conservation of metal binding residues is often seen in phosphoesterase domains. This domain is found in retinal degeneration B proteins, as well as a family of probable phospholipases. It has been shown that this domain is found in a longer C terminal region that binds to PYK2 tyrosine kinase. These proteins have been called N-terminal domain-interacting receptor (Nir1, Nir2 and Nir3). This suggests that this region is involved in functionally important interactions in other members of this family.","GO:0006888|ER to Golgi vesicle-mediated transport;GO:0034389|lipid particle organization;GO:0007626|locomotory behavior;GO:0090141|positive regulation of mitochondrial fission;GO:0019433|triglyceride catabolic process;GO:0008542|visual learning;","GO:0030134|ER to Golgi transport vesicle;GO:0005829|cytosol;GO:0005793|endoplasmic reticulum-Golgi intermediate compartment;GO:0005794|Golgi apparatus;GO:0016020|membrane;GO:0005815|microtubule organizing center;","GO:0046872|metal ion binding;GO:0004620|phospholipase activity;GO:0004806|triglyceride lipase activity;","K16545","DDHD2; phospholipase DDHD2 [EC:3.1.1.-]"]
["bta_circ_0013561",5,7,0,2.14061567832177,0,0,0,4.19310828194765,0.0379922968309685,"NA","up","yes","NC_037354.1:33425424..33430637:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0013565",0,0,0,2.20790418530688,7,0,4,-4.37630491127556,0.028464378751599,"NA","down","yes","NC_037354.1:33563176..33563442:-","gene31330","gi|741977533|ref|XP_010818622.1|",4165,0,"PREDICTED: fibroblast growth factor receptor 1 isoform X1 [Bos taurus]","gi|982969448|ref|XM_010820322.2|",3508,0,"PREDICTED: Bos taurus fibroblast growth factor receptor 1 (FGFR1), transcript variant X4, mRNA","P11362",1521,0,"Fibroblast growth factor receptor 1",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001525|angiogenesis;GO:0060117|auditory receptor cell development;GO:0060445|branching involved in salivary gland morphogenesis;GO:0048469|cell maturation;GO:0016477|cell migration;GO:0002062|chondrocyte differentiation;GO:0043009|chordate embryonic development;GO:0030326|embryonic limb morphogenesis;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0035607|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development;GO:0001701|in utero embryonic development;GO:0042472|inner ear morphogenesis;GO:0060484|lung-associated mesenchyme development;GO:0000165|MAPK cascade;GO:0048762|mesenchymal cell differentiation;GO:0030901|midbrain development;GO:0042474|middle ear morphogenesis;GO:0090272|negative regulation of fibroblast growth factor production;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0001764|neuron migration;GO:0001759|organ induction;GO:0042473|outer ear morphogenesis;GO:0048339|paraxial mesoderm development;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0048015|phosphatidylinositol-mediated signaling;GO:0043536|positive regulation of blood vessel endothelial cell migration;GO:0060045|positive regulation of cardiac muscle cell proliferation;GO:0008284|positive regulation of cell proliferation;GO:2000546|positive regulation of endothelial cell chemotaxis to fibroblast growth factor;GO:0043406|positive regulation of MAP kinase activity;GO:0043410|positive regulation of MAPK cascade;GO:0090080|positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:1903465|positive regulation of mitotic cell cycle DNA replication;GO:0045666|positive regulation of neuron differentiation;GO:0010976|positive regulation of neuron projection development;GO:2000830|positive regulation of parathyroid hormone secretion;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0010518|positive regulation of phospholipase activity;GO:0010863|positive regulation of phospholipase C activity;GO:0051897|positive regulation of protein kinase B signaling;GO:0046777|protein autophosphorylation;GO:0006468|protein phosphorylation;GO:0060665|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling;GO:0045595|regulation of cell differentiation;GO:2001239|regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:0048378|regulation of lateral mesodermal cell fate specification;GO:0010966|regulation of phosphate transport;GO:0007605|sensory perception of sound;GO:0001501|skeletal system development;GO:0048705|skeletal system morphogenesis;GO:0006351|transcription, DNA-templated;GO:0001657|ureteric bud development;GO:0021847|ventricular zone neuroblast division;GO:0070640|vitamin D3 metabolic process;","GO:0031410|cytoplasmic vesicle;GO:0005829|cytosol;GO:0005576|extracellular region;GO:0016021|integral component of membrane;GO:0005887|integral component of plasma membrane;GO:0005730|nucleolus;GO:0005886|plasma membrane;GO:0043235|receptor complex;","GO:0016303|1-phosphatidylinositol-3-kinase activity;GO:0005524|ATP binding;GO:0017134|fibroblast growth factor binding;GO:0005007|fibroblast growth factor-activated receptor activity;GO:0008201|heparin binding;GO:0042802|identical protein binding;GO:0046934|phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0042803|protein homodimerization activity;GO:0004713|protein tyrosine kinase activity;GO:0005088|Ras guanyl-nucleotide exchange factor activity;","K04362","FGFR1; fibroblast growth factor receptor 1 [EC:2.7.10.1]"]
["bta_circ_0013575",0,0,0,1.68075174231848,0,6,5,-4.00796222908903,0.0493796644707521,"NA","down","yes","NC_037354.1:34173885..34219442:+","gene31339","gi|982969441|ref|XP_015316355.1|",3475,0,"PREDICTED: disintegrin and metalloproteinase domain-containing protein 9 isoform X1 [Bos taurus]","gi|982969440|ref|XM_015460869.1|",2333,0,"PREDICTED: Bos taurus ADAM metallopeptidase domain 9 (ADAM9), transcript variant X1, mRNA","Q13443",1111,0,"Disintegrin and metalloproteinase domain-containing protein 9",".",".",".",".","pfam01421","Reprolysin","Reprolysin (M12B) family zinc metalloprotease. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as human ADAM8 and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.","GO:0000186|activation of MAPKK activity;GO:0007155|cell adhesion;GO:0033627|cell adhesion mediated by integrin;GO:0016477|cell migration;GO:0033631|cell-cell adhesion mediated by integrin;GO:0007160|cell-matrix adhesion;GO:0071222|cellular response to lipopolysaccharide;GO:0007229|integrin-mediated signaling pathway;GO:0030216|keratinocyte differentiation;GO:0006509|membrane protein ectodomain proteolysis;GO:0042117|monocyte activation;GO:0051088|PMA-inducible membrane protein ectodomain proteolysis;GO:0033630|positive regulation of cell adhesion mediated by integrin;GO:0051549|positive regulation of keratinocyte migration;GO:0034241|positive regulation of macrophage fusion;GO:0051044|positive regulation of membrane protein ectodomain proteolysis;GO:0050714|positive regulation of protein secretion;GO:0051592|response to calcium ion;GO:0051384|response to glucocorticoid;GO:0042542|response to hydrogen peroxide;GO:0034616|response to laminar fluid shear stress;GO:0010042|response to manganese ion;GO:0034612|response to tumor necrosis factor;GO:0007179|transforming growth factor beta receptor signaling pathway;","GO:0016323|basolateral plasma membrane;GO:0009986|cell surface;GO:0070062|extracellular exosome;GO:0005615|extracellular space;GO:0005925|focal adhesion;GO:0016021|integral component of membrane;GO:0031233|intrinsic component of external side of plasma membrane;","GO:0005518|collagen binding;GO:0005178|integrin binding;GO:0043236|laminin binding;GO:0046872|metal ion binding;GO:0004222|metalloendopeptidase activity;GO:0008237|metallopeptidase activity;GO:0005080|protein kinase C binding;GO:0017124|SH3 domain binding;","K06834","ADAM9; disintegrin and metalloproteinase domain-containing protein 9 [EC:3.4.24.-]"]
["bta_circ_0013610",0,0,0,1.5286908074986,3,4,2,-4.02030426064568,0.0465919556406166,"NA","down","yes","NC_037354.1:37568550..37584884:-","gene31387","gi|803200679|ref|XP_011961413.1|",1167,{"v":4e-146,"d":"4.00E-146"},"PREDICTED: E3 ubiquitin-protein ligase RNF170 isoform X3 [Ovis aries]","gi|742152011|ref|XM_010846391.1|",3546,0,"PREDICTED: Bison bison bison ring finger protein 170 (RNF170), transcript variant X1, mRNA","F1MK05",440,{"v":8e-143,"d":"8.00E-143"},"E3 ubiquitin-protein ligase RNF170",".",".",".",".","pfam00097","zf-C3HC4","Zinc finger, C3HC4 type (RING finger). The C3HC4 type zinc-finger (RING finger) is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C where X is any amino acid. Many proteins containing a RING finger play a key role in the ubiquitination pathway.","GO:0016567|protein ubiquitination;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0046872|metal ion binding;GO:0016740|transferase activity;",".","."]
["bta_circ_0013624",0,2,2,5.29412379894015,9,10,9,-2.94647695350996,0.018402555065868,"NA","down","yes","NC_037354.1:37822782..37825741:-","gene31393","gi|149642909|ref|NP_001092531.1|",3750,0,"integrator complex subunit 10 [Bos taurus]","gi|982969497|ref|XM_005226120.3|",1793,0,"PREDICTED: Bos taurus integrator complex subunit 10 (INTS10), transcript variant X1, mRNA","Q9NVR2",1407,0,"Integrator complex subunit 10",".",".",".",".","pfam07781","Reovirus_Mu2","Reovirus minor core protein Mu-2. This family represents the Reovirus core protein Mu-2. Mu-2 is a microtubule associated protein and is thought to play a key role in the formation and structural organisation of reovirus inclusion bodies.","GO:0016180|snRNA processing;GO:0042795|snRNA transcription from RNA polymerase II promoter;","GO:0032039|integrator complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;",".","K13147","INTS10; integrator complex subunit 10"]
["bta_circ_0013656",0,0,0,1.76784858930737,0,4,7,-4.07462092718037,0.0449525049853663,"NA","down","yes","NC_037354.1:42063715..42075759:+","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0013658",0,10,8,1.96841051563346,0,0,0,4.17311212257417,0.0391163597667584,"NA","up","yes","NC_037354.1:42680681..42691915:-","gene31424","gi|635085714|ref|XP_008007468.1|",801,{"v":5e-101,"d":"5.00E-101"},"PREDICTED: ubiquitin-conjugating enzyme E2 E2 isoform X1 [Chlorocebus sabaeus]","gi|926725900|ref|XM_013975495.1|",1275,0,"PREDICTED: Capra hircus ubiquitin-conjugating enzyme E2 E2 (LOC102174361), mRNA","Q96LR5",309,{"v":2e-101,"d":"2.00E-101"},"Ubiquitin-conjugating enzyme E2 E2","YDR059c",200,{"v":1e-60,"d":"1.00E-60"},"COG5078","pfam00179","UQ_con","Ubiquitin-conjugating enzyme. Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. TSG101 is one of several UBC homologues that lacks this active site cysteine.","GO:0006974|cellular response to DNA damage stimulus;GO:0032020|ISG15-protein conjugation;GO:1900087|positive regulation of G1/S transition of mitotic cell cycle;GO:0070979|protein K11-linked ubiquitination;GO:0070936|protein K48-linked ubiquitination;GO:0070534|protein K63-linked ubiquitination;",".","GO:0005524|ATP binding;GO:0042296|ISG15 transferase activity;GO:0061631|ubiquitin conjugating enzyme activity;GO:0004842|ubiquitin-protein transferase activity;",".","."]
["bta_circ_0013670",0,0,0,2.36232072462944,4,6,4,-4.70005897147586,0.0150810817001553,"NA","down","yes","NC_037355.1:1221428..1234460:+","gene31462","gi|529010336|ref|XP_005226253.1|",1252,{"v":1e-153,"d":"1.00E-153"},"PREDICTED: ras-related protein Rab-4A isoform X1 [Bos taurus]","gi|850494956|gb|CP011910.1|",4258,0,"Ovis canadensis canadensis isolate 43U chromosome 25 sequence","Q2TBH7",432,{"v":2e-136,"d":"2.00E-136"},"Ras-related protein Rab-4A",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0019882|antigen processing and presentation;GO:0030100|regulation of endocytosis;","GO:0031901|early endosome membrane;GO:0005768|endosome;GO:0070062|extracellular exosome;GO:0032593|insulin-responsive compartment;GO:0048471|perinuclear region of cytoplasm;GO:0055038|recycling endosome membrane;","GO:0019003|GDP binding;GO:0005525|GTP binding;GO:0003924|GTPase activity;GO:0008565|protein transporter activity;","K07879","RAB4A, RAB4; Ras-related protein Rab-4A"]
["bta_circ_0013676",0,0,0,2.21818354608931,6,7,0,-4.41545260034175,0.0266177936216261,"NA","down","yes","NC_037355.1:13143501..13144002:+","gene31570","gi|331028600|ref|NP_001178411.1|",3114,0,"zinc finger protein 248 [Bos taurus]","gi|982969940|ref|XM_005226261.3|",5242,0,"PREDICTED: Bos taurus zinc finger protein 248 (ZNF248), transcript variant X1, mRNA","Q8NDW4",994,0,"Zinc finger protein 248",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["bta_circ_0013715",0,0,0,3.88865592762536,7,6,9,-5.4348509909372,0.00319204110653594,"NA","down","yes","NC_037355.1:1436732..1439371:-","gene31467","gi|296472278|tpg|DAA14393.1|",5755,0,"TPA: nucleoporin 133kDa [Bos taurus]","gi|402767292|ref|NM_001076872.2|",4128,0,"Bos taurus nucleoporin 133kDa (NUP133), mRNA","Q8WUM0",1986,0,"Nuclear pore complex protein Nup133",".",".",".",".","pfam03177","Nucleoporin_C","Non-repetitive/WGA-negative nucleoporin C-terminal. This is the C-termainl half of a family of nucleoporin proteins. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells, and mediate bidirectional nucleocytoplasmic transport, especially of mRNA and proteins. Two nucleoporin classes are known: one is characterized by the FG repeat pfam03093; the other is represented by this family, and lacks any repeats. RNA undergoing nuclear export first encounters the basket of the nuclear pore and many nucleoporins are accessible on the basket side of the pore.","GO:0006325|chromatin organization;GO:0006406|mRNA export from nucleus;GO:0021915|neural tube development;GO:0022008|neurogenesis;GO:0031081|nuclear pore distribution;GO:0006999|nuclear pore organization;GO:0048339|paraxial mesoderm development;GO:0006606|protein import into nucleus;GO:0006355|regulation of transcription, DNA-templated;GO:0061053|somite development;GO:0000972|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery;GO:0016032|viral process;","GO:0000777|condensed chromosome kinetochore;GO:0005829|cytosol;GO:0016020|membrane;GO:0005635|nuclear envelope;GO:0031965|nuclear membrane;GO:0005643|nuclear pore;GO:0031080|nuclear pore outer ring;","GO:0017056|structural constituent of nuclear pore;","K14300","NUP133; nuclear pore complex protein Nup133"]
["bta_circ_0013722",9,2,0,2.84192338479151,0,0,0,4.52105967083302,0.0228269283368124,"NA","up","yes","NC_037355.1:14961484..15010413:-","gene31585","gi|982970056|ref|XP_015316462.1|",2619,0,"PREDICTED: protein FAM13C isoform X2 [Bos taurus]","gi|402745897|ref|NM_001078029.2|",3165,0,"Bos taurus family with sequence similarity 13 member C (FAM13C), mRNA",".",".",".",".",".",".",".",".","pfam09586","YfhO","Bacterial membrane protein YfhO. This protein is a conserved membrane protein. The yfhO gene is transcribed in Difco sporulation medium and the transcription is affected by the YvrGHb two-component system. Some members of this family have been annotated as glycosyl transferases of the PMT family.",".",".",".",".","."]
["bta_circ_0013762",3,18,0,2.60081758995439,0,0,0,4.50906399956014,0.0231046415712354,"NA","up","yes","NC_037355.1:23714799..23715062:-","gene31625","gi|379698823|ref|NP_001073106.4|",4467,0,"catenin alpha-3 [Bos taurus]","gi|982970442|ref|XM_005226477.3|",11066,0,"PREDICTED: Bos taurus catenin alpha 3 (CTNNA3), transcript variant X1, mRNA","Q9UI47",1634,0,"Catenin alpha-3",".",".",".",".","pfam01044","Vinculin","Vinculin family.","GO:0086073|bundle of His cell-Purkinje myocyte adhesion involved in cell communication;GO:0098609|cell-cell adhesion;GO:0086091|regulation of heart rate by cardiac conduction;GO:0098911|regulation of ventricular cardiac muscle cell action potential;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005916|fascia adherens;GO:0030027|lamellipodium;","GO:0051015|actin filament binding;GO:0008013|beta-catenin binding;GO:0045296|cadherin binding;","K05691","CTNNA; catenin alpha"]
["bta_circ_0013770",5,0,7,2.36050684459954,0,0,0,4.32610343612718,0.0310271414588432,"NA","up","yes","NC_037355.1:24511718..24532458:-","gene31636","gi|529010849|ref|XP_005226469.1|",5267,0,"PREDICTED: probable E3 ubiquitin-protein ligase HERC4 isoform X1 [Bos taurus]","gi|982970296|ref|XM_005226412.2|",4017,0,"PREDICTED: Bos taurus HECT and RLD domain containing E3 ubiquitin protein ligase 4 (HERC4), transcript variant X1, mRNA","Q5GLZ8",1977,0,"Probable E3 ubiquitin-protein ligase HERC4","SPBP8B7.27",238,{"v":3e-64,"d":"3.00E-64"},"COG5021","pfam00632","HECT","HECT-domain (ubiquitin-transferase). The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.","GO:0030154|cell differentiation;GO:0007283|spermatogenesis;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0001650|fibrillar center;","GO:0061630|ubiquitin protein ligase activity;","K10615","HERC4; E3 ubiquitin-protein ligase HERC4 [EC:2.3.2.26]"]
["bta_circ_0013802",0,0,0,4.40880602919397,3,23,4,-5.58737053968539,0.00231912279610548,"NA","down","yes","NC_037355.1:28724472..28725280:+","gene31720","gi|594073664|ref|XP_006060648.1|",1592,0,"PREDICTED: calcium uniporter protein, mitochondrial-like isoform X1 [Bubalus bubalis]","gi|982970356|ref|XM_015461006.1|",2924,0,"PREDICTED: Bos taurus mitochondrial calcium uniporter (MCU), transcript variant X1, mRNA","Q8NE86",572,0,"Calcium uniporter protein, mitochondrial",".",".",".",".","pfam04678","DUF607","Protein of unknown function, DUF607. This family represents a conserved region found in several uncharacterized eukaryotic proteins.","GO:0036444|calcium ion transmembrane import into mitochondrion;GO:0019722|calcium-mediated signaling;GO:0042593|glucose homeostasis;GO:0006851|mitochondrial calcium ion transport;GO:0032024|positive regulation of insulin secretion;GO:0051561|positive regulation of mitochondrial calcium ion concentration;GO:0051259|protein oligomerization;","GO:0034704|calcium channel complex;GO:0031305|integral component of mitochondrial inner membrane;GO:0005743|mitochondrial inner membrane;GO:0005739|mitochondrion;GO:1990246|uniplex complex;","GO:0005262|calcium channel activity;GO:0042802|identical protein binding;GO:0015292|uniporter activity;",".","."]
["bta_circ_0013812",0,4,0,5.54392062422276,15,4,8,-3.09359415433717,0.0222581509090188,"NA","down","yes","NC_037355.1:28874631..28891707:+","gene31720","gi|594073664|ref|XP_006060648.1|",1592,0,"PREDICTED: calcium uniporter protein, mitochondrial-like isoform X1 [Bubalus bubalis]","gi|982970356|ref|XM_015461006.1|",2924,0,"PREDICTED: Bos taurus mitochondrial calcium uniporter (MCU), transcript variant X1, mRNA","Q8NE86",572,0,"Calcium uniporter protein, mitochondrial",".",".",".",".","pfam04678","DUF607","Protein of unknown function, DUF607. This family represents a conserved region found in several uncharacterized eukaryotic proteins.","GO:0036444|calcium ion transmembrane import into mitochondrion;GO:0019722|calcium-mediated signaling;GO:0042593|glucose homeostasis;GO:0006851|mitochondrial calcium ion transport;GO:0032024|positive regulation of insulin secretion;GO:0051561|positive regulation of mitochondrial calcium ion concentration;GO:0051259|protein oligomerization;","GO:0034704|calcium channel complex;GO:0031305|integral component of mitochondrial inner membrane;GO:0005743|mitochondrial inner membrane;GO:0005739|mitochondrion;GO:1990246|uniplex complex;","GO:0005262|calcium channel activity;GO:0042802|identical protein binding;GO:0015292|uniporter activity;",".","."]
["bta_circ_0013827",3,8,3,2.02729309014895,0,0,0,4.31681871383954,0.0301754640383483,"NA","up","yes","NC_037355.1:29615138..29615472:+","gene31740","gi|555996803|ref|XP_005910135.1|",1268,{"v":3e-170,"d":"3.00E-170"},"PREDICTED: myozenin-1 [Bos mutus]","gi|942098177|ref|XM_005910073.2|",1305,0,"PREDICTED: Bos mutus myozenin 1 (MYOZ1), transcript variant X1, mRNA","Q8SQ24",482,{"v":9e-168,"d":"9.00E-168"},"Myozenin-1",".",".",".",".","pfam05556","Calsarcin","Calcineurin-binding protein (Calsarcin). This family consists of several mammalian calcineurin-binding proteins. The calcium- and calmodulin-dependent protein phosphatase calcineurin has been implicated in the transduction of signals that control the hypertrophy of cardiac muscle and slow fibre gene expression in skeletal muscle. Calsarcin-1 and calsarcin-2 are expressed in developing cardiac and skeletal muscle during embryogenesis, but calsarcin-1 is expressed specifically in adult cardiac and slow-twitch skeletal muscle, whereas calsarcin-2 is restricted to fast skeletal muscle. Calsarcins represent a novel family of sarcomeric proteins that link calcineurin with the contractile apparatus, thereby potentially coupling muscle activity to calcineurin activation. Calsarcin-3, is expressed specifically in skeletal muscle and is enriched in fast-twitch muscle fibres. Like calsarcin-1 and calsarcin-2, calsarcin-3 interacts with calcineurin, and the Z-disc proteins alpha-actinin, gamma-filamin, and telethonin.","GO:0030239|myofibril assembly;","GO:0015629|actin cytoskeleton;GO:0005634|nucleus;GO:0031143|pseudopodium;GO:0030018|Z disc;","GO:0003779|actin binding;GO:0051373|FATZ binding;GO:0031433|telethonin binding;",".","."]
["bta_circ_0013894",31,138,75,44.4980287823709,14,37,27,1.30369196046473,0.0129672928135459,0.292034240238397,"up","yes","NC_037355.1:42784526..42787997:+","gene31865","gi|741978863|ref|XP_010819018.1|",2438,0,"PREDICTED: mitogen-activated protein kinase 8 isoform X1 [Bos taurus]","gi|982970763|ref|XM_010820717.2|",5837,0,"PREDICTED: Bos taurus mitogen-activated protein kinase 8 (MAPK8), transcript variant X2, mRNA","P45983",808,0,"Mitogen-activated protein kinase 8",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0034198|cellular response to amino acid starvation;GO:0071276|cellular response to cadmium ion;GO:0071345|cellular response to cytokine stimulus;GO:0071222|cellular response to lipopolysaccharide;GO:0071260|cellular response to mechanical stimulus;GO:0034614|cellular response to reactive oxygen species;GO:0038095|Fc-epsilon receptor signaling pathway;GO:0007254|JNK cascade;GO:0007258|JUN phosphorylation;GO:0043066|negative regulation of apoptotic process;GO:0032091|negative regulation of protein binding;GO:0048666|neuron development;GO:0018105|peptidyl-serine phosphorylation;GO:0018107|peptidyl-threonine phosphorylation;GO:0043065|positive regulation of apoptotic process;GO:0031281|positive regulation of cyclase activity;GO:0090045|positive regulation of deacetylase activity;GO:0010628|positive regulation of gene expression;GO:1900740|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:0051247|positive regulation of protein metabolic process;GO:0006468|protein phosphorylation;GO:0042752|regulation of circadian rhythm;GO:1902595|regulation of DNA replication origin binding;GO:0016241|regulation of macroautophagy;GO:0032880|regulation of protein localization;GO:0009411|response to UV;GO:0048511|rhythmic process;GO:0051403|stress-activated MAPK cascade;","GO:0030424|axon;GO:0097441|basilar dendrite;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005739|mitochondrion;GO:0043005|neuron projection;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0019899|enzyme binding;GO:0042826|histone deacetylase binding;GO:0035033|histone deacetylase regulator activity;GO:0004705|JUN kinase activity;GO:0016301|kinase activity;GO:0004674|protein serine/threonine kinase activity;","K04440","JNK; c-Jun N-terminal kinase [EC:2.7.11.24]"]
["bta_circ_0013907",0,0,0,2.23959921042585,3,12,0,-4.43111282445219,0.0261047043078557,"NA","down","yes","NC_037355.1:43646315..43651389:-","gene31876","gi|300797826|ref|NP_001178272.1|",6996,0,"DNA excision repair protein ERCC-6 [Bos taurus]","gi|742180593|ref|XM_010854444.1|",6876,0,"PREDICTED: Bison bison bison excision repair cross-complementation group 6 (ERCC6), mRNA","Q03468",2219,0,"DNA excision repair protein ERCC-6",".",".",".",".","pfam00176","SNF2_N","SNF2 family N-terminal domain. This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1).","GO:0007256|activation of JNKK activity;GO:0007257|activation of JUN kinase activity;GO:0006284|base-excision repair;GO:0006281|DNA repair;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0035264|multicellular organism growth;GO:0045494|photoreceptor cell maintenance;GO:0032786|positive regulation of DNA-templated transcription, elongation;GO:0045815|positive regulation of gene expression, epigenetic;GO:0006290|pyrimidine dimer repair;GO:0032784|regulation of DNA-templated transcription, elongation;GO:0010332|response to gamma radiation;GO:0006979|response to oxidative stress;GO:0000303|response to superoxide;GO:0009636|response to toxic substance;GO:0009411|response to UV;GO:0010224|response to UV-B;GO:0010165|response to X-ray;GO:0006366|transcription from RNA polymerase II promoter;GO:0006362|transcription elongation from RNA polymerase I promoter;GO:0006283|transcription-coupled nucleotide-excision repair;","GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0008023|transcription elongation factor complex;","GO:0005524|ATP binding;GO:0003682|chromatin binding;GO:0003677|DNA binding;GO:0008094|DNA-dependent ATPase activity;GO:0004386|helicase activity;GO:0008022|protein C-terminus binding;GO:0047485|protein N-terminus binding;GO:0030296|protein tyrosine kinase activator activity;GO:0044877|macromolecular complex binding;GO:0070063|RNA polymerase binding;","K10841","ERCC6, CSB, RAD26; DNA excision repair protein ERCC-6"]
["bta_circ_0013964",12,21,27,37.210780878473,55,52,54,-1.64704374257503,0.00368448615957399,0.147515908833314,"down","yes","NC_037355.1:9359058..9370294:+","gene31549","gi|77736221|ref|NP_001029807.1|",4749,0,"alpha-actinin-2 [Bos taurus]","gi|77736220|ref|NM_001034635.1|",2925,0,"Bos taurus actinin alpha 2 (ACTN2), mRNA","Q3ZC55",1833,0,"Alpha-actinin-2","SPAC15A10.08",248,{"v":8e-70,"d":"8.00E-70"},"COG5069","pfam00307","CH","Calponin homology (CH) domain. The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.",".","GO:0030018|Z disc;","GO:0003779|actin binding;GO:0005509|calcium ion binding;",".","."]
["bta_circ_0013988",36,22,22,19.7750831137631,8,10,7,1.7560282251289,0.0264642538620307,0.397331367011878,"up","yes","NC_037356.1:1038665..1039763:-","gene31935","gi|926726665|ref|XP_013831195.1|",3379,0,"PREDICTED: mediator of RNA polymerase II transcription subunit 17 [Capra hircus]","gi|160333190|ref|NM_001034730.2|",2446,0,"Bos taurus mediator complex subunit 17 (MED17), mRNA","Q5BIR6",1273,0,"Mediator of RNA polymerase II transcription subunit 17",".",".",".",".","pfam10156","Med17","Subunit 17 of Mediator complex. This Mediator complex subunit was formerly known as Srb4 in yeasts or Trap80 in Drosophila and human. The Med17 subunit is located within the head domain and is essential for cell viability to the extent that a mutant strain of cerevisiae lacking it shows all RNA polymerase II-dependent transcription ceasing at non-permissive temperatures.","GO:0019827|stem cell population maintenance;GO:0006351|transcription, DNA-templated;","GO:0016592|mediator complex;","GO:0001104|RNA polymerase II transcription cofactor activity;","K15133","MED17; mediator of RNA polymerase II transcription subunit 17"]
["bta_circ_0014004",0,0,0,2.58241844660436,4,5,6,-4.83156755663404,0.0117373314482636,"NA","down","yes","NC_037356.1:12418200..12468133:-","gene32041","gi|742176131|ref|XP_010851507.1|",2271,0,"PREDICTED: ankyrin repeat domain-containing protein 42 isoform X8 [Bison bison bison]","gi|983009432|ref|XM_015469943.1|",3598,0,"PREDICTED: Bos taurus ankyrin repeat domain 42 (ANKRD42), transcript variant X11, mRNA","Q3V096",683,0,"Ankyrin repeat domain-containing protein 42","all2748",75.9,{"v":5e-15,"d":"5.00E-15"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:1900017|positive regulation of cytokine production involved in inflammatory response;GO:0051091|positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051092|positive regulation of NF-kappaB transcription factor activity;","GO:0005634|nucleus;","GO:0051059|NF-kappaB binding;","K17593","ANKRD42, SARP; ankyrin repeat domain-containing protein 42"]
["bta_circ_0014005",7,4,13,4.09207378869273,0,0,0,5.28593724201592,0.00471788097435945,"NA","up","yes","NC_037356.1:12418200..12468136:-","gene32041","gi|742176131|ref|XP_010851507.1|",2271,0,"PREDICTED: ankyrin repeat domain-containing protein 42 isoform X8 [Bison bison bison]","gi|983009432|ref|XM_015469943.1|",3598,0,"PREDICTED: Bos taurus ankyrin repeat domain 42 (ANKRD42), transcript variant X11, mRNA","Q3V096",683,0,"Ankyrin repeat domain-containing protein 42","all2748",75.9,{"v":5e-15,"d":"5.00E-15"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:1900017|positive regulation of cytokine production involved in inflammatory response;GO:0051091|positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051092|positive regulation of NF-kappaB transcription factor activity;","GO:0005634|nucleus;","GO:0051059|NF-kappaB binding;","K17593","ANKRD42, SARP; ankyrin repeat domain-containing protein 42"]
["bta_circ_0014013",35,38,48,74.8796073857317,57,213,81,-1.47023680015359,0.00585452996694646,0.19277034630468,"down","yes","NC_037356.1:12481285..12501155:-","gene32044","gi|742176135|ref|XP_010851508.1|",7422,0,"PREDICTED: pre-mRNA cleavage complex 2 protein Pcf11 isoform X1 [Bison bison bison]","gi|742176134|ref|XM_010853206.1|",6208,0,"PREDICTED: Bison bison bison PCF11 cleavage and polyadenylation factor subunit (PCF11), transcript variant X1, mRNA","O94913",1521,0,"Pre-mRNA cleavage complex 2 protein Pcf11",".",".",".",".","pfam12782","Innate_immun","Invertebrate innate immunity transcript family. The immune response of the purple sea urchin appears to be more complex than previously believed in that it uses immune-related gene families homologous to vertebrate Toll-like and NOD/NALP-like receptor families as well as C-type lectins and a rudimentary complement system. In addition, the species also produces this unusual family of mRNAs, also known as 185/333, which is strongly upregulated in response to pathogen challenge.","GO:0031124|mRNA 3'-end processing;GO:0006379|mRNA cleavage;GO:0006378|mRNA polyadenylation;GO:0000398|mRNA splicing, via spliceosome;GO:0006369|termination of RNA polymerase II transcription;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005849|mRNA cleavage factor complex;GO:0005654|nucleoplasm;","GO:0003729|mRNA binding;GO:0000993|RNA polymerase II core binding;","K14400","PCF11; pre-mRNA cleavage complex 2 protein Pcf11"]
["bta_circ_0014038",0,0,0,1.77884504491116,5,0,4,-4.04923082852261,0.0466318155344839,"NA","down","yes","NC_037356.1:22113153..22183973:-","gene32095","gi|157279911|ref|NP_001098471.1|",1417,0,"growth arrest-specific protein 2 [Bos taurus]","gi|982971295|ref|XM_005226733.3|",2525,0,"PREDICTED: Bos taurus growth arrest specific 2 (GAS2), transcript variant X2, mRNA","P11862",547,0,"Growth arrest-specific protein 2",".",".",".",".","pfam02187","GAS2","Growth-Arrest-Specific Protein 2 Domain.","GO:0006915|apoptotic process;GO:0007050|cell cycle arrest;GO:0008360|regulation of cell shape;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0016020|membrane;","GO:0008017|microtubule binding;",".","."]
["bta_circ_0014064",0,0,0,1.53425895927566,2,3,4,-4.02623864436462,0.0462042841189739,"NA","down","yes","NC_037356.1:2632206..2635511:-","gene31957","gi|982970938|ref|XP_015316582.1|",23458,0,"PREDICTED: protocadherin Fat 3 isoform X1 [Bos taurus]","gi|982970937|ref|XM_015461096.1|",16685,0,"PREDICTED: Bos taurus FAT atypical cadherin 3 (FAT3), transcript variant X1, mRNA","Q8TDW7",8508,0,"Protocadherin Fat 3",".",".",".",".","pfam02210","Laminin_G_2","Laminin G domain. This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.","GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007275|multicellular organismal development;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;","K16506","FAT1_2_3; protocadherin Fat 1/2/3"]
["bta_circ_0014073",0,0,0,2.34647321206996,6,0,6,-4.4787741961127,0.0240429662199425,"NA","down","yes","NC_037356.1:28857767..28872889:+","gene32272","gi|221136920|ref|NP_001137580.1|",2152,0,"homeobox protein PKNOX2 [Bos taurus]","gi|982971473|ref|XM_005226807.3|",3645,0,"PREDICTED: Bos taurus PBX/knotted 1 homeobox 2 (PKNOX2), transcript variant X2, mRNA","Q96KN3",825,0,"Homeobox protein PKNOX2",".",".",".",".","pfam05920","Homeobox_KN","Homeobox KN domain. This is a homeobox transcription factor KN domain conserved from fungi to human and plants.",".","GO:0015629|actin cytoskeleton;GO:0005737|cytoplasm;GO:0045171|intercellular bridge;GO:0015630|microtubule cytoskeleton;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0051015|actin filament binding;GO:0003785|actin monomer binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;",".","."]
["bta_circ_0014090",0,0,0,4.4237321268935,13,3,7,-5.56701951751052,0.00241421579302919,"NA","down","yes","NC_037356.1:36304037..36306238:+","gene32343","gi|119919082|ref|XP_001251235.1|",3414,0,"PREDICTED: amyloid-like protein 2 isoform X1 [Bos taurus]","gi|983009746|ref|XM_001251234.5|",3531,0,"PREDICTED: Bos taurus amyloid beta precursor like protein 2 (APLP2), transcript variant X1, mRNA","Q06481",1198,0,"Amyloid-like protein 2",".",".",".",".","pfam12925","APP_E2","E2 domain of amyloid precursor protein. The E2 domain is the largest of the conserved domains of the amyloid precursor protein. The structure of E2 consists of two coiled-coil sub-structures connected through a continuous helix, and bears an unexpected resemblance to the spectrin family of protein structures.E 2 can reversibly dimerise in solution, and the dimerization occurs along the longest dimension of the molecule in an antiparallel orientation, which enables the N-terminal substructure of one monomer to pack against the C-terminal substructure of a second monomer. The high degree of conservation of residues at the putative dimer interface suggests that the E2 dimer observed in the crystal could be physiologically relevant. Heparin sulfate proteoglycans, the putative ligands for the precursor present in extracellular matrix, bind to E2 at a conserved and positively charged site near the dimer interface.","GO:0044267|cellular protein metabolic process;GO:0007186|G-protein coupled receptor signaling pathway;GO:0002576|platelet degranulation;GO:0043687|post-translational protein modification;","GO:0005788|endoplasmic reticulum lumen;GO:0070062|extracellular exosome;GO:0016021|integral component of membrane;GO:0016020|membrane;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0031092|platelet alpha granule membrane;","GO:0003677|DNA binding;GO:0008201|heparin binding;GO:0042802|identical protein binding;GO:0004867|serine-type endopeptidase inhibitor activity;GO:0046914|transition metal ion binding;","K08117","APLP2; amyloid beta (A4) precursor-like protein 2"]
["bta_circ_0014093",21,26,36,52.555508941239,73,85,70,-1.58537227663259,0.00245114759583539,0.110403772962419,"down","yes","NC_037356.1:36428168..36429241:-","gene32347","gi|528928032|ref|XP_005197373.1|",3226,0,"PREDICTED: zinc finger and BTB domain-containing protein 44 isoform X1 [Bos taurus]","gi|983009752|ref|XM_005197316.3|",9215,0,"PREDICTED: Bos taurus zinc finger and BTB domain containing 44 (ZBTB44), transcript variant X1, mRNA","Q8NCP5",1094,0,"Zinc finger and BTB domain-containing protein 44",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K10515","ZBTB44, BTBD15; zinc finger and BTB domain-containing protein 44"]
["bta_circ_0014121",8,12,17,6.51515213635207,4,0,0,2.55591894987375,0.0435455544653885,0.456494092506297,"up","yes","NC_037356.1:45155729..45156123:+","gene32700","gi|742109186|ref|XP_010836018.1|",5675,0,"PREDICTED: lysine-specific demethylase 2A isoform X1 [Bison bison bison]","gi|742109185|ref|XM_010837716.1|",5506,0,"PREDICTED: Bison bison bison lysine (K)-specific demethylase 2A (KDM2A), transcript variant X1, mRNA","Q9Y2K7",2115,0,"Lysine-specific demethylase 2A",".",".",".",".","pfam02008","zf-CXXC","CXXC zinc finger domain. This domain contains eight conserved cysteine residues that bind to two zinc ions. The CXXC domain is found in a variety of chromatin-associated proteins. This domain binds to nonmethyl-CpG dinucleotides. The domain is characterized by two repeats, and shows a peculiar internal duplication in which the second unit is inserted into the first one. Each of these units is characterized by four conserved cysteines, displaying a CXXCXXCX(n)C motif that chelate a Zn+2 ion. The DNA binding interface has been identified by NMR. In eukaryotes, the CXXC domain is found in stramenopiles, plants and metazoans. Plants possess a mono-CXXC domain that is present in distinct chromatin proteins. Structural comparisons show that the mono-CXXC is homologous to the structural-zinc binding domain of medium chain dehydrogenases.","GO:0006303|double-strand break repair via nonhomologous end joining;GO:0070544|histone H3-K36 demethylation;GO:0006351|transcription, DNA-templated;","GO:0005654|nucleoplasm;","GO:0003677|DNA binding;GO:0032452|histone demethylase activity;GO:0051864|histone demethylase activity (H3-K36 specific);GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0008270|zinc ion binding;","K10276","FBXL10_11, KDM2; F-box and leucine-rich repeat protein 10/11 [EC:1.14.11.27]"]
["bta_circ_0014158",8,46,21,11.5309909842845,0,8,6,2.00804661472202,0.0342520965856432,0.439730132358439,"up","yes","NC_037356.1:48652711..48660506:+","gene32788","gi|529013185|ref|XP_005227390.1|",1628,0,"PREDICTED: nucleosome assembly protein 1-like 4 isoform X3 [Bos taurus]","gi|741980587|ref|XM_005227333.2|",2309,0,"PREDICTED: Bos taurus nucleosome assembly protein 1-like 4 (NAP1L4), transcript variant X3, mRNA","Q2TA40",588,0,"Nucleosome assembly protein 1-like 4",".",".",".",".","pfam00956","NAP","Nucleosome assembly protein (NAP). NAP proteins are involved in moving histones into the nucleus, nucleosome assembly and chromatin fluidity. They affect the transcription of many genes.","GO:0006334|nucleosome assembly;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0031491|nucleosome binding;","K11282","NAP1L4, NAP2; nucleosome assembly protein 1-like 4"]
["bta_circ_0014164",0,20,11,3.30278193316327,0,0,0,4.92737042239985,0.0106828860610288,"NA","up","yes","NC_037356.1:49588705..49589745:-","gene32810","gi|529013085|ref|XP_005227340.1|",972,{"v":4e-127,"d":"4.00E-127"},"PREDICTED: troponin T, fast skeletal muscle isoform X7 [Bos taurus]","gi|741980488|ref|XM_005227283.2|",1108,0,"PREDICTED: Bos taurus troponin T type 3 (skeletal, fast) (TNNT3), transcript variant X7, mRNA","P02641",301,{"v":6e-99,"d":"6.00E-99"},"Troponin T, fast skeletal muscle",".",".",".",".","pfam00992","Troponin","Troponin. Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). this Pfam contains members of the TnT subunit. Troponin is a complex of three proteins, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). The troponin complex regulates Ca++ induced muscle contraction. This family includes troponin T and troponin I. Troponin I binds to actin and troponin T binds to tropomyosin.","GO:0006942|regulation of striated muscle contraction;","GO:0005861|troponin complex;",".",".","."]
["bta_circ_0014196",11,35,56,44.8789548866896,52,83,51,-1.15463732237574,0.033104960035919,0.428634275476763,"down","yes","NC_037356.1:9552575..9567248:+","gene32025","gi|926726711|ref|XP_013831210.1|",3576,0,"PREDICTED: phosphatidylinositol-binding clathrin assembly protein isoform X1 [Capra hircus]","gi|965858137|ref|XM_012143546.2|",4070,0,"PREDICTED: Ovis aries musimon phosphatidylinositol binding clathrin assembly protein (PICALM), transcript variant X6, mRNA","Q7M6Y3",1296,0,"Phosphatidylinositol-binding clathrin assembly protein",".",".",".",".","pfam07651","ANTH","ANTH domain. AP180 is an endocytotic accessory proteins that has been implicated in the formation of clathrin-coated pits.  The domain is involved in phosphatidylinositol 4,5-bisphosphate binding and is a universal adaptor for nucleation of clathrin coats.","GO:0007409|axonogenesis;GO:0035459|cargo loading into vesicle;GO:0008283|cell proliferation;GO:0048268|clathrin coat assembly;GO:0072583|clathrin-mediated endocytosis;GO:0048813|dendrite morphogenesis;GO:0016197|endosomal transport;GO:0030097|hemopoiesis;GO:0055072|iron ion homeostasis;GO:0098711|iron ion import across plasma membrane;GO:0007611|learning or memory;GO:0090647|modulation of age-related behavioral decline;GO:0010629|negative regulation of gene expression;GO:1902963|negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process;GO:2000009|negative regulation of protein localization to cell surface;GO:1903077|negative regulation of protein localization to plasma membrane;GO:0048261|negative regulation of receptor-mediated endocytosis;GO:1900223|positive regulation of beta-amyloid clearance;GO:1902004|positive regulation of beta-amyloid formation;GO:1902961|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;GO:0050772|positive regulation of axonogenesis;GO:1903861|positive regulation of dendrite extension;GO:0043547|positive regulation of GTPase activity;GO:1901216|positive regulation of neuron death;GO:2000809|positive regulation of synaptic vesicle clustering;GO:1900244|positive regulation of synaptic vesicle endocytosis;GO:0045893|positive regulation of transcription, DNA-templated;GO:0031623|receptor internalization;GO:0006898|receptor-mediated endocytosis;GO:1902959|regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;GO:0030100|regulation of endocytosis;GO:0032880|regulation of protein localization;GO:0051223|regulation of protein transport;GO:1900242|regulation of synaptic vesicle endocytosis;GO:1902803|regulation of synaptic vesicle transport;GO:2000331|regulation of terminal button organization;GO:0097494|regulation of vesicle size;GO:0016188|synaptic vesicle maturation;GO:0045056|transcytosis;GO:0016050|vesicle organization;GO:0016192|vesicle-mediated transport;","GO:0030122|AP-2 adaptor complex;GO:0009986|cell surface;GO:0005905|coated pit;GO:0030136|clathrin-coated vesicle;GO:0005769|early endosome;GO:0005768|endosome;GO:0070381|endosome to plasma membrane transport vesicle;GO:0005794|Golgi apparatus;GO:0005622|intracellular;GO:0043231|intracellular membrane-bounded organelle;GO:0031224|intrinsic component of membrane;GO:0097418|neurofibrillary tangle;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0045211|postsynaptic membrane;GO:0042734|presynaptic membrane;GO:0045202|synapse;GO:0008021|synaptic vesicle;GO:0031982|vesicle;","GO:0005545|1-phosphatidylinositol binding;GO:0045296|cadherin binding;GO:0035615|clathrin adaptor activity;GO:0030276|clathrin binding;GO:0032050|clathrin heavy chain binding;GO:0042802|identical protein binding;GO:0050750|low-density lipoprotein particle receptor binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0017137|Rab GTPase binding;GO:0017124|SH3 domain binding;GO:0000149|SNARE binding;",".","."]
["bta_circ_0014202",7,27,13,25.2512580160878,34,32,42,-1.54514449771499,0.0154428354816962,0.298906981742218,"down","yes","NC_037356.1:9552575..9605079:+","gene32025","gi|926726711|ref|XP_013831210.1|",3576,0,"PREDICTED: phosphatidylinositol-binding clathrin assembly protein isoform X1 [Capra hircus]","gi|965858137|ref|XM_012143546.2|",4070,0,"PREDICTED: Ovis aries musimon phosphatidylinositol binding clathrin assembly protein (PICALM), transcript variant X6, mRNA","Q7M6Y3",1296,0,"Phosphatidylinositol-binding clathrin assembly protein",".",".",".",".","pfam07651","ANTH","ANTH domain. AP180 is an endocytotic accessory proteins that has been implicated in the formation of clathrin-coated pits.  The domain is involved in phosphatidylinositol 4,5-bisphosphate binding and is a universal adaptor for nucleation of clathrin coats.","GO:0007409|axonogenesis;GO:0035459|cargo loading into vesicle;GO:0008283|cell proliferation;GO:0048268|clathrin coat assembly;GO:0072583|clathrin-mediated endocytosis;GO:0048813|dendrite morphogenesis;GO:0016197|endosomal transport;GO:0030097|hemopoiesis;GO:0055072|iron ion homeostasis;GO:0098711|iron ion import across plasma membrane;GO:0007611|learning or memory;GO:0090647|modulation of age-related behavioral decline;GO:0010629|negative regulation of gene expression;GO:1902963|negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process;GO:2000009|negative regulation of protein localization to cell surface;GO:1903077|negative regulation of protein localization to plasma membrane;GO:0048261|negative regulation of receptor-mediated endocytosis;GO:1900223|positive regulation of beta-amyloid clearance;GO:1902004|positive regulation of beta-amyloid formation;GO:1902961|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;GO:0050772|positive regulation of axonogenesis;GO:1903861|positive regulation of dendrite extension;GO:0043547|positive regulation of GTPase activity;GO:1901216|positive regulation of neuron death;GO:2000809|positive regulation of synaptic vesicle clustering;GO:1900244|positive regulation of synaptic vesicle endocytosis;GO:0045893|positive regulation of transcription, DNA-templated;GO:0031623|receptor internalization;GO:0006898|receptor-mediated endocytosis;GO:1902959|regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;GO:0030100|regulation of endocytosis;GO:0032880|regulation of protein localization;GO:0051223|regulation of protein transport;GO:1900242|regulation of synaptic vesicle endocytosis;GO:1902803|regulation of synaptic vesicle transport;GO:2000331|regulation of terminal button organization;GO:0097494|regulation of vesicle size;GO:0016188|synaptic vesicle maturation;GO:0045056|transcytosis;GO:0016050|vesicle organization;GO:0016192|vesicle-mediated transport;","GO:0030122|AP-2 adaptor complex;GO:0009986|cell surface;GO:0005905|coated pit;GO:0030136|clathrin-coated vesicle;GO:0005769|early endosome;GO:0005768|endosome;GO:0070381|endosome to plasma membrane transport vesicle;GO:0005794|Golgi apparatus;GO:0005622|intracellular;GO:0043231|intracellular membrane-bounded organelle;GO:0031224|intrinsic component of membrane;GO:0097418|neurofibrillary tangle;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0045211|postsynaptic membrane;GO:0042734|presynaptic membrane;GO:0045202|synapse;GO:0008021|synaptic vesicle;GO:0031982|vesicle;","GO:0005545|1-phosphatidylinositol binding;GO:0045296|cadherin binding;GO:0035615|clathrin adaptor activity;GO:0030276|clathrin binding;GO:0032050|clathrin heavy chain binding;GO:0042802|identical protein binding;GO:0050750|low-density lipoprotein particle receptor binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0017137|Rab GTPase binding;GO:0017124|SH3 domain binding;GO:0000149|SNARE binding;",".","."]
["bta_circ_0014227",6,26,34,11.0465509316816,5,4,5,1.74229597998866,0.0495813876034767,0.476348344536443,"up","yes","NC_037357.1:105678395..105678852:-","gene34118","gi|594085955|ref|XP_006066494.1|",2092,0,"PREDICTED: membrane transport protein XK [Bubalus bubalis]","gi|983011503|ref|XM_015470519.1|",4242,0,"PREDICTED: Bos taurus X-linked Kx blood group (XK), transcript variant X2, mRNA","P51811",693,0,"Membrane transport protein XK",".",".",".",".","pfam09815","XK-related","XK-related protein. Members of this family comprise various XK-related proteins, that are involved in sodium-dependent transport of neutral amino acids or oligopeptides. These proteins are responsible for the Kx blood group system - defects results in McLeod syndrome, an X-linked multi-system disorder characterized by late onset abnormalities in the neuromuscular and hematopoietic systems.","GO:0006865|amino acid transport;GO:0006874|cellular calcium ion homeostasis;GO:0010961|cellular magnesium ion homeostasis;GO:0042552|myelination;GO:0031133|regulation of axon diameter;GO:0008361|regulation of cell size;GO:0048741|skeletal muscle fiber development;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0005215|transporter activity;","K19522","XK; membrane transport protein XK"]
["bta_circ_0014237",2,8,3,1.73272266869806,0,0,0,4.09904178813999,0.042367916117307,"NA","up","yes","NC_037357.1:110617904..110619470:+","gene34158","gi|555975635|ref|XP_005899799.1|",18321,0,"PREDICTED: dystrophin isoform X1 [Bos mutus]","gi|942066302|ref|XM_005899737.2|",13390,0,"PREDICTED: Bos mutus dystrophin (DMD), transcript variant X1, mRNA","Q5GN48",6719,0,"Dystrophin","ECU09g0290",147,{"v":3e-35,"d":"3.00E-35"},"COG5069","pfam09068","EF-hand_2","EF hand. Members of this family adopt a helix-loop-helix motif, as per other EF hand domains. However, since they do not contain the canonical pattern of calcium binding residues found in many EF hand domains, they do not bind calcium ions. The main function of this domain is the provision of specificity in beta-dystroglycan recognition, though in dystrophin it serves an additional role: stabilisation of the WW domain (pfam00397), enhancing dystroglycan binding.",".","GO:0030054|cell junction;GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0045211|postsynaptic membrane;GO:0042383|sarcolemma;","GO:0003779|actin binding;GO:0002162|dystroglycan binding;GO:0008270|zinc ion binding;","K10366","DMD; dystrophin"]
["bta_circ_0014265",0,0,0,1.78676880119091,4,3,3,-4.25571567454143,0.0325416421682752,"NA","down","yes","NC_037357.1:110922706..111104349:+","gene34158","gi|555975635|ref|XP_005899799.1|",18321,0,"PREDICTED: dystrophin isoform X1 [Bos mutus]","gi|942066302|ref|XM_005899737.2|",13390,0,"PREDICTED: Bos mutus dystrophin (DMD), transcript variant X1, mRNA","Q5GN48",6719,0,"Dystrophin","ECU09g0290",147,{"v":3e-35,"d":"3.00E-35"},"COG5069","pfam09068","EF-hand_2","EF hand. Members of this family adopt a helix-loop-helix motif, as per other EF hand domains. However, since they do not contain the canonical pattern of calcium binding residues found in many EF hand domains, they do not bind calcium ions. The main function of this domain is the provision of specificity in beta-dystroglycan recognition, though in dystrophin it serves an additional role: stabilisation of the WW domain (pfam00397), enhancing dystroglycan binding.",".","GO:0030054|cell junction;GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0045211|postsynaptic membrane;GO:0042383|sarcolemma;","GO:0003779|actin binding;GO:0002162|dystroglycan binding;GO:0008270|zinc ion binding;","K10366","DMD; dystrophin"]
["bta_circ_0014295",0,0,0,3.2292197044723,6,0,11,-4.95862302412337,0.0101461917765892,"NA","down","yes","NC_037357.1:119362465..119369191:+","gene34220","gi|115497246|ref|NP_001069107.1|",1048,{"v":3e-140,"d":"3.00E-140"},"MICOS complex subunit MIC26 precursor [Bos taurus]","gi|555984419|ref|XM_005904035.1|",854,0,"PREDICTED: Bos mutus apolipoprotein O (APOO), mRNA","Q148H0",408,{"v":1e-141,"d":"1.00E-141"},"MICOS complex subunit MIC26",".",".",".",".","pfam09769","ApoO","Apolipoprotein O. Members of this family promote cholesterol efflux from macrophage cells. They are present in various lipoprotein complexes, including HDL, LDL and VLDL. The apoprotein is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL.","GO:0042407|cristae formation;GO:0006869|lipid transport;","GO:0005789|endoplasmic reticulum membrane;GO:0005576|extracellular region;GO:0000139|Golgi membrane;GO:0034364|high-density lipoprotein particle;GO:0031305|integral component of mitochondrial inner membrane;GO:0034362|low-density lipoprotein particle;GO:0061617|MICOS complex;GO:0034361|very-low-density lipoprotein particle;",".",".","."]
["bta_circ_0014299",0,0,0,1.49071053578121,2,4,3,-3.98795477844532,0.0488172144896434,"NA","down","yes","NC_037357.1:121452079..121454262:-","gene34236","gi|741983630|ref|XP_010820447.1|",2836,0,"PREDICTED: membrane-bound transcription factor site-2 protease isoform X1 [Bos taurus]","gi|742197756|ref|XM_010858790.1|",3835,0,"PREDICTED: Bison bison bison transcriptional repressor protein YY1-like (LOC105002256), partial mRNA","O15391",395,{"v":2e-122,"d":"2.00E-122"},"Transcription factor YY2",".",".",".",".","pfam02163","Peptidase_M50","Peptidase family M50.","GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0006357|regulation of transcription from RNA polymerase II promoter;","GO:0005634|nucleus;","GO:0046872|metal ion binding;GO:0000987|core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0001228|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;","K09201","YY; transcription factor YY"]
["bta_circ_0014304",6,5,2,2.49801214728059,0,0,0,4.54829047259988,0.0205766586986696,"NA","up","yes","NC_037357.1:122956976..123009119:+","gene34246","gi|537132932|gb|ERE65852.1|",3751,0,"ribosomal protein S6 kinase alpha-3 [Cricetulus griseus]","gi|982974583|ref|XM_005228374.3|",7770,0,"PREDICTED: Bos taurus ribosomal protein S6 kinase, 90kDa, polypeptide 3 (RPS6KA3), transcript variant X1, mRNA","P18654",1429,0,"Ribosomal protein S6 kinase alpha-3",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0007049|cell cycle;GO:0035556|intracellular signal transduction;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0032496|response to lipopolysaccharide;GO:0002224|toll-like receptor signaling pathway;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0043027|cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0000287|magnesium ion binding;GO:0019901|protein kinase binding;GO:0004674|protein serine/threonine kinase activity;","K04373","RPS6KA, RSK2; p90 ribosomal S6 kinase [EC:2.7.11.1]"]
["bta_circ_0014304",6,5,2,2.49801214728059,0,0,0,4.54829047259988,0.0205766586986696,"NA","up","yes","NC_037357.1:122956976..123009119:+","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0014319",0,0,0,1.96888625144843,3,2,6,-4.39015973851376,0.0262997407740893,"NA","down","yes","NC_037357.1:125093662..125107425:+","gene34280","gi|529015903|ref|XP_005228452.1|",3554,0,"PREDICTED: sex comb on midleg-like protein 2 isoform X1 [Bos taurus]","gi|982974610|ref|XM_005228395.3|",4001,0,"PREDICTED: Bos taurus sex comb on midleg-like 2 (Drosophila) (SCML2), transcript variant X1, mRNA","Q9UQR0",1003,0,"Sex comb on midleg-like protein 2",".",".",".",".","pfam12140","DUF3588","Protein of unknown function (DUF3588). This family of proteins is found in eukaryotes. Proteins in this family are typically between 129 and 866 amino acids in length, and the family is found in association with pfam02820. The exact function of this family is not known.","GO:0009653|anatomical structure morphogenesis;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;GO:0031519|PcG protein complex;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;","K11465","SCML2; sex comb on midleg-like protein 2"]
["bta_circ_0014340",0,14,5,1.96956624023832,0,0,0,4.16970611211419,0.0393827908396483,"NA","up","yes","NC_037357.1:134514472..134561157:-","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0014355",7,8,0,2.82515131709031,0,0,0,4.58786997680683,0.0201000311839465,"NA","up","yes","NC_037357.1:136920456..136921001:+","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0014384",0,0,0,2.81043992485901,3,7,7,-4.96055337405347,0.00910245441308604,"NA","down","yes","NC_037357.1:3175025..3212537:+","gene32911","gi|331999937|ref|NP_001193606.1|",2083,0,"interleukin-13 receptor subunit alpha-1 precursor [Bos taurus]","gi|331999936|ref|NM_001206677.1|",3698,0,"Bos taurus interleukin 13 receptor, alpha 1 (IL13RA1), mRNA","P78552",679,0,"Interleukin-13 receptor subunit alpha-1",".",".",".",".","pfam09240","IL6Ra-bind","Interleukin-6 receptor alpha chain, binding. Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.","GO:0007166|cell surface receptor signaling pathway;GO:0019221|cytokine-mediated signaling pathway;","GO:0005898|interleukin-13 receptor complex;GO:0005886|plasma membrane;","GO:0004896|cytokine receptor activity;","K05076","IL13RA1; interleukin 13 receptor alpha-1"]
["bta_circ_0014424",0,4,16,2.41050429739871,0,0,0,4.43294338541692,0.0261793509520176,"NA","up","yes","NC_037357.1:51102360..51133602:+","gene33483","gi|529014456|ref|XP_005227876.1|",2944,0,"PREDICTED: LOW QUALITY PROTEIN: tRNA (uracil(54)-C(5))-methyltransferase homolog [Bos taurus]","gi|983010745|ref|XM_015470330.1|",2469,0,"PREDICTED: Bos taurus tRNA methyltransferase 2 homolog B (TRMT2B), mRNA","Q96GJ1",795,0,"tRNA (uracil(54)-C(5))-methyltransferase homolog","CAC1435",96.3,{"v":4e-20,"d":"4.00E-20"},"COG2265","pfam13847","Methyltransf_31","Methyltransferase domain. This family appears to be have methyltransferase activity.",".",".","GO:0030697|S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity;","K15331","TRMT2B, TRM2; tRNA (uracil-5-)-methyltransferase [EC:2.1.1.35]"]
["bta_circ_0014454",0,0,0,2.08518267110329,6,6,0,-4.31749837143554,0.0311397764847497,"NA","down","yes","NC_037357.1:58638385..58676788:-","gene33583","gi|593708517|ref|XP_007100878.1|",1221,{"v":9e-150,"d":"9.00E-150"},"PREDICTED: LOW QUALITY PROTEIN: AMME syndrome candidate gene 1 protein [Physeter catodon]","gi|594096803|ref|XM_006071596.1|",5148,0,"PREDICTED: Bubalus bubalis Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 (AMMECR1), transcript variant X1, mRNA","Q9Y4X0",471,{"v":5e-150,"d":"5.00E-150"},"AMME syndrome candidate gene 1 protein","SPAC688.03c",129,{"v":4e-32,"d":"4.00E-32"},"COG2078","pfam01871","AMMECR1","AMMECR1. This family consists of several AMMECR1 as well as several uncharacterized proteins. The contiguous gene deletion syndrome AMME is characterized by Alport syndrome, midface hypoplasia, mental retardation and elliptocytosis and is caused by a deletion in Xq22.3, comprising several genes including COL4A5, FACL4 and AMMECR1. This family contains sequences from several eukaryotic species as well as archaebacteria and it has been suggested that the AMMECR1 protein may have a basic cellular function, potentially in either the transcription, replication, repair or translation machinery.",".","GO:0005634|nucleus;",".",".","."]
["bta_circ_0014567",0,0,0,1.84616473724484,2,8,2,-4.3075407660565,0.0301969490433213,"NA","down","yes","NC_037357.1:91553159..91589316:-","gene33980","gi|983011363|ref|XP_015325981.1|",5011,0,"PREDICTED: LOW QUALITY PROTEIN: constitutive coactivator of PPAR-gamma-like protein 2 isoform X2 [Bos taurus]","gi|983011362|ref|XM_015470495.1|",7834,0,"PREDICTED: Bos taurus family with sequence similarity 120C (FAM120C), transcript variant X2, mRNA","Q9NX05",1803,0,"Constitutive coactivator of PPAR-gamma-like protein 2",".",".",".",".","pfam06346","Drf_FH1","Formin Homology Region 1. This region is found in some of the Diaphanous related formins (Drfs). It consists of low complexity repeats of around 12 residues.",".","GO:0005634|nucleus;","GO:0003723|RNA binding;",".","."]
["bta_circ_0014578",257,949,807,383.736240711954,138,342,227,1.21272016298648,0.000572608049926039,0.0442135215692891,"up","yes","NC_037357.1:92407499..92421831:-","gene33995","gi|741983100|ref|XP_010820287.1|",3157,0,"PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X1 [Bos taurus]","gi|982974154|ref|XM_010821985.2|",2452,0,"PREDICTED: Bos taurus 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (PFKFB1), transcript variant X1, mRNA","P49872",960,0,"6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1","YJL155c_2",228,{"v":2e-67,"d":"2.00E-67"},"COG0406","pfam01591","6PF2K","6-phosphofructo-2-kinase. This enzyme occurs as a bifunctional enzyme with fructose-2,6-bisphosphatase. The bifunctional enzyme catalyses both the synthesis and degradation of fructose-2,6-bisphosphate, a potent regulator of glycolysis. This enzyme contains a P-loop motif.","GO:0006003|fructose 2,6-bisphosphate metabolic process;GO:0006000|fructose metabolic process;","GO:0043540|6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex;","GO:0003873|6-phosphofructo-2-kinase activity;GO:0005524|ATP binding;GO:0004331|fructose-2,6-bisphosphate 2-phosphatase activity;","K19028","PFKFB1; 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 1 [EC:2.7.1.105 3.1.3.46]"]
["bta_circ_0014594",5,5,0,1.94982608658825,0,0,0,4.04273317719192,0.047352037077062,"NA","up","yes","NC_037357.1:96357678..96420419:+","gene34037","gi|982974274|ref|XP_015317205.1|",5905,0,"PREDICTED: rho guanine nucleotide exchange factor 9 isoform X1 [Bos taurus]","gi|982974273|ref|XM_015461719.1|",6956,0,"PREDICTED: Bos taurus Cdc42 guanine nucleotide exchange factor 9 (ARHGEF9), transcript variant X1, mRNA","Q58DL7",1152,0,"Rho guanine nucleotide exchange factor 9",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0035023|regulation of Rho protein signal transduction;","GO:0005829|cytosol;","GO:0005089|Rho guanyl-nucleotide exchange factor activity;",".","."]
["bta_circ_0014608",5,0,5,2.10689120535808,0,0,0,4.14934328614932,0.0406319064516502,"NA","up","yes","NW_020190741.1:102309..107253:+","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0014609",11,6,0,3.81264341116033,0,0,0,4.98078717843719,0.00981042038399304,"NA","up","yes","NW_020190741.1:102309..109701:+","Null",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["bta_circ_0014620",0,0,0,4.30671861241728,4,10,12,-5.58651014922784,0.00222375134096761,"NA","down","yes","NW_020190994.1:109502..140628:+","gene34652","gi|594101968|ref|XP_006074062.1|",5049,0,"PREDICTED: multidrug resistance-associated protein 4-like isoform X1 [Bubalus bubalis]","gi|982992187|ref|XM_015465772.1|",2594,0,"PREDICTED: Bos taurus multidrug resistance-associated protein 4 (LOC100299180), transcript variant X7, mRNA","O15439",1774,0,"Multidrug resistance-associated protein 4","SPAC3F10.11c",662,0,"COG1132","pfam00664","ABC_membrane","ABC transporter transmembrane region. This family represents a unit of six transmembrane helices. Many members of the ABC transporter family (pfam00005) have two such regions.","GO:0060271|cilium morphogenesis;GO:0002576|platelet degranulation;GO:0032310|prostaglandin secretion;GO:0055085|transmembrane transport;","GO:0016323|basolateral plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0005886|plasma membrane;GO:0031088|platelet dense granule membrane;","GO:0016404|15-hydroxyprostaglandin dehydrogenase (NAD+) activity;GO:0005524|ATP binding;GO:0015662|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;GO:0043225|anion transmembrane-transporting ATPase activity;","K05673","ABCC4; ATP-binding cassette, subfamily C (CFTR/MRP), member 4"]
["bta_circ_0014626",0,0,0,1.70524010597907,3,4,3,-4.19544627199463,0.035742357707695,"NA","down","yes","NW_020190994.1:91661..140628:+","gene34652","gi|594101968|ref|XP_006074062.1|",5049,0,"PREDICTED: multidrug resistance-associated protein 4-like isoform X1 [Bubalus bubalis]","gi|982992187|ref|XM_015465772.1|",2594,0,"PREDICTED: Bos taurus multidrug resistance-associated protein 4 (LOC100299180), transcript variant X7, mRNA","O15439",1774,0,"Multidrug resistance-associated protein 4","SPAC3F10.11c",662,0,"COG1132","pfam00664","ABC_membrane","ABC transporter transmembrane region. This family represents a unit of six transmembrane helices. Many members of the ABC transporter family (pfam00005) have two such regions.","GO:0060271|cilium morphogenesis;GO:0002576|platelet degranulation;GO:0032310|prostaglandin secretion;GO:0055085|transmembrane transport;","GO:0016323|basolateral plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0005886|plasma membrane;GO:0031088|platelet dense granule membrane;","GO:0016404|15-hydroxyprostaglandin dehydrogenase (NAD+) activity;GO:0005524|ATP binding;GO:0015662|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;GO:0043225|anion transmembrane-transporting ATPase activity;","K05673","ABCC4; ATP-binding cassette, subfamily C (CFTR/MRP), member 4"]
["bta_circ_0014640",14,12,12,7.32006518160371,0,0,3,3.30990751593896,0.00868685965177485,0.24390896840438,"up","yes","NW_020192294.1:968193..968781:+","gene35143","gi|803260035|ref|XP_011989763.1|",162,{"v":2e-09,"d":"2.00E-09"},"PREDICTED: EF-hand calcium-binding domain-containing protein 1 isoform X5 [Ovis aries musimon]","gi|983011779|ref|XR_001500190.1|",1179,0,"PREDICTED: Bos taurus uncharacterized LOC104970622 (LOC104970622), ncRNA",".",".",".",".",".",".",".",".","pfam04095","NAPRTase","Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyses the first reaction in the NAD salvage synthesis. This family also includes Pre-B cell enhancing factor that is a cytokine. This family is related to Quinolinate phosphoribosyltransferase pfam01729.",".",".",".",".","."]